LOCUS       NP_004657                513 aa            linear   PRI 24-SEP-2024
DEFINITION  pantetheinase precursor [Homo sapiens].
ACCESSION   NP_004657
VERSION     NP_004657.2
DBSOURCE    REFSEQ: accession NM_004666.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 513)
  AUTHORS   Zierfuss,B., Karlinger,A., Bojic,M., Koppensteiner,R.,
            Schernthaner,G.H. and Hobaus,C.
  TITLE     Urinary vanin-1 as a novel biomarker for survival in peripheral
            artery disease
  JOURNAL   Vasc Med 29 (4), 390-397 (2024)
   PUBMED   38607943
  REMARK    GeneRIF: Urinary vanin-1 as a novel biomarker for survival in
            peripheral artery disease.
REFERENCE   2  (residues 1 to 513)
  AUTHORS   Lu,P., Zhang,C., Fu,L., Wei,Y., Huang,Y., Wang,X., Lv,C. and
            Chen,L.
  TITLE     Near-Infrared Fluorescent Probe for Imaging and Evaluating the Role
            of Vanin-1 in Chemotherapy
  JOURNAL   Anal Chem 93 (29), 10378-10387 (2021)
   PUBMED   34275284
  REMARK    GeneRIF: Near-Infrared Fluorescent Probe for Imaging and Evaluating
            the Role of Vanin-1 in Chemotherapy.
REFERENCE   3  (residues 1 to 513)
  AUTHORS   Krzemien,G., Panczyk-Tomaszewska,M., Gorska,E. and Szmigielska,A.
  TITLE     Urinary vanin-1 for predicting acute pyelonephritis in young
            children with urinary tract infection: a pilot study
  JOURNAL   Biomarkers 26 (4), 318-324 (2021)
   PUBMED   33656956
  REMARK    GeneRIF: Urinary vanin-1 for predicting acute pyelonephritis in
            young children with urinary tract infection: a pilot study.
REFERENCE   4  (residues 1 to 513)
  AUTHORS   Xiang,H., Guo,F., Tao,X., Zhou,Q., Xia,S., Deng,D., Li,L. and
            Shang,D.
  TITLE     Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis
            by targeting VNN1-mediated ROS release to inhibit NLRP3 activation
  JOURNAL   Theranostics 11 (9), 4467-4482 (2021)
   PUBMED   33754072
  REMARK    GeneRIF: Pancreatic ductal deletion of S100A9 alleviates acute
            pancreatitis by targeting VNN1-mediated ROS release to inhibit
            NLRP3 activation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 513)
  AUTHORS   Bartucci,R., Salvati,A., Olinga,P. and Boersma,Y.L.
  TITLE     Vanin 1: Its Physiological Function and Role in Diseases
  JOURNAL   Int J Mol Sci 20 (16), 3891 (2019)
   PUBMED   31404995
  REMARK    GeneRIF: This review discusses the role of vanin 1 in the liver,
            kidney, intestine, and lung under physiological as well as
            pathophysiological conditions. [review]
            Review article
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 513)
  AUTHORS   Martin,F., Penet,M.F., Malergue,F., Lepidi,H., Dessein,A.,
            Galland,F., de Reggi,M., Naquet,P. and Gharib,B.
  TITLE     Vanin-1(-/-) mice show decreased NSAID- and Schistosoma-induced
            intestinal inflammation associated with higher glutathione stores
  JOURNAL   J Clin Invest 113 (4), 591-597 (2004)
   PUBMED   14966568
REFERENCE   7  (residues 1 to 513)
  AUTHORS   Martin,F., Malergue,F., Pitari,G., Philippe,J.M., Philips,S.,
            Chabret,C., Granjeaud,S., Mattei,M.G., Mungall,A.J., Naquet,P. and
            Galland,F.
  TITLE     Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and
            encode isoforms of pantetheinase ectoenzymes
  JOURNAL   Immunogenetics 53 (4), 296-306 (2001)
   PUBMED   11491533
REFERENCE   8  (residues 1 to 513)
  AUTHORS   Maras,B., Barra,D., Dupre,S. and Pitari,G.
  TITLE     Is pantetheinase the actual identity of mouse and human vanin-1
            proteins?
  JOURNAL   FEBS Lett 461 (3), 149-152 (1999)
   PUBMED   10567687
REFERENCE   9  (residues 1 to 513)
  AUTHORS   Galland,F., Malergue,F., Bazin,H., Mattei,M.G., Aurrand-Lions,M.,
            Theillet,C. and Naquet,P.
  TITLE     Two human genes related to murine vanin-1 are located on the long
            arm of human chromosome 6
  JOURNAL   Genomics 53 (2), 203-213 (1998)
   PUBMED   9790769
REFERENCE   10 (residues 1 to 513)
  AUTHORS   Aurrand-Lions,M., Galland,F., Bazin,H., Zakharyev,V.M., Imhof,B.A.
            and Naquet,P.
  TITLE     Vanin-1, a novel GPI-linked perivascular molecule involved in
            thymus homing
  JOURNAL   Immunity 5 (5), 391-405 (1996)
   PUBMED   8934567
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BJ995136.1, BC096266.3 and
            AL032821.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 14, 2009 this sequence version replaced NP_004657.1.
            
            Summary: This gene encodes a member of the vanin family of
            proteins, which share extensive sequence similarity with each
            other, and also with biotinidase. The family includes secreted and
            membrane-associated proteins, a few of which have been reported to
            participate in hematopoietic cell trafficking. No biotinidase
            activity has been demonstrated for any of the vanin proteins,
            however, they possess pantetheinase activity, which may play a role
            in oxidative-stress response. This protein, like its mouse homolog,
            is likely a GPI-anchored cell surface molecule. The mouse protein
            is expressed by the perivascular thymic stromal cells and regulates
            migration of T-cell progenitors to the thymus. This gene lies in
            close proximity to, and in the same transcriptional orientation as,
            two other vanin genes on chromosome 6q23-q24. [provided by RefSeq,
            Feb 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.177032.1, AJ132099.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367928.5/ ENSP00000356905.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     Protein         1..513
                     /product="pantetheinase precursor"
                     /EC_number="3.5.1.92"
                     /note="pantetheinase; vannin 1; pantetheine hydrolase;
                     vascular non-inflammatory molecule 1"
                     /calculated_mol_wt=54682
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2348
     mat_peptide     22..513
                     /product="pantetheinase"
                     /calculated_mol_wt=54682
     Region          25..330
                     /region_name="biotinidase_like"
                     /note="biotinidase and vanins (class 4 nitrilases);
                     cd07567"
                     /db_xref="CDD:143591"
     Site            38
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:15084671,
                     ECO:0007744|PDB:4CYF, ECO:0007744|PDB:4CYG,
                     ECO:0007744|PDB:4CYY; propagated from UniProtKB/Swiss-Prot
                     (O95497.2)"
     Site            order(79,178,182,185,211..212,214..215,237)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:143591"
     Site            order(79,178,211)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:143591"
     Site            130
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0007744|PDB:4CYF, ECO:0007744|PDB:4CYG,
                     ECO:0007744|PDB:4CYY; propagated from UniProtKB/Swiss-Prot
                     (O95497.2)"
     Site            order(179..182,184,191..193,212,214..218,221..222,
                     243..244,246..248,250..251,275..276,326..330)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:143591"
     Site            200
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255, ECO:0007744|PDB:4CYY; propagated
                     from UniProtKB/Swiss-Prot (O95497.2)"
     Site            283
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952; propagated from
                     UniProtKB/Swiss-Prot (O95497.2)"
     Site            315
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0007744|PDB:4CYF, ECO:0007744|PDB:4CYG,
                     ECO:0007744|PDB:4CYY; propagated from UniProtKB/Swiss-Prot
                     (O95497.2)"
     Region          333..483
                     /region_name="Vanin_C"
                     /note="Vanin C-terminal domain; pfam19018"
                     /db_xref="CDD:465946"
     Site            353
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:15084671,
                     ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218,
                     ECO:0007744|PDB:4CYF, ECO:0007744|PDB:4CYG,
                     ECO:0007744|PDB:4CYY; propagated from UniProtKB/Swiss-Prot
                     (O95497.2)"
     CDS             1..513
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /coded_by="NM_004666.3:21..1562"
                     /db_xref="CCDS:CCDS5159.1"
                     /db_xref="GeneID:8876"
                     /db_xref="HGNC:HGNC:12705"
                     /db_xref="MIM:603570"
ORIGIN      
        1 mttqlpayva illfyvsras cqdtftaavy ehaailpnat ltpvsreeal almnrnldil
       61 egaitsaadq gahiivtped aiygwnfnrd slypyledip dpevnwipcn nrnrfgqtpv
      121 qerlsclakn nsiyvvanig dkkpcdtsdp qcppdgryqy ntdvvfdsqg klvaryhkqn
      181 lfmgenqfnv pkepeivtfn ttfgsfgift cfdilfhdpa vtlvkdfhvd tivfptawmn
      241 vlphlsavef hsawamgmrv nflasnihyp skkmtgsgiy apnssrafhy dmkteegkll
      301 lsqldshpsh savvnwtsya ssiealssgn kefkgtvffd eftfvkltgv agnytvcqkd
      361 lcchlsykms enipnevyal gafdglhtve gryylqictl lkckttnlnt cgdsaetast
      421 rfemfslsgt fgtqyvfpev llsenqlapg efqvstdgrl fslkptsgpv ltvtlfgrly
      481 ekdwasnass gltaqariim liviapivcs lsw
//
