LOCUS       NM_003382               3854 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens vasoactive intestinal peptide receptor 2 (VIPR2),
            transcript variant 1, mRNA.
ACCESSION   NM_003382
VERSION     NM_003382.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3854)
  AUTHORS   Passang,T., Wang,S., Zhang,H., Zeng,F., Hsu,P.C., Wang,W., Li,J.M.,
            Liu,Y., Ravindranathan,S., Lesinski,G.B. and Waller,E.K.
  TITLE     VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in
            Pancreatic Cancer
  JOURNAL   Cancer Res 84 (18), 2954-2967 (2024)
   PUBMED   38809694
  REMARK    GeneRIF: VPAC2 Receptor Signaling Promotes Growth and
            Immunosuppression in Pancreatic Cancer.
REFERENCE   2  (bases 1 to 3854)
  AUTHORS   He,X., Lin,C., Zhang,F., Zhang,S., Kang,M., Wei,S., Li,H., Wang,N.
            and Li,S.M.
  TITLE     Outdoor time influences VIPR2 polymorphism rs2071623 to regulate
            axial length in Han Chinese children
  JOURNAL   Mol Vis 29, 266-273 (2023)
   PUBMED   38222453
  REMARK    GeneRIF: Outdoor time influences VIPR2 polymorphism rs2071623 to
            regulate axial length in Han Chinese children.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3854)
  AUTHORS   Park,H., Jeon,H., Lee,K.J., Kim,C.G. and Shin,D.
  TITLE     Seaweed intake modulates the association between VIPR2 variants and
            the incidence of metabolic syndrome in middle-aged Koreans
  JOURNAL   Food Funct 14 (20), 9446-9456 (2023)
   PUBMED   37807848
  REMARK    GeneRIF: Seaweed intake modulates the association between VIPR2
            variants and the incidence of metabolic syndrome in middle-aged
            Koreans.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3854)
  AUTHORS   Chuang,H.K., Hsieh,A.R., Ang,T.Y., Chen,S.W., Yang,Y.P.,
            Huang,H.J., Chiou,S.H., Lin,T.C., Chen,S.J., Hsu,C.C. and
            Hwang,D.K.
  TITLE     TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for Retinal
            Detachment: A Genome-Wide Association Study and Polygenic Risk
            Score Analysis
  JOURNAL   Invest Ophthalmol Vis Sci 64 (12), 17 (2023)
   PUBMED   37695605
  REMARK    GeneRIF: TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for
            Retinal Detachment: A Genome-Wide Association Study and Polygenic
            Risk Score Analysis.
REFERENCE   5  (bases 1 to 3854)
  AUTHORS   Lutz,E.M., Shen,S., Mackay,M., West,K. and Harmar,A.J.
  TITLE     Structure of the human VIPR2 gene for vasoactive intestinal peptide
            receptor type 2
  JOURNAL   FEBS Lett 458 (2), 197-203 (1999)
   PUBMED   10481065
REFERENCE   6  (bases 1 to 3854)
  AUTHORS   Mackay,M., Fantes,J., Scherer,S., Boyle,S., West,K., Tsui,L.C.,
            Belloni,E., Lutz,E., Van Heyningen,V. and Harmar,A.J.
  TITLE     Chromosomal localization in mouse and human of the vasoactive
            intestinal peptide receptor type 2 gene: a possible contributor to
            the holoprosencephaly 3 phenotype
  JOURNAL   Genomics 37 (3), 345-353 (1996)
   PUBMED   8938447
REFERENCE   7  (bases 1 to 3854)
  AUTHORS   Xia,M., Gaufo,G.O., Wang,Q., Sreedharan,S.P. and Goetzl,E.J.
  TITLE     Transduction of specific inhibition of HuT 78 human T cell
            chemotaxis by type I vasoactive intestinal peptide receptors
  JOURNAL   J Immunol 157 (3), 1132-1138 (1996)
   PUBMED   8757618
REFERENCE   8  (bases 1 to 3854)
  AUTHORS   Adamou,J.E., Aiyar,N., Van Horn,S. and Elshourbagy,N.A.
  TITLE     Cloning and functional characterization of the human vasoactive
            intestinal peptide (VIP)-2 receptor
  JOURNAL   Biochem Biophys Res Commun 209 (2), 385-392 (1995)
   PUBMED   7733904
REFERENCE   9  (bases 1 to 3854)
  AUTHORS   Svoboda,M., Tastenoy,M., Van Rampelbergh,J., Goossens,J.F., De
            Neef,P., Waelbroeck,M. and Robberecht,P.
  TITLE     Molecular cloning and functional characterization of a human VIP
            receptor from SUP-T1 lymphoblasts
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1617-1624 (1994)
   PUBMED   7811244
REFERENCE   10 (bases 1 to 3854)
  AUTHORS   Inagaki,N., Yoshida,H., Mizuta,M., Mizuno,N., Fujii,Y., Gonoi,T.,
            Miyazaki,J. and Seino,S.
  TITLE     Cloning and functional characterization of a third pituitary
            adenylate cyclase-activating polypeptide receptor subtype expressed
            in insulin-secreting cells
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2679-2683 (1994)
   PUBMED   8146174
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF027390.1, KC877184.1, AC007269.3 and AC004863.5.
            
            On Nov 23, 2018 this sequence version replaced NM_003382.4.
            
            Summary: This gene encodes a receptor for vasoactive intestinal
            peptide, a small neuropeptide. Vasoactive intestinal peptide is
            involved in smooth muscle relaxation, exocrine and endocrine
            secretion, and water and ion flux in lung and intestinal epithelia.
            Its actions are effected through integral membrane receptors
            associated with a guanine nucleotide binding protein which
            activates adenylate cyclase. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X95097.2, SRR14038193.2399620.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262178.7/ ENSP00000262178.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AF027390.1         34182-34328         c
            148-247             KC877184.1         370-469
            248-355             AC007269.3         67202-67309         c
            356-453             AC007269.3         61147-61244         c
            454-551             AC007269.3         15871-15968         c
            552-693             AC007269.3         425-566             c
            694-844             AC004863.5         126972-127122       c
            845-905             AC004863.5         126172-126232       c
            906-975             AC004863.5         124801-124870       c
            976-1067            AC004863.5         124433-124524       c
            1068-1197           AC004863.5         122158-122287       c
            1198-1239           AC004863.5         122048-122089       c
            1240-3854           AC004863.5         118395-121009       c
FEATURES             Location/Qualifiers
     source          1..3854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.3"
     gene            1..3854
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /note="vasoactive intestinal peptide receptor 2"
                     /db_xref="GeneID:7434"
                     /db_xref="HGNC:HGNC:12695"
                     /db_xref="MIM:601970"
     exon            1..147
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1413
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; vasoactive intestinal polypeptide receptor 2;
                     PACAP type III receptor; helodermin-preferring VIP
                     receptor; pituitary adenylate cyclase-activating
                     polypeptide type III receptor; VIP and PACAP receptor 2;
                     VPAC2 receptor"
                     /codon_start=1
                     /product="vasoactive intestinal polypeptide receptor 2
                     isoform 1 precursor"
                     /protein_id="NP_003373.2"
                     /db_xref="CCDS:CCDS5950.1"
                     /db_xref="GeneID:7434"
                     /db_xref="HGNC:HGNC:12695"
                     /db_xref="MIM:601970"
                     /translation="MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRS
                     QTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETF
                     PDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNY
                     IHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFF
                     WLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTND
                     HSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLI
                     PLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRS
                     RCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI"
     exon            148..247
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            248..355
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            356..453
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            454..551
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            552..693
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            694..844
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            845..905
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            906..975
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1067
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1197
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1239
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..3854
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1557..1562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /note="hexamer: ACTAAA"
     polyA_site      1576
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /note="major polyA site"
     regulatory      3830..3835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /note="hexamer: AATAAA"
     polyA_site      3854
                     /gene="VIPR2"
                     /gene_synonym="C16DUPq36.3; DUP7q36.3; PACAP-R-3;
                     PACAP-R3; VIP-R-2; VPAC2; VPAC2R; VPCAP2R"
                     /note="major polyA site"
ORIGIN      
        1 gcactcgctc ccggcccatg ctggaggcgg cggaaccgcg gggacctagg acggaggcgg
       61 cgggcgctgg gcggcccccg gcacgctgag ctcgggatgc ggacgctgct gcctcccgcg
      121 ctgctgacct gctggctgct cgcccccgtg aacagcattc acccagaatg ccgatttcat
      181 ctggaaatac aggaggaaga aacaaaatgt gcagagcttc tgaggtctca aacagaaaaa
      241 cacaaagcct gcagtggcgt ctgggacaac atcacgtgct ggcggcctgc caatgtggga
      301 gagaccgtca cggtgccctg cccaaaagtc ttcagcaatt tttacagcaa agcaggaaac
      361 ataagcaaaa actgtacgag tgacggatgg tcagagacgt tcccagattt cgtcgatgcc
      421 tgtggctaca gcgacccgga ggatgagagc aagatcacgt tttatattct ggtgaaggcc
      481 atttatacac tgggctacag tgtctctctg atgtctcttg caacaggaag cataattctg
      541 tgcctcttca ggaagctgca ctgcaccagg aattacatcc acctgaacct gttcctgtcc
      601 ttcatcctga gagccatctc agtgctggtc aaggacgacg ttctctactc cagctctggc
      661 acgttgcact gccctgacca gccatcctcc tgggtgggct gcaagctgag cctggtcttc
      721 ctgcagtact gcatcatggc caacttcttc tggctgctgg tggaggggct ctacctccac
      781 accctcctgg tggccatgct cccccctaga aggtgcttcc tggcctacct cctgatcgga
      841 tggggcctcc ccaccgtctg catcggtgca tggactgcgg ccaggctcta cttagaagac
      901 accggttgct gggatacaaa cgaccacagt gtgccctggt gggtcatacg aataccgatt
      961 ttaatttcca tcatcgtcaa ttttgtcctt ttcattagta ttatacgaat tttgctgcag
     1021 aagttaacat ccccagatgt cggcggcaac gaccagtctc agtacaagag gctggccaag
     1081 tccacgctcc tgcttatccc gctgttcggc gtccactaca tggtgtttgc cgtgtttccc
     1141 atcagcatct cctccaaata ccagatactg tttgagctgt gcctcgggtc gttccagggc
     1201 ctggtggtgg ccgtcctcta ctgtttcctg aacagtgagg tgcagtgcga gctgaagcga
     1261 aaatggcgaa gccggtgccc gaccccgtcc gcgagccggg attacagggt ctgcggttcc
     1321 tccttctccc gcaacggctc ggagggcgcc ctgcagttcc accgcggctc ccgcgcccag
     1381 tccttcctgc aaacggagac ctcggtcatc tagccccacc cctgcctgtc ggacgcggcg
     1441 ggaggcccac ggttcggggc ttctgcgggg ctgagacgcc ggcttcctcc ttccagatgc
     1501 ccgagcaccg tgtcgggcag gtcagcgcgg tcctgactcc gtcaagctgg ttgtccacta
     1561 aaccccatac ctggaattgg agtcgtgttg tcattgactc gatttaaact ccagcattta
     1621 gataatcttg tgcaaaatgt gtttcagccg tatagtggat ccactttttt tttttttttt
     1681 ttttttgaga cggagtctcg ctctgtcgcc caggctggac tgcagtggcc tgatctctgc
     1741 tccctgcaag ctccgcctcc cgggttcacg ccattctcct gcctcagcct cccatagctg
     1801 ggactacagg cgcccgccaa cacgcctggc taattttttg tatttttagt agagacaggg
     1861 tttcaccatg ttagccagga tggtctcgat ctcctgacct cgtgatgggc ccgcctcggc
     1921 ctcccaaagt gctgggatta aggcgtgagc cactgcgccc ggcccaagag aataggggag
     1981 ccaaggagga aatgtggaaa cgcagttgtg tggcccagca cgagcctggg cgaccaccgg
     2041 gtgacatccg tcccacatca gggcggcctc ccaggtccca taagggtagc cccctcatct
     2101 gcaggacaga gggaagccag tcagggcccc cctgacgtta ggaccaggag aaatcaacag
     2161 gagggcagcc cgtcctctct cttggggcgc ccacccggcc cggctgagcc ctgccccacc
     2221 caactccaca gggctgtttt gcctccccac ggaaggcggg ctgaggagac aaccagatca
     2281 ggagagcaag gtcatgaagg aggggacctc tccacacagg tgttccgtgg gaccctcagc
     2341 agctctggct ctgcctcagg aggtcacctg ccgccctgtg ggagccgcag agcctgacgc
     2401 tcagccccag gccagctgcg gccaggcctg cgggcccctg gtgatggggt tacgtggggt
     2461 gcgggataca gctgagtggg aaccggaaac ctattctctt tttaacaaaa ataatcttag
     2521 gataagaatt attttaacaa catataaaac tgtttcaagc cctcctcccc agagctggcg
     2581 ctcagcagcc ctagcggctg ctccttcagg cgaagggtgg tttgcagatg tggggagggt
     2641 gtctggggac gttgctgagc cagctgcaga agggtgggga tatcagggca cagtctccat
     2701 gtgtgtgcca agccctggcc cccacagcgc tcgatggacc tcagcaagct gcccagccct
     2761 ggcccaggtg ccccgactgt gggactcagt tgttctgagc acatttgact ccacttttcc
     2821 cttaaaaatg aatgtcttgt tcctgtgcat tggtggcatc acagacccca gctggggcgc
     2881 gatgtcaaag gtcgggacag ctgtgccggg aggcagccac agggaagctc acacatcctg
     2941 tcagtgtcac cttggtttgc aaaacccata tccccggtaa aatgaggccg gacagagggg
     3001 ctgttaggac agcaaagcag cagtgtccag agacccctca atccccaaag gtccgcaccc
     3061 tgtcctgcac accctgggcc acgccggcca cacccctctg ctgcaacaag ctcatccctg
     3121 gacttctggg agaatgaacc cgaggttggt ttggggagac aggtgaggcg gtcggatcta
     3181 cagaacaacc caccatttct gggggccgca gaggatccat cacagacgga tactggggag
     3241 taaacggccc aggccaggtg cccaggaaag gacggctgag catgtggagc gagagggagg
     3301 caggtggacg ctgcagaccc caggttcagt gcggcccctc ggctgttcct cccctgtagg
     3361 gtttggacag acccaccccc agccttgccc agctttcaaa ggacaaaagg gagcatcccc
     3421 cacctactct caggtttttg aggaaacaaa gatttgtggt aactgaaggt gttgggtcag
     3481 tggccaggtg ccgacactga gctgtgaccc agaggggacg ctgaggaagt gggcgtgagt
     3541 ggacgtgtca ggtggttacc aggcactggt tgttgatggt cggtggttgg gtgtgggcag
     3601 tcatcagtca tcaggtgtgc tcaggggaca atctcccctc aaccgcacat gtgccactgt
     3661 tcagcggagc tgactggttt ctcctggtag aggggccggc tgtttcctga cagatgcctg
     3721 gtgagcaggg gaagcaggac ccagtggtca gcaggtgtct ttaactgtca ttgtgtgtgg
     3781 aatgtcgcag actcctccac gtggcgggaa tgagctgtgt aaatacttca ataaagcctg
     3841 acttcacatc tgca
//
