LOCUS       NM_001193315            2530 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens VPS33B interacting protein, apical-basolateral
            polarity regulator, spe-39 homolog (VIPAS39), transcript variant 3,
            mRNA.
ACCESSION   NM_001193315
VERSION     NM_001193315.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Liu,R.J.Y., Al-Molieh,Y., Chen,S.Z., Drobac,M., Urban,D.,
            Chen,C.H., Yao,H.H.Y., Geng,R.S.Q., Li,L., Pluthero,F.G.,
            Benlekbir,S., Rubinstein,J.L. and Kahr,W.H.A.
  TITLE     The Sec1-Munc18 protein VPS33B forms a uniquely bidirectional
            complex with VPS16B
  JOURNAL   J Biol Chem 299 (6), 104718 (2023)
   PUBMED   37062417
  REMARK    GeneRIF: The Sec1-Munc18 protein VPS33B forms a uniquely
            bidirectional complex with VPS16B.
REFERENCE   2  (bases 1 to 2530)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2530)
  AUTHORS   Solinger,J.A., Rashid,H.O., Prescianotto-Baschong,C. and Spang,A.
  TITLE     FERARI is required for Rab11-dependent endocytic recycling
  JOURNAL   Nat Cell Biol 22 (2), 213-224 (2020)
   PUBMED   31988382
  REMARK    GeneRIF: The Rab-binding module of FERARI (factors for endosome
            recycling and Rab interactions) consists of Rab11FIP5 and
            rabenosyn-5, while the SNARE-interacting module comprises VPS45 and
            VIPAS39.
REFERENCE   4  (bases 1 to 2530)
  AUTHORS   Ambrosio,A.L. and Di Pietro,S.M.
  TITLE     Mechanism of platelet alpha-granule biogenesis: study of cargo
            transport and the VPS33B-VPS16B complex in a model system
  JOURNAL   Blood Adv 3 (17), 2617-2626 (2019)
   PUBMED   31501156
  REMARK    GeneRIF: Mechanism of platelet alpha-granule biogenesis: study of
            cargo transport and the VPS33B-VPS16B complex in a model system.
REFERENCE   5  (bases 1 to 2530)
  AUTHORS   Hunter,M.R., Hesketh,G.G., Benedyk,T.H., Gingras,A.C. and
            Graham,S.C.
  TITLE     Proteomic and Biochemical Comparison of the Cellular Interaction
            Partners of Human VPS33A and VPS33B
  JOURNAL   J Mol Biol 430 (14), 2153-2163 (2018)
   PUBMED   29778605
REFERENCE   6  (bases 1 to 2530)
  AUTHORS   Cullinane,A.R., Straatman-Iwanowska,A., Zaucker,A., Wakabayashi,Y.,
            Bruce,C.K., Luo,G., Rahman,F., Gurakan,F., Utine,E., Ozkan,T.B.,
            Denecke,J., Vukovic,J., Di Rocco,M., Mandel,H., Cangul,H.,
            Matthews,R.P., Thomas,S.G., Rappoport,J.Z., Arias,I.M., Wolburg,H.,
            Knisely,A.S., Kelly,D.A., Muller,F., Maher,E.R. and Gissen,P.
  TITLE     Mutations in VIPAR cause an arthrogryposis, renal dysfunction and
            cholestasis syndrome phenotype with defects in epithelial
            polarization
  JOURNAL   Nat Genet 42 (4), 303-312 (2010)
   PUBMED   20190753
  REMARK    Erratum:[Nat Genet. 2011 Mar;43(3):277]
REFERENCE   7  (bases 1 to 2530)
  AUTHORS   Zhu,G.D., Salazar,G., Zlatic,S.A., Fiza,B., Doucette,M.M.,
            Heilman,C.J., Levey,A.I., Faundez,V. and L'hernault,S.W.
  TITLE     SPE-39 family proteins interact with the HOPS complex and function
            in lysosomal delivery
  JOURNAL   Mol Biol Cell 20 (4), 1223-1240 (2009)
   PUBMED   19109425
  REMARK    GeneRIF: SPE-39 homologues are present in RAB5-, RAB7-, and
            RAB11-positive endosomes where they play a conserved role in
            lysosomal delivery and probably function via their interaction with
            the core HOPS complex.
REFERENCE   8  (bases 1 to 2530)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   9  (bases 1 to 2530)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   10 (bases 1 to 2530)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF111168.2, AK022769.1 and
            AW629161.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 25, 2020 this sequence version replaced NM_001193315.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022925.1, AK222706.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000557658.6/ ENSP00000452191.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AF111168.2         60182-60196         c
            16-945              AK022769.1         3-932
            946-946             AF111168.2         38512-38512         c
            947-1863            AK022769.1         934-1850
            1864-1864           AF111168.2         29936-29936         c
            1865-2116           AK022769.1         1852-2103
            2117-2117           AF111168.2         29683-29683         c
            2118-2139           AK022769.1         2105-2126
            2140-2140           AF111168.2         29660-29660         c
            2141-2525           AK022769.1         2128-2512
            2526-2530           AW629161.1         12-16               c
FEATURES             Location/Qualifiers
     source          1..2530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2530
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /note="VPS33B interacting protein, apical-basolateral
                     polarity regulator, spe-39 homolog"
                     /db_xref="GeneID:63894"
                     /db_xref="HGNC:HGNC:20347"
                     /db_xref="MIM:613401"
     exon            1..107
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1589
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /note="isoform 1 is encoded by transcript variant 3;
                     VPS33B-interacting protein involved in polarity and apical
                     protein restriction; spermatogenesis-defective protein 39
                     homolog"
                     /codon_start=1
                     /product="spermatogenesis-defective protein 39 homolog
                     isoform 1"
                     /protein_id="NP_001180244.1"
                     /db_xref="CCDS:CCDS9862.1"
                     /db_xref="GeneID:63894"
                     /db_xref="HGNC:HGNC:20347"
                     /db_xref="MIM:613401"
                     /translation="MNRTKGDEEEYWNSSKFKAFTFDDEDDELSQLKESKRAVNSLRD
                     FVDDDDDDDLERVSWSGEPVGSISWSIRETAGNSGSTHEGREQLKSRNSFSSYAQLPK
                     PTSTYSLSSFFRGRTRPGSFQSLSDALSDTPAKSYAPELGRPKGEYRDYSNDWSPSDT
                     VRRLRKGKVCSLERFRSLQDKLQLLEEAVSMHDGNVITAVLIFLKRTLSKEILFRELE
                     VRQVALRHLIHFLKEIGDQKLLLDLFRFLDRTEELALSHYREHLNIQDPDKRKEFLKT
                     CVGLPFSAEDSAHIQDHYTLLERQIIIEANDRHLESAGQTEIFRKHPRKASILNMPLV
                     TTLFYSCFYHYTEAEGTFSSPVNLKKTFKIPDKQYVLTALAARAKLRAWNDVDALFTT
                     KNWLGYTKKRAPIGFHRVVEILHKNNAPVQILQEYVNLVEDVDTKLNLATKFKCHDVV
                     IDTYRDLKDRQQLLAYRSKVDKGSAEEEKIDALLSSSQIRWKN"
     exon            108..200
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            201..303
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            304..450
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            451..489
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            490..554
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            555..611
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            612..704
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            705..738
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            739..841
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            842..869
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            870..943
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1019
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1154
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1196
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1286
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1373
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1463
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1568
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..2530
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2502..2507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /note="hexamer: AATAAA"
     polyA_site      2530
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /note="major polyA site"
ORIGIN      
        1 attcccttcc gcccccttct ctaagctgca cagcctgaat agaagggctg gtccagcggc
       61 ggcggaggct ggcgctgtcc tgagagggag ggctctgtgc ggaagagatg aatcggacaa
      121 agggtgatga ggaggagtat tggaacagct ccaagttcaa ggcttttacc tttgacgatg
      181 aagacgatga gctttcacag ttaaaggagt ccaagcgggc ggtgaacagc ctccgagact
      241 tcgtggatga tgatgacgat gatgacctgg agcgagtcag ctggagtggg gaacctgtgg
      301 gaagtatctc atggtccatc agagagactg ctggtaatag cggctcaacc cacgaggggc
      361 gtgaacagct aaagagccga aacagcttct cctcctatgc acaactaccc aagcctactt
      421 ctacctactc cctgagcagc ttttttagag gtagaactag acctggaagt ttccagtccc
      481 tttctgatgc tctgtcagac acacctgcca aaagctatgc tccagagctg gggagaccca
      541 aaggggagta tagggattac agcaatgact ggagccccag tgatacagtg cgacgtctcc
      601 ggaagggcaa ggtttgctca ctagagagat tccgctcctt acaggacaaa ctacaactcc
      661 tagaagaggc agtaagcatg catgatggaa acgtcattac tgcagttctg attttcctga
      721 agaggacact gagcaaagag atcctcttcc gagagctgga ggtgcgacag gttgccctga
      781 gacatcttat tcacttcctt aaggaaatag gggatcaaaa gttgctttta gacctcttca
      841 ggttcctaga tagaacagaa gagcttgcgc tatctcatta tcgagagcat ttgaacattc
      901 aggaccctga caaacgaaaa gaatttctta aaacctgtgt tggtttgcca ttttcagcag
      961 aagattccgc acacatacag gaccattaca cgctcctgga acgtcagatc attattgagg
     1021 caaatgatcg ccatctagaa tcagcaggac agactgagat cttccgaaag cacccccgca
     1081 aagcctccat cctcaacatg ccactagtga caacactttt ctactcctgc ttctatcact
     1141 acacagaggc tgaggggaca ttcagcagtc ccgtcaacct gaagaagaca tttaagatcc
     1201 cagataaaca gtatgtgctg acagccctgg ctgctcgtgc caagcttcga gcctggaatg
     1261 atgtagatgc cctattcacc acaaagaact ggctgggcta taccaagaag agagcaccca
     1321 ttggcttcca tcgggttgtc gaaattttgc acaagaacaa tgcccctgtg cagatattac
     1381 aggagtatgt caatctggtg gaagatgtgg acacgaagtt gaacttagcc actaagttca
     1441 agtgccatga tgtcgtcatt gatacctacc gggacctgaa ggatcgtcaa cagttgctag
     1501 catacaggag taaggtagat aaaggatcag cagaggagga gaagattgat gctcttctca
     1561 gcagctcgca aattcgatgg aagaattaag tggcattgac taccttgaag cctgcctcat
     1621 ttcctcctct cctgcctgtg aaagcagaga gagctcttct ttgggagagc tgcggcatca
     1681 catcgcttgg gcccattacc catgggcagt gccagctact cttgacacag ataacttcag
     1741 actgatcttc tgtccaagga acatcatctg aggatcgaga tctaaagctt tgagtcatga
     1801 gaatgattct ctccacctgg tgctcatatg aaggtgggag tgatttctag attgggcccc
     1861 tactgggtaa gatctcactt ggtctgagaa aagtgactgc tccagaaagg aagaggtatg
     1921 ggagtcatag ggtggctact gcattccact cagctaatta tgatccagga cttggcgctg
     1981 gacattggca gttctgctct gaatgaagtc agaacagaac caaaatggcc tcaggaagga
     2041 atgccagtgt ttcccaagac ctcctggaga tgcactcaca ccagactgca cagacccctc
     2101 cacattatgc cacacatggc ctagacgttg tgtttcctca gccattttcc ctctgctgcc
     2161 ccagtttact ctgtccaaaa ccctaaggtt cttctctcac ttgaacacag acgaccttgc
     2221 ttgggtgatg agacatcccc tttatctctt cctctactgc tggccaagac ccgtcacttt
     2281 ataagaagct cagatgcagc agtgctggag agctctctct ttatgcaaaa atctcatttc
     2341 accaggagct ttcagaagtt tcacctgggc taaattcagc agcatttctg ttaggatatt
     2401 tagatggagg ttttattttc acacttggat tcttgctctg taccaatatt tgcctccttt
     2461 tctgtgactg aactgggttt ttctgacatg cctagactcc taataaaggt atttcttcct
     2521 tggtgccttc
//
