LOCUS       NM_014667               3519 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens vestigial like family member 4 (VGLL4), transcript
            variant 2, mRNA.
ACCESSION   NM_014667 XM_052386
VERSION     NM_014667.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3519)
  AUTHORS   Wang,Z., Quan,Y., Hu,M., Xu,Y., Chen,Y., Jin,P., Ma,J., Chen,X.,
            Fan,J., Fan,X., Gong,Y., Li,M. and Wang,Y.
  TITLE     VGLL4-TEAD1 promotes vascular smooth muscle cell differentiation
            from human pluripotent stem cells via TET2
  JOURNAL   J Mol Cell Cardiol 176, 21-32 (2023)
   PUBMED   36657637
  REMARK    GeneRIF: VGLL4-TEAD1 promotes vascular smooth muscle cell
            differentiation from human pluripotent stem cells via TET2.
REFERENCE   2  (bases 1 to 3519)
  AUTHORS   Geng,H., Liu,G., Hu,J., Li,J., Wang,D., Zou,S. and Xu,X.
  TITLE     HOXB13 suppresses proliferation, migration and invasion, and
            promotes apoptosis of gastric cancer cells through transcriptional
            activation of VGLL4 to inhibit the involvement of TEAD4 in the
            Hippo signaling pathway
  JOURNAL   Mol Med Rep 24 (4) (2021)
   PUBMED   34396425
  REMARK    GeneRIF: HOXB13 suppresses proliferation, migration and invasion,
            and promotes apoptosis of gastric cancer cells through
            transcriptional activation of VGLL4 to inhibit the involvement of
            TEAD4 in the Hippo signaling pathway.
REFERENCE   3  (bases 1 to 3519)
  AUTHORS   Mesrouze,Y., Meyerhofer,M., Zimmermann,C., Fontana,P., Erdmann,D.
            and Chene,P.
  TITLE     Biochemical properties of VGLL4 from Homo sapiens and Tgi from
            Drosophila melanogaster and possible biological implications
  JOURNAL   Protein Sci 30 (9), 1871-1881 (2021)
   PUBMED   34075638
  REMARK    GeneRIF: Biochemical properties of VGLL4 from Homo sapiens and Tgi
            from Drosophila melanogaster and possible biological implications.
REFERENCE   4  (bases 1 to 3519)
  AUTHORS   Mickle,M., Adhikary,G., Shrestha,S., Xu,W. and Eckert,R.L.
  TITLE     VGLL4 inhibits YAP1/TEAD signaling to suppress the epidermal
            squamous cell carcinoma cancer phenotype
  JOURNAL   Mol Carcinog 60 (7), 497-507 (2021)
   PUBMED   34004031
  REMARK    GeneRIF: VGLL4 inhibits YAP1/TEAD signaling to suppress the
            epidermal squamous cell carcinoma cancer phenotype.
REFERENCE   5  (bases 1 to 3519)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3519)
  AUTHORS   Jin,H.S., Park,H.S., Shin,J.H., Kim,D.H., Jun,S.H., Lee,C.J. and
            Lee,T.H.
  TITLE     A novel inhibitor of apoptosis protein (IAP)-interacting protein,
            Vestigial-like (Vgl)-4, counteracts apoptosis-inhibitory function
            of IAPs by nuclear sequestration
  JOURNAL   Biochem Biophys Res Commun 412 (3), 454-459 (2011)
   PUBMED   21839727
  REMARK    GeneRIF: Vgl-4 may play a role in the apoptotic pathways by
            regulating translocation of IAPs between different cell
            compartments.
REFERENCE   7  (bases 1 to 3519)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   8  (bases 1 to 3519)
  AUTHORS   Teng,A.C., Kuraitis,D., Deeke,S.A., Ahmadi,A., Dugan,S.G.,
            Cheng,B.L., Crowson,M.G., Burgon,P.G., Suuronen,E.J., Chen,H.H. and
            Stewart,A.F.
  TITLE     IRF2BP2 is a skeletal and cardiac muscle-enriched
            ischemia-inducible activator of VEGFA expression
  JOURNAL   FASEB J 24 (12), 4825-4834 (2010)
   PUBMED   20702774
  REMARK    GeneRIF: IRF2BP2 was identifies as a novel VGLL4 partner.
REFERENCE   9  (bases 1 to 3519)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 3519)
  AUTHORS   Chen,H.H., Mullett,S.J. and Stewart,A.F.
  TITLE     Vgl-4, a novel member of the vestigial-like family of transcription
            cofactors, regulates alpha1-adrenergic activation of gene
            expression in cardiac myocytes
  JOURNAL   J Biol Chem 279 (29), 30800-30806 (2004)
   PUBMED   15140898
  REMARK    GeneRIF: Vgl-4 modulates the activity of TEF-1 factors and
            counteracts alpha1-adrenergic activation of gene expression in
            cardiac myocytes
            GeneRIF: A transcriptional cofactor of transcriptional enhancer
            factor-1 (TEF-1) transcription factors.  Interacts with TEF-1
            factors through 2 TDU (tondu) motifs.  Controls gene expression in
            cardiac myocytes.
            GeneRIF: This gene is named Vestigial-like 4, to distinguish it
            from 3 previously described genes Vgl-1, Vgl-2 and Vgl-3. Contains
            2 motifs, found in the Drosophila transcription cofactor Vestigial,
            that interact with the TEF-1 family of transcription factors.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK130542.1, DA383197.1, D50911.3 and BU682809.1.
            
            On May 31, 2019 this sequence version replaced NM_014667.3.
            
            Transcript Variant: This variant (2) contains alternate 5' exon
            structure and it thus differs in the 5' UTR and 5' coding region,
            compared to variant 1. The encoded isoform (b) has a distinct
            N-terminus and is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50911.3, AK130542.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AK130542.1         25-278
            255-526             DA383197.1         279-550
            527-2829            D50911.3           504-2806
            2830-3519           BU682809.1         18-707              c
FEATURES             Location/Qualifiers
     source          1..3519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3-p25.2"
     gene            1..3519
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /note="vestigial like family member 4"
                     /db_xref="GeneID:9686"
                     /db_xref="HGNC:HGNC:28966"
                     /db_xref="MIM:618692"
     exon            1..146
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            147..223
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1032
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /note="isoform b is encoded by transcript variant 2;
                     Vestigial-like 4; transcription cofactor vestigial-like
                     protein 4; vestigial like 4"
                     /codon_start=1
                     /product="transcription cofactor vestigial-like protein 4
                     isoform b"
                     /protein_id="NP_055482.2"
                     /db_xref="CCDS:CCDS2606.1"
                     /db_xref="GeneID:9686"
                     /db_xref="HGNC:HGNC:28966"
                     /db_xref="MIM:618692"
                     /translation="METPLDVLSRAASLVHADDEKREAALRGEPRIQTLPVASALSSH
                     RTGPPPISPSKRKFSMEPGDEDLDCDNDHVSKMSRIFNPHLNKTANGDCRRDPRERSR
                     SPIERAVAPTMSLHGSHLYTSLPSLGLEQPLALTKNSLDASRPAGLSPTLTPGERQQN
                     RPSVITCASAGARNCNLSHCPIAHSGCAAPGPASYRRPPSAATTCDPVVEEHFRRSLG
                     KNYKEPEPAPNSVSITGSVDDHFAKALGDTWLQIKAAKDGASSSPESASRRGQPASPS
                     AHMVSHSHSPSVVS"
     exon            224..413
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            414..636
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            637..760
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            761..3519
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3500..3505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /note="hexamer: AATAAA"
     polyA_site      3519
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /note="major polyA site"
ORIGIN      
        1 gcgagtgtga agtgcagcgc tggagtgcaa catgctgtaa tgggaggaaa cccagcggcg
       61 tcggagcgcc cgggaccgcc gcggccgttc tgagcgcagt ggcgccgagc agcccctccc
      121 gcagccggtg tgacctgtcc cttcaggctc caaccaggaa tggagacgcc attggatgtt
      181 ttgtccaggg cagcatctct ggtgcatgct gatgacgaaa aacgcgaagc tgctctcagg
      241 ggagaaccca gaatacagac cctgccggtg gcctctgccc tcagcagtca ccgcaccggc
      301 cctcccccaa tcagccccag caagaggaag ttcagcatgg agccaggtga cgaggaccta
      361 gactgtgaca acgaccacgt ctccaaaatg agtcgcatct tcaaccccca tctgaacaag
      421 actgccaatg gagactgccg cagagacccc cgggagcgga gccgcagccc catcgagcgc
      481 gctgtggccc ccaccatgag cctgcacggc agccacctgt acacctccct ccccagcctt
      541 ggcctggagc agcccctcgc actgaccaag aacagcctgg acgccagcag gccagccggc
      601 ctctcgccca cactgacccc gggggagcgg cagcagaacc ggccctccgt gatcacctgt
      661 gcctcggctg gcgcccgcaa ctgcaacctc tcgcactgcc ccatcgcgca cagcggctgt
      721 gccgcgcccg ggcctgccag ctaccggagg ccaccgagcg ctgccaccac ctgtgacccc
      781 gtggtggagg agcatttccg caggagcctg ggcaagaatt acaaggagcc cgagccggca
      841 cccaactccg tgtccatcac gggctccgtg gacgaccact ttgccaaagc tctgggtgac
      901 acgtggctcc agatcaaagc ggccaaggac ggagcatcca gcagccctga gtccgcctct
      961 cgcaggggcc agcccgccag cccctctgcc cacatggtca gccacagtca ctccccctct
     1021 gtggtctcct gaagggagcg cctcctccaa caacacgtgg atctgcatgg tttgcctgag
     1081 ctttgaacag tcagtactta aaaaaaaaaa aatcatgggg gtggggtggg gggaagggaa
     1141 gggatggttt atttgcaaaa accatgttgt tgggatttgt gttctgtttt tgtacttgct
     1201 tggtatccgt acaagggggc cctcaaacat gatagcagga actacgcgtg gaacatctgt
     1261 ctaatgtagc atccttactt cctgcctcag ttaccaaaga aacctctgat gcaggtctgc
     1321 tgccccgacg gggccaggac tccacagcgc tttctcagtc acaagccatg atgaattggt
     1381 gactcagacg ctttgtgctt tttcctttgc ttcttgagac cggggtgtgt gtggctcagc
     1441 ttccacggcg tgtttggttc ggtccatgtg tgtgcgtgtg tatacttgaa gagaactgtc
     1501 gtgtctgatt tgcactattg gaggaggact aaagttgcct gacaacttta tgtgttatgc
     1561 cagaactctg agggcaaact gctgaaaaac aaagggttta aggatgacat ttctgaccat
     1621 ttgtgtgttt gttgttgtta ctgtttttgt tttttttaat gtagacaata cagctttgga
     1681 aggggaagtc tcatacaggt tataggtctt tctctctcta gatttcaggt gcttgcaact
     1741 ggactgcaga ctctaccaat cacgggcatt ttatcttctc tgaacactgc agtttgttag
     1801 actagagctg aggttggagg attccatagt gctttaaacg tgatgcatgt tttaatggag
     1861 aaaaaatagc tggtttctat taattatata gacagtaaac aaaaacctta atacttacta
     1921 tcttcttttc agaattagtt tatttttgtc agttacagtc ctagatatac ttactgctgg
     1981 tacagttgta ctctaagatt ggtatttgat attcacttta ctcacaagta gtgcgggagg
     2041 ccagctcctg gcaggccctc gcgatgagca gtgggtcagc tgcggtgtgg gatgctggag
     2101 tttggctgca ggctgacatc atttattttt gcatccctgt ctgctttgtt acaagctccc
     2161 aggggaggtg gggtttgtgt cttccaactt ccctacatgc agaaactgct ccctttgaac
     2221 tctcttggct gaacagcaga ttactgacag acaatctgtg atatggtgtt ttatacgctt
     2281 cctcgtacgc tggggccaag gcagtataca ttcctctgac tttatactgt tattactgca
     2341 tttattattt gctatattaa tagctactaa ctagaaatta gatgaagcaa gcatgacaga
     2401 cacagctgtg gaggtcacag ctgctccttt ttggtcaatg agcgtttcta tcccctcccc
     2461 ctggggtgtg ctgtgtccca cctggcccac cagaggctca cgacgatggc acctgaccag
     2521 gtgacgtggg cgtggtcacc tcacctgcaa ggctttgtgg actctgcaca ccgtatgacc
     2581 cccggtttta cagtttttag ctgttgaatt ttggaaattg gcactgggtg aaaaggtcgg
     2641 aggactggct cttgtagtca cagagtggct gcaggccttt gaaaagtgga ggaaagaaaa
     2701 gcccttctcc ttgccccgca cacatttcac tcccactgta ctgggcttcc aagctttggc
     2761 attcaggccc ctatattttc tgtaggaaaa atcgttgaga acacttttct atatgggtga
     2821 ttttgagacc atcgttacgc tgtgcgtaaa gaatgtacag agaaatttgt aggtattttt
     2881 tgaagaacat taatttgtta atgatatgta gctatttaat ttttcccttt cctattgtaa
     2941 tcattcattt tttttgttgt tcggaaaaaa aaagttgatc tttttttttg tcgtagattt
     3001 gtctgtaaaa gtgcaggaac agttattcta tgagaacact gcatctgcat tcatagccac
     3061 gagtttgtta ttgctacagg ctactgagcg tcgtaacagg aaaaccaccc acagctgacc
     3121 ggctcggtgg aggacactcc tgggacaggt ctctttgtca gtgaacaagg gcgtcactct
     3181 gggaggggtc ggcggtgctg gcggccgggt ccctggtgca ctgacctatc tgggataggc
     3241 agtaccctgg aggggggcct ggggcagagg aggcagcaga aaaccaaaca tttcactgag
     3301 aaagccccct ccctgctcta agaaggggct ccgtgaagtt cttcccagag ccgcgctgcc
     3361 tgcagtgcgc tctgaccttc tcttcatgtg tgtaaatctg taatatacca ttctctgtgg
     3421 cctgtttttc ctggaagaag aaaaaaaaag gtttggcagg ccatcttttt ttgtacttaa
     3481 aagtagcctt aagaacaata ataaagtgct cttaaacca
//
