LOCUS       NM_003380               2154 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens vimentin (VIM), mRNA.
ACCESSION   NM_003380
VERSION     NM_003380.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2154)
  AUTHORS   Liang,Y., He,S., Liu,Q., Liu,T., Tan,Y., Peng,T., Huang,C., Lu,X.
            and Zheng,S.
  TITLE     Vimentin, inversely correlating with infiltration of CD8 + T
            lymphocytes, promotes nuclear translocation of PD-L1 in esophageal
            squamous cell carcinoma
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119781 (2024)
   PUBMED   38901494
  REMARK    GeneRIF: Vimentin, inversely correlating with infiltration of CD8 +
            T lymphocytes, promotes nuclear translocation of PD-L1 in
            esophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 2154)
  AUTHORS   Yan,H., Zang,R., Cui,T., Liu,Y., Zhang,B., Zhao,L., Li,H., Zhou,J.,
            Wang,H., Zeng,Q., Xu,L., Zhou,Y., Pei,X., Xi,J. and Yue,W.
  TITLE     PROTAC-mediated vimentin degradation promotes terminal erythroid
            differentiation of pluripotent stem cells
  JOURNAL   Stem Cell Res Ther 15 (1), 310 (2024)
   PUBMED   39294765
  REMARK    GeneRIF: PROTAC-mediated vimentin degradation promotes terminal
            erythroid differentiation of pluripotent stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2154)
  AUTHORS   Wen,L., Xie,B., Li,H., Huang,J., Shi,Y., Tao,Y. and Chen,Y.
  TITLE     EP300 through upregulating the expression of vimentin to promote
            the progression of chordoma
  JOURNAL   Neurosurg Focus 56 (5), E17 (2024)
   PUBMED   38691868
  REMARK    GeneRIF: EP300 through upregulating the expression of vimentin to
            promote the progression of chordoma.
REFERENCE   4  (bases 1 to 2154)
  AUTHORS   Li,H., Zhu,Y.Z., Xu,L., Han,T., Luan,J., Li,X., Liu,Y., Wang,Z.,
            Liu,Q., Kong,X., Zou,C., Su,L., Hou,Y., Chen,X., Chen,L., Wang,R.,
            Xu,Z. and Zhao,M.
  TITLE     Exploring new frontiers: cell surface vimentin as an emerging
            marker for circulating tumor cells and a promising therapeutic
            target in advanced gastric Cancer
  JOURNAL   J Exp Clin Cancer Res 43 (1), 129 (2024)
   PUBMED   38685125
  REMARK    GeneRIF: Exploring new frontiers: cell surface vimentin as an
            emerging marker for circulating tumor cells and a promising
            therapeutic target in advanced gastric Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2154)
  AUTHORS   Zhang,Y., Wang,X., Liu,W., Lei,T., Qiao,T., Feng,W. and Song,W.
  TITLE     CircGLIS3 promotes gastric cancer progression by regulating the
            miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation
  JOURNAL   J Transl Med 22 (1), 251 (2024)
   PUBMED   38459513
  REMARK    GeneRIF: CircGLIS3 promotes gastric cancer progression by
            regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2154)
  AUTHORS   Brunkener,M. and Georgatos,S.D.
  TITLE     Membrane-binding properties of filensin, a cytoskeletal protein of
            the lens fiber cells
  JOURNAL   J Cell Sci 103 (Pt 3), 709-718 (1992)
   PUBMED   1478967
REFERENCE   7  (bases 1 to 2154)
  AUTHORS   Norwitz,E.R., Fernandez-Shaw,S., Barlow,D.H. and Starkey,P.M.
  TITLE     Expression of intermediate filament in endometrial glands changes
            with the onset of pregnancy and in endometriosis
  JOURNAL   Hum Reprod 6 (10), 1470-1473 (1991)
   PUBMED   1722806
REFERENCE   8  (bases 1 to 2154)
  AUTHORS   Merdes,A., Brunkener,M., Horstmann,H. and Georgatos,S.D.
  TITLE     Filensin: a new vimentin-binding, polymerization-competent, and
            membrane-associated protein of the lens fiber cell
  JOURNAL   J Cell Biol 115 (2), 397-410 (1991)
   PUBMED   1918147
REFERENCE   9  (bases 1 to 2154)
  AUTHORS   Honore,B., Madsen,P., Basse,B., Andersen,A., Walbum,E., Celis,J.E.
            and Leffers,H.
  TITLE     Nucleotide sequence of cDNA covering the complete coding part of
            the human vimentin gene
  JOURNAL   Nucleic Acids Res 18 (22), 6692 (1990)
   PUBMED   2251132
REFERENCE   10 (bases 1 to 2154)
  AUTHORS   Gupta,A.K., Aubin,J.E. and Waye,M.M.
  TITLE     Isolation of a human vimentin cDNA with a long 3'-noncoding region
            from a human osteosarcoma cell line (MG-63)
  JOURNAL   Gene 86 (2), 303-304 (1990)
   PUBMED   2323579
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA980400.1, BQ050765.1 and
            BC000163.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003380.4.
            
            Summary: This gene encodes a type III intermediate filament
            protein. Intermediate filaments, along with microtubules and actin
            microfilaments, make up the cytoskeleton. The encoded protein is
            responsible for maintaining cell shape and integrity of the
            cytoplasm, and stabilizing cytoskeletal interactions. This protein
            is involved in neuritogenesis and cholesterol transport and
            functions as an organizer of a number of other critical proteins
            involved in cell attachment, migration, and signaling. Bacterial
            and viral pathogens have been shown to attach to this protein on
            the host cell surface. Mutations in this gene are associated with
            congenital cataracts in human patients. [provided by RefSeq, Aug
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066956.1, SRR14372080.1103016.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000544301.7/ ENSP00000446007.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA980400.1         32-49
            19-307              BQ050765.1         1-289
            308-2154            BC000163.2         1-1847
FEATURES             Location/Qualifiers
     source          1..2154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..2154
                     /gene="VIM"
                     /note="vimentin"
                     /db_xref="GeneID:7431"
                     /db_xref="HGNC:HGNC:12692"
                     /db_xref="MIM:193060"
     exon            1..284
                     /gene="VIM"
                     /inference="alignment:Splign:2.1.0"
     exon            285..994
                     /gene="VIM"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..1832
                     /gene="VIM"
                     /note="epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="vimentin"
                     /protein_id="NP_003371.2"
                     /db_xref="CCDS:CCDS7120.1"
                     /db_xref="GeneID:7431"
                     /db_xref="HGNC:HGNC:12692"
                     /db_xref="MIM:193060"
                     /translation="MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSAL
                     RPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTN
                     EKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQ
                     VDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARL
                     DLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQY
                     ESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALK
                     GTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMA
                     LDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETR
                     DGQVINETSQHHDDLE"
     exon            995..1055
                     /gene="VIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1151
                     /gene="VIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1313
                     /gene="VIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1439
                     /gene="VIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1660
                     /gene="VIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1704
                     /gene="VIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1790
                     /gene="VIM"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..2154
                     /gene="VIM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2134..2139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VIM"
                     /note="hexamer: AATAAA"
     polyA_site      2154
                     /gene="VIM"
                     /note="major polyA site"
ORIGIN      
        1 gggaggccca cgtatggcgc ctctccaaag gctgcagaag tttcttgcta acaaaaagtc
       61 cgcacattcg agcaaagaca ggctttagcg agttattaaa aacttagggg cgctcttgtc
      121 ccccacaggg cccgaccgca cacagcaagg cgatggccca gctgtaagtt ggtagcactg
      181 agaactagca gcgcgcgcgg agcccgctga gacttgaatc aatctggtct aacggtttcc
      241 cctaaaccgc taggagccct caatcggcgg gacagcaggg cgcgtcctct gccactctcg
      301 ctccgaggtc cccgcgccag agacgcagcc gcgctcccac cacccacacc caccgcgccc
      361 tcgttcgcct cttctccggg agccagtccg cgccaccgcc gccgcccagg ccatcgccac
      421 cctccgcagc catgtccacc aggtccgtgt cctcgtcctc ctaccgcagg atgttcggcg
      481 gcccgggcac cgcgagccgg ccgagctcca gccggagcta cgtgactacg tccacccgca
      541 cctacagcct gggcagcgcg ctgcgcccca gcaccagccg cagcctctac gcctcgtccc
      601 cgggcggcgt gtatgccacg cgctcctctg ccgtgcgcct gcggagcagc gtgcccgggg
      661 tgcggctcct gcaggactcg gtggacttct cgctggccga cgccatcaac accgagttca
      721 agaacacccg caccaacgag aaggtggagc tgcaggagct gaatgaccgc ttcgccaact
      781 acatcgacaa ggtgcgcttc ctggagcagc agaataagat cctgctggcc gagctcgagc
      841 agctcaaggg ccaaggcaag tcgcgcctgg gggacctcta cgaggaggag atgcgggagc
      901 tgcgccggca ggtggaccag ctaaccaacg acaaagcccg cgtcgaggtg gagcgcgaca
      961 acctggccga ggacatcatg cgcctccggg agaaattgca ggaggagatg cttcagagag
     1021 aggaagccga aaacaccctg caatctttca gacaggatgt tgacaatgcg tctctggcac
     1081 gtcttgacct tgaacgcaaa gtggaatctt tgcaagaaga gattgccttt ttgaagaaac
     1141 tccacgaaga ggaaatccag gagctgcagg ctcagattca ggaacagcat gtccaaatcg
     1201 atgtggatgt ttccaagcct gacctcacgg ctgccctgcg tgacgtacgt cagcaatatg
     1261 aaagtgtggc tgccaagaac ctgcaggagg cagaagaatg gtacaaatcc aagtttgctg
     1321 acctctctga ggctgccaac cggaacaatg acgccctgcg ccaggcaaag caggagtcca
     1381 ctgagtaccg gagacaggtg cagtccctca cctgtgaagt ggatgccctt aaaggaacca
     1441 atgagtccct ggaacgccag atgcgtgaaa tggaagagaa ctttgccgtt gaagctgcta
     1501 actaccaaga cactattggc cgcctgcagg atgagattca gaatatgaag gaggaaatgg
     1561 ctcgtcacct tcgtgaatac caagacctgc tcaatgttaa gatggccctt gacattgaga
     1621 ttgccaccta caggaagctg ctggaaggcg aggagagcag gatttctctg cctcttccaa
     1681 acttttcctc cctgaacctg agggaaacta atctggattc actccctctg gttgataccc
     1741 actcaaaaag gacacttctg attaagacgg ttgaaactag agatggacag gttatcaacg
     1801 aaacttctca gcatcacgat gaccttgaat aaaaattgca cacactcagt gcagcaatat
     1861 attaccagca agaataaaaa agaaatccat atcttaaaga aacagctttc aagtgccttt
     1921 ctgcagtttt tcaggagcgc aagatagatt tggaatagga ataagctcta gttcttaaca
     1981 accgacactc ctacaagatt tagaaaaaag tttacaacat aatctagttt acagaaaaat
     2041 cttgtgctag aatacttttt aaaaggtatt ttgaatacca ttaaaactgc tttttttttt
     2101 ccagcaagta tccaaccaac ttggttctgc ttcaataaat ctttggaaaa actc
//
