LOCUS       NM_182566                698 bp    mRNA    linear   PRI 27-FEB-2025
DEFINITION  Homo sapiens vitelline membrane outer layer 1 homolog (VMO1),
            transcript variant 1, mRNA.
ACCESSION   NM_182566
VERSION     NM_182566.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 698)
  AUTHORS   Wang,L., Yin,M., Zhang,Z., Liu,S., Liu,Y., Geng,X. and Zheng,G.
  TITLE     Methylation and transcriptome analyses construct a prognostic model
            and reveal the suppressor role of VMO1 in lung adenocarcinoma
  JOURNAL   Cell Signal 122, 111313 (2024)
   PUBMED   39053673
  REMARK    GeneRIF: Methylation and transcriptome analyses construct a
            prognostic model and reveal the suppressor role of VMO1 in lung
            adenocarcinoma.
REFERENCE   2  (bases 1 to 698)
  AUTHORS   Shamsi,F.A., Chen,Z., Liang,J., Li,K., Al-Rajhi,A.A.,
            Chaudhry,I.A., Li,M. and Wu,K.
  TITLE     Analysis and comparison of proteomic profiles of tear fluid from
            human, cow, sheep, and camel eyes
  JOURNAL   Invest Ophthalmol Vis Sci 52 (12), 9156-9165 (2011)
   PUBMED   22025569
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 698)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 698)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC104195.1 and CD367284.1.
            
            On Nov 22, 2018 this sequence version replaced NM_182566.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF521892.1, BC104195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328739.6/ ENSP00000328397.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-683               BC104195.1         39-721
            684-698             CD367284.1         18-32               c
FEATURES             Location/Qualifiers
     source          1..698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..698
                     /gene="VMO1"
                     /gene_synonym="ERGA6350; PRO21055"
                     /note="vitelline membrane outer layer 1 homolog"
                     /db_xref="GeneID:284013"
                     /db_xref="HGNC:HGNC:30387"
                     /db_xref="MIM:621110"
     exon            1..207
                     /gene="VMO1"
                     /gene_synonym="ERGA6350; PRO21055"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..621
                     /gene="VMO1"
                     /gene_synonym="ERGA6350; PRO21055"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; vitelline membrane outer layer protein 1
                     homolog"
                     /codon_start=1
                     /product="vitelline membrane outer layer protein 1 homolog
                     isoform 1 precursor"
                     /protein_id="NP_872372.1"
                     /db_xref="CCDS:CCDS11055.1"
                     /db_xref="GeneID:284013"
                     /db_xref="HGNC:HGNC:30387"
                     /db_xref="MIM:621110"
                     /translation="MERGAGAKLLPLLLLLRATGFTCAQTDGRNGYTAVIEVTSGGPW
                     GDWAWPEMCPDGFFASGFSLKVEPPQGIPGDDTALNGIRLHCARGNVLGNTHVVESQS
                     GSWGEWSEPLWCRGGAYLVAFSLRVEAPTTLGDNTAANNVRFRCSDGEELQGPGLSWG
                     DFGDWSDHCPKGACGLQTKIQGPRGLGDDTALNDARLFCCRS"
     exon            208..323
                     /gene="VMO1"
                     /gene_synonym="ERGA6350; PRO21055"
                     /inference="alignment:Splign:2.1.0"
     exon            324..698
                     /gene="VMO1"
                     /gene_synonym="ERGA6350; PRO21055"
                     /inference="alignment:Splign:2.1.0"
     regulatory      678..683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VMO1"
                     /gene_synonym="ERGA6350; PRO21055"
                     /note="hexamer: ATTAAA"
     polyA_site      698
                     /gene="VMO1"
                     /gene_synonym="ERGA6350; PRO21055"
                     /note="major polyA site"
ORIGIN      
        1 agacgctaca ggatggagcg gggcgcagga gccaagctgc tgccgctgct gctgcttctg
       61 cgggcgactg gtttcacatg tgcacagaca gatggccgga acggctacac ggcggtcatc
      121 gaagtgacca gcgggggtcc ctggggcgac tgggcctggc ctgagatgtg tcccgatgga
      181 ttcttcgcca gcgggttctc gctcaaggtg gagcctcccc aaggcattcc tggcgacgac
      241 actgcactga atgggatcag gctgcactgc gcgcgcggga acgtcctagg caatacgcac
      301 gtggtagagt cccagtctgg aagctggggc gaatggagtg agccgctgtg gtgtcgcggc
      361 ggcgcctacc tagtggcttt ctcgcttcgc gtggaggcac ccacgaccct cggtgacaac
      421 acagcagcga acaacgtgcg cttccgctgt tcagacggcg aggaactgca ggggcctggg
      481 ctgagctggg gagactttgg agactggagt gaccattgcc ccaagggcgc gtgcggcctg
      541 cagaccaaga tccagggacc tagaggcctc ggcgatgaca ctgcgctgaa cgacgcgcgc
      601 ttattctgct gccgcagttg aacggcgccg ccgccgccgc tctctcccgg gccaggaggc
      661 tagtcccacc tcttgctatt aaagcttctc tgagttga
//
