LOCUS       NM_003383               9213 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens very low density lipoprotein receptor (VLDLR),
            transcript variant 1, mRNA.
ACCESSION   NM_003383
VERSION     NM_003383.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9213)
  AUTHORS   Cao,D., Ma,B., Cao,Z., Xu,X., Zhang,X. and Xiang,Y.
  TITLE     The receptor VLDLR binds Eastern Equine Encephalitis virus through
            multiple distinct modes
  JOURNAL   Nat Commun 15 (1), 6866 (2024)
   PUBMED   39127734
  REMARK    GeneRIF: The receptor VLDLR binds Eastern Equine Encephalitis virus
            through multiple distinct modes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9213)
  AUTHORS   Song,Y., Jiao,H., Lin,Q., Zhang,X., Chen,X., Wei,Z. and Yi,L.
  TITLE     Identification of the miR-423-3p/VLDLR Regulatory Network for
            Glioma Using Transcriptome Analysis
  JOURNAL   Neurochem Res 47 (12), 3864-3901 (2022)
   PUBMED   36352275
  REMARK    GeneRIF: Identification of the miR-423-3p/VLDLR Regulatory Network
            for Glioma Using Transcriptome Analysis.
REFERENCE   3  (bases 1 to 9213)
  AUTHORS   Ma,X., Takahashi,Y., Wu,W., Liang,W., Chen,J., Chakraborty,D.,
            Li,Y., Du,Y., Benyajati,S. and Ma,J.X.
  TITLE     ADAM17 mediates ectodomain shedding of the soluble VLDL receptor
            fragment in the retinal epithelium
  JOURNAL   J Biol Chem 297 (4), 101185 (2021)
   PUBMED   34509473
  REMARK    GeneRIF: ADAM17 mediates ectodomain shedding of the soluble VLDL
            receptor fragment in the retinal epithelium.
REFERENCE   4  (bases 1 to 9213)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 9213)
  AUTHORS   Mosapour,A., Karami Tehrani,F.S. and Atri,M.
  TITLE     Expression level of VLDL receptor and VLDL-c levels in the
            malignant and benign breast tumors: The correlation with miRNA-4465
            and miRNA-1297
  JOURNAL   Mol Cell Probes 53, 101624 (2020)
   PUBMED   32711022
  REMARK    GeneRIF: Expression level of VLDL receptor and VLDL-c levels in the
            malignant and benign breast tumors: The correlation with miRNA-4465
            and miRNA-1297.
REFERENCE   6  (bases 1 to 9213)
  AUTHORS   Argraves,K.M., Battey,F.D., MacCalman,C.D., McCrae,K.R.,
            Gafvels,M., Kozarsky,K.F., Chappell,D.A., Strauss,J.F. 3rd and
            Strickland,D.K.
  TITLE     The very low density lipoprotein receptor mediates the cellular
            catabolism of lipoprotein lipase and urokinase-plasminogen
            activator inhibitor type I complexes
  JOURNAL   J Biol Chem 270 (44), 26550-26557 (1995)
   PUBMED   7592875
REFERENCE   7  (bases 1 to 9213)
  AUTHORS   Okuizumi,K., Onodera,O., Namba,Y., Ikeda,K., Yamamoto,T., Seki,K.,
            Ueki,A., Nanko,S., Tanaka,H., Takahashi,H., Oyanagi,K.,
            Mizusawa,H., Kanazawa,I. and Tsuji,S.
  TITLE     Genetic association of the very low density lipoprotein (VLDL)
            receptor gene with sporadic Alzheimer's disease
  JOURNAL   Nat Genet 11 (2), 207-209 (1995)
   PUBMED   7550352
REFERENCE   8  (bases 1 to 9213)
  AUTHORS   Takahashi,S., Suzuki,J., Kohno,M., Oida,K., Tamai,T., Miyabo,S.,
            Yamamoto,T. and Nakai,T.
  TITLE     Enhancement of the binding of triglyceride-rich lipoproteins to the
            very low density lipoprotein receptor by apolipoprotein E and
            lipoprotein lipase
  JOURNAL   J Biol Chem 270 (26), 15747-15754 (1995)
   PUBMED   7797576
REFERENCE   9  (bases 1 to 9213)
  AUTHORS   Wittmaack,F.M., Gafvels,M.E., Bronner,M., Matsuo,H., McCrae,K.R.,
            Tomaszewski,J.E., Robinson,S.L., Strickland,D.K. and Strauss,J.F.
            3rd.
  TITLE     Localization and regulation of the human very low density
            lipoprotein/apolipoprotein-E receptor: trophoblast expression
            predicts a role for the receptor in placental lipid transport
  JOURNAL   Endocrinology 136 (1), 340-348 (1995)
   PUBMED   7828550
REFERENCE   10 (bases 1 to 9213)
  AUTHORS   Boycott,K.M., MacDonald,S.K. and Parboosingh,J.S.
  TITLE     VLDLR Cerebellar Hypoplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH,
            Gripp KW and Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301729
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA386669.1, BC136562.1 and
            AL450467.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003383.4.
            
            Summary: The low density lipoprotein receptor (LDLR) gene family
            consists of cell surface proteins involved in receptor-mediated
            endocytosis of specific ligands. This gene encodes a lipoprotein
            receptor that is a member of the LDLR family and plays important
            roles in VLDL-triglyceride metabolism and the reelin signaling
            pathway. Mutations in this gene cause VLDLR-associated cerebellar
            hypoplasia. Alternative splicing generates multiple transcript
            variants encoding distinct isoforms for this gene. [provided by
            RefSeq, Aug 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.62893.1,
                                           SRR1660807.229768.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382100.8/ ENSP00000371532.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               DA386669.1         14-279
            267-334             BC136562.1         1-68
            335-335             AL450467.8         28433-28433
            336-3471            BC136562.1         70-3205
            3472-9213           AL450467.8         60627-66368
FEATURES             Location/Qualifiers
     source          1..9213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.2"
     gene            1..9213
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /note="very low density lipoprotein receptor"
                     /db_xref="GeneID:7436"
                     /db_xref="HGNC:HGNC:12698"
                     /db_xref="MIM:192977"
     exon            1..485
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..3025
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; VLDL receptor"
                     /codon_start=1
                     /product="very low-density lipoprotein receptor isoform a
                     precursor"
                     /protein_id="NP_003374.3"
                     /db_xref="CCDS:CCDS6446.1"
                     /db_xref="GeneID:7436"
                     /db_xref="HGNC:HGNC:12698"
                     /db_xref="MIM:192977"
                     /translation="MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGR
                     CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSD
                     ESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFT
                     CSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADC
                     SDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSR
                     TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI
                     SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRK
                     TCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRD
                     IRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKM
                     IDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPL
                     SGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHML
                     SSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLV
                     NNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGY
                     NVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGINVTTAVSEVSVPPKGTSA
                     AWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASV
                     GHTYPAISVVSTDDDLA"
     exon            486..605
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            606..728
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            729..851
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1223
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1346
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1469
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1589
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1715
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1887
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2106
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2225
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2365
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2507
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2654
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2738
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2819
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2989
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..9213
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3619..3624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /note="hexamer: ATTAAA"
     polyA_site      3642
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /note="major polyA site"
     regulatory      5236..5241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /note="hexamer: AATAAA"
     polyA_site      5260
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /note="major polyA site"
     polyA_site      5323
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
     regulatory      9190..9195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
                     /note="hexamer: AATAAA"
     polyA_site      9213
                     /gene="VLDLR"
                     /gene_synonym="CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH"
ORIGIN      
        1 accccgctct ccggccgccg ccggtgcggg tgctccgcta ccggctcctc tccgttctgt
       61 gctctcttct gctctcggct ccccaccccc tctcccttcc ctcctctccc cttgcctccc
      121 ctcctctgca gcgcctgcat tattttctgc ccgcaggctc ggcttgcact gctgctgcag
      181 cccggggagg tggctgggtg ggtggggagg agactgtgca agttgtaggg gagggggtgc
      241 cctcttcttc cccgctccct tcccccgcca actccttccc ctccttctcc ccctttcccc
      301 tccccgcccc caccttcttc ctcctttcgg aaggactggt aacttgtcgt gcggagcgaa
      361 cggcggcggc ggcggcggcg gcggcaccat ccaggcgggc accatgggca cgtccgcgct
      421 ctgggcgctc tggctgctgc tcgcgctgtg ctgggcgccc cgggagagcg gcgccaccgg
      481 aaccgggaga aaagccaaat gtgaaccctc ccaattccag tgcacaaatg gtcgctgtat
      541 tacgctgttg tggaaatgtg atggggatga agactgtgtt gacggcagtg atgaaaagaa
      601 ctgtgtaaag aagacgtgtg ctgaatctga cttcgtgtgc aacaatggcc agtgtgttcc
      661 cagccgatgg aagtgtgatg gagatcctga ctgcgaagat ggttcagatg aaagcccaga
      721 acagtgccat atgagaacat gccgcataca tgaaatcagc tgtggcgccc attctactca
      781 gtgtatccca gtgtcctgga gatgtgatgg tgaaaatgat tgtgacagtg gagaagatga
      841 agaaaactgt ggcaatataa catgtagtcc cgacgagttc acctgctcca gtggccgctg
      901 catctccagg aactttgtat gcaatggcca ggatgactgc agcgatggca gtgatgagct
      961 ggactgtgcc ccgccaacct gtggcgccca tgagttccag tgcagcacct cctcctgcat
     1021 ccccatcagc tgggtatgcg acgatgatgc agactgctcc gaccaatctg atgagtccct
     1081 ggagcagtgt ggccgtcagc cagtcataca caccaagtgt ccagccagcg aaatccagtg
     1141 cggctctggc gagtgcatcc ataagaagtg gcgatgtgat ggggaccctg actgcaagga
     1201 tggcagtgat gaggtcaact gtccctctcg aacttgccga cctgaccaat ttgaatgtga
     1261 ggatggcagc tgcatccatg gcagcaggca gtgtaatggt atccgagact gtgtcgatgg
     1321 ttccgatgaa gtcaactgca aaaatgtcaa tcagtgcttg ggccctggaa aattcaagtg
     1381 cagaagtgga gaatgcatag atatcagcaa agtatgtaac caggagcagg actgcaggga
     1441 ctggagtgat gagcccctga aagagtgtca tataaacgaa tgcttggtaa ataatggtgg
     1501 atgttctcat atctgcaaag acctagttat aggctacgag tgtgactgtg cagctgggtt
     1561 tgaactgata gataggaaaa cctgtggaga tattgatgaa tgccaaaatc caggaatctg
     1621 cagtcaaatt tgtatcaact taaaaggcgg ttacaagtgt gaatgtagtc gtggctatca
     1681 aatggatctt gctactggcg tgtgcaaggc agtaggcaaa gagccaagtc tgatcttcac
     1741 taatcgaaga gacatcagga agattggctt agagaggaaa gaatatatcc aactagttga
     1801 acagctaaga aacactgtgg ctctcgatgc tgacattgct gcccagaaac tattctgggc
     1861 cgatctaagc caaaaggcta tcttcagtgc ctcaattgat gacaaggttg gtagacatgt
     1921 taaaatgatc gacaatgtct ataatcctgc agccattgct gttgattggg tgtacaagac
     1981 catctactgg actgatgcgg cttctaagac tatttcagta gctaccctag atggaaccaa
     2041 gaggaagttc ctgtttaact ctgacttgcg agagcctgcc tccatagctg tggacccact
     2101 gtctggcttt gtttactggt cagactgggg tgaaccagct aaaatagaaa aagcaggaat
     2161 gaatggattc gatagacgtc cactggtgac agcggatatc cagtggccta acggaattac
     2221 acttgacctt ataaaaagtc gcctctattg gcttgattct aagttgcaca tgttatccag
     2281 cgtggacttg aatggccaag atcgtaggat agtactaaag tctctggagt tcctagctca
     2341 tcctcttgca ctaacaatat ttgaggatcg tgtctactgg atagatgggg aaaatgaagc
     2401 agtctatggt gccaataaat tcactggatc agagctagcc actctagtca acaacctgaa
     2461 tgatgcccaa gacatcattg tctatcatga acttgtacag ccatcaggta aaaattggtg
     2521 tgaagaagac atggagaatg gaggatgtga atacctatgc ctgccagcac cacagattaa
     2581 tgatcactct ccaaaatata cctgttcctg tcccagtggg tacaatgtag aggaaaatgg
     2641 ccgagactgt caaagtactg caactactgt gacttacagt gagacaaaag atacgaacac
     2701 aacagaaatt tcagcaacta gtggactagt tcctggaggg atcaatgtga ccacagcagt
     2761 atcagaggtc agtgttcccc caaaagggac ttctgccgca tgggccattc ttcctctctt
     2821 gctcttagtg atggcagcag taggtggcta cttgatgtgg cggaattggc aacacaagaa
     2881 catgaaaagc atgaactttg acaatcctgt gtacttgaaa accactgaag aggacctctc
     2941 catagacatt ggtagacaca gtgcttctgt tggacacacg tacccagcaa tatcagttgt
     3001 aagcacagat gatgatctag cttgacttct gtgacaaatg ttgacctttg aggtctaaac
     3061 aaataatacc cccgtcggaa tggtaaccga gccagcagct gaagtctctt tttcttcctc
     3121 tcggctggaa gaacatcaag atacctttgc gtggatcaag cttgtgtact tgaccgtttt
     3181 tatattactt ttgtaaatat tcttgtccac attctacttc agctttggat gtggttaccg
     3241 agtatctgta acccttgaat ttctagacag tattgccacc tctggccaaa tatgcacttt
     3301 ccctagaaag ccatattcca gcagtgaaac ttgtgctata gtgtatacca cctgtacata
     3361 cattgtatag gccatctgta aatatcccag agaacaatca ctattcttaa gcactttgaa
     3421 aatatttcta tgtaaattat tgtaaacttt ttcaatggtt gggacaatgg caataggaca
     3481 aaacgggtta ctaagatgaa attgccaaaa aaatttataa actaattttg tacgtatgaa
     3541 tgatatcttt gacctcaatg gaggtttgca aagactgagt gttcaaacta ctgtacattt
     3601 tttttcaagt gctaaaaaat taaaccaagc agcttaacca tggtttgtgc ctgttcctct
     3661 aggatgaact cctatcctga gtagtaccaa gtgttctaac taaatgtgtg agctgtagtt
     3721 cttgatgttg tataactaag cctgtaattg ggctggtttc tcttacaccc tagcacagtt
     3781 aaaaaatgaa gtactgttta acatttgctc ccgaaatatt tcttactgtg taaaagaagc
     3841 tagcttagtc tgtacctaga attcctcttg gttagaggag tgagtttctt ttttttccat
     3901 taacttgttt cctgatcgag aaacacgtgc taagatttct atgaattctg cttctttata
     3961 gttaagtctc tgttttccat gttctgtcat ttatataggt caaggacaag tgccttctaa
     4021 ggcatggata agggctttct tcttatgaaa gtctagactg tcttactgtg aagatggcca
     4081 gggaggatag caagcaatgg cattcttgaa cagtctaagg caggtttctc agtgtggtcc
     4141 tgagaacaga agcatctgca tcacctggga atgtattaga aatgcaagtt cccagcccca
     4201 tcccagacct actgaatcag aaactctggg ggcgagggct gaaacctgct ttcataagcc
     4261 cttcaggcga tactgatgta aactaaagct taaaaaccac cgttttactg tgacttcatg
     4321 aagaatataa ttgcaatatc acctaaattt ttatcctggc tgggatgggg cagattctta
     4381 ctatggacaa tttctggaac ttacagtatg aagagcagat gaggagtttg agacaaagaa
     4441 aaaattgtac agggagttta gtgaattttc catcaggttg gccattactt tctttctcta
     4501 aagtctcagg atgtctggaa gcaaggaaag acaaaagact tgaagcaccg ggtgcatgct
     4561 gtgtgtcaca agtgaggtgg agagttggct gtggaaggta cagcaattcc tctggaatta
     4621 aatgaccgac caacacagta ccaagaggat gaagagaaga tgttttgcgt tgctacgtga
     4681 atcagtggat gactcatatt tcacttgcat atgaaatata aggcagttaa catcttgttt
     4741 gtggcttaag caaggacatt aatcctacta gatgaagggg aagttggttc tgttgtctta
     4801 agggatgccc ccttgtgatt ttggtcaact gaatgaaaaa gaaaagatag ccttggactt
     4861 ttttttcatg ggaggtttgg aggtcaagca tgtagaagga aaaggctgta gtcatgaata
     4921 tagaactgtc tgctctccac cttttcctca ctctacattt agtcatcaca ctgaacagga
     4981 tgtggcctgc tgacagtgag tagctgaagt gcctgtttgg taagtaggtt agcattcatc
     5041 atgaactctg aaagccattt cagagtttgg ctgctgctct gaccctgctg tggtacaaaa
     5101 aacatggatt tttttttttt taactggagt aataccaaat tccctttaga agcttgaagt
     5161 ttgatactat tgctttcccc attataagga ttatacagta ttaattaatt ataaggccca
     5221 aagtttgttt tggcaaataa agtattattc tctatcatca tcttttgaat tcctgtccct
     5281 agtatgttct ttcatgttct gggtaaaatt tccaaccctc aaagagtcta aaacgtctca
     5341 ttttttttta ccacgtcctc cccagtaaga agccaaggta caactcattg tacctacgag
     5401 gtacaaactc atttgtagaa acaaagtaac tagatattcc tattgaaata agaatagata
     5461 tattggtggg ccaggcatgg tggctcacgc ctataatccc agcactttgg aaggccaagg
     5521 caggaggatc acttgaggcc aggagttcga gaccagcctg agcaacatgg tgagaccctg
     5581 tctctacaaa aaaaaaattt ataaaaataa aagaaaaaaa tagttatatg actaaactac
     5641 tagtcaatac agcttgcaat aatagtgcat gaatgataac aggcctcggc tttatcaccc
     5701 aaaaaataac ttgaattcta tgtgaaatgt gttaggataa gtttgctctg tctctagagt
     5761 tcaatgtaga agataattaa gaggtaaaat atgaagctta tcatacacta aaggagaata
     5821 tttggagtta gatgagcctg tcacacaaag tgaaagtgga ccctccagaa attttaggaa
     5881 ttgccacaaa gattgatgat agatgaataa acagatttgt ggcctctggt aaagaaatcc
     5941 agccaagttc ctctgtccaa atttttaagt gccctttgca agctaatcta tttggcaaaa
     6001 aaatagtccc agttgttcaa ctagctccct taaaacattc tagtaggtgt tttaaagcct
     6061 aggtatcgct gcctctttag ttcttgatga atacaaggca aaaaaaaaaa aaaaaaaaaa
     6121 aaaaaaattg aggctttcac tttggcattt gcttctgttc cttgtatctg tggaagtcaa
     6181 gtagcccttc tcaaaaatga gaagccaagc tttaaatagc aaactacagg gtattaaaag
     6241 actaactctt cagttaagaa cactgtagaa atggtagacc aacttaaagt ctacctttta
     6301 acaatcttta ccccaaacct aaagattcta ggggtcactt atctctatta cgtaatctaa
     6361 ctggaataat ttcctagaat tcttactagt gaaatcttac ccaagtaaaa caatttatta
     6421 ttttgaatcc aaatgaaagc tatactgttt gctttcaatg gtggcaaaaa cttgcaaaaa
     6481 gcagatatac ttttgctaat ttaagttgaa gtactatgaa tacaacctgc taatcttgat
     6541 ccccaaatct gagcccttca gtttcataat tgttttatcc tgaacgtagt tgtgacatag
     6601 acatttctca aaagggtctg atacatcaaa ctcctaacaa gtaggagcag caactagcta
     6661 aagagtagaa agaagcttcc cttattgtgg gtgatgaggc ggtgcctaaa aaccacatat
     6721 atataatccc ctgggtatta catattctgc aagccctgtt agtggggaga tggtagtggc
     6781 aatagcagcg atagttgcgt cagtgctaac tgctgctgct gcccgttctg ttggcggctg
     6841 ctggccaagt gtgcacactt agccctggtt gaggtgcatt gtctgctgtc gtctgttaag
     6901 catctaaccg gagtgggagg gcacatcaag cgatttcact ctcttaaaga aaaggttttt
     6961 aggtattttt ggtattatat agtctctaag gccagaaggg gcttataatg acttctcttc
     7021 tagaattgta atactaaaaa actactcgag taaatatcct aacaagtatg atttttcttg
     7081 ggaaaactaa aaattgtaca tccatgcttc agccatatca tgggcctaaa ctatgagagt
     7141 tcagaaatat ataaaagtac aaaaatcttc aaaggtactt atttccaaat atggagggaa
     7201 tgaatctgaa gagggaacaa tggcgttttt cgaacttatt tctctctaat ccagcctgga
     7261 ggatttttag ccgaaacagt tgcatgtgaa ggattatcag ccatctttgc atatcccttt
     7321 cacatctacc ttcacacagg aaagctgaat gcattttacc agtgaggctc tagatatgaa
     7381 acttagggat ccatagataa ataagctact aacaaactga taacagtggt gttccatctc
     7441 tctatcatgt ctcctgagtc cgtttcacgt ttttgagcct ggctaatgag aaaaagaaca
     7501 aagtaggacc atgacccagt gttctcctgt aaatctcact gtaaaaatct caatgcaaaa
     7561 acactgagac aggagtgaga ccagctgcgg gtggggagtt tgtgctccgc aggttacctc
     7621 atggcatatc aaaaatggct tttttcttca ctgcgctcaa ggaaaaagtc agatgggtga
     7681 caaggtggtt ctgtttagaa gcagcaggca atgtagttaa cagcatagac ttccgtgtct
     7741 tgtgtgtggt accttgggca agttactaac tccctctgta aagtagagac gatggggact
     7801 gtctcactgt gacaaggtaa gatttaagtg agatgcacac aaaaagctca gcacagtgtc
     7861 tggcatctaa tatgtgcagg gcagatgtca ctactgaata tcacatcaat gctagggctg
     7921 tatttactgt cacacacagg caccggtaag tgactttacc ggtgaaagtc acaggtacct
     7981 ttatctatga tgaatgtaat gtgttagatg gtgaccgaag tgttctccac tacacctgtc
     8041 tgaagagatc taagtctgat atttaaggag tgatagcatc ttgcatactt aagaaggctt
     8101 aaaagactgc atggtttaaa ccctagaaac ataaatggaa tgtttctgcc tcagttcttt
     8161 tgactacctc ctaggacatg gaaacaaata tttgggagcc tgcatagtct ttagatggct
     8221 gccaaagcac ttaaaatctc ctttaaattc ttaccatatg cttacttttg tactaagtaa
     8281 gtgctcccaa gtcttttact tgctcttcac agcaacccta ataggtatct ccattttaca
     8341 taggtaaaaa ctgaggctac aaacaatcta tggttccaaa tcctatgtgc ttactgccgt
     8401 cttctcttag aaggggatgc agtactgtac aaagattgag ctggatgtcg cattgcatgt
     8461 ttgctgagtc ctcctcattg ctgatgttag gatccttcaa cagtttctca gatgccagct
     8521 atggctggca tccagtatgg tggtgtaatg gaagtgtact actagcacta ctacatcagg
     8581 tcagcacaga ttaactcagt tacgtgttat accttcaaga cgctagacat tccagaatta
     8641 ttttccttgg ccatccaagt gaagtagaag tagattgttg gattgcaaag aaaatgataa
     8701 agattcccta aaggaattta taagcaggca acttcattcc tatgtataag atattgggag
     8761 aaaacaaact gtaccacaac aaatcttaag tttcaaggct ctcctatagg gagaaacatg
     8821 gccaaaaaga caggaagaac tgtggcttgt aactcaatga tgctataact ccagcactgg
     8881 atcttaagta ttctggaata taccagattg gtagaactac cagacttggg tatttctcag
     8941 ttaacacaca tgcaaggagg aagagagttt ttttgaacaa aatgactggc tttgacaaaa
     9001 ctatcttgct ctttttaaat gtcacttgat actagaatgc gatttaaaag catgtaatgc
     9061 ctcaggagtc cggcatatac aaccaaatta tcatgctcag gatcttcaga attctaaagg
     9121 cacatgttag aatgcagagt cctgatgacc tgtcaataaa ctttttttta ctaatgaact
     9181 gtacatttaa ataaaagttt atttttggga taa
//
