LOCUS       NM_016206              10438 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens vestigial like family member 3 (VGLL3), transcript
            variant 1, mRNA.
ACCESSION   NM_016206 XM_371654
VERSION     NM_016206.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10438)
  AUTHORS   Liu,Y., Chen,S., Zhang,E., Xu,Y., Deng,X., Hu,Z., Nie,S., Lin,Y.
            and Huang,Y.
  TITLE     Exploring the potential of VGLL3 methylation as a prognostic
            indicator for intracranial aneurysm with gender-specific
            considerations
  JOURNAL   Biosci Rep 44 (3) (2024)
   PUBMED   38348744
  REMARK    GeneRIF: Exploring the potential of VGLL3 methylation as a
            prognostic indicator for intracranial aneurysm with gender-specific
            considerations.
REFERENCE   2  (bases 1 to 10438)
  AUTHORS   Horii,Y., Matsuda,S., Toyota,C., Morinaga,T., Nakaya,T.,
            Tsuchiya,S., Ohmuraya,M., Hironaka,T., Yoshiki,R., Kasai,K.,
            Yamauchi,Y., Takizawa,N., Nagasaka,A., Tanaka,A., Kosako,H. and
            Nakaya,M.
  TITLE     VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis
            through liquid-liquid phase separation
  JOURNAL   Nat Commun 14 (1), 550 (2023)
   PUBMED   36754961
  REMARK    GeneRIF: VGLL3 is a mechanosensitive protein that promotes cardiac
            fibrosis through liquid-liquid phase separation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10438)
  AUTHORS   Agaimy,A., Dermawan,J.K., Leong,I., Stoehr,R., Swanson,D.,
            Weinreb,I., Zhang,L., Antonescu,C.R. and Dickson,B.C.
  TITLE     Recurrent VGLL3 fusions define a distinctive subset of spindle cell
            rhabdomyosarcoma with an indolent clinical course and striking
            predilection for the head and neck
  JOURNAL   Genes Chromosomes Cancer 61 (12), 701-709 (2022)
   PUBMED   35766997
  REMARK    GeneRIF: Recurrent VGLL3 fusions define a distinctive subset of
            spindle cell rhabdomyosarcoma with an indolent clinical course and
            striking predilection for the head and neck.
REFERENCE   4  (bases 1 to 10438)
  AUTHORS   Du,Y., Cui,R., Tian,N., Chen,M., Zhang,X.L. and Dai,S.M.
  TITLE     Regulation of type I interferon signature by VGLL3 in the
            fibroblast-like synoviocytes of rheumatoid arthritis patients via
            targeting the Hippo pathway
  JOURNAL   Arthritis Res Ther 24 (1), 188 (2022)
   PUBMED   35941675
  REMARK    GeneRIF: Regulation of type I interferon signature by VGLL3 in the
            fibroblast-like synoviocytes of rheumatoid arthritis patients via
            targeting the Hippo pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10438)
  AUTHORS   Kawamura,T., Takehora,Y., Hori,N., Takakura,Y., Yamaguchi,N.,
            Takano,H. and Yamaguchi,N.
  TITLE     VGLL3 increases the dependency of cancer cells on de novo
            nucleotide synthesis through GART expression
  JOURNAL   J Cell Biochem 123 (6), 1064-1076 (2022)
   PUBMED   35434822
  REMARK    GeneRIF: VGLL3 increases the dependency of cancer cells on de novo
            nucleotide synthesis through GART expression.
REFERENCE   6  (bases 1 to 10438)
  AUTHORS   Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
            Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     A genome-wide search for loci interacting with known prostate
            cancer risk-associated genetic variants
  JOURNAL   Carcinogenesis 33 (3), 598-603 (2012)
   PUBMED   22219177
REFERENCE   7  (bases 1 to 10438)
  AUTHORS   Elks,C.E., Perry,J.R., Sulem,P., Chasman,D.I., Franceschini,N.,
            He,C., Lunetta,K.L., Visser,J.A., Byrne,E.M., Cousminer,D.L.,
            Gudbjartsson,D.F., Esko,T., Feenstra,B., Hottenga,J.J.,
            Koller,D.L., Kutalik,Z., Lin,P., Mangino,M., Marongiu,M.,
            McArdle,P.F., Smith,A.V., Stolk,L., van Wingerden,S.H., Zhao,J.H.,
            Albrecht,E., Corre,T., Ingelsson,E., Hayward,C., Magnusson,P.K.,
            Smith,E.N., Ulivi,S., Warrington,N.M., Zgaga,L., Alavere,H.,
            Amin,N., Aspelund,T., Bandinelli,S., Barroso,I., Berenson,G.S.,
            Bergmann,S., Blackburn,H., Boerwinkle,E., Buring,J.E., Busonero,F.,
            Campbell,H., Chanock,S.J., Chen,W., Cornelis,M.C., Couper,D.,
            Coviello,A.D., d'Adamo,P., de Faire,U., de Geus,E.J., Deloukas,P.,
            Doring,A., Smith,G.D., Easton,D.F., Eiriksdottir,G., Emilsson,V.,
            Eriksson,J., Ferrucci,L., Folsom,A.R., Foroud,T., Garcia,M.,
            Gasparini,P., Geller,F., Gieger,C., Gudnason,V., Hall,P.,
            Hankinson,S.E., Ferreli,L., Heath,A.C., Hernandez,D.G., Hofman,A.,
            Hu,F.B., Illig,T., Jarvelin,M.R., Johnson,A.D., Karasik,D.,
            Khaw,K.T., Kiel,D.P., Kilpelainen,T.O., Kolcic,I., Kraft,P.,
            Launer,L.J., Laven,J.S., Li,S., Liu,J., Levy,D., Martin,N.G.,
            McArdle,W.L., Melbye,M., Mooser,V., Murray,J.C., Murray,S.S.,
            Nalls,M.A., Navarro,P., Nelis,M., Ness,A.R., Northstone,K.,
            Oostra,B.A., Peacock,M., Palmer,L.J., Palotie,A., Pare,G.,
            Parker,A.N., Pedersen,N.L., Peltonen,L., Pennell,C.E., Pharoah,P.,
            Polasek,O., Plump,A.S., Pouta,A., Porcu,E., Rafnar,T., Rice,J.P.,
            Ring,S.M., Rivadeneira,F., Rudan,I., Sala,C., Salomaa,V., Sanna,S.,
            Schlessinger,D., Schork,N.J., Scuteri,A., Segre,A.V.,
            Shuldiner,A.R., Soranzo,N., Sovio,U., Srinivasan,S.R.,
            Strachan,D.P., Tammesoo,M.L., Tikkanen,E., Toniolo,D., Tsui,K.,
            Tryggvadottir,L., Tyrer,J., Uda,M., van Dam,R.M., van Meurs,J.B.,
            Vollenweider,P., Waeber,G., Wareham,N.J., Waterworth,D.M.,
            Weedon,M.N., Wichmann,H.E., Willemsen,G., Wilson,J.F., Wright,A.F.,
            Young,L., Zhai,G., Zhuang,W.V., Bierut,L.J., Boomsma,D.I.,
            Boyd,H.A., Crisponi,L., Demerath,E.W., van Duijn,C.M., Econs,M.J.,
            Harris,T.B., Hunter,D.J., Loos,R.J., Metspalu,A., Montgomery,G.W.,
            Ridker,P.M., Spector,T.D., Streeten,E.A., Stefansson,K.,
            Thorsteinsdottir,U., Uitterlinden,A.G., Widen,E., Murabito,J.M.,
            Ong,K.K. and Murray,A.
  CONSRTM   GIANT Consortium
  TITLE     Thirty new loci for age at menarche identified by a meta-analysis
            of genome-wide association studies
  JOURNAL   Nat Genet 42 (12), 1077-1085 (2010)
   PUBMED   21102462
REFERENCE   8  (bases 1 to 10438)
  AUTHORS   Helias-Rodzewicz,Z., Perot,G., Chibon,F., Ferreira,C., Lagarde,P.,
            Terrier,P., Coindre,J.M. and Aurias,A.
  TITLE     YAP1 and VGLL3, encoding two cofactors of TEAD transcription
            factors, are amplified and overexpressed in a subset of soft tissue
            sarcomas
  JOURNAL   Genes Chromosomes Cancer 49 (12), 1161-1171 (2010)
   PUBMED   20842732
  REMARK    GeneRIF: data suggest that the amplification and overexpression of
            YAP1 and VGLL3 could be involved in oncogenesis and progression of
            soft tissue sarcomas
REFERENCE   9  (bases 1 to 10438)
  AUTHORS   Maeda,T., Chapman,D.L. and Stewart,A.F.
  TITLE     Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2
            transcription factors that promotes skeletal muscle differentiation
  JOURNAL   J Biol Chem 277 (50), 48889-48898 (2002)
   PUBMED   12376544
  REMARK    GeneRIF: This protein was named Vestigial-like 3, because it is
            related to the Drosophila protein Vestigial. Like other members of
            this family, it contains a consensus TEF-1 and MEF2(TDU)interaction
            domain.
REFERENCE   10 (bases 1 to 10438)
  AUTHORS   Wang,L., Lu,W., Chen,Y.G., Zhou,X.M. and Gu,J.R.
  TITLE     Comparison of gene expression between normal colon mucosa and colon
            carcinoma by means of messenger RNA differential display
  JOURNAL   World J Gastroenterol 5 (6), 533-534 (1999)
   PUBMED   11819507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108709.3, DA828655.1, BC094780.1, DB319377.1, AA455617.1 and
            AI379920.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016206.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR936700.1, DRR138517.403111.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398399.7/ ENSP00000381436.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC108709.3         78434-78459         c
            27-30               DA828655.1         171-174
            31-1343             BC094780.1         1-1313
            1344-1694           DB319377.1         63-413              c
            1695-1755           DB319377.1         1-61                c
            1756-2063           AA455617.1         161-468
            2064-2535           AI379920.1         1-472               c
            2536-10438          AC108709.3         25283-33185         c
FEATURES             Location/Qualifiers
     source          1..10438
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p12.1"
     gene            1..10438
                     /gene="VGLL3"
                     /gene_synonym="VGL-3; VGL3"
                     /note="vestigial like family member 3"
                     /db_xref="GeneID:389136"
                     /db_xref="HGNC:HGNC:24327"
                     /db_xref="MIM:609980"
     exon            1..532
                     /gene="VGLL3"
                     /gene_synonym="VGL-3; VGL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..1387
                     /gene="VGLL3"
                     /gene_synonym="VGL-3; VGL3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription cofactor vestigial-like protein 3; colon
                     carcinoma related protein"
                     /codon_start=1
                     /product="transcription cofactor vestigial-like protein 3
                     isoform 1"
                     /protein_id="NP_057290.2"
                     /db_xref="CCDS:CCDS43110.1"
                     /db_xref="GeneID:389136"
                     /db_xref="HGNC:HGNC:24327"
                     /db_xref="MIM:609980"
                     /translation="MSCAEVMYHPQPYGASQYLPNPMAATTCPTAYYQPAPQPGQQKK
                     LAVFSKMQDSLEVTLPSKQEEEDEEEEEEEKDQPAEMEYLNSRCVLFTYFQGDIGSVV
                     DEHFSRALGQAITLHPESAISKSKMGLTPLWRDSSALSSQRNSFPTSFWTSSYQPPPA
                     PCLGGVHPDFQVTGPPGTFSAADPSPWPGHNLHQTGPAPPPAVSESWPYPLTSQVSPS
                     YSHMHDVYMRHHHPHAHMHHRHRHHHHHHHPPAGSALDPSYGPLLMPSVHAARIPAPQ
                     CDITKTEPTTVTSATSAWAGAFHGTVDIVPSVGFDTGLQHQDKSKESPWY"
     exon            533..809
                     /gene="VGLL3"
                     /gene_synonym="VGL-3; VGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1343
                     /gene="VGLL3"
                     /gene_synonym="VGL-3; VGL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..10438
                     /gene="VGLL3"
                     /gene_synonym="VGL-3; VGL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7755..7760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VGLL3"
                     /gene_synonym="VGL-3; VGL3"
                     /note="hexamer: AATAAA"
     regulatory      7759..7764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VGLL3"
                     /gene_synonym="VGL-3; VGL3"
                     /note="hexamer: AATAAT"
     polyA_site      7774
                     /gene="VGLL3"
                     /gene_synonym="VGL-3; VGL3"
                     /note="major polyA site"
     polyA_site      7779
                     /gene="VGLL3"
                     /gene_synonym="VGL-3; VGL3"
     regulatory      10418..10423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VGLL3"
                     /gene_synonym="VGL-3; VGL3"
                     /note="hexamer: AATAAA"
     polyA_site      10438
                     /gene="VGLL3"
                     /gene_synonym="VGL-3; VGL3"
ORIGIN      
        1 gtatatgcaa accggagctg ggctccccac ggctgcccga cccgggcctg ggctgtggct
       61 gtgactggcg ctgccgtggg cgccgcagcc ctcgcgggag ccggacgcgg taatgcccca
      121 gcggcgcagc gggcggctgc gtccctgagc cgctatataa gcgcggcagg gaacatccgg
      181 aggggctgaa gatgaaggtg cccgcgcatg ggcccccgct gattgccagt ccctcccgac
      241 cccgcgcccc gcgcggagcc cgaggccgcc gaggacccgc cttcgccgca gtagcagctg
      301 gagcagcgac agaggcggca gctgcggcgg cggcggcgcc cgcgcccctc gcgccagcgc
      361 gtagagcggc ggcggcagct cgggggccgc cactgccccg gctgccatga gttgtgcgga
      421 ggtgatgtat cacccccagc cttatggagc gtcccagtat ctgcccaacc ccatggcagc
      481 gacaacctgc cccacagcct actatcagcc ggcgccccaa cctggccagc agaagaagtt
      541 agcggtattc agcaagatgc aggactctct ggaagtcacc cttcccagca aacaagagga
      601 ggaggatgag gaggaggagg aggaggagaa agaccagcct gccgagatgg agtaccttaa
      661 ctctcgctgt gtccttttca cttatttcca gggagacatt gggtcagtag tggatgaaca
      721 cttctcaaga gctttgggcc aagccatcac cctccatcca gaatctgcca tttcaaaaag
      781 caagatgggg ctaacccccc tatggcgaga cagctcagct ctctcaagcc agcggaatag
      841 tttcccaact tccttttgga ccagctctta ccagccccca cctgcacctt gtttgggggg
      901 agttcatcct gacttccagg tcactggacc ccctggcacc ttttctgcag ctgatcccag
      961 tccttggccg ggacacaacc tgcatcagac tggcccagcc cctccccctg ctgtgtctga
     1021 gtcctggcct tatcctttga catctcaggt gagcccatcc tacagccata tgcatgacgt
     1081 gtacatgcgg caccaccacc ctcatgccca catgcaccac cgccaccgcc accatcatca
     1141 ccatcaccac cctcctgctg gctctgccct ggatccatcc tatgggcctc tgctgatgcc
     1201 ttcagtgcat gcggccagga ttcctgctcc ccagtgtgac atcacaaaga cagaaccaac
     1261 tacagtcacc tctgctacct cagcatgggc tggagccttt catggaacag tagacatagt
     1321 gcccagcgtg ggattcgata caggtctaca gcatcaagac aagagtaagg aatcaccgtg
     1381 gtactgaaac acacaatctt agtgagttaa gttgcagcat aaatccaagg gcccactggg
     1441 aaaagatact gtcgggtttt tccattcagc aataggacac gaaaggcata gaaggagaag
     1501 acaaagtgtc acgcagttga ctggttttcg gcctttcttg agaaagcaaa gtgggtccca
     1561 gacattgaag aaaagcattt ttatttgttt atttcctcat ctgagccttt gccaactgtg
     1621 caactctctc cttttgttat cttgctttta tcaatatata gctaagtttt tgtttcattt
     1681 tgattttttt ttttagccaa ccaccttgtc aggaaaggat gaaccacaca ttaaaatgtt
     1741 cattctttca ggaatacaag tttgtagctc tatgtgcatc tatttttgta gaaatacaaa
     1801 aagtttggtt tagcattgat gggctatttt tgagggatgt atttttttta aaattgtaaa
     1861 aattgttgag ttctgtttaa agaacttgct ctcagagaag cactggcaaa aatgtttaaa
     1921 atgcttatct ctaagatgtc tattatatgc tctgtctgtg ctttctaggt tacctcaaat
     1981 gttttgtttt tttccttctt acaaaagtag ctataccgta gtcaaaccaa tgcagtattg
     2041 tttttacatt gaatctcagt aaagatttaa ttccatgcta gctcaattag ttttgaatta
     2101 tatgtatagc ttgaaaagtt tttttttaat gactgtgcta aagaaatgat attttattgc
     2161 tttgatttct cccaaagaat aacttggagg ttgactaata agaaagttgg cataaacttt
     2221 caatcaaatg aagagtttgc ctagaggaga ctaattctct ttctagccca tccaaatttg
     2281 ataaatggaa ccagaggtta tatacaacta caaggaaaaa aatgcattta accatgccac
     2341 ctatgagtgc cagtgactta ttttacttgt ttttaattat tcattcatgg caatttaaaa
     2401 agtcatattt taagtgggat ttgtttttcc tgaagggcat ttgaaggaac aatatctggg
     2461 aaggtactag agaaattaca aagcccgagc tctttcttat aatgccacct atccctgtaa
     2521 gctaaacaaa caaacaaaca aacaaacaaa cagttctata tataatagtt tcaacacaga
     2581 acttaacaag tctctttttt tgtttgttta aatctggctt tacttgattt aattcctttt
     2641 tagaaagaaa tttagggcaa aataaagtgt atattaggat ttaaatttat gccacaattt
     2701 aaaaataaaa ccagaggtta tatacaattt aaattgggct aaaaattaaa aatttgagga
     2761 tttaacttga tatagctctc aggatctaaa taaagtttaa attatcatta agacactgct
     2821 aggagaagat taagattatg aaagtaacag ttattgatac tgctggactt caaaggcaaa
     2881 gttcatttct tccattaact gcttccagag atgtcatgta aaaaagttag tgtattagag
     2941 aagtttttta gctttataaa gaggtttttt caaatttctc ccatttttct ctccacccac
     3001 ataaaatagt atgttcagtg aaatgccact ttctatcttt aattgttcgt atcatatatg
     3061 cgaacttttt agacatgaac atgacatgtt cagctaggca gagttctcat agataatttt
     3121 caaatatttt ccttggctgt aatttatgta ttcatttata tcctatccgt cttttgagct
     3181 tcagatctat atactctttt gtactctcat cactccgcac tttgctgttt cttacctaga
     3241 ctctctttta cacaatatgc acatttttac cattgtgggg tccaaattta agataccttc
     3301 cactcactaa taatatgaac ttatatttcc tgggagtagc caggttaaat tttctatact
     3361 ttggtccata atttgatttg atatgattgt ttcatttata atttgcccaa atacatggag
     3421 cacaaaattt agtgaattta taaatctgga tttgccttgt gtccttctga gttttcaaag
     3481 gcaagtattc aacagtccct gtgtgatgac tgacagggtt atttgcctca tccacatcca
     3541 ccttcggaat acattaactt cctttgtaat ttatttgaaa gtagtgttaa actcattcag
     3601 atcattcagt tggattttcc caatgaagag gaaaaggaaa gtagttattc ctagctccat
     3661 ttcttatttt ccaccaaatt taattgaagg gcattaatta gatgtcttca ccctgaattt
     3721 agactttgct ctgtgttctc ccggtaactg tcagacaaaa agtttattgg ctctgaggaa
     3781 ctgagaaatg ttgggaacct ggtttctgct gtacacagga aagatttgta agtgagctct
     3841 ctctttgaaa acaggaccca ggctgggcac agcagctcat gcctgtaatc ctagtattat
     3901 aggaggcaga ggctcgggag gattgcttga gcccaggagt tcaagatcag cctaggcaac
     3961 atagggagac cctatcccta caaaaaattt ctgaaaaatt acctgggcat tgtggggcac
     4021 acctgttgtc ccagctactc tggaggctga gtccggagga acgtttgagc ctgggagttt
     4081 gagtttgcag cttgcagtga gctgtgattg caccactgta ctccagcttg ggcaacagag
     4141 caagatcctg tctcaaaagg aaaaagaaaa caggacctag gtgtttgggg tacactgcca
     4201 cccagggagt ggatcaaaaa tatacataga aagagaatga gcatgtctct ataattgtct
     4261 tctaggacca tattgctgtt agaagtccta aaagaggatg ggttgtaatt tagcataata
     4321 ttctgaattc attccaagtt taaaatcctg tcattctctg gctcttcttt tttcacatca
     4381 aaatgatgct gttggactta gaggcttccg aactgtttta ttgagggcta ctatctgcct
     4441 ccacaatttt attaaaacca ctccaccttt agacaaaggt gacttttgtc tgattttaca
     4501 aatcagattt tattcaagct ttctaaatat ctgtgaagta gaccctagaa aattgtctcg
     4561 tttattttaa atagaatcta tgcttccacc aataaaccat cgggagctaa gaaacaacat
     4621 aatgttgaca aatcaggaac ctaacagatt attttgtctc tcattattaa tttgaaagag
     4681 cctctaaact tttgagaaat caatgtgtct tcttaagaaa gttaagcacc ctctcttaac
     4741 tttcccctct atttgctctc ctttttcttt cttcttaaga gtatttatat tattttgtta
     4801 agcaaaaatg gctaagattg ctctaaaatt tgcaaaatga ggagtggatt gcaaataatt
     4861 gagggattta tttctttaac tttataagac tttaaaaaaa aaacccaaat tctaagcact
     4921 gacatgaaag ttgcctttga gaagcttgtt attcattata caaaaagtat ttgcccattc
     4981 ctattctaag atttgcagaa tatgtcaccc tatctagctt ttgagtttgc tatctggttt
     5041 aatgttgtat ttataattta aagtggaaat cagaaactgt ttcaagaacc tgtattctat
     5101 tccttactga gtgtcccttc tttaaatagt gtttgctgaa ttaagccgat gggggcagtg
     5161 gcgttaagtg gtggaaaaag gaaagtatat atgttagagt tttgaatgag ggataaatag
     5221 aaagcagaat gaattaatgg aaaagaactc ggctgttagg ccattctcta aattctagtt
     5281 tagccaaaag tttatgtgtg gtttggggct tcatttattt atctcatgag taaaatggaa
     5341 taatacctaa caggcaggct ctggaagttg gaaatcacat acacacacac acacacacag
     5401 acacacacac acacgatcaa tcatgtagct catattagat gttcaataaa taacagctac
     5461 tacagatgcc tatcagttga gtaagtagtt cattaaattg agctcccaaa ggtctcttct
     5521 cttcacatcc atatccgttt ctgcagcaat caaatagata catgattgtt tttctgtaag
     5581 aaattactgc aaagagaatc tttttctcct actaactgtt ccttctacct ggtataggag
     5641 ataaatgtac gtttcttaat tagctgactt tttagtatgt catttctgaa ggaaaaataa
     5701 attaacctta aagtggcatg taggtccaat tcagttttcc tacatgttcc aaaattttat
     5761 ttaaattact gtgtccaaaa ttatgaggac agtgtcattc attcaccata gtttatattt
     5821 ttagttatat atcaaacttc cttggcacct aggataagaa catttctttt gaagttatcc
     5881 aatttttttt tatttttact tgacttgaag gaaagttgga aaatatggtg gaaaaaatct
     5941 tccgcattaa aagggggaaa aacacaacca tttacgatct cagtcagcag atttactcta
     6001 ctcaaggaaa aaaagaaaca atcttattgg aagcagatgt tgacactgtg tcagttattg
     6061 aagacggaag gagttcactt gagccattgc agttacaaag gggtattgat ggcagtttgg
     6121 attcctgatt gatcaccttt gcagccaagg gaaagacagc agaaactgta tgggatcaga
     6181 aatgaaatca gcctgccagt ttaatggaga ggctcctaga aactcatttt ttttctttcc
     6241 tgtaagataa aagacatctt tcagaataag aaaggcttgt ttgagagaga aattacagtt
     6301 tattctctga aaatatttaa aggccaaagt gccctttaaa tctattatta aagcattgaa
     6361 actgttatta aaatcattat agaaaaatta ggtaaaaatt ttagcctaac tttcaacatc
     6421 cattcaaaaa cgaatgttga aaacaaacat ataacctata aaaaagtgaa tggctctggc
     6481 aagtgggggc atgggtggag tccataagga aacctcagtc tcaataactt caaaatgtta
     6541 cttttcatgg taacttggtc atggagattg gtcacagcac agacatttag aattttttag
     6601 caggtttttt ttttcttttg aatcttgtag tgctctctgg gaattgcacc atgtacactt
     6661 ttacaaccta cagaaatcgt cattattgtt aaagtatctc aacttttcta tttcttttat
     6721 tgtctattgt gcttttttgt ttaaaaatac ttttatagtt ttaaagtatt ggtcaaagta
     6781 gtattctctt gaagttctag tcaatttaat ttgatccaat aagtttttct gaatctcctt
     6841 tttaagttcc aagaaattct attataaata agtgtacttt taccaattcc attgtataag
     6901 caaacagaca ccttttagaa aaggataagt aatcatcaat ttgttttttt aaaaaaaaaa
     6961 acaatttcta gactactaaa tttggcataa gaataattct tttaaaatgc aacatacttt
     7021 aattagtttt tttggtatat gcataagatg tgaactttcc tattgatatc actttatatt
     7081 aatagagatg tacatttctt tctatgccgt ggctagagca aaagttaata atgattattt
     7141 acacaattga tttaatttct taggatatgt ataatattgg atattatatc tgatttaaaa
     7201 atactattcc atacattttt tttttcagga gataaaacat agggaaaggt tttcatgtga
     7261 attctttgta tcactttgaa gtacatatat ttaaagggaa gatggataca atttgttttt
     7321 attatataaa tctaggtaag gtgaaatgct tttgtcaaca aaaatacagt gtagtgaatt
     7381 ttatatttgt cacttgatta ggtaaactga aaactaacaa tagaaatatt attttactgc
     7441 attgaaatac catgaacttt cagacttgtt agttctacaa gaagttgtgc taccttaatt
     7501 ttgtgtttcc agaaataaaa attaacctta gttatgctgt catttttaac taataaaaaa
     7561 agtataattc ataaaacttt tggctttata agataattat aaaattatat atttttttct
     7621 gtttttgtgg ggttgggaaa acattttctt atttctattc actcttcaaa tgcaggtctc
     7681 ataatatgtg tcaatgatat aagatgatgg aagactttgt aataaaaaca tatgtcatta
     7741 tcttcaattt gttcaataaa taatttaatg tgaattgaat gtttgtattt taacatagca
     7801 tttggatttg gtctgcattt cttgagaatt taaagctctt tttgtttcct ccttattcaa
     7861 ttaagcatct tataaatatt ttggaaatta caacatctta ggtgttatta attaagaagt
     7921 taatttctag ggccaagaag tctatatgtt acagcaagga atagattata aaatacatgt
     7981 ttataatgga aaagaaaatg aaatggggta tattaattac ataacagcaa gagtcttgag
     8041 aattttataa tacaatgctt ctaaggatat tggttgacca aggtgtattt tattgttttt
     8101 acatttgttg acagggactc tgccataagt agtatgaaaa aacaaacaaa aacttttcta
     8161 cgattcatta acattgaaaa gagaattcca agaccttgta ttctgaagaa agctagagtt
     8221 tctctaagtg ggccttcaat tttcttatta cacgtatctt taatgtgaaa gtactaaagt
     8281 ctgaaaatca gcatttaaat aatagacttt ccagcattac agatgaaata atttggcgca
     8341 ggctttttaa ctgtctacca tatttagaat gtggtgtcaa aatgagattt ttagaactgc
     8401 tgtaaaatat tactacatta ctacaacgat aacggcctaa aacaacacaa atttattatc
     8461 ttacagctct gtcagtcaga cattcagcaa agatcttagt cttggtgggc tacagaatgt
     8521 aggaggcatt tcctggatgc ttccaagaga gaatcttgct gttccctgct tctagagtcc
     8581 tttgcttagt ttccttccat cttcaaatcc agcaacctgg tcaagacctt ctcacatgac
     8641 atcactgact tcctcttctt cctctccctt acatatttaa ggactcatgt gattacaata
     8701 gctgcatctg tgtaatccag aataatctct tcatctcaag gtttttgttc tgttttgttt
     8761 ttttgttttg ttttgttttg ttttgttttg atggagtctt gctctgtcgt caggctggag
     8821 tgcagtggcg cgatctcggc tcactccaac ctccacctcc cgggttcaaa ggattcccct
     8881 gcctcagcct ctcgagtagc tgggactaca gatgcgtgct accacacaag gctaatattt
     8941 tgtattttag tagagacggg atttcaccat gttggccagg atggtctccg tctcctgacc
     9001 tcgtgatctg cctgccttgg cctcccaaag tgttgggatt acaggcataa gccattgcgc
     9061 catgctcaag gttcttaatt acatctttaa aggccctttt tccatgtaca gtaacatatt
     9121 caatggttct ggggattagg acttggagcc attattctac ctacaacaat tagtattgga
     9181 cttccatcat tttctatcac tcttgtaatc gagaaggact atttcactgg gagtagcaag
     9241 tcataatgtt tgcgttggca tttgtgtggg ggtttatctt cattcattaa ataattgcat
     9301 gtaaagaaaa ttcctgtcac tatttcaaat gtttcatgta gttattatag tgcttcagaa
     9361 tccaaagggt tatgtgttac ttatgtaaga tgagcagtct agggggtgga gaacaggtca
     9421 tctagtgcag attcttccta gctgaagtgt gttttctctg gggacaacca agtaggattt
     9481 aattgttttg cttccttttt tgggaactta gacccatctt gcgatgtcct aagtctccaa
     9541 gcatcttatt tgacctgctt atacacattt gactaaatag ctaaatatga ccacattgac
     9601 gtggtaaagc tttaacactt ttgtccagat tgaatcactc catctgctat cagttaagca
     9661 gtggaaaact gttatggaaa agcaaacatg ttttgataga tttaatgtgt aaagaaggta
     9721 tccatactct ggaatgctgc tgatcaataa atgagctgca agactttgtt cgaaacaaca
     9781 ctcaagcaca actgttttac tttccatacc aagtttggct gtgactgaat gaagaacatc
     9841 agcattgatc tttgctttgc acttgtacaa gagactattt gcagagagcc aaatatagca
     9901 acagaggatt taatatcttg ccaaaaaata caaaatctgt tcccctttaa gcatgacact
     9961 ctatcctttc ttgtggatct tgctaaaagg aaaatatagc tttaaactcc cctattcctt
    10021 ctgttgaaag cttaagaatc tttttcaaat gagctatgta tggttttgtg gtattttatg
    10081 tttccaaaag aaaatggcta catgaaaaat ctgtccagtg ttatcatttt tcttacaaaa
    10141 aatacttcta gttatggttg tattaattaa tttgattgtg ataatgatta cacaatgttt
    10201 acctatatca aatcatcata tcgtatacct taaatatata taacttttat gtgtcaatta
    10261 taactcagta agtctgggaa aatatcgtta agtcaaagat tagagtcaac agaaataaag
    10321 aaaaatcata ctttgataac ttcaggacta atcaaggatc aatgggtgac atgatatcat
    10381 gctatgtgcc attttgtgtt aaacaaatta caccaacaat aaaaaaaatt ggcttcaa
//
