LOCUS       NM_004624               2754 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens vasoactive intestinal peptide receptor 1 (VIPR1),
            transcript variant 1, mRNA.
ACCESSION   NM_004624
VERSION     NM_004624.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2754)
  AUTHORS   Piper,S.J., Deganutti,G., Lu,J., Zhao,P., Liang,Y.L., Lu,Y.,
            Fletcher,M.M., Hossain,M.A., Christopoulos,A., Reynolds,C.A.,
            Danev,R., Sexton,P.M. and Wootten,D.
  TITLE     Understanding VPAC receptor family peptide binding and selectivity
  JOURNAL   Nat Commun 13 (1), 7013 (2022)
   PUBMED   36385145
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2754)
  AUTHORS   Tasma,Z., Siow,A., Harris,P.W.R., Brimble,M.A., O'Carroll,S.J.,
            Hay,D.L. and Walker,C.S.
  TITLE     PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human
            Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor
            Antibodies
  JOURNAL   Int J Mol Sci 23 (22), 13797 (2022)
   PUBMED   36430275
  REMARK    GeneRIF: PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and
            Human Trigeminal Ganglia: Characterization of PACAP-Responsive
            Receptor Antibodies.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2754)
  AUTHORS   Ning,S., He,C., Guo,Z., Zhang,H. and Mo,Z.
  TITLE     [VIPR1 promoter methylation promotes transcription factor AP-2alpha
            binding to inhibit VIPR1 expression and promote hepatocellular
            carcinoma cell growth in vitro]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (7), 957-965 (2022)
   PUBMED   35869757
  REMARK    GeneRIF: [VIPR1 promoter methylation promotes transcription factor
            AP-2alpha binding to inhibit VIPR1 expression and promote
            hepatocellular carcinoma cell growth in vitro].
REFERENCE   4  (bases 1 to 2754)
  AUTHORS   Fu,Y., Liu,S., Rodrigues,R.M., Han,Y., Guo,C., Zhu,Z., He,Y.,
            Mackowiak,B., Feng,D., Gao,B., Zeng,S. and Shen,H.
  TITLE     Activation of VIPR1 suppresses hepatocellular carcinoma progression
            by regulating arginine and pyrimidine metabolism
  JOURNAL   Int J Biol Sci 18 (11), 4341-4356 (2022)
   PUBMED   35864952
  REMARK    GeneRIF: Activation of VIPR1 suppresses hepatocellular carcinoma
            progression by regulating arginine and pyrimidine metabolism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2754)
  AUTHORS   Duan,J., Shen,D.D., Zhou,X.E., Bi,P., Liu,Q.F., Tan,Y.X.,
            Zhuang,Y.W., Zhang,H.B., Xu,P.Y., Huang,S.J., Ma,S.S., He,X.H.,
            Melcher,K., Zhang,Y., Xu,H.E. and Jiang,Y.
  TITLE     Cryo-EM structure of an activated VIP1 receptor-G protein complex
            revealed by a NanoBiT tethering strategy
  JOURNAL   Nat Commun 11 (1), 4121 (2020)
   PUBMED   32807782
  REMARK    GeneRIF: Cryo-EM structure of an activated VIP1 receptor-G protein
            complex revealed by a NanoBiT tethering strategy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2754)
  AUTHORS   Sreedharan,S.P., Huang,J.X., Cheung,M.C. and Goetzl,E.J.
  TITLE     Structure, expression, and chromosomal localization of the type I
            human vasoactive intestinal peptide receptor gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (7), 2939-2943 (1995)
   PUBMED   7708752
REFERENCE   7  (bases 1 to 2754)
  AUTHORS   Couvineau,A., Gaudin,P., Maoret,J.J., Rouyer-Fessard,C., Nicole,P.
            and Laburthe,M.
  TITLE     Highly conserved aspartate 68, tryptophane 73 and glycine 109 in
            the N-terminal extracellular domain of the human VIP receptor are
            essential for its ability to bind VIP
  JOURNAL   Biochem Biophys Res Commun 206 (1), 246-252 (1995)
   PUBMED   7818527
REFERENCE   8  (bases 1 to 2754)
  AUTHORS   Couvineau,A., Rouyer-Fessard,C., Darmoul,D., Maoret,J.J.,
            Carrero,I., Ogier-Denis,E. and Laburthe,M.
  TITLE     Human intestinal VIP receptor: cloning and functional expression of
            two cDNA encoding proteins with different N-terminal domains
  JOURNAL   Biochem Biophys Res Commun 200 (2), 769-776 (1994)
   PUBMED   8179610
REFERENCE   9  (bases 1 to 2754)
  AUTHORS   Gagnon,A.W., Aiyar,N. and Elshourbagy,N.A.
  TITLE     Molecular cloning and functional characterization of a human liver
            vasoactive intestinal peptide receptor
  JOURNAL   Cell Signal 6 (3), 321-333 (1994)
   PUBMED   7917790
REFERENCE   10 (bases 1 to 2754)
  AUTHORS   .
  TITLE     [Quaternary structure of rabbit skeletal muscle glycogen
            synthetase]
  JOURNAL   Dokl Akad Nauk SSSR 222 (4), 997-1000 (1975)
   PUBMED   807467
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA200439.1, X75299.1, L13288.1,
            AC092047.3 and BU681817.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_004624.3.
            
            Summary: This gene encodes a receptor for vasoactive intestinal
            peptide, a small neuropeptide. Vasoactive intestinal peptide is
            involved in smooth muscle relaxation, exocrine and endocrine
            secretion, and water and ion flux in lung and intestinal epithelia.
            Its actions are effected through integral membrane receptors
            associated with a guanine nucleotide binding protein which
            activates adenylate cyclase. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064424.1, L13288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325123.5/ ENSP00000327246.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                DA200439.1         32-113
            83-596              X75299.1           1-514
            597-1882            L13288.1           598-1883
            1883-2255           X75299.1           1801-2173
            2256-2462           AC092047.3         75424-75630         c
            2463-2754           BU681817.1         24-315              c
FEATURES             Location/Qualifiers
     source          1..2754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..2754
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /note="vasoactive intestinal peptide receptor 1"
                     /db_xref="GeneID:7433"
                     /db_xref="HGNC:HGNC:12694"
                     /db_xref="MIM:192321"
     exon            1..171
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1467
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; VIP receptor, type I; PACAP type II receptor;
                     pituitary adenylate cyclase activating polypeptide
                     receptor, type II; VIP and PACAP receptor 1; VPAC1
                     receptor; type 1 vasoactive intestinal peptide receptor"
                     /codon_start=1
                     /product="vasoactive intestinal polypeptide receptor 1
                     isoform 1 precursor"
                     /protein_id="NP_004615.2"
                     /db_xref="CCDS:CCDS2698.1"
                     /db_xref="GeneID:7433"
                     /db_xref="HGNC:HGNC:12694"
                     /db_xref="MIM:192321"
                     /translation="MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIE
                     VQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVS
                     RSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVA
                     TAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAA
                     MVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIA
                     RIHFEDYGCWDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSS
                     PYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLN
                     GEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSF
                     QAEVSLV"
     exon            172..277
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     exon            278..385
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     exon            386..492
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     exon            493..596
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     exon            597..729
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     exon            730..883
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     exon            884..944
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1011
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1103
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1233
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1275
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..2754
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2737..2742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /note="hexamer: AATAAA"
     polyA_site      2754
                     /gene="VIPR1"
                     /gene_synonym="HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG;
                     VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R"
                     /note="major polyA site"
ORIGIN      
        1 actctgccag gctcccggcc atcgcccgcc tggtgcgccg cccgccagct ctttgcccgc
       61 gcggggccgc ccgccgcggg ctcagggcag accatgcgcc cgccaagtcc gctgcccgcc
      121 cgctggctat gcgtgctggc aggcgccctc gcctgggccc ttgggccggc gggcggccag
      181 gcggccaggc tgcaggagga gtgtgactat gtgcagatga tcgaggtgca gcacaagcag
      241 tgcctggagg aggcccagct ggagaatgag acaataggct gcagcaagat gtgggacaac
      301 ctcacctgct ggccagccac ccctcggggc caggtagttg tcttggcctg tcccctcatc
      361 ttcaagctct tctcctccat tcaaggccgc aatgtaagcc gcagctgcac cgacgaaggc
      421 tggacgcacc tggagcctgg cccgtacccc attgcctgtg gtttggatga caaggcagcg
      481 agtttggatg agcagcagac catgttctac ggttctgtga agaccggcta caccattggc
      541 tacggcctgt ccctcgccac ccttctggtc gccacagcta tcctgagcct gttcaggaag
      601 ctccactgca cgcggaacta catccacatg cacctcttca tatccttcat cctgagggct
      661 gccgctgtct tcatcaaaga cttggccctc ttcgacagcg gggagtcgga ccagtgctcc
      721 gagggctcgg tgggctgtaa ggcagccatg gtctttttcc aatattgtgt catggctaac
      781 ttcttctggc tgctggtgga gggcctctac ctgtacaccc tgcttgccgt ctccttcttc
      841 tctgagcgga agtacttctg ggggtacata ctcatcggct ggggggtacc cagcacattc
      901 accatggtgt ggaccatcgc caggatccat tttgaggatt atgggtgctg ggacaccatc
      961 aactcctcac tgtggtggat cataaagggc cccatcctca cctccatctt ggtaaacttc
     1021 atcctgttta tttgcatcat ccgaatcctg cttcagaaac tgcggccccc agatatcagg
     1081 aagagtgaca gcagtccata ctcaaggcta gccaggtcca cactcctgct gatccccctg
     1141 tttggagtac actacatcat gttcgccttc tttccggaca attttaagcc tgaagtgaag
     1201 atggtctttg agctcgtcgt ggggtctttc cagggttttg tggtggctat cctctactgc
     1261 ttcctcaatg gtgaggtgca ggcggagctg aggcggaagt ggcggcgctg gcacctgcag
     1321 ggcgtcctgg gctggaaccc caaataccgg cacccgtcgg gaggcagcaa cggcgccacg
     1381 tgcagcacgc aggtttccat gctgacccgc gtcagcccag gtgcccgccg ctcctccagc
     1441 ttccaagccg aagtctccct ggtctgacca ccaggatccc aggggcccaa ggcggcccct
     1501 cccgcccctt cccactcacc ccggcagacg ccggggacag aggcctgccc gggcgcggcc
     1561 agccccggcc ctgggctcgg aggctgcccc cggccccctg gtctctggtc cggacactcc
     1621 tagagaacgc agccctagag cctgcctgga gcgtttctag caagtgagag agatgggagc
     1681 tcctctcctg gaggattgca ggtggaactc agtcattaga ctcctcctcc aaaggccccc
     1741 tacgccaatc aagggcaaaa agtctacata ctttcatcct gactctgccc cctgctggct
     1801 cttctgccca attggaggaa agcaaccggt ggatcctcaa acaacactgg tgtgacctga
     1861 gggcagaaag gttctgcccg ggaaggtcac cagcaccaac accacggtag tgcctgaaat
     1921 ttcaccattg ctgtcaagtt cctttgggtt aagcattacc actcaggcat ttgactgaag
     1981 atgcagctca ctaccctatt ctctctttac gcttagttat cagcttttta aagtgggtta
     2041 ttctggagtt tttgtttgga gagcacacct atcttagtgg ttccccaccg aagtggactg
     2101 gcccctgggt cagtctggtg ggaggacggt gcaacccaag gactgaggga ctctgaagcc
     2161 tctgggaaat gagaaggcag ccaccagcga atgctaggtc tcggactaag cctacctgct
     2221 ctccaagtct cagtggcttc atctgtcaag tgggatctgt cacaccagcc atacttatct
     2281 ctctgtgctg tggaagcaac aggaatcaag agctgccctc cttgtccacc cacctatgtg
     2341 ccaactgttg taactaggct cagagatgtg cacccatggg ctctgacaga aagcagatac
     2401 ctcaccctgc tacacataca ggatttgaac tcagatctgt ctgataggaa tgtgaaagca
     2461 cggactctta ctgctaactt ttgtgtatcg taaccagcca gatcctcttg gttatttgtt
     2521 taccacttgt attattaatg ccattatccc tgaatccccc ttgccacccc accctccctg
     2581 gagtgtggct gaggaggcct ccatctcatg tatcatctgg ataggagcct gctggtcaca
     2641 gcctcctctg tctgcccttc accccagtgg ccactcagct tcctacccac acctctgcca
     2701 gaagatcccc tcaggactgc aacaggcttg tgcaacaata aatgttggct tgga
//
