LOCUS       NM_003378               2551 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens VGF nerve growth factor inducible (VGF), mRNA.
ACCESSION   NM_003378
VERSION     NM_003378.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2551)
  AUTHORS   Branciamore,S., Gogoshin,G., Rodin,A.S. and Myers,A.J.
  TITLE     Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with
            APOE E4 to alter risk for late onset Alzheimer's disease
  JOURNAL   Sci Rep 14 (1), 14954 (2024)
   PUBMED   38942763
  REMARK    GeneRIF: Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L
            act with APOE E4 to alter risk for late onset Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2551)
  AUTHORS   Yu,L., Petyuk,V.A., Lopes,K.P., Tasaki,S., Menon,V., Wang,Y.,
            Schneider,J.A., De Jager,P.L. and Bennett,D.A.
  TITLE     Associations of VGF with Neuropathologies and Cognitive Health in
            Older Adults
  JOURNAL   Ann Neurol 94 (2), 232-244 (2023)
   PUBMED   37177846
  REMARK    GeneRIF: Associations of VGF with Neuropathologies and Cognitive
            Health in Older Adults.
REFERENCE   3  (bases 1 to 2551)
  AUTHORS   Park,O.S., Bang,J.K., Cheong,C. and Jeon,Y.H.
  TITLE     Structure of AQEE-30 of VGF Neuropeptide in Membrane-Mimicking
            Environments
  JOURNAL   Int J Mol Sci 23 (22), 13953 (2022)
   PUBMED   36430431
  REMARK    GeneRIF: Structure of AQEE-30 of VGF Neuropeptide in
            Membrane-Mimicking Environments.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2551)
  AUTHORS   Yang,L.H., Lee,R.K., Kuo,M.H., Miao,C.C., Wang,Y.X., Chen,A.,
            Jhu,Y.W., Cheng,H.I., Pan,S.T. and Chou,Y.T.
  TITLE     Neuronal survival factor VGF promotes chemoresistance and predicts
            poor prognosis in lung cancers with neuroendocrine feature
  JOURNAL   Int J Cancer 151 (9), 1611-1625 (2022)
   PUBMED   35762443
  REMARK    GeneRIF: Neuronal survival factor VGF promotes chemoresistance and
            predicts poor prognosis in lung cancers with neuroendocrine
            feature.
REFERENCE   5  (bases 1 to 2551)
  AUTHORS   Ye,Q., Zhang,Y., Zhang,Y., Chen,Z., Yu,C., Zheng,C., Yu,H., Zhou,D.
            and Li,X.
  TITLE     Low VGF is associated with executive dysfunction in patients with
            major depressive disorder
  JOURNAL   J Psychiatr Res 152, 182-186 (2022)
   PUBMED   35738161
  REMARK    GeneRIF: Low VGF is associated with executive dysfunction in
            patients with major depressive disorder.
REFERENCE   6  (bases 1 to 2551)
  AUTHORS   Pasinetti,G.M., Ungar,L.H., Lange,D.J., Yemul,S., Deng,H., Yuan,X.,
            Brown,R.H., Cudkowicz,M.E., Newhall,K., Peskind,E., Marcus,S. and
            Ho,L.
  TITLE     Identification of potential CSF biomarkers in ALS
  JOURNAL   Neurology 66 (8), 1218-1222 (2006)
   PUBMED   16481598
  REMARK    GeneRIF: Application of neurosecretory protein VGF biomarker model
            to current diagnostic criteria provides an objective biomarker
            pattern that identifies patients with amyotrophic lateral
            sclerosis.
REFERENCE   7  (bases 1 to 2551)
  AUTHORS   Yuan,X. and Desiderio,D.M.
  TITLE     Human cerebrospinal fluid peptidomics
  JOURNAL   J Mass Spectrom 40 (2), 176-181 (2005)
   PUBMED   15706611
REFERENCE   8  (bases 1 to 2551)
  AUTHORS   Nagasaki,K., Sasaki,K., Maass,N., Tsukada,T., Hanzawa,H. and
            Yamaguchi,K.
  TITLE     Staurosporine enhances cAMP-induced expression of neural-specific
            gene VGF and tyrosine hydroxylase
  JOURNAL   Neurosci Lett 267 (3), 177-180 (1999)
   PUBMED   10381005
REFERENCE   9  (bases 1 to 2551)
  AUTHORS   Canu,N., Possenti,R., Ricco,A.S., Rocchi,M. and Levi,A.
  TITLE     Cloning, structural organization analysis, and chromosomal
            assignment of the human gene for the neurosecretory protein VGF
  JOURNAL   Genomics 45 (2), 443-446 (1997)
   PUBMED   9344675
REFERENCE   10 (bases 1 to 2551)
  AUTHORS   Canu,N., Possenti,R., Rinaldi,A.M., Trani,E. and Levi,A.
  TITLE     Molecular cloning and characterization of the human VGF promoter
            region
  JOURNAL   J Neurochem 68 (4), 1390-1399 (1997)
   PUBMED   9084409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036537.1 and BC063835.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003378.3.
            
            Summary: This gene is specifically expressed in a subpopulation of
            neuroendocrine cells, and is upregulated by nerve growth factor.
            The structural organization of this gene is similar to that of the
            rat gene, and both the translated and the untranslated regions show
            a high degree of sequence similarity to the rat gene. The encoded
            secretory protein also shares similarities with the
            secretogranin/chromogranin family, however, its exact function is
            not known. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225839.1, BC036537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249330.3/ ENSP00000249330.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BC036537.1         25-41
            18-2551             BC063835.1         1-2534
FEATURES             Location/Qualifiers
     source          1..2551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2551
                     /gene="VGF"
                     /gene_synonym="SCG7; SgVII"
                     /note="VGF nerve growth factor inducible"
                     /db_xref="GeneID:7425"
                     /db_xref="HGNC:HGNC:12684"
                     /db_xref="MIM:602186"
     exon            1..196
                     /gene="VGF"
                     /gene_synonym="SCG7; SgVII"
                     /inference="alignment:Splign:2.1.0"
     exon            197..2551
                     /gene="VGF"
                     /gene_synonym="SCG7; SgVII"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..2064
                     /gene="VGF"
                     /gene_synonym="SCG7; SgVII"
                     /note="neuro-endocrine specific protein VGF;
                     neurosecretory protein VGF"
                     /codon_start=1
                     /product="neurosecretory protein VGF precursor"
                     /protein_id="NP_003369.2"
                     /db_xref="CCDS:CCDS5712.1"
                     /db_xref="GeneID:7425"
                     /db_xref="HGNC:HGNC:12684"
                     /db_xref="MIM:602186"
                     /translation="MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVA
                     GDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGS
                     QQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALA
                     SLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVP
                     ERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPF
                     PKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQ
                     YLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEA
                     EEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQ
                     TIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQP
                     PPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHY
                     HHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENYIEHVLLRRP"
     regulatory      2527..2532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VGF"
                     /gene_synonym="SCG7; SgVII"
                     /note="hexamer: AATAAA"
     polyA_site      2551
                     /gene="VGF"
                     /gene_synonym="SCG7; SgVII"
                     /note="major polyA site"
ORIGIN      
        1 agcgtgctga agccggagcg agctagccgc ccggagccgc gccgacccag ctgagcccag
       61 cccacgggac gccagacctc gaccgtcgct cctaccccgg ccaccgctcg gagccgaggc
      121 ggacgcgtcc cgatcttccc ctgtccccac cctgccccga ccctcctctc cacctctcgc
      181 gtcgtgacac cagctgtctc cggcagcctc ttggtcatga aagccctcag attgtcggct
      241 tccgccctct tctgccttct gctgatcaac gggttagggg cagcaccccc tggtcgccct
      301 gaggcgcagc ctcctcctct cagctctgag cataaagagc cggtagccgg ggacgcagtg
      361 cccgggccaa aggatggcag cgccccagag gtccgaggcg ctcggaattc cgagccgcag
      421 gacgagggag agcttttcca gggcgtggat ccccgggcgc tggccgcggt gctgctgcag
      481 gcactcgacc gtcccgcctc acccccggca ccaagcggct cccagcaggg gccggaggaa
      541 gaagcagctg aagctctgct gaccgagacc gtgcgcagcc agacccacag cctcccggcg
      601 ccggagagcc cggagcccgc ggctccgcct cgccctcaga ctccggagaa tgggcccgag
      661 gcgagcgatc cctccgagga gctcgaggcg ctagcgtccc tgctccagga actgcgagat
      721 ttcagtccaa gtagcgccaa gcgccagcag gagacggcgg cagcagagac ggaaacccgc
      781 acgcacacgc tgacccgagt gaatctggag agcccggggc cagagcgcgt atggcgcgct
      841 tcctggggag agttccaggc gcgtgtcccg gagcgcgcgc ccctgccgcc cccggccccc
      901 tctcaattcc aggcgcgtat gcccgacagc gggccccttc ccgaaaccca caagttcggg
      961 gaaggagtgt cctcccccaa aacacaccta ggcgaggcat tggcacccct gtccaaggcg
     1021 taccaaggcg tggccgcccc gttccccaag gcgcgccggc cggagagcgc actcctgggc
     1081 ggctccgagg cgggcgagcg ccttctccag caagggctgg cgcaggtgga ggccgggcgg
     1141 cggcaggcgg aggccacgcg gcaggccgcg gcgcaggaag agcggctggc cgacctcgcc
     1201 tcggacctgc tgctccagta tttgctgcag ggcggggccc ggcagcgcgg cctcgggggt
     1261 cgggggctgc aggaggcggc ggaggagcga gagagtgcaa gggaggagga ggaggcggag
     1321 caggagagac gcggcgggga ggagagggtg ggggaagagg atgaggaggc ggccgaggcg
     1381 gaggcagagg cggaggaggc ggagagggcg cggcagaacg cgctcctgtt cgcggaggag
     1441 gaggacgggg aagccggcgc cgaggacaag cgctcccagg aggagacgcc gggccaccgg
     1501 cggaaggagg ccgaggggac agaggagggc ggggaggagg aggacgacga ggagatggat
     1561 ccgcagacga tcgacagcct cattgagctg tccaccaaac tccacctgcc agcggacgac
     1621 gtggtcagca tcatcgagga ggtggaggag aagcggaagc ggaagaagaa cgcccctccc
     1681 gagcccgtgc cgcccccccg tgccgccccc gcccccaccc acgtccgctc cccgcagccc
     1741 ccgccccccg cccccgctcc cgcacgagac gagctgccgg actggaacga ggtgctcccg
     1801 ccctgggatc gggaggagga cgaggtgtac ccgccagggc cgtaccaccc tttccccaac
     1861 tacatccggc cgcggacact gcagccgccc tcggccttgc gccgccgcca ctaccaccac
     1921 gccttgccgc cttcgcgcca ctatcccggc cgggaggccc aggcgcggcg cgcgcaggag
     1981 gaggcggagg cggaggagcg ccggctgcag gagcaggagg agctggagaa ttacatcgag
     2041 cacgtgctgc tccggcgccc gtgactgccc ttcccggtcc cgcccccgcg cgcccccgcc
     2101 gcgcgcgcgc gccggcgccc ccctccgtgt tgcccgctcc ccctcggtgt ttgcatgcgc
     2161 cccggccctg ccccttggcc ctgcccctgt ccccgggctg cgtcgggacc tgccagaccc
     2221 ccctcccggg tcctgagccc gaactcccag agctcacccg cgggtgaccg ggggccagcc
     2281 caggagggcg ggtggtttgt gcgagttccc ttgccacgcg gggccccggc cccatcaagt
     2341 ccctctgggg acgtccccgt cggaaaccgg aaaaagcagt tccagttaat tgtgtgaagt
     2401 gtgtctgtct ccagcccttc gggcctccca cgagcccctc cagcctctcc aagtcgctgt
     2461 gaattgaccc cttctttcct ttctctgttg taaatacccc tcacggagga aatagttttg
     2521 ctaagaaata aaagtgacta ttttattagg a
//
