LOCUS       NM_053276               2800 bp    mRNA    linear   PRI 12-APR-2024
DEFINITION  Homo sapiens vitrin (VIT), transcript variant 1, mRNA.
ACCESSION   NM_053276
VERSION     NM_053276.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2800)
  AUTHORS   Tadayon,S.H., Vaziri-Pashkam,M., Kahali,P., Ansari Dezfouli,M. and
            Abbassian,A.
  TITLE     Common Genetic Variant in VIT Is Associated with Human Brain
            Asymmetry
  JOURNAL   Front Hum Neurosci 10, 236 (2016)
   PUBMED   27252636
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2800)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   3  (bases 1 to 2800)
  AUTHORS   Tomarev,S.I., Wistow,G., Raymond,V., Dubois,S. and Malyukova,I.
  TITLE     Gene expression profile of the human trabecular meshwork: NEIBank
            sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 44 (6), 2588-2596 (2003)
   PUBMED   12766061
REFERENCE   4  (bases 1 to 2800)
  AUTHORS   Whittaker,C.A. and Hynes,R.O.
  TITLE     Distribution and evolution of von Willebrand/integrin A domains:
            widely dispersed domains with roles in cell adhesion and elsewhere
  JOURNAL   Mol Biol Cell 13 (10), 3369-3387 (2002)
   PUBMED   12388743
  REMARK    Review article
REFERENCE   5  (bases 1 to 2800)
  AUTHORS   Mayne,R., Ren,Z.X., Liu,J., Cook,T., Carson,M. and Narayana,S.
  TITLE     VIT-1: the second member of a new branch of the von Willebrand
            factor A domain superfamily
  JOURNAL   Biochem Soc Trans 27 (6), 832-835 (1999)
   PUBMED   10830112
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007363.3, AK056772.1 and
            CD679226.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_053276.3.
            
            Summary: This gene encodes an extracellular matrix (ECM) protein.
            The protein may be associated with cell adhesion and migration.
            High levels of expression of the protein in specific parts of the
            brain suggest its likely role in neural development. [provided by
            RefSeq, Jun 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the shortest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056772.1, SRR1660805.237194.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379242.8/ ENSP00000368544.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC007363.3         127787-127850       c
            65-2793             AK056772.1         1-2729
            2794-2800           CD679226.1         429-435
FEATURES             Location/Qualifiers
     source          1..2800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2"
     gene            1..2800
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /note="vitrin"
                     /db_xref="GeneID:5212"
                     /db_xref="HGNC:HGNC:12697"
                     /db_xref="MIM:617693"
     exon            1..267
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            268..337
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..2367
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="vitrin isoform 1 precursor"
                     /protein_id="NP_444506.2"
                     /db_xref="CCDS:CCDS33180.1"
                     /db_xref="GeneID:5212"
                     /db_xref="HGNC:HGNC:12697"
                     /db_xref="MIM:617693"
                     /translation="MRTVVLTMKASVIEMFLVLLVTGVHSNKETAKKIKRPKFTVPQI
                     NCDVKAGKIIDPEFIVKCPAGCQDPKYHVYGTDVYASYSSVCGAAVHSGVLDNSGGKI
                     LVRKVAGQSGYKGSYSNGVQSLSLPRWRESFIVLESKPKKGVTYPSALTYSSSKSPAA
                     QAGETTKAYQRPPIPGTTAQPVTLMQLLAVTVAVATPTTLPRPSPSAASTTSIPRPQS
                     VGHRSQEMDLWSTATYTSSQNRPRADPGIQRQDPSGAAFQKPVGADVSLGEMDSWKPG
                     SVLLDEGLVPKEELSTQSLEPVSLGDPNCKIDLSFLIDGSTSIGKRRFRIQKQLLADV
                     AQALDIGPAGPLMGVVQYGDNPATHFNLKTHTNSRDLKTAIEKITQRGGLSNVGRAIS
                     FVTKNFFSKANGNRSGAPNVVVVMVDGWPTDKVEEASRLARESGINIFFITIEGAAEN
                     EKQYVVEPNFANKAVCRTNGFYSLHVQSWFGLHKTLQPLVKRVCDTDRLACSKTCLNS
                     ADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEFEISDTDTRIGAVQYTYEQRLEFGFDK
                     YSSKPDILNAIKRVGYWSGGTSTGAAINFALEQLFKKSKPNKRKLMILITDGRSYDDV
                     RIPAMAAHLKGVITYAIGVAWAAQEELEVIATHPARDHSFFVDEFDNLHQYVPRIIQN
                     ICTEFNSQPRN"
     exon            338..403
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..560
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..694
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..772
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..964
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1021
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1087
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1132
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1195
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1343
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1447
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1674
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..2188
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2800
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2773..2778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /note="hexamer: ATTAAA"
     polyA_site      2800
                     /gene="VIT"
                     /gene_synonym="VIT1"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgagaa gcagtatgtg tgagcatgtg tgtgtgtgta tgtgtgtggg ggggggtgta
       61 aaatgtgttt ttcaaagtac tgagaggttg atgggactgt tcgattagct cctctgagaa
      121 gaagagaaaa ggttcttgga cctctccctg tttcttcctt agaataattt ggatgggatt
      181 tgtgatgcag gaaagcctaa gggaaaaaga atattcattc tgtgtggtga aaattttttg
      241 aaaaaaaaat tgccttcttc aaacaagggt gtcattctga tatttatgag gactgttgtt
      301 ctcactatga aggcatctgt tattgaaatg ttccttgttt tgctggtgac tggagtacat
      361 tcaaacaaag aaacggcaaa gaagattaaa aggcccaagt tcactgtgcc tcagatcaac
      421 tgcgatgtca aagccggaaa gatcatcgat cctgagttca ttgtgaaatg tccagcagga
      481 tgccaagacc ccaaatacca tgtttatggc actgacgtgt atgcatccta ctccagtgtg
      541 tgtggcgctg ccgtacacag tggtgtgctt gataattcag gagggaaaat acttgttcgg
      601 aaggttgctg gacagtctgg ttacaaaggg agttattcca acggtgtcca atcgttatcc
      661 ctaccacgat ggagagaatc ctttatcgtc ttagaaagta aacccaaaaa gggtgtaacc
      721 tacccatcag ctcttacata ctcatcatcg aaaagtccag ctgcccaagc aggtgagacc
      781 acaaaagcct atcagaggcc acctattcca gggacaactg cacagccggt cactctgatg
      841 cagcttctgg ctgtcactgt agctgtggcc acccccacca ccttgccaag gccatcccct
      901 tctgctgctt ctaccaccag catccccaga ccacaatcag tgggccacag gagccaggag
      961 atggatctct ggtccactgc cacctacaca agcagccaaa acaggcccag agctgatcca
     1021 ggtatccaaa ggcaagatcc ttcaggagct gccttccaga aacctgttgg agcggatgtc
     1081 agcctgggag agatggactc atggaaacct ggatcggtcc ttttagatga aggacttgtt
     1141 ccaaaagaag aattgagcac acagtctttg gagccagtat ccctgggaga tccaaactgc
     1201 aaaattgact tgtcgttttt aattgatggg agcaccagca ttggcaaacg gcgattccga
     1261 atccagaagc agctcctggc tgatgttgcc caagctcttg acattggccc tgccggtcca
     1321 ctgatgggtg ttgtccagta tggagacaac cctgctactc actttaacct caagacacac
     1381 acgaattctc gagatctgaa gacagccata gagaaaatta ctcagagagg aggactttct
     1441 aatgtaggtc gggccatctc ctttgtgacc aagaacttct tttccaaagc caatggaaac
     1501 agaagcgggg ctcccaatgt ggtggtggtg atggtggatg gctggcccac ggacaaagtg
     1561 gaggaggctt caagacttgc gagagagtca ggaatcaaca ttttcttcat caccattgaa
     1621 ggtgctgctg aaaatgagaa gcagtatgtg gtggagccca actttgcaaa caaggccgtg
     1681 tgcagaacaa acggcttcta ctcgctccac gtgcagagct ggtttggcct ccacaagacc
     1741 ctgcagcctc tggtgaagcg ggtctgcgac actgaccgcc tggcctgcag caagacctgc
     1801 ttgaactcgg ctgacattgg cttcgtcatc gacggctcca gcagtgtggg gacgggcaac
     1861 ttccgcaccg tcctccagtt tgtgaccaac ctcaccaaag agtttgagat ttccgacacg
     1921 gacacgcgca tcggggccgt gcagtacacc tacgaacagc ggctggagtt tgggttcgac
     1981 aagtacagca gcaagcctga catcctcaac gccatcaaga gggtgggcta ctggagtggt
     2041 ggcaccagca cgggggctgc catcaacttc gccctggagc agctcttcaa gaagtccaag
     2101 cccaacaaga ggaagttaat gatcctcatc accgacggga ggtcctacga cgacgtccgg
     2161 atcccagcca tggctgccca tctgaaggga gtgatcacct atgcgatagg cgttgcctgg
     2221 gctgcccaag aggagctaga agtcattgcc actcaccccg ccagagacca ctccttcttt
     2281 gtggacgagt ttgacaacct ccatcagtat gtccccagga tcatccagaa catttgtaca
     2341 gagttcaact cacagcctcg gaactgaatt cagagcaggc agagcaccag caagtgctgc
     2401 tttactaact gacgtgttgg accaccccac cgcttaatgg ggcacgcacg gtgcatcaag
     2461 tcttgggcag ggcatggaga aacaaatgtc ttgttattat tctttgccat catgcttttt
     2521 catattccaa aacttggagt tacaaagatg atcacaaacg tatagaatga gccaaaaggc
     2581 tacatcatgt tgagggtgct ggagatttta cattttgaca attgttttca aaataaatgt
     2641 tcggaataca gtgcagccct tacgacaggc ttacgtagag cttttgtgag atttttaagt
     2701 tgttatttct gattagaact ctgtaaccct cagcaagttt catttttgtc atgacaatgt
     2761 aggaattgct gaattaaatg tttagaagga tgacatgcaa
//
