LOCUS       NM_001400327            2497 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens VPS33B interacting protein, apical-basolateral
            polarity regulator, spe-39 homolog (VIPAS39), transcript variant 9,
            mRNA.
ACCESSION   NM_001400327
VERSION     NM_001400327.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2497)
  AUTHORS   Liu,R.J.Y., Al-Molieh,Y., Chen,S.Z., Drobac,M., Urban,D.,
            Chen,C.H., Yao,H.H.Y., Geng,R.S.Q., Li,L., Pluthero,F.G.,
            Benlekbir,S., Rubinstein,J.L. and Kahr,W.H.A.
  TITLE     The Sec1-Munc18 protein VPS33B forms a uniquely bidirectional
            complex with VPS16B
  JOURNAL   J Biol Chem 299 (6), 104718 (2023)
   PUBMED   37062417
  REMARK    GeneRIF: The Sec1-Munc18 protein VPS33B forms a uniquely
            bidirectional complex with VPS16B.
REFERENCE   2  (bases 1 to 2497)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2497)
  AUTHORS   Solinger,J.A., Rashid,H.O., Prescianotto-Baschong,C. and Spang,A.
  TITLE     FERARI is required for Rab11-dependent endocytic recycling
  JOURNAL   Nat Cell Biol 22 (2), 213-224 (2020)
   PUBMED   31988382
  REMARK    GeneRIF: The Rab-binding module of FERARI (factors for endosome
            recycling and Rab interactions) consists of Rab11FIP5 and
            rabenosyn-5, while the SNARE-interacting module comprises VPS45 and
            VIPAS39.
REFERENCE   4  (bases 1 to 2497)
  AUTHORS   Ambrosio,A.L. and Di Pietro,S.M.
  TITLE     Mechanism of platelet alpha-granule biogenesis: study of cargo
            transport and the VPS33B-VPS16B complex in a model system
  JOURNAL   Blood Adv 3 (17), 2617-2626 (2019)
   PUBMED   31501156
  REMARK    GeneRIF: Mechanism of platelet alpha-granule biogenesis: study of
            cargo transport and the VPS33B-VPS16B complex in a model system.
REFERENCE   5  (bases 1 to 2497)
  AUTHORS   Hunter,M.R., Hesketh,G.G., Benedyk,T.H., Gingras,A.C. and
            Graham,S.C.
  TITLE     Proteomic and Biochemical Comparison of the Cellular Interaction
            Partners of Human VPS33A and VPS33B
  JOURNAL   J Mol Biol 430 (14), 2153-2163 (2018)
   PUBMED   29778605
REFERENCE   6  (bases 1 to 2497)
  AUTHORS   Cullinane,A.R., Straatman-Iwanowska,A., Zaucker,A., Wakabayashi,Y.,
            Bruce,C.K., Luo,G., Rahman,F., Gurakan,F., Utine,E., Ozkan,T.B.,
            Denecke,J., Vukovic,J., Di Rocco,M., Mandel,H., Cangul,H.,
            Matthews,R.P., Thomas,S.G., Rappoport,J.Z., Arias,I.M., Wolburg,H.,
            Knisely,A.S., Kelly,D.A., Muller,F., Maher,E.R. and Gissen,P.
  TITLE     Mutations in VIPAR cause an arthrogryposis, renal dysfunction and
            cholestasis syndrome phenotype with defects in epithelial
            polarization
  JOURNAL   Nat Genet 42 (4), 303-312 (2010)
   PUBMED   20190753
  REMARK    Erratum:[Nat Genet. 2011 Mar;43(3):277]
REFERENCE   7  (bases 1 to 2497)
  AUTHORS   Zhu,G.D., Salazar,G., Zlatic,S.A., Fiza,B., Doucette,M.M.,
            Heilman,C.J., Levey,A.I., Faundez,V. and L'hernault,S.W.
  TITLE     SPE-39 family proteins interact with the HOPS complex and function
            in lysosomal delivery
  JOURNAL   Mol Biol Cell 20 (4), 1223-1240 (2009)
   PUBMED   19109425
  REMARK    GeneRIF: SPE-39 homologues are present in RAB5-, RAB7-, and
            RAB11-positive endosomes where they play a conserved role in
            lysosomal delivery and probably function via their interaction with
            the core HOPS complex.
REFERENCE   8  (bases 1 to 2497)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   9  (bases 1 to 2497)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   10 (bases 1 to 2497)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF111168.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AF111168.2         60090-60196         c
            108-200             AF111168.2         56605-56697         c
            201-303             AF111168.2         55894-55996         c
            304-450             AF111168.2         53782-53928         c
            451-489             AF111168.2         52309-52347         c
            490-554             AF111168.2         51888-51952         c
            555-611             AF111168.2         51089-51145         c
            612-671             AF111168.2         46844-46903         c
            672-705             AF111168.2         45714-45747         c
            706-808             AF111168.2         45155-45257         c
            809-836             AF111168.2         43661-43688         c
            837-910             AF111168.2         40403-40476         c
            911-986             AF111168.2         38439-38514         c
            987-1121            AF111168.2         37854-37988         c
            1122-1163           AF111168.2         36857-36898         c
            1164-1253           AF111168.2         36437-36526         c
            1254-1340           AF111168.2         32276-32362         c
            1341-1430           AF111168.2         31601-31690         c
            1431-1535           AF111168.2         30965-31069         c
            1536-2497           AF111168.2         29270-30231         c
FEATURES             Location/Qualifiers
     source          1..2497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2497
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /note="VPS33B interacting protein, apical-basolateral
                     polarity regulator, spe-39 homolog"
                     /db_xref="GeneID:63894"
                     /db_xref="HGNC:HGNC:20347"
                     /db_xref="MIM:613401"
     exon            1..107
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1556
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /note="isoform 4 is encoded by transcript variant 9;
                     VPS33B-interacting protein involved in polarity and apical
                     protein restriction; spermatogenesis-defective protein 39
                     homolog"
                     /codon_start=1
                     /product="spermatogenesis-defective protein 39 homolog
                     isoform 4"
                     /protein_id="NP_001387256.1"
                     /db_xref="GeneID:63894"
                     /db_xref="HGNC:HGNC:20347"
                     /db_xref="MIM:613401"
                     /translation="MNRTKGDEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVNSLRD
                     FVDDDDDDDLERVSWSGEPVGSISWSIRETAGNSGSTHEGREQLKSRNSFSSYAQLPK
                     PTSTYSLSSFFRGRTRPGSFQSLSDALSDTPAKSYAPELGRPKGEYRDYSNDWSPSDT
                     VRRLRKGKDKLQLLEEAVSMHDGNVITAVLIFLKRTLSKEILFRELEVRQVALRHLIH
                     FLKEIGDQKLLLDLFRFLDRTEELALSHYREHLNIQDPDKRKEFLKTCVGLPFSAEDS
                     AHIQDHYTLLERQIIIEANDRHLESAGQTEIFRKHPRKASILNMPLVTTLFYSCFYHY
                     TEAEGTFSSPVNLKKTFKIPDKQYVLTALAARAKLRAWNDVDALFTTKNWLGYTKKRA
                     PIGFHRVVEILHKNNAPVQILQEYVNLVEDVDTKLNLATKFKCHDVVIDTYRDLKDRQ
                     QLLAYRSKVDKGSAEEEKIDALLSSSQIRWKN"
     exon            108..200
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            201..303
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            304..450
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            451..489
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            490..554
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            555..611
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            612..671
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            672..705
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            706..808
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            809..836
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            837..910
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            911..986
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1121
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1163
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1253
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1340
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1430
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1535
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..2497
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2469..2474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /note="hexamer: AATAAA"
     polyA_site      2497
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /note="major polyA site"
ORIGIN      
        1 attcccttcc gcccccttct ctaagctgca cagcctgaat agaagggctg gtccagcggc
       61 ggcggaggct ggcgctgtcc tgagagggag ggctctgtgc ggaagagatg aatcggacaa
      121 agggtgatga ggaggagtat tggaacagct ccaagttcaa ggcttttacc tttgacgatg
      181 aagacgatga gctttcacag ttaaaggagt ccaagcgggc ggtgaacagc ctccgagact
      241 tcgtggatga tgatgacgat gatgacctgg agcgagtcag ctggagtggg gaacctgtgg
      301 gaagtatctc atggtccatc agagagactg ctggtaatag cggctcaacc cacgaggggc
      361 gtgaacagct aaagagccga aacagcttct cctcctatgc acaactaccc aagcctactt
      421 ctacctactc cctgagcagc ttttttagag gtagaactag acctggaagt ttccagtccc
      481 tttctgatgc tctgtcagac acacctgcca aaagctatgc tccagagctg gggagaccca
      541 aaggggagta tagggattac agcaatgact ggagccccag tgatacagtg cgacgtctcc
      601 ggaagggcaa ggacaaacta caactcctag aagaggcagt aagcatgcat gatggaaacg
      661 tcattactgc agttctgatt ttcctgaaga ggacactgag caaagagatc ctcttccgag
      721 agctggaggt gcgacaggtt gccctgagac atcttattca cttccttaag gaaatagggg
      781 atcaaaagtt gcttttagac ctcttcaggt tcctagatag aacagaagag cttgcgctat
      841 ctcattatcg agagcatttg aacattcagg accctgacaa acgaaaagaa tttcttaaaa
      901 cctgtgttgg tttgccattt tcagcagaag attccgcaca catacaggac cattacacgc
      961 tcctggaacg tcagatcatt attgaggcaa atgatcgcca tctagaatca gcaggacaga
     1021 ctgagatctt ccgaaagcac ccccgcaaag cctccatcct caacatgcca ctagtgacaa
     1081 cacttttcta ctcctgcttc tatcactaca cagaggctga ggggacattc agcagtcccg
     1141 tcaacctgaa gaagacattt aagatcccag ataaacagta tgtgctgaca gccctggctg
     1201 ctcgtgccaa gcttcgagcc tggaatgatg tagatgccct attcaccaca aagaactggc
     1261 tgggctatac caagaagaga gcacccattg gcttccatcg ggttgtcgaa attttgcaca
     1321 agaacaatgc ccctgtgcag atattacagg agtatgtcaa tctggtggaa gatgtggaca
     1381 cgaagttgaa cttagccact aagttcaagt gccatgatgt cgtcattgat acctaccggg
     1441 acctgaagga tcgtcaacag ttgctagcat acaggagtaa ggtagataaa ggatcagcag
     1501 aggaggagaa gattgatgct cttctcagca gctcgcaaat tcgatggaag aattaagtgg
     1561 cattgactac cttgaagcct gcctcatttc ctcctctcct gcctgtgaaa gcagagagag
     1621 ctcttctttg ggagagctgc ggcatcacat cgcttgggcc cattacccat gggcagtgcc
     1681 agctactctt gacacagata acttcagact gatcttctgt ccaaggaaca tcatctgagg
     1741 atcgagatct aaagctttga gtcatgagaa tgattctctc cacctggtgc tcatatgaag
     1801 gtgggagtga tttctagatt gggcccctac tgggtaagat ctcacttggt ctgagaaaag
     1861 tgactgctcc agaaaggaag aggtatggga gtcatagggt ggctactgca ttccactcag
     1921 ctaattatga tccaggactt ggcgctggac attggcagtt ctgctctgaa tgaagtcaga
     1981 acagaaccaa aatggcctca ggaaggaatg ccagtgtttc ccaagacctc ctggagatgc
     2041 actcacacca gactgcacag acccctccac attatgccac acatggccta gacgttgtgt
     2101 ttcctcagcc attttccctc tgctgcccca gtttactctg tccaaaaccc taaggttctt
     2161 ctctcacttg aacacagacg accttgcttg ggtgatgaga catccccttt atctcttcct
     2221 ctactgctgg ccaagacccg tcactttata agaagctcag atgcagcagt gctggagagc
     2281 tctctcttta tgcaaaaatc tcatttcacc aggagctttc agaagtttca cctgggctaa
     2341 attcagcagc atttctgtta ggatatttag atggaggttt tattttcaca cttggattct
     2401 tgctctgtac caatatttgc ctccttttct gtgactgaac tgggtttttc tgacatgcct
     2461 agactcctaa taaaggtatt tcttccttgg tgccttc
//
