LOCUS       NM_015496               6478 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens vir like m6A methyltransferase associated (VIRMA),
            transcript variant 1, mRNA.
ACCESSION   NM_015496
VERSION     NM_015496.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6478)
  AUTHORS   Huang,J., Guo,J. and Jia,R.
  TITLE     N6-Methyladenosine Methyltransferase Component KIAA1429 Is a
            Potential Target of Cancer Therapy
  JOURNAL   Biomolecules 14 (10), 1319 (2024)
   PUBMED   39456252
  REMARK    GeneRIF: N6-Methyladenosine Methyltransferase Component KIAA1429 Is
            a Potential Target of Cancer Therapy.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6478)
  AUTHORS   Chen,H., Zhu,P., Zhu,D., Jin,J., Yang,Q. and Han,X.
  TITLE     Role and mechanism of KIAA1429 in regulating cellular ferroptosis
            and radioresistance in colorectal cancer
  JOURNAL   Biomol Biomed 24 (6), 1669-1681 (2024)
   PUBMED   38843497
  REMARK    GeneRIF: Role and mechanism of KIAA1429 in regulating cellular
            ferroptosis and radioresistance in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6478)
  AUTHORS   Wu,Y., Luo,Y., Yao,X., Shi,X., Xu,Z., Re,J., Shi,M., Li,M., Liu,J.,
            He,Y. and Du,X.
  TITLE     KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A
            modification to promote aerobic glycolysis and tumorigenesis in
            multiple myeloma
  JOURNAL   Cell Biol Toxicol 40 (1), 58 (2024)
   PUBMED   39060874
  REMARK    GeneRIF: KIAA1429 increases FOXM1 expression through
            YTHDF1-mediated m6A modification to promote aerobic glycolysis and
            tumorigenesis in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6478)
  AUTHORS   Guo,W., Wang,T., Huai,Q., Guo,L., Wang,X. and He,J.
  TITLE     KIAA1429 regulates lung adenocarcinoma proliferation and metastasis
            through the PI3K/AKT pathway by modulating ARHGAP30 expression
  JOURNAL   Thorac Cancer 15 (18), 1397-1409 (2024)
   PUBMED   38717936
  REMARK    GeneRIF: KIAA1429 regulates lung adenocarcinoma proliferation and
            metastasis through the PI3K/AKT pathway by modulating ARHGAP30
            expression.
REFERENCE   5  (bases 1 to 6478)
  AUTHORS   Xu,D., Wang,Z. and Li,F.
  TITLE     KIAA1429 Induces m6A Modification of LINC01106 to Enhance the
            Malignancy of Lung Adenocarcinoma Cells via the JAK/STAT3 Pathway
  JOURNAL   Crit Rev Immunol 44 (6), 49-61 (2024)
   PUBMED   38848293
  REMARK    GeneRIF: KIAA1429 Induces m6A Modification of LINC01106 to Enhance
            the Malignancy of Lung Adenocarcinoma Cells via the JAK/STAT3
            Pathway.
REFERENCE   6  (bases 1 to 6478)
  AUTHORS   Horiuchi,K., Kawamura,T., Iwanari,H., Ohashi,R., Naito,M.,
            Kodama,T. and Hamakubo,T.
  TITLE     Identification of Wilms' tumor 1-associating protein complex and
            its role in alternative splicing and the cell cycle
  JOURNAL   J Biol Chem 288 (46), 33292-33302 (2013)
   PUBMED   24100041
REFERENCE   7  (bases 1 to 6478)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 6478)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 6478)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   10 (bases 1 to 6478)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC113380.1, AB037850.1, AL832487.1, AC023632.19 and AA731668.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015496.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.90244.1,
                                           SRR1803615.180969.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297591.10/ ENSP00000297591.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BC113380.1         50-76
            28-5071             AB037850.1         1-5044
            5072-5534           AL832487.1         5062-5524
            5535-5995           AC023632.19        74034-74494         c
            5996-6390           AA731668.1         18-412              c
            6391-6478           AC023632.19        73551-73638         c
FEATURES             Location/Qualifiers
     source          1..6478
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..6478
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /note="vir like m6A methyltransferase associated"
                     /db_xref="GeneID:25962"
                     /db_xref="HGNC:HGNC:24500"
                     /db_xref="MIM:616447"
     exon            1..85
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..5461
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /note="isoform 1 is encoded by transcript variant 1;
                     functional spliceosome-associated protein 121; virilizer
                     homolog; protein virilizer homolog"
                     /codon_start=1
                     /product="protein virilizer homolog isoform 1"
                     /protein_id="NP_056311.2"
                     /db_xref="CCDS:CCDS34923.1"
                     /db_xref="GeneID:25962"
                     /db_xref="HGNC:HGNC:24500"
                     /db_xref="MIM:616447"
                     /translation="MAVDSAMELLFLDTFKHPSAEQSSHIDVVRFPCVVYINEVRVIP
                     PGVRAHSSLPDNRAYGETSPHTFQLDLFFNNVSKPSAPVFDRLGSLEYDENTSIIFRP
                     NSKVNTDGLVLRGWYNCLTLAIYGSVDRVISHDRDSPPPPPPPPPPPQPQPSLKRNPK
                     HADGEKEDQFNGSPPRPQPRGPRTPPGPPPPDDDEDDPVPLPVSGDKEEDAPHREDYF
                     EPISPDRNSVPQEGQYSDEGEVEEEQQEEGEEDEDDVDVEEEEDEDEDDRRTVDSIPE
                     EEEEDEEEEGEEDEEGEGDDGYEQISSDEDGIADLERETFKYPNFDVEYTAEDLASVP
                     PMTYDPYDRELVPLLYFSCPYKTTFEIEISRMKDQGPDKENSGAIEASVKLTELLDLY
                     REDRGAKWVTALEEIPSLIIKGLSYLQLKNTKQDSLGQLVDWTMQALNLQVALRQPIA
                     LNVRQLKAGTKLVSSLAECGAQGVTGLLQAGVISGLFELLFADHVSSSLKLNAFKALD
                     SVISMTEGMEAFLRGRQNEKSGYQKLLELILLDQTVRVVTAGSAILQKCHFYEVLSEI
                     KRLGDHLAEKTSSLPNHSEPDHDTDAGLERTNPEYENEVEASMDMDLLESSNISEGEI
                     ERLINLLEEVFHLMETAPHTMIQQPVKSFPTMARITGPPERDDPYPVLFRYLHSHHFL
                     ELVTLLLSIPVTSAHPGVLQATKDVLKFLAQSQKGLLFFMSEYEATNLLIRALCHFYD
                     QDEEEGLQSDGVIDDAFALWLQDSTQTLQCITELFSHFQRCTASEETDHSDLLGTLHN
                     LYLITFNPVGRSAVGHVFSLEKNLQSLITLMEYYSKEALGDSKSKKSVAYNYACILIL
                     VVVQSSSDVQMLEQHAASLLKLCKADENNAKLQELGKWLEPLKNLRFEINCIPNLIEY
                     VKQNIDNLMTPEGVGLTTALRVLCNVACPPPPVEGQQKDLKWNLAVIQLFSAEGMDTF
                     IRVLQKLNSILTQPWRLHVNMGTTLHRVTTISMARCTLTLLKTMLTELLRGGSFEFKD
                     MRVPSALVTLHMLLCSIPLSGRLDSDEQKIQNDIIDILLTFTQGVNEKLTISEETLAN
                     NTWSLMLKEVLSSILKVPEGFFSGLILLSELLPLPLPMQTTQVIEPHDISVALNTRKL
                     WSMHLHVQAKLLQEIVRSFSGTTCQPIQHMLRRICVQLCDLASPTALLIMRTVLDLIV
                     EDLQSTSEDKEKQYTSQTTRLLALLDALASHKACKLAILHLINGTIKGDERYAEIFQD
                     LLALVRSPGDSVIRQQCVEYVTSILQSLCDQDIALILPSSSEGSISELEQLSNSLPNK
                     ELMTSICDCLLATLANSESSYNCLLTCVRTMMFLAEHDYGLFHLKSSLRKNSSALHSL
                     LKRVVSTFSKDTGELASSFLEFMRQILNSDTIGCCGDDNGLMEVEGAHTSRTMSINAA
                     ELKQLLQSKEESPENLFLELEKLVLEHSKDDDNLDSLLDSVVGLKQMLESSGDPLPLS
                     DQDVEPVLSAPESLQNLFNNRTAYVLADVMDDQLKSMWFTPFQAEEIDTDLDLVKVDL
                     IELSEKCCSDFDLHSELERSFLSEPSSPGRTKTTKGFKLGKHKHETFITSSGKSEYIE
                     PAKRAHVVPPPRGRGRGGFGQGIRPHDIFRQRKQNTSRPPSMHVDDFVAAESKEVVPQ
                     DGIPPPKRPLKVSQKISSRGGFSGNRGGRGAFHSQNRFFTPPASKGNYSRREGTRGSS
                     WSAQNTPRGNYNESRGGQSNFNRGPLPPLRPLSSTGYRPSPRDRASRGRGGLGPSWAS
                     ANSGSGGSRGKFVSGGSGRGRHVRSFTR"
     exon            86..201
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            202..288
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            289..337
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            338..506
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            507..629
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            630..902
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            903..2043
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2535
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2690
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2773
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2867
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3412
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3648
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            3649..3901
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..4119
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            4120..4252
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            4253..4405
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            4406..4566
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            4567..4663
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            4664..4830
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            4831..5162
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            5163..5306
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     exon            5307..6478
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5623..5628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /note="hexamer: AATAAA"
     polyA_site      5647
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /note="major polyA site"
     regulatory      6346..6351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /note="hexamer: AATAAA"
     regulatory      6371..6376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /note="hexamer: AATAAA"
     polyA_site      6372
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
     polyA_site      6390
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
     regulatory      6453..6458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
                     /note="hexamer: AATACA"
     polyA_site      6478
                     /gene="VIRMA"
                     /gene_synonym="fSAP121; KIAA1429; MSTP054"
ORIGIN      
        1 ctgttccccg cccgcggcaa acatggcggt ggactcggcg atggagctgt tatttttaga
       61 tacttttaaa cacccgagcg ctgagcaaag ttctcatata gatgtggttc gttttccatg
      121 tgtggtttat atcaatgaag tccgagtcat acccccagga gtaagagccc atagcagtct
      181 gccagacaat agagcatatg gagagacatc tccccataca tttcaattag acttattctt
      241 caacaatgta agcaaaccaa gtgcccctgt tttcgatagg ttgggaagcc tggaatatga
      301 tgagaatact tccatcatct ttagacctaa ctcaaaggtg aatactgatg gtctggtgct
      361 aagaggctgg tataactgtc tgacactggc aatatatgga tcagtggata gagtgataag
      421 tcatgacaga gactctccac caccaccacc tccaccgcca ccacctcccc agccacaacc
      481 aagtttgaaa aggaatccaa aacatgctga tggggagaaa gaagatcagt ttaatggaag
      541 ccctccaaga ccacagccaa ggggaccaag aactcctcca ggaccccctc cacctgatga
      601 tgatgaagat gatcctgtgc ctctgccagt gtctggtgac aaggaagagg atgctcctca
      661 tagagaagat tactttgagc ccatttctcc tgatcggaat tctgttcccc aggaagggca
      721 atattctgat gaaggagaag tagaagagga acaacaagaa gaaggagaag aagatgaaga
      781 tgatgtggat gtagaggaag aagaggatga ggatgaggat gatcgacgaa cagtagacag
      841 tattcctgag gaggaagagg aagatgaaga ggaagaaggt gaagaggatg aagaaggtga
      901 aggggatgat ggttatgaac aaatttccag tgatgaagat ggaattgctg acttggaacg
      961 tgaaacattt aagtatccaa actttgatgt tgaatacact gctgaagact tagcttcagt
     1021 tcctcctatg acatatgatc catatgacag ggagcttgta ccactcttat acttcagttg
     1081 tccatacaag actacttttg aaattgaaat cagtagaatg aaggatcaag gtccagataa
     1141 agaaaattca ggggcaatcg aagcctcagt gaagttaaca gaactcttag atttgtatag
     1201 agaagataga ggtgcaaaat gggtaacagc tttagaagaa attccaagtt taataataaa
     1261 agggttaagc tatttgcaat tgaaaaacac aaaacaagac tcccttggcc agttggtaga
     1321 ctggaccatg caagctttaa atttacaagt agcgcttcgc caacctatcg ccttaaatgt
     1381 tcgacagctc aaagctggga ccaaattagt gtcctcacta gcagaatgtg gggctcaagg
     1441 agttacagga ctgctacaag caggagtgat cagtggatta tttgaacttc tgtttgctga
     1501 tcacgtatca tcttctctta agttaaatgc ttttaaagct ttggacagtg tcattagtat
     1561 gacagaagga atggaagctt ttttaagagg taggcagaat gaaaaaagtg gttatcaaaa
     1621 gcttctggaa ctcatacttt tagatcagac tgtgagggtt gttactgctg gttcagctat
     1681 tctccaaaaa tgccatttct atgaagtctt gtcagagatt aaaagacttg gtgaccattt
     1741 agcagagaag acttcatctc ttcctaacca cagtgaacct gatcacgaca cagatgctgg
     1801 acttgagaga acaaacccag aatatgaaaa tgaggtggaa gcttctatgg atatggatct
     1861 tttggaatcc tcaaatataa gtgaagggga aatagaaagg cttattaacc tcctagaaga
     1921 agtttttcat ttaatggaaa ctgcccctca tacaatgatc caacaacctg ttaagtcttt
     1981 cccaacgatg gcacgaatta ctggacctcc agagagggat gatccatacc ctgttctctt
     2041 tagatatctt cacagtcatc acttcttgga gttggttacc ttgcttctgt caattccagt
     2101 aacaagtgct caccctggtg tgctgcaagc cacaaaagat gttttgaagt ttcttgcaca
     2161 gtcacagaag ggtcttcttt tttttatgtc ggaatatgaa gcaacaaatt tattgatccg
     2221 agctctgtgt cacttttatg atcaagatga ggaggaaggt ctccaatctg atggtgttat
     2281 tgatgatgca tttgccttgt ggctacagga ctcaacacag acattgcaat gtattacaga
     2341 actgttcagc cattttcagc gttgtacagc cagtgaagaa acagaccatt cagatctctt
     2401 gggaaccctg cacaatcttt atttgattac ttttaatcct gtgggaagat cagctgttgg
     2461 ccatgttttt agtctggaga aaaatctcca aagtcttatt actctaatgg agtactattc
     2521 caaagaagcc ttgggtgatt ccaaatctaa gaagtcagta gcttataatt acgcatgcat
     2581 acttattttg gtggtggttc agtcttccag tgatgttcaa atgctagaac aacatgcagc
     2641 atctctcttg aagctttgta aagcagatga aaataatgct aaattgcaag aacttggcaa
     2701 gtggcttgaa cctctgaaaa accttagatt tgaaattaac tgcatcccaa acttaattga
     2761 gtatgttaag cagaatatcg ataacttgat gaccccagaa ggagttggcc ttaccactgc
     2821 cttacgtgtt ctctgtaatg ttgcatgccc accacctcct gttgaaggtc aacagaaaga
     2881 tctgaaatgg aatcttgccg ttattcagct tttttctgct gaaggaatgg acacgtttat
     2941 tcgagttctg caaaaattga acagtattct gactcagcct tggaggctcc atgtcaacat
     3001 ggggactacc cttcacagag ttactactat ttcaatggct cgctgcacac tcactcttct
     3061 taaaactatg ttaacggaac tcctgagagg tggatccttt gagtttaagg acatgcgtgt
     3121 tccttcagcg cttgttactt tacatatgct cctgtgctct atccccctct caggtcgttt
     3181 ggatagtgat gaacagaaaa ttcagaatga tatcattgat attttactga cttttacaca
     3241 aggagttaat gaaaaactca caatctcaga agagactctg gccaataata cttggtcttt
     3301 aatgttaaaa gaagttcttt cttcaatctt gaaggttcct gaaggatttt tttctggact
     3361 catactcctt tcagagctgc tgcctcttcc attgcccatg caaacaactc aggttattga
     3421 gccacatgat atatcagtgg cactcaacac ccgaaaattg tggagcatgc accttcatgt
     3481 tcaagcaaag ttgctccaag aaatagttcg ctctttctct ggcacaacct gccagcccat
     3541 tcaacatatg ttacggcgta tttgtgttca attgtgtgac cttgcctcac caactgcact
     3601 tctgattatg agaactgtgt tggatttgat tgtagaagac ttgcaaagca cttcagaaga
     3661 taaagaaaaa cagtatacta gccaaaccac caggttgctt gctcttcttg atgctctggc
     3721 ttcacacaaa gcttgtaaat tagctatttt gcatctaatt aatggaacta ttaaaggtga
     3781 tgaaagatat gcagagatat tccaggatct tttagctttg gtgcggtctc ctggagacag
     3841 tgttattcgc caacagtgtg ttgaatatgt cacatccatt ttgcagtctc tctgtgatca
     3901 ggacattgca cttatcttac caagctcttc tgaaggttct atttctgaac tggagcagct
     3961 ctccaattct ctaccaaata aagaattgat gacctcaatc tgtgactgtc tgttggctac
     4021 gctagctaac tctgagagca gttacaactg tttactgaca tgtgtcagaa caatgatgtt
     4081 tcttgcagag catgattatg gattatttca tttaaaaagt tctttaagga aaaacagtag
     4141 tgctctgcat agtttactga aacgagtggt cagcacattt agtaaggaca caggagagct
     4201 tgcatcttca tttttagaat ttatgagaca aattcttaac tctgacacaa ttggatgctg
     4261 tggagatgat aatggtctca tggaagtaga gggagctcat acatcacgga cgatgagtat
     4321 taatgctgca gagttaaaac agcttctaca aagcaaagaa gaaagtccag aaaatttgtt
     4381 ccttgaacta gagaagcttg ttttggaaca ttcaaaagat gatgacaatc tggattcttt
     4441 gttggacagt gtagttggac ttaagcagat gctggagtca tcaggtgacc ctttacctct
     4501 cagtgaccag gatgtagaac cagtactttc agctccagaa tctcttcaga atctgtttaa
     4561 caataggact gcctatgtgc ttgctgatgt catggatgat cagttgaaat ctatgtggtt
     4621 cactccattt caggctgaag agatagatac agatctggat ttggtaaagg ttgacttaat
     4681 tgaactctct gaaaaatgct gtagtgactt tgatttgcac tcagaattag agcgctcatt
     4741 tttgtcagaa ccatcatctc caggaagaac caagactact aaaggattca aacttgggaa
     4801 gcacaagcat gagaccttta taacgtcaag tggaaaatct gaatacattg aacctgccaa
     4861 aagagctcat gttgtgccac caccaagagg aaggggcagg ggaggatttg gacagggtat
     4921 acgacctcat gatatttttc gtcagagaaa acagaacaca agtagaccac catctatgca
     4981 tgtggatgac tttgttgctg ctgaaagtaa agaagtggtt cctcaagatg gaatacctcc
     5041 accaaaacgg ccactcaaag tatcacagaa gatttcttcc cgtggtgggt tttcaggcaa
     5101 tagaggagga cggggtgctt tccacagtca gaataggttt ttcacaccac ctgcttcaaa
     5161 aggaaactac agtcgtcggg aaggaacaag aggctccagt tggagtgctc agaatactcc
     5221 tcgaggaaat tacaatgaaa gtcgtggagg ccagagcaat tttaacagag gccctcttcc
     5281 accattacga ccccttagtt ctacaggtta ccgcccaagt cctcgggacc gtgcttctag
     5341 aggtcgtggg ggacttggac cttcctgggc tagtgcaaat agcggcagtg gaggctcaag
     5401 aggaaagttt gttagtggag gcagtggtag aggtcgtcat gtacgctcct ttacacgata
     5461 aaaatccttt tgggaacatc ttaactgtat atgaacattt cacgaggaca ataaaaataa
     5521 gacattgaag gaccaattta gacttagcag ttatctggag acatctgaga gaatattttt
     5581 atctgaagaa agcagaattt gtttgatacc taacaagatt tcaataaaaa tccaaacttt
     5641 gtatgtacgt ttgtatatat tttccctttt ttgtatgact atttatttag aaaatttcta
     5701 ggtgaaaaac taaatgatgt tttgtatttt tcttgcctat agcacagata ttctcaaact
     5761 ttctcagctc atgacactat ttagtgcctc agtacttttt tcacagcata cctggtccaa
     5821 aagaaatatc taatacttgt gtttattaag cagttagatc caacagctta ataagaatgt
     5881 acatcatcac cactagtaac tgtggacact gcatgtctca aaccttggaa tcagtatcat
     5941 tttcttttcc tctctgcttc ttgcacagta ctttttatca aactgctgaa aacccagttt
     6001 tgtaaagata tgttgttata gaaaggaata taatgctatt taatgttgaa aatgtaaact
     6061 acctcaaagt agtagtttat gtgatgtcca acaggtgttg ctatgttttt ctcaaaaatt
     6121 ttaaaatatt gtgtggcacc catgttaatt tgctaaggtg ccctgctaca cagtttggga
     6181 accatggctg taccaaaaga aacaaaatac tcctctcctt tgtattagaa atctgaactt
     6241 tgcatttcag ctttggacct actgacacta ttttattata caaattattt aaagcctaaa
     6301 ataaggaata tcctaatact attattttgg gaatcagaaa catctaataa agctggactt
     6361 tatacataga aataaagctt acaactttga gaaagtagcc atattttccc caagatacgt
     6421 cttaacacac tgagtctata taagtggcgt aaaatacaga gttatcttaa tcagaaaa
//
