LOCUS       NM_016267               1144 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens vestigial like family member 1 (VGLL1), mRNA.
ACCESSION   NM_016267
VERSION     NM_016267.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1144)
  AUTHORS   Parimita,S., Das,A. and Samanta,S.
  TITLE     VGLL1 stabilization of cytoplasmic TAZ promotes EGFR expression and
            maintains tumor initiating cells in breast cancer independent of
            TEAD
  JOURNAL   Cell Signal 118, 111120 (2024)
   PUBMED   38417636
  REMARK    GeneRIF: VGLL1 stabilization of cytoplasmic TAZ promotes EGFR
            expression and maintains tumor initiating cells in breast cancer
            independent of TEAD.
REFERENCE   2  (bases 1 to 1144)
  AUTHORS   Yang,Y., Jia,W., Luo,Z., Li,Y., Liu,H., Fu,L., Li,J., Jiang,Y.,
            Lai,J., Li,H., Saeed,B.J., Zou,Y., Lv,Y., Wu,L., Zhou,T., Shan,Y.,
            Liu,C., Lai,Y., Liu,L., Hutchins,A.P., Esteban,M.A., Mazid,M.A. and
            Li,W.
  TITLE     VGLL1 cooperates with TEAD4 to control human trophectoderm lineage
            specification
  JOURNAL   Nat Commun 15 (1), 583 (2024)
   PUBMED   38233381
  REMARK    GeneRIF: VGLL1 cooperates with TEAD4 to control human trophectoderm
            lineage specification.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1144)
  AUTHORS   Sonnemann,H.M., Pazdrak,B., Antunes,D.A., Roszik,J. and Lizee,G.
  TITLE     Vestigial-like 1 (VGLL1): An ancient co-transcriptional activator
            linking wing, placenta, and tumor development
  JOURNAL   Biochim Biophys Acta Rev Cancer 1878 (3), 188892 (2023)
   PUBMED   37004960
  REMARK    GeneRIF: Vestigial-like 1 (VGLL1): An ancient co-transcriptional
            activator linking wing, placenta, and tumor development.
            Review article
REFERENCE   4  (bases 1 to 1144)
  AUTHORS   Im,J.Y., Kim,D.M., Park,H., Kang,M.J., Kim,D.Y., Chang,K.Y.,
            Kim,B.K. and Won,M.
  TITLE     VGLL1 phosphorylation and activation promotes gastric cancer
            malignancy via TGF-beta/ERK/RSK2 signaling
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (1), 118892 (2021)
   PUBMED   33069758
  REMARK    GeneRIF: VGLL1 phosphorylation and activation promotes gastric
            cancer malignancy via TGF-beta/ERK/RSK2 signaling.
REFERENCE   5  (bases 1 to 1144)
  AUTHORS   Bradley,S.D., Talukder,A.H., Lai,I., Davis,R., Alvarez,H.,
            Tiriac,H., Zhang,M., Chiu,Y., Melendez,B., Jackson,K.R.,
            Katailiha,A., Sonnemann,H.M., Li,F., Kang,Y., Qiao,N., Pan,B.F.,
            Lorenzi,P.L., Hurd,M., Mittendorf,E.A., Peterson,C.B., Javle,M.,
            Bristow,C., Kim,M., Tuveson,D.A., Hawke,D., Kopetz,S., Wolff,R.A.,
            Hwu,P., Maitra,A., Roszik,J., Yee,C. and Lizee,G.
  TITLE     Vestigial-like 1 is a shared targetable cancer-placenta antigen
            expressed by pancreatic and basal-like breast cancers
  JOURNAL   Nat Commun 11 (1), 5332 (2020)
   PUBMED   33087697
  REMARK    GeneRIF: Vestigial-like 1 is a shared targetable cancer-placenta
            antigen expressed by pancreatic and basal-like breast cancers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1144)
  AUTHORS   Kundishora,A.J., Reeves,B.C., Nelson-Williams,C., Hong,C.S.,
            Gopal,P.P., Snuderl,M., Kahle,K.T. and Erson-Omay,E.Z.
  TITLE     Novel EWSR1-VGLL1 fusion in a pediatric neuroepithelial neoplasm
  JOURNAL   Clin Genet 97 (5), 791-792 (2020)
   PUBMED   31925773
  REMARK    GeneRIF: Novel EWSR1-VGLL1 fusion in a pediatric neuroepithelial
            neoplasm.
REFERENCE   7  (bases 1 to 1144)
  AUTHORS   Castilla,M.A., Lopez-Garcia,M.A., Atienza,M.R., Rosa-Rosa,J.M.,
            Diaz-Martin,J., Pecero,M.L., Vieites,B., Romero-Perez,L.,
            Benitez,J., Calcabrini,A. and Palacios,J.
  TITLE     VGLL1 expression is associated with a triple-negative basal-like
            phenotype in breast cancer
  JOURNAL   Endocr Relat Cancer 21 (4), 587-599 (2014)
   PUBMED   24891455
  REMARK    GeneRIF: VGLL1 expression is associated with a triple-negative
            basal-like phenotype in breast cancer
REFERENCE   8  (bases 1 to 1144)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   9  (bases 1 to 1144)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   10 (bases 1 to 1144)
  AUTHORS   Vaudin,P., Delanoue,R., Davidson,I., Silber,J. and Zider,A.
  TITLE     TONDU (TDU), a novel human protein related to the product of
            vestigial (vg) gene of Drosophila melanogaster interacts with
            vertebrate TEF factors and substitutes for Vg function in wing
            formation
  JOURNAL   Development 126 (21), 4807-4816 (1999)
   PUBMED   10518497
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000045.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016267.3.
            
            Summary: The protein encoded by this gene binds proteins of the TEA
            domain family of transcription factors (TEFs) through the Vg
            (vestigial) homology region found in its N-terminus. It may thus
            function as a specific coactivator for the mammalian TEFs.
            [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003362.1, BC000045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370634.8/ ENSP00000359668.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1144              BC000045.1         64-1207
FEATURES             Location/Qualifiers
     source          1..1144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..1144
                     /gene="VGLL1"
                     /gene_synonym="TDU; VGL1"
                     /note="vestigial like family member 1"
                     /db_xref="GeneID:51442"
                     /db_xref="HGNC:HGNC:20985"
                     /db_xref="MIM:300583"
     exon            1..82
                     /gene="VGLL1"
                     /gene_synonym="TDU; VGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            83..321
                     /gene="VGLL1"
                     /gene_synonym="TDU; VGL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..884
                     /gene="VGLL1"
                     /gene_synonym="TDU; VGL1"
                     /note="TONDU; vestigial like 1; WUGSC:H_GS188P18.1b;
                     vgl-1"
                     /codon_start=1
                     /product="transcription cofactor vestigial-like protein 1"
                     /protein_id="NP_057351.1"
                     /db_xref="CCDS:CCDS14658.1"
                     /db_xref="GeneID:51442"
                     /db_xref="HGNC:HGNC:20985"
                     /db_xref="MIM:300583"
                     /translation="MEEMKKTAIRLPKGKQKPIKTEWNSRCVLFTYFQGDISSVVDEH
                     FSRALSNIKSPQELTPSSQSEGVMLKNDDSMSPNQWRYSSPWTKPQPEVPVTNRAANC
                     NLHVPGPMAVNQFSPSLARRASVRPGELWHFSSLAGTSSLEPGYSHPFPARHLVPEPQ
                     PDGKREPLLSLLQQDRCLARPQESAARENGNPGQIAGSTGLLFNLPPGSVHYKKLYVS
                     RGSASTSLPNETLSELETPGKYSLTPPNHWGHPHRYLQHL"
     exon            322..741
                     /gene="VGLL1"
                     /gene_synonym="TDU; VGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..795
                     /gene="VGLL1"
                     /gene_synonym="TDU; VGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1144
                     /gene="VGLL1"
                     /gene_synonym="TDU; VGL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1123..1128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VGLL1"
                     /gene_synonym="TDU; VGL1"
                     /note="hexamer: AATAAA"
     polyA_site      1144
                     /gene="VGLL1"
                     /gene_synonym="TDU; VGL1"
                     /note="major polyA site"
ORIGIN      
        1 actaacctgc tctgaagtga gccaggcagc tctggccatc ttttcccagc cacagaatca
       61 ggtgatggtc cagaattaag agctgtcacc tgtgtcattc actcacaatg gaagaaatga
      121 agaagactgc catccggctg cccaaaggca aacagaagcc tataaagacg gaatggaatt
      181 cccggtgtgt ccttttcacc tacttccaag gggacatcag cagcgtagtg gatgaacact
      241 tctccagagc tctgagcaat atcaagagcc cccaggaatt gaccccctcg agtcagagtg
      301 aaggtgtgat gctgaaaaac gatgatagca tgtctccaaa tcagtggcgt tactcgtctc
      361 catggacaaa gccacaacca gaagtacctg tcacaaaccg tgccgccaac tgcaacttgc
      421 atgtgcctgg tcccatggct gtgaatcagt tctcaccgtc cctggctagg agggcctctg
      481 ttcggcctgg ggagctgtgg catttctcct ccctggcggg caccagctcc ttagagcctg
      541 gctactctca tcccttcccc gctcggcacc tggttccaga gccccagcct gatgggaaac
      601 gtgagcctct cctaagtctc ctccagcaag acagatgcct agcccgtcct caggaatctg
      661 ccgccaggga gaatggcaac cctggccaga tagctggaag cacagggttg ctcttcaacc
      721 tgcctcccgg ctcagttcac tataagaaac tatatgtatc tcgtggatct gccagtacca
      781 gccttccaaa tgaaactctt tcagagttag agacacctgg gaaatactca cttacaccac
      841 caaaccactg gggccaccca catcgatacc tgcagcatct ttagtcaagt tggaggagaa
      901 agacaacact tggtctaaga cacggcagca agacatccct gcatattgtt ccagataaaa
      961 atgaaagctg ctcacaccca cttgcctccc caatctgtta aacagcttcg tgtctagtat
     1021 gagctcagta cttgccctgt gaaaatccca gaagcccccg ctgtcaatgt tccccatcca
     1081 caccctgctt gctcctgtgt aacagctcag atgatgaata ataataaaac tgtacttttt
     1141 tgga
//
