LOCUS       NP_057351                258 aa            linear   PRI 28-APR-2025
DEFINITION  transcription cofactor vestigial-like protein 1 [Homo sapiens].
ACCESSION   NP_057351
VERSION     NP_057351.1
DBSOURCE    REFSEQ: accession NM_016267.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 258)
  AUTHORS   Parimita,S., Das,A. and Samanta,S.
  TITLE     VGLL1 stabilization of cytoplasmic TAZ promotes EGFR expression and
            maintains tumor initiating cells in breast cancer independent of
            TEAD
  JOURNAL   Cell Signal 118, 111120 (2024)
   PUBMED   38417636
  REMARK    GeneRIF: VGLL1 stabilization of cytoplasmic TAZ promotes EGFR
            expression and maintains tumor initiating cells in breast cancer
            independent of TEAD.
REFERENCE   2  (residues 1 to 258)
  AUTHORS   Yang,Y., Jia,W., Luo,Z., Li,Y., Liu,H., Fu,L., Li,J., Jiang,Y.,
            Lai,J., Li,H., Saeed,B.J., Zou,Y., Lv,Y., Wu,L., Zhou,T., Shan,Y.,
            Liu,C., Lai,Y., Liu,L., Hutchins,A.P., Esteban,M.A., Mazid,M.A. and
            Li,W.
  TITLE     VGLL1 cooperates with TEAD4 to control human trophectoderm lineage
            specification
  JOURNAL   Nat Commun 15 (1), 583 (2024)
   PUBMED   38233381
  REMARK    GeneRIF: VGLL1 cooperates with TEAD4 to control human trophectoderm
            lineage specification.
            Erratum:[Nat Commun. 2025 Mar 18;16(1):2643. doi:
            10.1038/s41467-025-57929-w. PMID: 40102433]
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 258)
  AUTHORS   Sonnemann,H.M., Pazdrak,B., Antunes,D.A., Roszik,J. and Lizee,G.
  TITLE     Vestigial-like 1 (VGLL1): An ancient co-transcriptional activator
            linking wing, placenta, and tumor development
  JOURNAL   Biochim Biophys Acta Rev Cancer 1878 (3), 188892 (2023)
   PUBMED   37004960
  REMARK    GeneRIF: Vestigial-like 1 (VGLL1): An ancient co-transcriptional
            activator linking wing, placenta, and tumor development.
            Review article
REFERENCE   4  (residues 1 to 258)
  AUTHORS   Im,J.Y., Kim,D.M., Park,H., Kang,M.J., Kim,D.Y., Chang,K.Y.,
            Kim,B.K. and Won,M.
  TITLE     VGLL1 phosphorylation and activation promotes gastric cancer
            malignancy via TGF-beta/ERK/RSK2 signaling
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (1), 118892 (2021)
   PUBMED   33069758
  REMARK    GeneRIF: VGLL1 phosphorylation and activation promotes gastric
            cancer malignancy via TGF-beta/ERK/RSK2 signaling.
REFERENCE   5  (residues 1 to 258)
  AUTHORS   Bradley,S.D., Talukder,A.H., Lai,I., Davis,R., Alvarez,H.,
            Tiriac,H., Zhang,M., Chiu,Y., Melendez,B., Jackson,K.R.,
            Katailiha,A., Sonnemann,H.M., Li,F., Kang,Y., Qiao,N., Pan,B.F.,
            Lorenzi,P.L., Hurd,M., Mittendorf,E.A., Peterson,C.B., Javle,M.,
            Bristow,C., Kim,M., Tuveson,D.A., Hawke,D., Kopetz,S., Wolff,R.A.,
            Hwu,P., Maitra,A., Roszik,J., Yee,C. and Lizee,G.
  TITLE     Vestigial-like 1 is a shared targetable cancer-placenta antigen
            expressed by pancreatic and basal-like breast cancers
  JOURNAL   Nat Commun 11 (1), 5332 (2020)
   PUBMED   33087697
  REMARK    GeneRIF: Vestigial-like 1 is a shared targetable cancer-placenta
            antigen expressed by pancreatic and basal-like breast cancers.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 258)
  AUTHORS   Kundishora,A.J., Reeves,B.C., Nelson-Williams,C., Hong,C.S.,
            Gopal,P.P., Snuderl,M., Kahle,K.T. and Erson-Omay,E.Z.
  TITLE     Novel EWSR1-VGLL1 fusion in a pediatric neuroepithelial neoplasm
  JOURNAL   Clin Genet 97 (5), 791-792 (2020)
   PUBMED   31925773
  REMARK    GeneRIF: Novel EWSR1-VGLL1 fusion in a pediatric neuroepithelial
            neoplasm.
REFERENCE   7  (residues 1 to 258)
  AUTHORS   Castilla,M.A., Lopez-Garcia,M.A., Atienza,M.R., Rosa-Rosa,J.M.,
            Diaz-Martin,J., Pecero,M.L., Vieites,B., Romero-Perez,L.,
            Benitez,J., Calcabrini,A. and Palacios,J.
  TITLE     VGLL1 expression is associated with a triple-negative basal-like
            phenotype in breast cancer
  JOURNAL   Endocr Relat Cancer 21 (4), 587-599 (2014)
   PUBMED   24891455
  REMARK    GeneRIF: VGLL1 expression is associated with a triple-negative
            basal-like phenotype in breast cancer
REFERENCE   8  (residues 1 to 258)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   9  (residues 1 to 258)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   10 (residues 1 to 258)
  AUTHORS   Vaudin,P., Delanoue,R., Davidson,I., Silber,J. and Zider,A.
  TITLE     TONDU (TDU), a novel human protein related to the product of
            vestigial (vg) gene of Drosophila melanogaster interacts with
            vertebrate TEF factors and substitutes for Vg function in wing
            formation
  JOURNAL   Development 126 (21), 4807-4816 (1999)
   PUBMED   10518497
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000045.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene binds proteins of the TEA
            domain family of transcription factors (TEFs) through the Vg
            (vestigial) homology region found in its N-terminus. It may thus
            function as a specific coactivator for the mammalian TEFs.
            [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003362.1, BC000045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370634.8/ ENSP00000359668.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..258
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     Protein         1..258
                     /product="transcription cofactor vestigial-like protein 1"
                     /note="TONDU; vestigial like 1; WUGSC:H_GS188P18.1b;
                     vgl-1"
                     /calculated_mol_wt=28576
     Region          21..51
                     /region_name="Vg_Tdu"
                     /note="Vestigial/Tondu family; pfam07545"
                     /db_xref="CDD:462203"
     Region          55..93
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99990.1)"
     CDS             1..258
                     /gene="VGLL1"
                     /gene_synonym="TDU; VGL1"
                     /coded_by="NM_016267.4:108..884"
                     /db_xref="CCDS:CCDS14658.1"
                     /db_xref="GeneID:51442"
                     /db_xref="HGNC:HGNC:20985"
                     /db_xref="MIM:300583"
ORIGIN      
        1 meemkktair lpkgkqkpik tewnsrcvlf tyfqgdissv vdehfsrals nikspqeltp
       61 ssqsegvmlk nddsmspnqw rysspwtkpq pevpvtnraa ncnlhvpgpm avnqfspsla
      121 rrasvrpgel whfsslagts slepgyshpf parhlvpepq pdgkreplls llqqdrclar
      181 pqesaareng npgqiagstg llfnlppgsv hykklyvsrg sastslpnet lseletpgky
      241 sltppnhwgh phrylqhl
//
