LOCUS       NM_030938               3686 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens vacuole membrane protein 1 (VMP1), transcript variant
            1, mRNA.
ACCESSION   NM_030938
VERSION     NM_030938.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3686)
  AUTHORS   Zack,S.R., Venkatesan,M., Nikolaienko,R., Cook,B., Melki,R.,
            Zima,A.V. and Campbell,E.M.
  TITLE     Altered vacuole membrane protein 1 (VMP1) expression is associated
            with increased NLRP3 inflammasome activation and mitochondrial
            dysfunction
  JOURNAL   Inflamm Res 73 (4), 563-580 (2024)
   PUBMED   38411635
  REMARK    GeneRIF: Altered vacuole membrane protein 1 (VMP1) expression is
            associated with increased NLRP3 inflammasome activation and
            mitochondrial dysfunction.
REFERENCE   2  (bases 1 to 3686)
  AUTHORS   Renna,F.J., Gonzalez,C.D. and Vaccaro,M.I.
  TITLE     Decoding the Versatile Landscape of Autophagic Protein VMP1 in
            Cancer: A Comprehensive Review across Tissue Types and Regulatory
            Mechanisms
  JOURNAL   Int J Mol Sci 25 (7), 3758 (2024)
   PUBMED   38612567
  REMARK    GeneRIF: Decoding the Versatile Landscape of Autophagic Protein
            VMP1 in Cancer: A Comprehensive Review across Tissue Types and
            Regulatory Mechanisms.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3686)
  AUTHORS   Chen,H.Y., Li,X.N., Yang,L., Ye,C.X., Chen,Z.L. and Wang,Z.J.
  TITLE     CircVMP1 promotes glycolysis and disease progression by
            upregulating HKDC1 in colorectal cancer
  JOURNAL   Environ Toxicol 39 (3), 1617-1630 (2024)
   PUBMED   38009649
  REMARK    GeneRIF: CircVMP1 promotes glycolysis and disease progression by
            upregulating HKDC1 in colorectal cancer.
REFERENCE   4  (bases 1 to 3686)
  AUTHORS   Qu,M., Liu,X., Wang,X., Li,Z., Zhou,L. and Li,H.
  TITLE     Palmitoylation of vacuole membrane protein 1 promotes small
            extracellular vesicle secretion via interaction with ALIX and
            influences intercellular communication
  JOURNAL   Cell Commun Signal 22 (1), 150 (2024)
   PUBMED   38403678
  REMARK    GeneRIF: Palmitoylation of vacuole membrane protein 1 promotes
            small extracellular vesicle secretion via interaction with ALIX and
            influences intercellular communication.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3686)
  AUTHORS   Renna,F.J., Enrique Steinberg,J.H., Gonzalez,C.D., Manifava,M.,
            Tadic,M.S., Orquera,T., Vecino,C.V., Ropolo,A., Guardavaccaro,D.,
            Rossi,M., Ktistakis,N.T. and Vaccaro,M.I.
  TITLE     Ubiquitination Is a Novel Post-Translational Modification of VMP1
            in Autophagy of Human Tumor Cells
  JOURNAL   Int J Mol Sci 24 (16), 12981 (2023)
   PUBMED   37629161
  REMARK    GeneRIF: Ubiquitination Is a Novel Post-Translational Modification
            of VMP1 in Autophagy of Human Tumor Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3686)
  AUTHORS   Sauermann,M., Sahin,O., Sultmann,H., Hahne,F., Blaszkiewicz,S.,
            Majety,M., Zatloukal,K., Fuzesi,L., Poustka,A., Wiemann,S. and
            Arlt,D.
  TITLE     Reduced expression of vacuole membrane protein 1 affects the
            invasion capacity of tumor cells
  JOURNAL   Oncogene 27 (9), 1320-1326 (2008)
   PUBMED   17724469
  REMARK    GeneRIF: Endogenously expressed Vmp1 is essentially a cell membrane
            protein that is involved in cell-cell adhesion, invasion and
            metastasis.
REFERENCE   7  (bases 1 to 3686)
  AUTHORS   Ropolo,A., Grasso,D., Pardo,R., Sacchetti,M.L., Archange,C., Lo
            Re,A., Seux,M., Nowak,J., Gonzalez,C.D., Iovanna,J.L. and
            Vaccaro,M.I.
  TITLE     The pancreatitis-induced vacuole membrane protein 1 triggers
            autophagy in mammalian cells
  JOURNAL   J Biol Chem 282 (51), 37124-37133 (2007)
   PUBMED   17940279
  REMARK    GeneRIF: VMP1 as a novel autophagy-related membrane protein
            involved in the initial steps of the mammalian cell autophagic
            process.
REFERENCE   8  (bases 1 to 3686)
  AUTHORS   Starkuviene,V., Liebel,U., Simpson,J.C., Erfle,H., Poustka,A.,
            Wiemann,S. and Pepperkok,R.
  TITLE     High-content screening microscopy identifies novel proteins with a
            putative role in secretory membrane traffic
  JOURNAL   Genome Res 14 (10A), 1948-1956 (2004)
   PUBMED   15466293
REFERENCE   9  (bases 1 to 3686)
  AUTHORS   Dusetti,N.J., Jiang,Y., Vaccaro,M.I., Tomasini,R., Azizi Samir,A.,
            Calvo,E.L., Ropolo,A., Fiedler,F., Mallo,G.V., Dagorn,J.C. and
            Iovanna,J.L.
  TITLE     Cloning and expression of the rat vacuole membrane protein 1
            (VMP1), a new gene activated in pancreas with acute pancreatitis,
            which promotes vacuole formation
  JOURNAL   Biochem Biophys Res Commun 290 (2), 641-649 (2002)
   PUBMED   11785947
REFERENCE   10 (bases 1 to 3686)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC009758.2, AK024969.1,
            CA412810.1, CB216599.1, BM803108.1 and BQ002999.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_030938.4.
            
            Summary: This gene encodes a transmembrane protein that plays a key
            regulatory role in the process of autophagy. The ectopic
            overexpression of the encoded protein in cultured cells triggers
            autophagy even under nutrient-rich conditions. This gene is
            overexpressed in pancreatitis affected acinar cells where the
            encoded protein mediates sequestration and degradation of
            potentially deleterious activated zymogen granules in a process
            termed, zymophagy. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.8293.1,
                                           SRR1803612.59691.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262291.9/ ENSP00000262291.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1776              BC009758.2         4-1779
            1777-2024           AK024969.1         1779-2026
            2025-2525           CA412810.1         18-518              c
            2526-3049           CB216599.1         105-628
            3050-3524           BM803108.1         272-746
            3525-3686           BQ002999.1         18-179              c
FEATURES             Location/Qualifiers
     source          1..3686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.1"
     gene            1..3686
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /note="vacuole membrane protein 1"
                     /db_xref="GeneID:81671"
                     /db_xref="HGNC:HGNC:29559"
                     /db_xref="MIM:611753"
     exon            1..95
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /inference="alignment:Splign:2.1.0"
     exon            96..197
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1342
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 49; ectopic P-granules autophagy
                     protein 3 homolog; transport and golgi organization 5
                     homolog"
                     /codon_start=1
                     /product="vacuole membrane protein 1 isoform 1"
                     /protein_id="NP_112200.2"
                     /db_xref="CCDS:CCDS11619.1"
                     /db_xref="GeneID:81671"
                     /db_xref="HGNC:HGNC:29559"
                     /db_xref="MIM:611753"
                     /translation="MAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNI
                     VLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLLAVLIATYYVEGVHQQY
                     VQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEP
                     PYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAE
                     PDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGI
                     TCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSL
                     QKPFQEYLEAQRQKLHHKSEMGTPQGENWLSWMFEKLVVVMVCYFILSIINSMAQSYA
                     KRIQQRLNSEEKTK"
     exon            198..333
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /inference="alignment:Splign:2.1.0"
     exon            334..424
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /inference="alignment:Splign:2.1.0"
     exon            425..535
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /inference="alignment:Splign:2.1.0"
     exon            536..703
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /inference="alignment:Splign:2.1.0"
     exon            704..835
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /inference="alignment:Splign:2.1.0"
     exon            836..916
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1033
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1095
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1198
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..3686
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1997..2002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /note="hexamer: TATAAA"
     polyA_site      2024
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /note="major polyA site"
     regulatory      3646..3651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
                     /note="hexamer: AATAAA"
     polyA_site      3686
                     /gene="VMP1"
                     /gene_synonym="EPG3; TANGO5; TMEM49"
ORIGIN      
        1 gggttccggt tgtctggagc ccagcggcgg gtgtgagagt ccgtaaggag cagcttccag
       61 gatcctgaga tccggagcag ccggggtcgg agcggctcct caagagttac tgatctatga
      121 aatggcagag aatggaaaaa attgtgacca gagacgtgta gcaatgaaca aggaacatca
      181 taatggaaat ttcacagacc cctcttcagt gaatgaaaag aagaggaggg agcgggaaga
      241 aaggcagaat attgtcctgt ggagacagcc gctcattacc ttgcagtatt tttctctgga
      301 aatccttgta atcttgaagg aatggacctc aaaattatgg catcgtcaaa gcattgtggt
      361 gtctttttta ctgctgcttg ctgtgcttat agctacgtat tatgttgaag gagtgcatca
      421 acagtatgtg caacgtatag agaaacagtt tcttttgtat gcctactgga taggcttagg
      481 aattttgtct tctgttgggc ttggaacagg gctgcacacc tttctgcttt atctgggtcc
      541 acatatagcc tcagttacat tagctgctta tgaatgcaat tcagttaatt ttcccgaacc
      601 accctatcct gatcagatta tttgtccaga tgaagagggc actgaaggaa ccatttcttt
      661 gtggagtatc atctcaaaag ttaggattga agcctgcatg tggggtatcg gtacagcaat
      721 cggagagctg cctccatatt tcatggccag agcagctcgc ctctcaggtg ctgaaccaga
      781 tgatgaagag tatcaggaat ttgaagagat gctggaacat gcagagtctg cacaagactt
      841 tgcctcccgg gccaaactgg cagttcaaaa actagtacag aaagttggat tttttggaat
      901 tttggcctgt gcttcaattc caaatccttt atttgatctg gctggaataa cgtgtggaca
      961 ctttctggta cctttttgga ccttctttgg tgcaacccta attggaaaag caataataaa
     1021 aatgcatatc cagaaaattt ttgttataat aacattcagc aagcacatag tggagcaaat
     1081 ggtggctttc attggtgctg tccccggcat aggtccatct ctgcagaagc catttcagga
     1141 gtacctggag gctcaacggc agaagcttca ccacaaaagc gaaatgggca caccacaggg
     1201 agaaaactgg ttgtcctgga tgtttgaaaa gttggtcgtt gtcatggtgt gttacttcat
     1261 cctatctatc attaactcca tggcacaaag ttatgccaaa cgaatccagc agcggttgaa
     1321 ctcagaggag aaaactaaat aagtagagaa agttttaaac tgcagaaatt ggagtggatg
     1381 ggttctgcct taaattggga ggactccaag ccgggaagga aaattccctt ttccaacctg
     1441 tatcaatttt tacaactttt ttcctgaaag cagtttagtc catactttgc actgacatac
     1501 tttttccttc tgtgctaagg taaggtatcc accctcgatg caatccacct tgtgttttct
     1561 tagggtggaa tgtgatgttc agcagcaaac ttgcaacaga ctggccttct gtttgttact
     1621 ttcaaaaggc ccacatgata caattagaga attcccaccg cacaaaaaaa gttcctaagt
     1681 atgttaaata tgtcaagctt tttaggcttg tcacaaatga ttgctttgtt ttcctaagtc
     1741 atcaaaatgt atataaatta tctagattgg ataacagtct tgcatgttta tcatgttaca
     1801 atttaatatt ccatcctgcc caacccttcc tctcccatcc tcaaaaaagg gccattttat
     1861 gatgcattgc acaccctctg gggaaattga tctttaaatt ttgagacagt ataaggaaaa
     1921 tctggttggt gtcttacaag tgagctgaca ccatttttta ttctgtgtat ttagaatgaa
     1981 gtcttgaaaa aaactttata aagacatctt taatcattcc aaaattgtgt ccgttttctt
     2041 gagcgttttg attttttact tttagcttat accagctgaa tggcagcctt gcctaatcca
     2101 cctacaacaa gaatttctta agctttcttt tatttgcatg agagagccac taccaaggca
     2161 tgttttgtta tgctgaaact gggctgctgc atactgctaa atggcacctc tgggattggc
     2221 ctacctgggg atttcttggt ttgtgaaaac aggagaggag aaatatctca tacaagtgaa
     2281 aggatactgg agagagaaat tacccatttc taaaaaaaaa ccacactctg tcgtatctgt
     2341 gttaatgttt tctagcatgt actctggttt caacagacac aaatttatat gttaacccag
     2401 ttttcttgcc gttctgtaag tgttttattc ttagtgtgat ttttttccat tgggatgttt
     2461 ttgattgaac ttgttcattt tgttttgctt gggaggaaaa taaacaattt tacttttttc
     2521 ctttaggagc attatgagca ttatgtcaga atagaataga attggggttc gatcttaaca
     2581 ggccagaaat gcctgggttt ttttggtttg tttttgtttt tgttttttta tcaaatcctg
     2641 cctgactgtc tgcttgtttt gcctaccatc gtgacatctc catggctgta ccaccttgtc
     2701 gggtagctta tcagactgat gttgactgtt gaatctcatg gcaacaccag tcgatgggct
     2761 gtctgacatt ttggtatctt tcatctgacc atccatatcc aatgttctca tttaaacatt
     2821 acccagcatc attgtttata atcagaaact ctggtccttc tgtctggtgg cacttagagt
     2881 cttttgtgcc ataatgcagc agtatggagg gaggatttta tggagaaatg gggatagtct
     2941 tcatgaccac aaataaataa aggaaaacta agctgcattg tgggttttga aaaggttatt
     3001 atacttctta acaattcttt ttttcaggga cttttctagc tgtatgactg ttacttgacc
     3061 ttctttgaaa agcattccca aaatgctcta ttttagatag attaacatta accaacataa
     3121 ttttttttag atcgagtcag cataaatttc taagtcagcc tctagtcgtg gttcatctct
     3181 ttcacctgca ttttatttgg tgtttgtctg aagaaaggaa agaggaaagc aaatacgaat
     3241 tgtactattt gtaccaaatc tttgggattc attggcaaat aatttcagtg tggtgtatta
     3301 ttaaatagaa aaaaaaaatt ttgtttccta ggttgaaggt ctaattgata cgtttgactt
     3361 atgatgacca tttatgcact ttcaaatgaa tttgctttca aaataaatga agagcagctg
     3421 tccttctttc ctcttttaag tgttcagctg tggcatgctc agaggttcct gctggattcc
     3481 agctggagcg gtgtgatacc cttctttttc agctgttcgt gccttccttt cttgtatcca
     3541 ccaaagtgga gacaaataca tgatctcaaa gatacacagt acctacttaa ttccagctga
     3601 tgggagacca aagaatttgc aagtggatgg tttggtatca ctgtaaataa aaagagggcc
     3661 tgggaattct tgcgattcca tctcta
//
