LOCUS       NM_001400331            2843 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens VPS33B interacting protein, apical-basolateral
            polarity regulator, spe-39 homolog (VIPAS39), transcript variant
            11, mRNA.
ACCESSION   NM_001400331
VERSION     NM_001400331.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2843)
  AUTHORS   Liu,R.J.Y., Al-Molieh,Y., Chen,S.Z., Drobac,M., Urban,D.,
            Chen,C.H., Yao,H.H.Y., Geng,R.S.Q., Li,L., Pluthero,F.G.,
            Benlekbir,S., Rubinstein,J.L. and Kahr,W.H.A.
  TITLE     The Sec1-Munc18 protein VPS33B forms a uniquely bidirectional
            complex with VPS16B
  JOURNAL   J Biol Chem 299 (6), 104718 (2023)
   PUBMED   37062417
  REMARK    GeneRIF: The Sec1-Munc18 protein VPS33B forms a uniquely
            bidirectional complex with VPS16B.
REFERENCE   2  (bases 1 to 2843)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2843)
  AUTHORS   Solinger,J.A., Rashid,H.O., Prescianotto-Baschong,C. and Spang,A.
  TITLE     FERARI is required for Rab11-dependent endocytic recycling
  JOURNAL   Nat Cell Biol 22 (2), 213-224 (2020)
   PUBMED   31988382
  REMARK    GeneRIF: The Rab-binding module of FERARI (factors for endosome
            recycling and Rab interactions) consists of Rab11FIP5 and
            rabenosyn-5, while the SNARE-interacting module comprises VPS45 and
            VIPAS39.
REFERENCE   4  (bases 1 to 2843)
  AUTHORS   Ambrosio,A.L. and Di Pietro,S.M.
  TITLE     Mechanism of platelet alpha-granule biogenesis: study of cargo
            transport and the VPS33B-VPS16B complex in a model system
  JOURNAL   Blood Adv 3 (17), 2617-2626 (2019)
   PUBMED   31501156
  REMARK    GeneRIF: Mechanism of platelet alpha-granule biogenesis: study of
            cargo transport and the VPS33B-VPS16B complex in a model system.
REFERENCE   5  (bases 1 to 2843)
  AUTHORS   Hunter,M.R., Hesketh,G.G., Benedyk,T.H., Gingras,A.C. and
            Graham,S.C.
  TITLE     Proteomic and Biochemical Comparison of the Cellular Interaction
            Partners of Human VPS33A and VPS33B
  JOURNAL   J Mol Biol 430 (14), 2153-2163 (2018)
   PUBMED   29778605
REFERENCE   6  (bases 1 to 2843)
  AUTHORS   Cullinane,A.R., Straatman-Iwanowska,A., Zaucker,A., Wakabayashi,Y.,
            Bruce,C.K., Luo,G., Rahman,F., Gurakan,F., Utine,E., Ozkan,T.B.,
            Denecke,J., Vukovic,J., Di Rocco,M., Mandel,H., Cangul,H.,
            Matthews,R.P., Thomas,S.G., Rappoport,J.Z., Arias,I.M., Wolburg,H.,
            Knisely,A.S., Kelly,D.A., Muller,F., Maher,E.R. and Gissen,P.
  TITLE     Mutations in VIPAR cause an arthrogryposis, renal dysfunction and
            cholestasis syndrome phenotype with defects in epithelial
            polarization
  JOURNAL   Nat Genet 42 (4), 303-312 (2010)
   PUBMED   20190753
  REMARK    Erratum:[Nat Genet. 2011 Mar;43(3):277]
REFERENCE   7  (bases 1 to 2843)
  AUTHORS   Zhu,G.D., Salazar,G., Zlatic,S.A., Fiza,B., Doucette,M.M.,
            Heilman,C.J., Levey,A.I., Faundez,V. and L'hernault,S.W.
  TITLE     SPE-39 family proteins interact with the HOPS complex and function
            in lysosomal delivery
  JOURNAL   Mol Biol Cell 20 (4), 1223-1240 (2009)
   PUBMED   19109425
  REMARK    GeneRIF: SPE-39 homologues are present in RAB5-, RAB7-, and
            RAB11-positive endosomes where they play a conserved role in
            lysosomal delivery and probably function via their interaction with
            the core HOPS complex.
REFERENCE   8  (bases 1 to 2843)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   9  (bases 1 to 2843)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   10 (bases 1 to 2843)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF111168.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-507               AF111168.2         59690-60196         c
            508-600             AF111168.2         56605-56697         c
            601-703             AF111168.2         55894-55996         c
            704-850             AF111168.2         53782-53928         c
            851-889             AF111168.2         52309-52347         c
            890-954             AF111168.2         51888-51952         c
            955-1011            AF111168.2         51089-51145         c
            1012-1104           AF111168.2         46844-46936         c
            1105-1138           AF111168.2         45714-45747         c
            1139-1241           AF111168.2         45155-45257         c
            1242-1269           AF111168.2         43661-43688         c
            1270-1343           AF111168.2         40403-40476         c
            1344-1419           AF111168.2         38439-38514         c
            1420-1554           AF111168.2         37854-37988         c
            1555-1596           AF111168.2         36857-36898         c
            1597-1686           AF111168.2         36437-36526         c
            1687-1776           AF111168.2         31601-31690         c
            1777-1881           AF111168.2         30965-31069         c
            1882-2843           AF111168.2         29270-30231         c
FEATURES             Location/Qualifiers
     source          1..2843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2843
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /note="VPS33B interacting protein, apical-basolateral
                     polarity regulator, spe-39 homolog"
                     /db_xref="GeneID:63894"
                     /db_xref="HGNC:HGNC:20347"
                     /db_xref="MIM:613401"
     exon            1..507
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     CDS             508..1902
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /note="isoform 5 is encoded by transcript variant 11;
                     VPS33B-interacting protein involved in polarity and apical
                     protein restriction; spermatogenesis-defective protein 39
                     homolog"
                     /codon_start=1
                     /product="spermatogenesis-defective protein 39 homolog
                     isoform 5"
                     /protein_id="NP_001387260.1"
                     /db_xref="GeneID:63894"
                     /db_xref="HGNC:HGNC:20347"
                     /db_xref="MIM:613401"
                     /translation="MNRTKGDEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVNSLRD
                     FVDDDDDDDLERVSWSGEPVGSISWSIRETAGNSGSTHEGREQLKSRNSFSSYAQLPK
                     PTSTYSLSSFFRGRTRPGSFQSLSDALSDTPAKSYAPELGRPKGEYRDYSNDWSPSDT
                     VRRLRKGKVCSLERFRSLQDKLQLLEEAVSMHDGNVITAVLIFLKRTLSKEILFRELE
                     VRQVALRHLIHFLKEIGDQKLLLDLFRFLDRTEELALSHYREHLNIQDPDKRKEFLKT
                     CVGLPFSAEDSAHIQDHYTLLERQIIIEANDRHLESAGQTEIFRKHPRKASILNMPLV
                     TTLFYSCFYHYTEAEGTFSSPVNLKKTFKIPDKQYVLTALAARAKLRAWNDVDALFTT
                     KILQEYVNLVEDVDTKLNLATKFKCHDVVIDTYRDLKDRQQLLAYRSKVDKGSAEEEK
                     IDALLSSSQIRWKN"
     exon            508..600
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            601..703
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            704..850
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            851..889
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            890..954
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1011
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1104
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1138
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1241
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1269
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1343
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1419
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1554
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1596
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1686
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1776
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1881
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2843
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2815..2820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /note="hexamer: AATAAA"
     polyA_site      2843
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /note="major polyA site"
ORIGIN      
        1 attcccttcc gcccccttct ctaagctgca cagcctgaat agaagggctg gtccagcggc
       61 ggcggaggct ggcgctgtcc tgagagggag ggctctgtgc ggaagaggtg agggtgtccc
      121 aagccccttg ggtcgcgtat ctggctggat ccagcctctc cgcatcttga tcttttcccc
      181 tcttctagga ggcatcccta caccctatga ctacaggcct gattctcttc tttcagtcag
      241 ggcgaccctt gggcgctgga gtacgcttgg gactggggct gcgagtgagc accagcgatt
      301 ggttcggaag cggacatttg gttcagaacg agcatttaac tctgccaggg atccgctggg
      361 ctctgacgac tgcggtagat ccatggcttc ctggacgttc acccgtagag tcatcctagc
      421 ttaactcttg ttccctggtc tcagttcaca agcctcacct gtatcttcct ggctcggaag
      481 ataattgaaa ccaagtctga cttctcaatg aatcggacaa agggtgatga ggaggagtat
      541 tggaacagct ccaagttcaa ggcttttacc tttgacgatg aagacgatga gctttcacag
      601 ttaaaggagt ccaagcgggc ggtgaacagc ctccgagact tcgtggatga tgatgacgat
      661 gatgacctgg agcgagtcag ctggagtggg gaacctgtgg gaagtatctc atggtccatc
      721 agagagactg ctggtaatag cggctcaacc cacgaggggc gtgaacagct aaagagccga
      781 aacagcttct cctcctatgc acaactaccc aagcctactt ctacctactc cctgagcagc
      841 ttttttagag gtagaactag acctggaagt ttccagtccc tttctgatgc tctgtcagac
      901 acacctgcca aaagctatgc tccagagctg gggagaccca aaggggagta tagggattac
      961 agcaatgact ggagccccag tgatacagtg cgacgtctcc ggaagggcaa ggtttgctca
     1021 ctagagagat tccgctcctt acaggacaaa ctacaactcc tagaagaggc agtaagcatg
     1081 catgatggaa acgtcattac tgcagttctg attttcctga agaggacact gagcaaagag
     1141 atcctcttcc gagagctgga ggtgcgacag gttgccctga gacatcttat tcacttcctt
     1201 aaggaaatag gggatcaaaa gttgctttta gacctcttca ggttcctaga tagaacagaa
     1261 gagcttgcgc tatctcatta tcgagagcat ttgaacattc aggaccctga caaacgaaaa
     1321 gaatttctta aaacctgtgt tggtttgcca ttttcagcag aagattccgc acacatacag
     1381 gaccattaca cgctcctgga acgtcagatc attattgagg caaatgatcg ccatctagaa
     1441 tcagcaggac agactgagat cttccgaaag cacccccgca aagcctccat cctcaacatg
     1501 ccactagtga caacactttt ctactcctgc ttctatcact acacagaggc tgaggggaca
     1561 ttcagcagtc ccgtcaacct gaagaagaca tttaagatcc cagataaaca gtatgtgctg
     1621 acagccctgg ctgctcgtgc caagcttcga gcctggaatg atgtagatgc cctattcacc
     1681 acaaagatat tacaggagta tgtcaatctg gtggaagatg tggacacgaa gttgaactta
     1741 gccactaagt tcaagtgcca tgatgtcgtc attgatacct accgggacct gaaggatcgt
     1801 caacagttgc tagcatacag gagtaaggta gataaaggat cagcagagga ggagaagatt
     1861 gatgctcttc tcagcagctc gcaaattcga tggaagaatt aagtggcatt gactaccttg
     1921 aagcctgcct catttcctcc tctcctgcct gtgaaagcag agagagctct tctttgggag
     1981 agctgcggca tcacatcgct tgggcccatt acccatgggc agtgccagct actcttgaca
     2041 cagataactt cagactgatc ttctgtccaa ggaacatcat ctgaggatcg agatctaaag
     2101 ctttgagtca tgagaatgat tctctccacc tggtgctcat atgaaggtgg gagtgatttc
     2161 tagattgggc ccctactggg taagatctca cttggtctga gaaaagtgac tgctccagaa
     2221 aggaagaggt atgggagtca tagggtggct actgcattcc actcagctaa ttatgatcca
     2281 ggacttggcg ctggacattg gcagttctgc tctgaatgaa gtcagaacag aaccaaaatg
     2341 gcctcaggaa ggaatgccag tgtttcccaa gacctcctgg agatgcactc acaccagact
     2401 gcacagaccc ctccacatta tgccacacat ggcctagacg ttgtgtttcc tcagccattt
     2461 tccctctgct gccccagttt actctgtcca aaaccctaag gttcttctct cacttgaaca
     2521 cagacgacct tgcttgggtg atgagacatc ccctttatct cttcctctac tgctggccaa
     2581 gacccgtcac tttataagaa gctcagatgc agcagtgctg gagagctctc tctttatgca
     2641 aaaatctcat ttcaccagga gctttcagaa gtttcacctg ggctaaattc agcagcattt
     2701 ctgttaggat atttagatgg aggttttatt ttcacacttg gattcttgct ctgtaccaat
     2761 atttgcctcc ttttctgtga ctgaactggg tttttctgac atgcctagac tcctaataaa
     2821 ggtatttctt ccttggtgcc ttc
//
