LOCUS       NM_020633               2351 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens vomeronasal 1 receptor 1 (VN1R1), mRNA.
ACCESSION   NM_020633
VERSION     NM_020633.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2351)
  AUTHORS   Henningsson,S., Hovey,D., Vass,K., Walum,H., Sandnabba,K.,
            Santtila,P., Jern,P. and Westberg,L.
  TITLE     A missense polymorphism in the putative pheromone receptor gene
            VN1R1 is associated with sociosexual behavior
  JOURNAL   Transl Psychiatry 7 (4), e1102 (2017)
   PUBMED   28440809
  REMARK    GeneRIF: the reported association in this study suggests that, as a
            result of genetic variation, naturally occurring endogenous
            modulation of VN1R1 function affects women's socio-sexual behavior,
            and that humans thus communicate via chemo-signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2351)
  AUTHORS   Corin,K., Baaske,P., Geissler,S., Wienken,C.J., Duhr,S., Braun,D.
            and Zhang,S.
  TITLE     Structure and function analyses of the purified GPCR human
            vomeronasal type 1 receptor 1
  JOURNAL   Sci Rep 1, 172 (2011)
   PUBMED   22355687
  REMARK    GeneRIF: Structure and function analyses of the purified GPCR human
            vomeronasal type 1 receptor 1
REFERENCE   3  (bases 1 to 2351)
  AUTHORS   Young,J.M., Massa,H.F., Hsu,L. and Trask,B.J.
  TITLE     Extreme variability among mammalian V1R gene families
  JOURNAL   Genome Res 20 (1), 10-18 (2010)
   PUBMED   19952141
REFERENCE   4  (bases 1 to 2351)
  AUTHORS   Mitropoulos,C., Papachatzopoulou,A., Menounos,P.G., Kolonelou,C.,
            Pappa,M., Bertolis,G., Gerou,S. and Patrinos,G.P.
  TITLE     Association study of human VN1R1 pheromone receptor gene alleles
            and gender
  JOURNAL   Genet Test 11 (2), 128-132 (2007)
   PUBMED   17627382
  REMARK    GeneRIF: The human VN1R1 gene are unlikely to be associated with
            gender and hence to contribute to distinct gender-specific
            behavior.
            GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2351)
  AUTHORS   Zhang,J. and Webb,D.M.
  TITLE     Evolutionary deterioration of the vomeronasal pheromone
            transduction pathway in catarrhine primates
  JOURNAL   Proc Natl Acad Sci U S A 100 (14), 8337-8341 (2003)
   PUBMED   12826614
REFERENCE   6  (bases 1 to 2351)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   7  (bases 1 to 2351)
  AUTHORS   Pantages,E. and Dulac,C.
  TITLE     A novel family of candidate pheromone receptors in mammals
  JOURNAL   Neuron 28 (3), 835-845 (2000)
   PUBMED   11163270
REFERENCE   8  (bases 1 to 2351)
  AUTHORS   Giorgi,D., Friedman,C., Trask,B.J. and Rouquier,S.
  TITLE     Characterization of nonfunctional V1R-like pheromone receptor
            sequences in human
  JOURNAL   Genome Res 10 (12), 1979-1985 (2000)
   PUBMED   11116092
REFERENCE   9  (bases 1 to 2351)
  AUTHORS   Rodriguez,I., Greer,C.A., Mok,M.Y. and Mombaerts,P.
  TITLE     A putative pheromone receptor gene expressed in human olfactory
            mucosa
  JOURNAL   Nat Genet 26 (1), 18-19 (2000)
   PUBMED   10973240
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004076.1.
            
            On Oct 2, 2020 this sequence version replaced NM_020633.3.
            
            Summary: Pheromones are chemical signals that elicit specific
            behavioral responses and physiologic alterations in recipients of
            the same species. The protein encoded by this gene is similar to
            pheromone receptors and is primarily localized to the olfactory
            mucosa. An alternate splice variant of this gene is thought to
            exist, but its full length nature has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK094452.1, BC095508.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321039.5/ ENSP00000322339.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2351              AC004076.1         24413-26763         c
FEATURES             Location/Qualifiers
     source          1..2351
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2351
                     /gene="VN1R1"
                     /gene_synonym="V1RL1; VNR19I1; ZVNH1; ZVNR1"
                     /note="vomeronasal 1 receptor 1"
                     /db_xref="GeneID:57191"
                     /db_xref="HGNC:HGNC:13548"
                     /db_xref="MIM:605234"
     exon            1..2351
                     /gene="VN1R1"
                     /gene_synonym="V1RL1; VNR19I1; ZVNH1; ZVNR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             655..1716
                     /gene="VN1R1"
                     /gene_synonym="V1RL1; VNR19I1; ZVNH1; ZVNR1"
                     /note="vomeronasal olfactory receptor, (chromosome 19)
                     subtype I, member 1; V1R-like 1; hGPCR24; V1r-like
                     receptor 1; V3r-related gene protein; G-protein coupled
                     receptor GPCR24; vomeronasal olfactory receptor chromosome
                     19 subtype I member 1"
                     /codon_start=1
                     /product="vomeronasal type-1 receptor 1"
                     /protein_id="NP_065684.1"
                     /db_xref="CCDS:CCDS12951.1"
                     /db_xref="GeneID:57191"
                     /db_xref="HGNC:HGNC:13548"
                     /db_xref="MIM:605234"
                     /translation="MVGDTLKLLSPLMTRYFFLLFYSTDSSDLNENQHPLDFDEMAFG
                     KVKSGISFLIQTGVGILGNSFLLCFYNLILFTGHKLRPTDLILSQLALANSMVLFFKG
                     IPQTMAAFGLKYLLNDTGCKFVFYYHRVGTRVSLSTICLLNGFQAIKLNPSICRWMEI
                     KIRSPRFIDFCCLLCWAPHVLMNASVLLLVNGPLNSKNSSAKNNYGYCSYKASKRFSS
                     LHAVLYFSPDFMSLGFMVWASGSMVFFLYRHKQQVQHNHSNRLSCRPSQEARATHTIM
                     VLVSSFFVFYSVHSFLTIWTTVVANPGQWIVTNSVLVASCFPARSPFVLIMSDTHISQ
                     FCFACRTRKTLFPNLVVMP"
ORIGIN      
        1 ccaggttcaa gcgattctcc tgcctcagcc tcccgagtag ctgggactag cacgcgccgc
       61 catgcccggc taatttttgt attattagta ttttgtatta ttagtagaga cagggtttca
      121 ccatgttggc caggatggtc tccatcttgg cctcccgaag tgctggaatt acaggtgtga
      181 gccactgcac ccggcctaaa atttgtttca atgcatcaat aacaatggtg tttactaaaa
      241 tattagtgtg gaaaaggttt tatggtgtat tatttttgct tttcatatct ccaggctact
      301 taattgaagg ttttattgaa ataagtgtag actcacaagc agtcataaga aataatacag
      361 aaaaagccct gtccatatta cccagggttc cgtcatgatt acattttgca aactatagta
      421 taatatcact ctaatgatat tgactcttct gtgttctgtt tttatatatt tccctagttt
      481 tgcttgtatt tacttgttgc atgtgtgtaa gccctgagtt ttataggttt gatttgtgga
      541 tctgttgtgc ggttgagccc tcattcattc acctgcttct ctgcagttgg acacacaagc
      601 aattgccttt gcacgaacag ggacaatctt aatttctgtt taagatgaga aaatatggtt
      661 ggagacacat taaaacttct gtctccactg atgacaagat acttctttct gcttttttat
      721 tctactgatt cttcagacct caatgaaaat caacatcccc tagattttga tgaaatggct
      781 tttggaaaag taaaatcagg gattagcttc ctcattcaga ctggagttgg gatcctggga
      841 aattcctttc tcctttgttt ttataactta attttgttca ctggacacaa gctgagaccc
      901 acggacttga ttctcagcca actggccttg gctaactcca tggtcctttt ctttaaaggg
      961 atacctcaga caatggcagc ttttggattg aaatatttgc tgaatgacac tggatgtaag
     1021 tttgtctttt attatcacag ggtgggcaca agagtttccc tcagcaccat ctgccttctc
     1081 aatggattcc aagccattaa gctcaacccc agtatatgca ggtggatgga gatcaagatt
     1141 agatccccaa ggtttattga cttctgttgt ctcctctgct gggcccccca tgtcttgatg
     1201 aatgcatctg ttcttctatt agtgaatggc ccactgaata gcaaaaacag tagtgcaaaa
     1261 aacaattatg gatactgttc ttacaaagca tcaaagagat ttagctcatt acatgcagtc
     1321 ttatattttt cccctgattt tatgagtttg ggcttcatgg tctgggccag tggctccatg
     1381 gtcttcttcc tctacagaca caagcagcaa gtccaacaca atcacagcaa cagactctcc
     1441 tgcagacctt cccaggaagc cagagccaca cacaccatca tggtcctggt gagctccttt
     1501 tttgttttct attcagtcca tagttttctg acaatttgga caactgtagt tgcaaaccca
     1561 ggccagtgga tagtgaccaa ctctgtgttg gtcgcctcat gtttcccagc acgcagccct
     1621 tttgtcctca tcatgagtga tactcatatc tctcagttct gttttgcctg caggacaagg
     1681 aaaacactct ttcctaatct ggttgtcatg ccatgagtct tttctcttca tggaattcag
     1741 ctatttatca taactcttgc taagatttag gaaatattaa ctactagtta tttgtgatag
     1801 caacatacac atggccagta atgctcttgt ccaggaagat ctaataccag agctaaaaat
     1861 gaaagtcatg gatactgtta cacaaagaac actctatata actgtgttaa gtccttcaga
     1921 caagttcagg aaatcaaaaa gtttaaaaag ggaattcttt agagatttag gggagatttc
     1981 tcatttttgt actatgaaga atcatggaat gttttaaaaa tatttttaaa gcacagtttg
     2041 attcaggtgc ttcttgaaca gcataaatcc cctggagagt ccacatgtaa gaaagacatg
     2101 tgcaggccgg gcacagtggc tcacgcctgt aatcccaccg ttttgggagg ctgaggcact
     2161 cccaaatgcc tcaagtgatc cactcaagat gacttgaggc caggagttcg agaccagcct
     2221 ggccaacatg gcaaaaaccc tgtctcaaat acaaaaatta gccaaccatg tggcacacac
     2281 ctgtagtccc agctactcca gagggtgaag cacgagaatt acttaccagc ttgggtgacg
     2341 gagggagact c
//
