LOCUS       NM_001017921            2240 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens vimentin type intermediate filament associated
            coiled-coil protein (VMAC), mRNA.
ACCESSION   NM_001017921 XM_375560
VERSION     NM_001017921.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2240)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2240)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 2240)
  AUTHORS   Yamamoto,Y., Irie,K., Kurihara,H., Sakai,T. and Takai,Y.
  TITLE     Vmac: a novel protein associated with vimentin-type intermediate
            filament in podocytes of rat kidney
  JOURNAL   Biochem Biophys Res Commun 315 (4), 1120-1125 (2004)
   PUBMED   14985129
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA541168.1, AK124162.1, AC104532.2 and BC110802.1.
            
            On May 17, 2019 this sequence version replaced NM_001017921.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK124162.1, BC110802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339485.4/ ENSP00000343348.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA541168.1         32-33
            3-884               AK124162.1         1-882
            885-1174            AC104532.2         10331-10620
            1175-1639           BC110802.1         1173-1637
            1640-2240           AC104532.2         11086-11686
FEATURES             Location/Qualifiers
     source          1..2240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2240
                     /gene="VMAC"
                     /note="vimentin type intermediate filament associated
                     coiled-coil protein"
                     /db_xref="GeneID:400673"
                     /db_xref="HGNC:HGNC:33803"
                     /db_xref="MIM:617204"
     exon            1..210
                     /gene="VMAC"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..529
                     /gene="VMAC"
                     /note="vimentin-type IF-associated coiled-coil protein"
                     /codon_start=1
                     /product="vimentin-type intermediate filament-associated
                     coiled-coil protein"
                     /protein_id="NP_001017921.1"
                     /db_xref="CCDS:CCDS32881.1"
                     /db_xref="GeneID:400673"
                     /db_xref="HGNC:HGNC:33803"
                     /db_xref="MIM:617204"
                     /translation="MSAPPALQIREANAHLAAVHRRAAELEARLDAAERTVHAQAERL
                     ALHDQQLRAALDELGRAKDREIATLQEQLMTSEATVHSLQATVHQRDELIRQLQPRAE
                     LLQDICRRRPPLAGLLDALAEAERLGPLPASDPGHPPPGGPGPPLDNSTGEEADRDHL
                     QPAVFGTTV"
     exon            211..2240
                     /gene="VMAC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      543..548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VMAC"
                     /note="hexamer: ATTACA"
     polyA_site      563
                     /gene="VMAC"
                     /note="major polyA site"
     regulatory      1228..1233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VMAC"
                     /note="hexamer: AATATA"
     polyA_site      1248
                     /gene="VMAC"
     regulatory      1607..1612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VMAC"
                     /note="hexamer: AATAAA"
     polyA_site      1639
                     /gene="VMAC"
                     /note="major polyA site"
ORIGIN      
        1 ctgtacagca gcctgggcca tgtcggcgcc gccggccctg cagatccggg aggcaaacgc
       61 acacctggca gccgtgcacc ggcgcgcagc ggagctggag gcgcggctgg acgcggcgga
      121 gcgcacggtg cacgcccaag ccgagcgcct ggccctccac gaccagcagc tgcgcgccgc
      181 cctagacgaa ctgggtcgcg ccaaggaccg tgagattgcc acactccagg agcagctgat
      241 gacctcagaa gccactgtcc acagcctgca ggccaccgtg caccagaggg acgagctcat
      301 taggcagttg cagccccggg ctgagctgct gcaggacatc tgccgccgcc ggccacccct
      361 ggctgggctg ctggatgccc tggctgaggc tgagcgcctg gggcccctgc cggccagtga
      421 ccccggccac ccaccccccg gtgggcctgg tccacccctt gacaacagca ctggggaaga
      481 ggcggacagg gaccacctcc agcctgcagt gtttgggacc acagtgtgag cccggaatgc
      541 agattacaga atggagacag aaagccactg ctgtcagtgt ccttgggagt caccagcacc
      601 ctgcaggggg accctacggc agagccaaag tcctgtctaa gcatcagaac aggctgaaca
      661 gtcaaaaagt tttcaaatag gcccacaggc caggtgcaga cgtttaaccc agacagaagt
      721 gttcttgttt gtttttaagc tttgaatcag tcacccttgc taaaaacctg gcaatgcaaa
      781 cacaaagatc tggatttctg gcaagacttg gccaagcttg cctggagttc agggcaccct
      841 ctttagccag ggtgtgagtt tctgtttttt gttttttttt ttttaagaca gagtcccact
      901 ctgtcgccct ggctggggtg cagtggtgcg attttggcta actgcaacct ccgcctccca
      961 ggttcaagcg attctcctgt ctcatccttc agagtagctg ggattacagg cgcccaccac
     1021 cacacccgga tattttatat ttttggtaga gaccggggag gggagggggt ttcaccatgt
     1081 tgaccaggct ggtctcaaac tcctgacctt aggtgatcca cccgcctcgg ccttcgaaag
     1141 tgctgcagtt ataggtgtaa gccaccgcgc ccggccctag cctagctttt gtagcatgca
     1201 actgtctcct ttttatacgc cctaaagaat atatttttga actccttgtt tctgcgctgt
     1261 ccttcttagc ccaggacatt cagggtgctt tgcttgttgt caaaccaggg aaaggagaaa
     1321 actcctgtgc ctttctgggc cagcctgtca ccctggcctg gtcggcagcc attcccctac
     1381 ctcctcactc aggaactgtc acaccaggaa ccggcgaggg gcacagcctg tttcagacca
     1441 gaaaggtcgg aggccaccca cggccttcag gatggcgccc gcctgcctgc ctggcaacag
     1501 tgacccctca gtgcagtaac aatgggccca ttttctcctc tggatgaaca aggagggggg
     1561 ttgtttgtac aaaggaaagg caggctgggg cctgtctgtg ctcaagaata aaccggatga
     1621 tttcctggcc tgggggcaag agggaggccc tctgtgttat ttgtgcctcc tggtagggtc
     1681 ctgctgggcc aggtagaatc tagggagtgt aggccaagca ctctctacag cgattgcatc
     1741 taatcttcga gtttccctgt agacacaggc tttgtcctca ttttacagct gtggaaagtg
     1801 aggcccaggc cgggcgcggt gtctcacgcc tgtaatccca gcactttggg atgcgggtgg
     1861 atcacctgag gtcaggagtt cgagaccacc ctggccaaca tggtgaaacc ccgtctctac
     1921 taaaaatact aaaattagcc gggcttggtg gcgggtgcct gtaatcccag ctactgaacc
     1981 cgggaggcgg aggttgcagt gagtggagat tgcaccactg cactccagcc tgggagacag
     2041 agtgagactc agtctcaaag aaaacaacaa caacaacaac aacaacaaca acaacaacaa
     2101 acagaggccc agaggtgtga agggaacaca ctccgggtct ggagggccag ggccacttcc
     2161 aattctgggg gaagttattg ctgaaattct gttttctttc tttctttctt ttttttttaa
     2221 agagacaaag tctcactgtt
//
