LOCUS       NM_015873               2831 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens villin like (VILL), transcript variant 1, mRNA.
ACCESSION   NM_015873
VERSION     NM_015873.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2831)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2831)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   3  (bases 1 to 2831)
  AUTHORS   Piana,S., Laio,A., Marinelli,F., Van Troys,M., Bourry,D., Ampe,C.
            and Martins,J.C.
  TITLE     Predicting the effect of a point mutation on a protein fold: the
            villin and advillin headpieces and their Pro62Ala mutants
  JOURNAL   J Mol Biol 375 (2), 460-470 (2008)
   PUBMED   18022635
  REMARK    GeneRIF: Predicting the effect of a point mutation on a protein
            fold: the villin and advillin headpieces and their Pro62Ala
            mutants.
REFERENCE   4  (bases 1 to 2831)
  AUTHORS   Yamamichi,N., Inada,K., Ichinose,M., Yamamichi-Nishina,M.,
            Mizutani,T., Watanabe,H., Shiogama,K., Fujishiro,M., Okazaki,T.,
            Yahagi,N., Haraguchi,T., Fujita,S., Tsutsumi,Y., Omata,M. and
            Iba,H.
  TITLE     Frequent loss of Brm expression in gastric cancer correlates with
            histologic features and differentiation state
  JOURNAL   Cancer Res 67 (22), 10727-10735 (2007)
   PUBMED   18006815
  REMARK    GeneRIF: Brm is required for villin expression, a definitive marker
            of intestinal metaplasia and differentiation
REFERENCE   5  (bases 1 to 2831)
  AUTHORS   Tomar,A., George,S., Kansal,P., Wang,Y. and Khurana,S.
  TITLE     Interaction of phospholipase C-gamma1 with villin regulates
            epithelial cell migration
  JOURNAL   J Biol Chem 281 (42), 31972-31986 (2006)
   PUBMED   16921170
  REMARK    GeneRIF: phospholipase C-gamma1 interaction with villin regulates
            epithelial cell migration
REFERENCE   6  (bases 1 to 2831)
  AUTHORS   Ishikawa,S., Kai,M., Tamari,M., Takei,Y., Takeuchi,K., Bandou,H.,
            Yamane,Y., Ogawa,M. and Nakamura,Y.
  TITLE     Sequence analysis of a 685-kb genomic region on chromosome
            3p22-p21.3 that is homozygously deleted in a lung carcinoma cell
            line
  JOURNAL   DNA Res 4 (1), 35-43 (1997)
   PUBMED   9179494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105752.2 and AC144536.4.
            
            On Jul 8, 2020 this sequence version replaced NM_015873.3.
            
            Summary: The protein encoded by this gene belongs to the
            villin/gelsolin family. It contains 6 gelsolin-like repeats and a
            headpiece domain. It may play a role in actin-bundling. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.18959.1,
                                           SRR11853567.20603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383759.7/ ENSP00000373266.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC105752.2         126313-126356
            45-190              AC105752.2         129114-129259
            191-265             AC105752.2         129425-129499
            266-471             AC105752.2         129788-129993
            472-580             AC105752.2         131266-131374
            581-691             AC105752.2         132604-132714
            692-894             AC105752.2         133010-133212
            895-973             AC105752.2         133617-133695
            974-1072            AC105752.2         133793-133891
            1073-1211           AC105752.2         134439-134577
            1212-1312           AC105752.2         134866-134966
            1313-1450           AC105752.2         136983-137120
            1451-1609           AC105752.2         137229-137387
            1610-1789           AC105752.2         137923-138102
            1790-1935           AC105752.2         138695-138840
            1936-2080           AC105752.2         139782-139926
            2081-2263           AC105752.2         141319-141501
            2264-2335           AC105752.2         141708-141779
            2336-2587           AC105752.2         141976-142227
            2588-2644           AC105752.2         142469-142525
            2645-2831           AC144536.4         55593-55779         c
FEATURES             Location/Qualifiers
     source          1..2831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..2831
                     /gene="VILL"
                     /note="villin like"
                     /db_xref="GeneID:50853"
                     /db_xref="HGNC:HGNC:30906"
                     /db_xref="MIM:619666"
     exon            1..44
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            45..190
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2701
                     /gene="VILL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     villin-like protein"
                     /codon_start=1
                     /product="villin-like protein isoform 1"
                     /protein_id="NP_056957.3"
                     /db_xref="CCDS:CCDS2670.2"
                     /db_xref="GeneID:50853"
                     /db_xref="HGNC:HGNC:30906"
                     /db_xref="MIM:619666"
                     /translation="MDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVIL
                     HVPQSPKATQGASSDLHYWVGKQAGAEAQGAAEAFQQRLQDELGGQTVLHREAQGHES
                     DCFCSYFRPGIIYRKGGLASDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNK
                     GDIFLLDLGKMMIQWNGPKTSISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPD
                     LMQIMEAVLGRRVGSLRAATPSKDINQLQKANVRLYHVYEKGKDLVVLELATPPLTQD
                     LLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDG
                     AESAAFKQLFRTWSEKRRRNQKLGGRDKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGK
                     VEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTYQRLGRVQYILYLWQGHQATADEIE
                     ALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQGQLVIFQERAGHHGKGQSASTT
                     RLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMARVV
                     VTVISRKNEETVLEGQEPPHFWEALGGRAPYPSNKRLPEEVPSFQPRLFECSSHMGCL
                     VLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAASEWKEAVAWGQEYLKTHPAGRSP
                     ATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAASTISEITAEVNNL
                     RLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSRTSSSVSSTSATINGGLRR
                     EQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF
                     "
     exon            191..265
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            266..471
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            472..580
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            581..691
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            692..894
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            895..973
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1072
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1211
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1312
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1450
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1609
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1789
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1935
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2080
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2263
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2335
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2587
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2831
                     /gene="VILL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2811..2816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VILL"
                     /note="hexamer: AGTAAA"
     polyA_site      2831
                     /gene="VILL"
                     /note="major polyA site"
ORIGIN      
        1 actgcccaca ggcagggcga aggcgcggga gcagtttcca gcagttgtac aggtagccag
       61 gtgtcggtct ccagcctgag aactctggct gttgttcctt gtgtcgtccc atattcctgc
      121 ctggcctgcg atggacatca gcaagggcct cccaggcatg cagggaggcc tccacatatg
      181 gatctctgag aaccggaaga tggtgccggt acccgagggg gcttacggga acttttttga
      241 ggaacactgc tatgtcatcc tccacgtccc ccagagcccg aaggccacgc agggggcgtc
      301 cagcgacctg cactactggg tcgggaagca ggcgggtgcg gaagcgcagg gcgctgcgga
      361 ggccttccag cagcgcctac aggacgagct ggggggccag accgtgctgc accgcgaggc
      421 gcagggccac gagtccgact gcttctgcag ctacttccgc ccgggaatca tctacaggaa
      481 gggaggccta gcatctgacc tcaagcatgt ggagaccaac ttgttcaaca tccagcgact
      541 gctgcacatc aaagggagga agcacgtgtc tgccactgag gtggagctct cctggaacag
      601 ctttaataag ggtgacatct tcctgctgga cctaggcaag atgatgattc agtggaatgg
      661 gcccaagacc agcatttctg agaaggctcg ggggctggct ttgacctaca gcctccggga
      721 cagggaacgt ggtggtggtc gtgcacagat tggtgtggtg gatgatgagg ccaaagcccc
      781 ggacctcatg cagatcatgg aggctgtgct gggccgcagg gtgggcagcc tgcgtgccgc
      841 cacgcccagc aaggatatca accagctgca gaaggccaat gttcgcctgt accatgtcta
      901 tgagaagggc aaagacctgg tggtcctgga gttggcgacc cccccactga cccaggacct
      961 gctgcaggag gaggacttct acatcctgga ccagggtggc ttcaagatct atgtgtggca
     1021 gggacgcatg tctagcctcc aggagagaaa ggctgccttc agccgggctg tgggcttcat
     1081 ccaggccaag ggctacccga cctacaccaa cgtggaggtg gtgaacgacg gcgccgagtc
     1141 ggccgcgttc aagcagctct tccggacttg gtctgagaag cggcgcagga accagaagct
     1201 cggcgggagg gataaatcga ttcatgtaaa gctggacgtg ggcaagctgc acacccagcc
     1261 taagttagcg gcccagctca ggatggtgga cgacggctct gggaaggtgg aggtgtggtg
     1321 catccaggac ttacacaggc agcccgtgga ccccaagcgt catggacagc tgtgtgcagg
     1381 caactgctac cttgtgctct acacatacca gaggctgggc cgtgtccagt acatcctgta
     1441 cctatggcag ggccaccagg ccactgcgga tgagattgag gccctgaaca gcaacgctga
     1501 ggaactagat gtcatgtatg gtggcgtcct agtacaggag catgtgacca tgggcagcga
     1561 gcccccccac ttcctcgcca tcttccaggg ccagctggtg atcttccagg agagagctgg
     1621 gcaccatgga aaggggcagt cagcatccac cacaaggctt ttccaagtgc aaggcactga
     1681 cagccacaac accaggacca tggaggtgcc agcccgtgcc tcatccctca actccagtga
     1741 catcttcttg ctggtcacag ccagcgtctg ctacctctgg tttgggaagg gctgtaatgg
     1801 tgatcagcgt gagatggcac gggtggtggt cactgtcatt tccaggaaga atgaggaaac
     1861 ggtgctggag ggtcaggagc ctccccactt ctgggaggcc ctgggaggcc gggcccccta
     1921 ccccagcaac aagaggctcc ctgaggaggt ccccagcttc cagccacgac tgtttgagtg
     1981 ctccagccac atgggctgcc tggtcctcgc agaagtgggg ttcttcagcc aggaggacct
     2041 ggacaagtat gacatcatgt tactggacac ctggcaggag atcttcctgt ggcttgggga
     2101 agctgcaagt gagtggaagg aggcggtggc ctggggccag gagtacctga agactcaccc
     2161 agcagggagg agcccggcca cacccatcgt gctggtcaag cagggccatg agcctcccac
     2221 cttcattgga tggttcttca cttgggaccc ctacaagtgg actagccacc cgtcccacaa
     2281 ggaagtggtg gatggcagcc cggcagcagc atcaaccatc tctgagataa cagcagaagt
     2341 caacaacttg cggctatcca gatggccggg caatggcagg gcaggtgccg tggccctgca
     2401 ggccctcaag ggctcccagg acagctcaga gaatgatctg gtgcgaagcc ccaagtcggc
     2461 tggcagcaga accagcagct ccgtcagcag caccagcgcc acgatcaacg ggggcctgcg
     2521 ccgggaacaa ctgatgcacc aggctgttga ggacctgcca gagggcgtgg accctgcccg
     2581 cagggagttc tatctctcag actctgactt ccaagatatc tttgggaaat ccaaggagga
     2641 attctacagc atggccacgt ggaggcagcg gcaggagaaa aagcagctgg gcttcttctg
     2701 aacccaagcc ctctcgactg cccctatccc ctggacccca acatacctac aatgctgggg
     2761 aggccctgct tccactcccc tcagaggctt ttggtcatcc tctgcgtgtc agtaaaagca
     2821 ggcagcccat a
//
