LOCUS       NM_001128219            3775 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens vestigial like family member 4 (VGLL4), transcript
            variant 1, mRNA.
ACCESSION   NM_001128219
VERSION     NM_001128219.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3775)
  AUTHORS   Wang,Z., Quan,Y., Hu,M., Xu,Y., Chen,Y., Jin,P., Ma,J., Chen,X.,
            Fan,J., Fan,X., Gong,Y., Li,M. and Wang,Y.
  TITLE     VGLL4-TEAD1 promotes vascular smooth muscle cell differentiation
            from human pluripotent stem cells via TET2
  JOURNAL   J Mol Cell Cardiol 176, 21-32 (2023)
   PUBMED   36657637
  REMARK    GeneRIF: VGLL4-TEAD1 promotes vascular smooth muscle cell
            differentiation from human pluripotent stem cells via TET2.
REFERENCE   2  (bases 1 to 3775)
  AUTHORS   Geng,H., Liu,G., Hu,J., Li,J., Wang,D., Zou,S. and Xu,X.
  TITLE     HOXB13 suppresses proliferation, migration and invasion, and
            promotes apoptosis of gastric cancer cells through transcriptional
            activation of VGLL4 to inhibit the involvement of TEAD4 in the
            Hippo signaling pathway
  JOURNAL   Mol Med Rep 24 (4) (2021)
   PUBMED   34396425
  REMARK    GeneRIF: HOXB13 suppresses proliferation, migration and invasion,
            and promotes apoptosis of gastric cancer cells through
            transcriptional activation of VGLL4 to inhibit the involvement of
            TEAD4 in the Hippo signaling pathway.
REFERENCE   3  (bases 1 to 3775)
  AUTHORS   Mesrouze,Y., Meyerhofer,M., Zimmermann,C., Fontana,P., Erdmann,D.
            and Chene,P.
  TITLE     Biochemical properties of VGLL4 from Homo sapiens and Tgi from
            Drosophila melanogaster and possible biological implications
  JOURNAL   Protein Sci 30 (9), 1871-1881 (2021)
   PUBMED   34075638
  REMARK    GeneRIF: Biochemical properties of VGLL4 from Homo sapiens and Tgi
            from Drosophila melanogaster and possible biological implications.
REFERENCE   4  (bases 1 to 3775)
  AUTHORS   Mickle,M., Adhikary,G., Shrestha,S., Xu,W. and Eckert,R.L.
  TITLE     VGLL4 inhibits YAP1/TEAD signaling to suppress the epidermal
            squamous cell carcinoma cancer phenotype
  JOURNAL   Mol Carcinog 60 (7), 497-507 (2021)
   PUBMED   34004031
  REMARK    GeneRIF: VGLL4 inhibits YAP1/TEAD signaling to suppress the
            epidermal squamous cell carcinoma cancer phenotype.
REFERENCE   5  (bases 1 to 3775)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3775)
  AUTHORS   Jin,H.S., Park,H.S., Shin,J.H., Kim,D.H., Jun,S.H., Lee,C.J. and
            Lee,T.H.
  TITLE     A novel inhibitor of apoptosis protein (IAP)-interacting protein,
            Vestigial-like (Vgl)-4, counteracts apoptosis-inhibitory function
            of IAPs by nuclear sequestration
  JOURNAL   Biochem Biophys Res Commun 412 (3), 454-459 (2011)
   PUBMED   21839727
  REMARK    GeneRIF: Vgl-4 may play a role in the apoptotic pathways by
            regulating translocation of IAPs between different cell
            compartments.
REFERENCE   7  (bases 1 to 3775)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   8  (bases 1 to 3775)
  AUTHORS   Teng,A.C., Kuraitis,D., Deeke,S.A., Ahmadi,A., Dugan,S.G.,
            Cheng,B.L., Crowson,M.G., Burgon,P.G., Suuronen,E.J., Chen,H.H. and
            Stewart,A.F.
  TITLE     IRF2BP2 is a skeletal and cardiac muscle-enriched
            ischemia-inducible activator of VEGFA expression
  JOURNAL   FASEB J 24 (12), 4825-4834 (2010)
   PUBMED   20702774
  REMARK    GeneRIF: IRF2BP2 was identifies as a novel VGLL4 partner.
REFERENCE   9  (bases 1 to 3775)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 3775)
  AUTHORS   Chen,H.H., Mullett,S.J. and Stewart,A.F.
  TITLE     Vgl-4, a novel member of the vestigial-like family of transcription
            cofactors, regulates alpha1-adrenergic activation of gene
            expression in cardiac myocytes
  JOURNAL   J Biol Chem 279 (29), 30800-30806 (2004)
   PUBMED   15140898
  REMARK    GeneRIF: Vgl-4 modulates the activity of TEF-1 factors and
            counteracts alpha1-adrenergic activation of gene expression in
            cardiac myocytes
            GeneRIF: A transcriptional cofactor of transcriptional enhancer
            factor-1 (TEF-1) transcription factors.  Interacts with TEF-1
            factors through 2 TDU (tondu) motifs.  Controls gene expression in
            cardiac myocytes.
            GeneRIF: This gene is named Vestigial-like 4, to distinguish it
            from 3 previously described genes Vgl-1, Vgl-2 and Vgl-3. Contains
            2 motifs, found in the Drosophila transcription cofactor Vestigial,
            that interact with the TEF-1 family of transcription factors.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA386938.1, DR159250.1, DA383197.1, D50911.3 and BU682809.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001128219.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.19963.1,
                                           SRR11853561.20246.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000430365.7/ ENSP00000404251.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               DA386938.1         10-321
            313-510             DR159250.1         9-206
            511-782             DA383197.1         279-550
            783-3085            D50911.3           504-2806
            3086-3775           BU682809.1         18-707              c
FEATURES             Location/Qualifiers
     source          1..3775
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3-p25.2"
     gene            1..3775
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /note="vestigial like family member 4"
                     /db_xref="GeneID:9686"
                     /db_xref="HGNC:HGNC:28966"
                     /db_xref="MIM:618692"
     exon            1..479
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..1288
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /note="isoform a is encoded by transcript variant 1;
                     Vestigial-like 4; transcription cofactor vestigial-like
                     protein 4; vestigial like 4"
                     /codon_start=1
                     /product="transcription cofactor vestigial-like protein 4
                     isoform a"
                     /protein_id="NP_001121691.1"
                     /db_xref="CCDS:CCDS46754.1"
                     /db_xref="GeneID:9686"
                     /db_xref="HGNC:HGNC:28966"
                     /db_xref="MIM:618692"
                     /translation="MLFMKMDLLNYQYLDKMNNNIGILCYEGEAALRGEPRIQTLPVA
                     SALSSHRTGPPPISPSKRKFSMEPGDEDLDCDNDHVSKMSRIFNPHLNKTANGDCRRD
                     PRERSRSPIERAVAPTMSLHGSHLYTSLPSLGLEQPLALTKNSLDASRPAGLSPTLTP
                     GERQQNRPSVITCASAGARNCNLSHCPIAHSGCAAPGPASYRRPPSAATTCDPVVEEH
                     FRRSLGKNYKEPEPAPNSVSITGSVDDHFAKALGDTWLQIKAAKDGASSSPESASRRG
                     QPASPSAHMVSHSHSPSVVS"
     exon            480..669
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            670..892
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1016
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..3775
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3756..3761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /note="hexamer: AATAAA"
     polyA_site      3775
                     /gene="VGLL4"
                     /gene_synonym="VGL-4"
                     /note="major polyA site"
ORIGIN      
        1 atagccctca tgtcagcgct gccggcttgc agcgggctgt gagaggggcc ggcgccgctt
       61 tgtcctagga aacgggctgc gcgtttctct ttttcactct tttccatttc caggaaggac
      121 ttgtaaggac ttctgaaacg ctgttttcat actcgatcgg ggatacagta catacaccgt
      181 ctaccagtaa gcccttgaag ggtttcgtgt gagctcgatt tttttgtgcc tgattttttt
      241 ttttttaact tttgcatact ttgttttgat agtctgaggc tgggcctctg cctttgtgaa
      301 gttgaagagc caggagctac tcagcaacaa ttgatttttg aaacttaact cttttggggc
      361 aaaagcaaag agctggtttt ctttgctagc ccaataaatg ctatttatga agatggacct
      421 gttgaactat cagtacttgg acaagatgaa caacaatatc ggcattctgt gctacgaagg
      481 cgaagctgct ctcaggggag aacccagaat acagaccctg ccggtggcct ctgccctcag
      541 cagtcaccgc accggccctc ccccaatcag ccccagcaag aggaagttca gcatggagcc
      601 aggtgacgag gacctagact gtgacaacga ccacgtctcc aaaatgagtc gcatcttcaa
      661 cccccatctg aacaagactg ccaatggaga ctgccgcaga gacccccggg agcggagccg
      721 cagccccatc gagcgcgctg tggcccccac catgagcctg cacggcagcc acctgtacac
      781 ctccctcccc agccttggcc tggagcagcc cctcgcactg accaagaaca gcctggacgc
      841 cagcaggcca gccggcctct cgcccacact gaccccgggg gagcggcagc agaaccggcc
      901 ctccgtgatc acctgtgcct cggctggcgc ccgcaactgc aacctctcgc actgccccat
      961 cgcgcacagc ggctgtgccg cgcccgggcc tgccagctac cggaggccac cgagcgctgc
     1021 caccacctgt gaccccgtgg tggaggagca tttccgcagg agcctgggca agaattacaa
     1081 ggagcccgag ccggcaccca actccgtgtc catcacgggc tccgtggacg accactttgc
     1141 caaagctctg ggtgacacgt ggctccagat caaagcggcc aaggacggag catccagcag
     1201 ccctgagtcc gcctctcgca ggggccagcc cgccagcccc tctgcccaca tggtcagcca
     1261 cagtcactcc ccctctgtgg tctcctgaag ggagcgcctc ctccaacaac acgtggatct
     1321 gcatggtttg cctgagcttt gaacagtcag tacttaaaaa aaaaaaaatc atgggggtgg
     1381 ggtgggggga agggaaggga tggtttattt gcaaaaacca tgttgttggg atttgtgttc
     1441 tgtttttgta cttgcttggt atccgtacaa gggggccctc aaacatgata gcaggaacta
     1501 cgcgtggaac atctgtctaa tgtagcatcc ttacttcctg cctcagttac caaagaaacc
     1561 tctgatgcag gtctgctgcc ccgacggggc caggactcca cagcgctttc tcagtcacaa
     1621 gccatgatga attggtgact cagacgcttt gtgctttttc ctttgcttct tgagaccggg
     1681 gtgtgtgtgg ctcagcttcc acggcgtgtt tggttcggtc catgtgtgtg cgtgtgtata
     1741 cttgaagaga actgtcgtgt ctgatttgca ctattggagg aggactaaag ttgcctgaca
     1801 actttatgtg ttatgccaga actctgaggg caaactgctg aaaaacaaag ggtttaagga
     1861 tgacatttct gaccatttgt gtgtttgttg ttgttactgt ttttgttttt tttaatgtag
     1921 acaatacagc tttggaaggg gaagtctcat acaggttata ggtctttctc tctctagatt
     1981 tcaggtgctt gcaactggac tgcagactct accaatcacg ggcattttat cttctctgaa
     2041 cactgcagtt tgttagacta gagctgaggt tggaggattc catagtgctt taaacgtgat
     2101 gcatgtttta atggagaaaa aatagctggt ttctattaat tatatagaca gtaaacaaaa
     2161 accttaatac ttactatctt cttttcagaa ttagtttatt tttgtcagtt acagtcctag
     2221 atatacttac tgctggtaca gttgtactct aagattggta tttgatattc actttactca
     2281 caagtagtgc gggaggccag ctcctggcag gccctcgcga tgagcagtgg gtcagctgcg
     2341 gtgtgggatg ctggagtttg gctgcaggct gacatcattt atttttgcat ccctgtctgc
     2401 tttgttacaa gctcccaggg gaggtggggt ttgtgtcttc caacttccct acatgcagaa
     2461 actgctccct ttgaactctc ttggctgaac agcagattac tgacagacaa tctgtgatat
     2521 ggtgttttat acgcttcctc gtacgctggg gccaaggcag tatacattcc tctgacttta
     2581 tactgttatt actgcattta ttatttgcta tattaatagc tactaactag aaattagatg
     2641 aagcaagcat gacagacaca gctgtggagg tcacagctgc tcctttttgg tcaatgagcg
     2701 tttctatccc ctccccctgg ggtgtgctgt gtcccacctg gcccaccaga ggctcacgac
     2761 gatggcacct gaccaggtga cgtgggcgtg gtcacctcac ctgcaaggct ttgtggactc
     2821 tgcacaccgt atgacccccg gttttacagt ttttagctgt tgaattttgg aaattggcac
     2881 tgggtgaaaa ggtcggagga ctggctcttg tagtcacaga gtggctgcag gcctttgaaa
     2941 agtggaggaa agaaaagccc ttctccttgc cccgcacaca tttcactccc actgtactgg
     3001 gcttccaagc tttggcattc aggcccctat attttctgta ggaaaaatcg ttgagaacac
     3061 ttttctatat gggtgatttt gagaccatcg ttacgctgtg cgtaaagaat gtacagagaa
     3121 atttgtaggt attttttgaa gaacattaat ttgttaatga tatgtagcta tttaattttt
     3181 ccctttccta ttgtaatcat tcattttttt tgttgttcgg aaaaaaaaag ttgatctttt
     3241 tttttgtcgt agatttgtct gtaaaagtgc aggaacagtt attctatgag aacactgcat
     3301 ctgcattcat agccacgagt ttgttattgc tacaggctac tgagcgtcgt aacaggaaaa
     3361 ccacccacag ctgaccggct cggtggagga cactcctggg acaggtctct ttgtcagtga
     3421 acaagggcgt cactctggga ggggtcggcg gtgctggcgg ccgggtccct ggtgcactga
     3481 cctatctggg ataggcagta ccctggaggg gggcctgggg cagaggaggc agcagaaaac
     3541 caaacatttc actgagaaag ccccctccct gctctaagaa ggggctccgt gaagttcttc
     3601 ccagagccgc gctgcctgca gtgcgctctg accttctctt catgtgtgta aatctgtaat
     3661 ataccattct ctgtggcctg tttttcctgg aagaagaaaa aaaaaggttt ggcaggccat
     3721 ctttttttgt acttaaaagt agccttaaga acaataataa agtgctctta aacca
//
