LOCUS       NM_182645               2231 bp    mRNA    linear   PRI 04-JUN-2024
DEFINITION  Homo sapiens vestigial like family member 2 (VGLL2), transcript
            variant 1, mRNA.
ACCESSION   NM_182645
VERSION     NM_182645.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2231)
  AUTHORS   Watson,S., LaVigne,C.A., Xu,L., Surdez,D., Cyrta,J., Calderon,D.,
            Cannon,M.V., Kent,M.R., Silvius,K.M., Kucinski,J.P., Harrison,E.N.,
            Murchison,W., Rakheja,D., Tirode,F., Delattre,O., Amatruda,J.F. and
            Kendall,G.C.
  TITLE     VGLL2-NCOA2 leverages developmental programs for pediatric
            sarcomagenesis
  JOURNAL   Cell Rep 42 (1), 112013 (2023)
   PUBMED   36656711
  REMARK    GeneRIF: VGLL2-NCOA2 leverages developmental programs for pediatric
            sarcomagenesis.
REFERENCE   2  (bases 1 to 2231)
  AUTHORS   Mesrouze,Y., Aguilar,G., Bokhovchuk,F., Martin,T., Delaunay,C.,
            Villard,F., Meyerhofer,M., Zimmermann,C., Fontana,P., Wille,R.,
            Vorherr,T., Erdmann,D., Furet,P., Scheufler,C., Schmelzle,T.,
            Affolter,M. and Chene,P.
  TITLE     A new perspective on the interaction between the Vg/VGLL1-3
            proteins and the TEAD transcription factors
  JOURNAL   Sci Rep 10 (1), 17442 (2020)
   PUBMED   33060790
  REMARK    GeneRIF: A new perspective on the interaction between the
            Vg/VGLL1-3 proteins and the TEAD transcription factors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2231)
  AUTHORS   Alaggio,R., Zhang,L., Sung,Y.S., Huang,S.C., Chen,C.L., Bisogno,G.,
            Zin,A., Agaram,N.P., LaQuaglia,M.P., Wexler,L.H. and Antonescu,C.R.
  TITLE     A Molecular Study of Pediatric Spindle and Sclerosing
            Rhabdomyosarcoma: Identification of Novel and Recurrent
            VGLL2-related Fusions in Infantile Cases
  JOURNAL   Am J Surg Pathol 40 (2), 224-235 (2016)
   PUBMED   26501226
  REMARK    GeneRIF: Identify novel and recurrent VGLL2-related fusions in
            pediatric spindle and sclerosing rhabdomyosarcomas.
REFERENCE   4  (bases 1 to 2231)
  AUTHORS   Rosenfeld,J.A., Amrom,D., Andermann,E., Andermann,F., Veilleux,M.,
            Curry,C., Fisher,J., Deputy,S., Aylsworth,A.S., Powell,C.M.,
            Manickam,K., Heese,B., Maisenbacher,M., Stevens,C., Ellison,J.W.,
            Upton,S., Moeschler,J., Torres-Martinez,W., Stevens,A., Marion,R.,
            Pereira,E.M., Babcock,M., Morrow,B., Sahoo,T., Lamb,A.N.,
            Ballif,B.C., Paciorkowski,A.R. and Shaffer,L.G.
  TITLE     Genotype-phenotype correlation in interstitial 6q deletions: a
            report of 12 new cases
  JOURNAL   Neurogenetics 13 (1), 31-47 (2012)
   PUBMED   22218741
REFERENCE   5  (bases 1 to 2231)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   6  (bases 1 to 2231)
  AUTHORS   Gunther,S., Mielcarek,M., Kruger,M. and Braun,T.
  TITLE     VITO-1 is an essential cofactor of TEF1-dependent muscle-specific
            gene regulation
  JOURNAL   Nucleic Acids Res 32 (2), 791-802 (2004)
   PUBMED   14762206
  REMARK    GeneRIF: VITO-1 is a crucial new cofactor of the muscle regulatory
            programme
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2231)
  AUTHORS   Maeda,T., Chapman,D.L. and Stewart,A.F.
  TITLE     Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2
            transcription factors that promotes skeletal muscle differentiation
  JOURNAL   J Biol Chem 277 (50), 48889-48898 (2002)
   PUBMED   12376544
  REMARK    GeneRIF: role in promoting skeletal muscle differention
REFERENCE   8  (bases 1 to 2231)
  AUTHORS   Mielcarek,M., Gunther,S., Kruger,M. and Braun,T.
  TITLE     VITO-1, a novel vestigial related protein is predominantly
            expressed in the skeletal muscle lineage
  JOURNAL   Mech Dev 119 Suppl 1, S269-S274 (2002)
   PUBMED   14516696
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY056583.1 and AJ578053.1.
            
            On Jul 24, 2012 this sequence version replaced NM_182645.2.
            
            Summary: This gene encodes a protein with a transcriptional
            enhancer factor 1 (TEF-1) interaction domain. The encoded protein
            may act as a co-factor of TEF-1 regulated gene expression during
            skeletal muscle development. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed. [provided
            by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ578053.1, AK096878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326274.6/ ENSP00000320957.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AY056583.1         1-16
            17-2228             AJ578053.1         1-2212
            2229-2231           AY056583.1         1707-1709
FEATURES             Location/Qualifiers
     source          1..2231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.1"
     gene            1..2231
                     /gene="VGLL2"
                     /gene_synonym="VGL2; VITO1"
                     /note="vestigial like family member 2"
                     /db_xref="GeneID:245806"
                     /db_xref="HGNC:HGNC:20232"
                     /db_xref="MIM:609979"
     exon            1..287
                     /gene="VGLL2"
                     /gene_synonym="VGL2; VITO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1160
                     /gene="VGLL2"
                     /gene_synonym="VGL2; VITO1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription cofactor vestigial-like protein 2; Vestigial
                     and Tondu related protein 1; vestigial like 2"
                     /codon_start=1
                     /product="transcription cofactor vestigial-like protein 2
                     isoform 1"
                     /protein_id="NP_872586.1"
                     /db_xref="CCDS:CCDS5115.1"
                     /db_xref="GeneID:245806"
                     /db_xref="HGNC:HGNC:20232"
                     /db_xref="MIM:609979"
                     /translation="MSCLDVMYQVYGPPQPYFAAAYTPYHQKLAYYSKMQEAQECNAS
                     PSSSGSGSSSFSSQTPASIKEEEGSPEKERPPEAEYINSRCVLFTYFQGDISSVVDEH
                     FSRALSQPSSYSPSCTSSKAPRSSGPWRDCSFPMSQRSFPASFWNSAYQAPVPPPLGS
                     PLATAHSELPFAAADPYSPAALHGHLHQGATEPWHHAHPHHAHPHHPYALGGALGAQA
                     APYPRPAAVHEVYAPHFDPRYGPLLMPAASGRPARLATAPAPAPGSPPCELSGKGEPA
                     GAAWAGPGGPFASPSGDVAQGLGLSVDSARRYSLCGASLLS"
     exon            288..597
                     /gene="VGLL2"
                     /gene_synonym="VGL2; VITO1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..1119
                     /gene="VGLL2"
                     /gene_synonym="VGL2; VITO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..2231
                     /gene="VGLL2"
                     /gene_synonym="VGL2; VITO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2208..2213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VGLL2"
                     /gene_synonym="VGL2; VITO1"
                     /note="hexamer: ATTAAA"
     polyA_site      2231
                     /gene="VGLL2"
                     /gene_synonym="VGL2; VITO1"
                     /note="major polyA site"
ORIGIN      
        1 gcttctgccc tggagcgcgg tcgggagtaa aatcgcagga gtgggagggt agcgagccag
       61 ctggattccg agccgcggag cgcgctggct ttgctccgcc tgatgactcc agagcgcggg
      121 tccaagcgcc gcccatgcag cacccctgag ctccggggaa ggagagttaa tgaaaaaaca
      181 cttaaccgtc tccgctgcgg agagtcatga gctgtctgga tgttatgtac caagtctatg
      241 gtcctccgca gccctacttc gcagccgcct acacccccta ccaccagaaa ctagcctatt
      301 attccaaaat gcaggaagcg caggagtgca atgccagccc cagcagcagt ggcagcggca
      361 gctcctcatt ttccagccaa accccagcca gtataaaaga ggaagaaggc agcccagaga
      421 aagagcgccc accagaggca gagtacatca actcccgctg cgtcctcttc acttatttcc
      481 agggggacat cagctccgtg gtggatgaac atttcagcag ggccctgagc caacccagca
      541 gctactctcc tagctgtacc agcagcaaag caccaaggag ctctgggccc tggcgagact
      601 gctccttccc gatgagccag cgcagcttcc ccgcctcctt ctggaatagc gcgtaccagg
      661 cgccagtgcc cccgccgctg ggcagccctc tggccaccgc gcactcggag ctgcccttcg
      721 ccgccgccga cccctactcg cccgccgcgc tgcatggcca cctgcaccag ggcgccacgg
      781 agccctggca ccacgcgcac ccgcaccacg cgcacccgca tcacccctac gccctgggcg
      841 gcgccctcgg cgcccaggcc gccccctacc cgcgccccgc cgccgtgcac gaagtctacg
      901 cgccgcactt cgacccgcgc tatgggccgc tgctgatgcc agccgcctcg gggcgcccgg
      961 cccgcctcgc aaccgccccg gcgcccgcgc ccggcagtcc tccctgcgag ctctccggca
     1021 aaggcgagcc ggcgggcgcc gcgtgggccg ggcccggggg acccttcgcg agcccctcgg
     1081 gggacgtggc ccagggtctg ggcctcagcg tggactcagc tcgtcgttat tccctctgtg
     1141 gtgcatccct cctgagctga tctgctgacc cagggtttcc ccttcccctt cccttctgac
     1201 cagccttgga ggctcagcat ctgtgcctct cactccgtgg atgaggacat gggggaaggc
     1261 agagacttca gacttctcag tgtgttggga aaaccaaaaa ccacaactac agaaattcat
     1321 ctaaaaataa gtcctgctgc tgaaagagca aatccaaaga ctgagttatg tttaatgact
     1381 tttggccgaa tcactggaaa tatctgtggt gagattgctg agtcaggtga tgtgatatca
     1441 taagctttct tggaacgggg gaaagaaaat gaaacttttt ggtgtgaata ttttttatgc
     1501 tgatgtgaat tattttgtta ggtagtgtga ttatagcact actactgtca gattttaaat
     1561 tgtatgtgta cttgcatcta agactgtggt agagaagtaa agagaagtca attccttctt
     1621 cctcacctct cagcctccag atcccttcct gcccatccct tccctacaat gcccactcca
     1681 gacgcaaaga tacacttttt tcctttggac tgtgaacatg gaagcctcag cctgaatgtg
     1741 agtggcaagt ggcttatctg gagccacctg cccaagtctt actaaaatgc agctgttgtt
     1801 agacaactgt tgaaaactcc agaaatacat cacccaaggt ggcagttctc agtatttggc
     1861 agaacaattg caattgcact gggtatatta tatatatata tgtatgcata tatatcatat
     1921 tttttacaag gaacatttta tgatgaaaga agaaaccctt ctctgccttc tctcccacga
     1981 attctgtccc tgtatcctct ggatgtaaaa agcaaggaga gaccccaact gtctccatgg
     2041 agaagaacta ggaatcacca caaggggaag aaatgtacat gaagtctcca ttacctcgaa
     2101 tttttttctc agtctcactg gttgtgattt ggtcacttta gtgttgggac aggggaaagg
     2161 gtctgtgcgt gggcaaagct gaaggtgatg aggaagaaga gacgaacatt aaagatgtct
     2221 atttactatg a
//
