LOCUS       NM_017599               4510 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens vezatin, adherens junctions transmembrane protein
            (VEZT), transcript variant 1, mRNA.
ACCESSION   NM_017599
VERSION     NM_017599.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4510)
  AUTHORS   Wang,Y., Yuan,J., Yu,X., Liu,X., Tan,C., Chen,Y. and Xu,T.
  TITLE     Vezatin regulates seizures by controlling AMPAR-mediated synaptic
            activity
  JOURNAL   Cell Death Dis 12 (10), 936 (2021)
   PUBMED   34642320
  REMARK    GeneRIF: Vezatin regulates seizures by controlling AMPAR-mediated
            synaptic activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4510)
  AUTHORS   Matalliotakis,M., Zervou,M.I., Matalliotaki,C., Rahmioglu,N.,
            Koumantakis,G., Kalogiannidis,I., Prapas,I., Zondervan,K.,
            Spandidos,D.A., Matalliotakis,I. and Goulielmos,G.N.
  TITLE     The role of gene polymorphisms in endometriosis
  JOURNAL   Mol Med Rep 16 (5), 5881-5886 (2017)
   PUBMED   28901453
  REMARK    GeneRIF: We found a genetic association between rs11031006 (FSHB)
            SNP and endometriosis. WNT4 and VEZT genes constitute the most
            consistently associated genes with endometriosis. In the present
            study, an association of rs7521902 (WNT4) and rs10859871 (VEZT) was
            confirmed in women with endometriosis at the genotypic but not the
            allelic level.
REFERENCE   3  (bases 1 to 4510)
  AUTHORS   Xie,D., Shang,L., Peng,L. and Li,L.
  TITLE     Up-regulation of VEZT by small activating RNA inhibits the
            proliferation, invasion and migration of gastric cancer cells
  JOURNAL   Biochem Biophys Res Commun 482 (4), 542-548 (2017)
   PUBMED   27856244
  REMARK    GeneRIF: This study identified the most effective small activating
            RNA via real-time PCR and Western blot. The selected small
            activating RNA inhibited the growth, invasion and migration of
            gastric cancer cells by specially reactivating VEZT.
REFERENCE   4  (bases 1 to 4510)
  AUTHORS   Pagliardini,L., Gentilini,D., Sanchez,A.M., Candiani,M., Vigano,P.
            and Di Blasio,A.M.
  TITLE     Replication and meta-analysis of previous genome-wide association
            studies confirm vezatin as the locus with the strongest evidence
            for association with endometriosis
  JOURNAL   Hum Reprod 30 (4), 987-993 (2015)
   PUBMED   25678572
  REMARK    GeneRIF: vezatin and nearby SNP rs10859871 may have a role in
            endometriosis [meta-analysis]
REFERENCE   5  (bases 1 to 4510)
  AUTHORS   Li,Y.S., Chen,Y.Z., Guo,X.B., Liu,X. and Li,L.P.
  TITLE     VEZT as a novel independent prognostic factor in gastric cancer
  JOURNAL   Cancer Biomark 15 (4), 375-380 (2015)
   PUBMED   25792470
  REMARK    GeneRIF: VEZT expression levels can be considered as a biomarker
            for gastric cancer progression, lymphatic metastasis and as a novel
            independent prognostic factor.
REFERENCE   6  (bases 1 to 4510)
  AUTHORS   Nyholt,D.R., Low,S.K., Anderson,C.A., Painter,J.N., Uno,S.,
            Morris,A.P., MacGregor,S., Gordon,S.D., Henders,A.K., Martin,N.G.,
            Attia,J., Holliday,E.G., McEvoy,M., Scott,R.J., Kennedy,S.H.,
            Treloar,S.A., Missmer,S.A., Adachi,S., Tanaka,K., Nakamura,Y.,
            Zondervan,K.T., Zembutsu,H. and Montgomery,G.W.
  TITLE     Genome-wide association meta-analysis identifies new endometriosis
            risk loci
  JOURNAL   Nat Genet 44 (12), 1355-1359 (2012)
   PUBMED   23104006
REFERENCE   7  (bases 1 to 4510)
  AUTHORS   Guo,X., Jing,C., Li,L., Zhang,L., Shi,Y., Wang,J., Liu,J. and Li,C.
  TITLE     Down-regulation of VEZT gene expression in human gastric cancer
            involves promoter methylation and miR-43c
  JOURNAL   Biochem Biophys Res Commun 404 (2), 622-627 (2011)
   PUBMED   21156161
  REMARK    GeneRIF: miR-43c directly targets adherens junctions' transmembrane
            protein (VEZT) and suppresses VEZT protein expression.
REFERENCE   8  (bases 1 to 4510)
  AUTHORS   Hyenne,V., Louvet-Vallee,S., El-Amraoui,A., Petit,C., Maro,B. and
            Simmler,M.C.
  TITLE     Vezatin, a protein associated to adherens junctions, is required
            for mouse blastocyst morphogenesis
  JOURNAL   Dev Biol 287 (1), 180-191 (2005)
   PUBMED   16199027
  REMARK    GeneRIF: function of mouse vezatin in mouse blastocyst
            morphogenesis
REFERENCE   9  (bases 1 to 4510)
  AUTHORS   Blaschuk,O.W. and Rowlands,T.M.
  TITLE     Plasma membrane components of adherens junctions (Review)
  JOURNAL   Mol Membr Biol 19 (2), 75-80 (2002)
   PUBMED   12126233
  REMARK    Review article
REFERENCE   10 (bases 1 to 4510)
  AUTHORS   Kussel-Andermann,P., El-Amraoui,A., Safieddine,S., Nouaille,S.,
            Perfettini,I., Lecuit,M., Cossart,P., Wolfrum,U. and Petit,C.
  TITLE     Vezatin, a novel transmembrane protein, bridges myosin VIIA to the
            cadherin-catenins complex
  JOURNAL   EMBO J 19 (22), 6020-6029 (2000)
   PUBMED   11080149
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB136255.1, AF225417.1,
            AK225303.1, AL133113.1, BI835735.1, BQ023048.1 and AC084879.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017599.3.
            
            Summary: This gene encodes a transmembrane protein which has been
            localized to adherens junctions and shown to bind to myosin VIIA.
            Examination of expression of this gene in gastric cancer tissues
            have shown that expression is decreased which appears to be related
            to hypermethylation of the promoter. Expression of this gene may
            also be inhibited by binding of a specific microRNA to a target
            sequence in the 3' UTR of the transcripts. A pseudogene of this
            gene is located on the X chromosome. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) encodes isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.256577.1,
                                           SRR1660805.39775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000436874.6/ ENSP00000410083.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DB136255.1         62-92
            32-1044             AF225417.1         64-1076
            1045-1486           AK225303.1         1119-1560
            1487-1893           AF225417.1         1519-1925
            1894-2328           AL133113.1         681-1115
            2329-2714           BI835735.1         75-460
            2715-4409           AL133113.1         1502-3196
            4410-4501           BQ023048.1         19-110              c
            4502-4510           AC084879.23        111739-111747       c
FEATURES             Location/Qualifiers
     source          1..4510
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22"
     gene            1..4510
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /note="vezatin, adherens junctions transmembrane protein"
                     /db_xref="GeneID:55591"
                     /db_xref="HGNC:HGNC:18258"
                     /db_xref="MIM:619749"
     exon            1..80
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..2384
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /note="isoform b is encoded by transcript variant 1"
                     /codon_start=1
                     /product="vezatin isoform b"
                     /protein_id="NP_060069.3"
                     /db_xref="CCDS:CCDS44954.1"
                     /db_xref="GeneID:55591"
                     /db_xref="HGNC:HGNC:18258"
                     /db_xref="MIM:619749"
                     /translation="MTPEFDEEVVFENSPLYQYLQDLGHTDFEICSSLSPKTEKCTTE
                     GQQKPPTRVLPKQGILLKVAETIKSWIFFSQCNKKDDLLHKLDIGFRLDSLHTILQQE
                     VLLQEDVELIELLDPSILSAGQSQQQENGHLPTLCSLATPNIWDLSMLFAFISLLVML
                     PTWWIVSSWLVWGVILFVYLVIRALRLWRTAKLQVTLKKYSVHLEDMATNSRAFTNLV
                     RKALRLIQETEVISRGFTLVSAACPFNKAGQHPSQHLIGLRKAVYRTLRANFQAARLA
                     TLYMLKNYPLNSESDNVTNYICVVPFKELGLGLSEEQISEEEAHNFTDGFSLPALKVL
                     FQLWVAQSSEFFRRLALLLSTANSPPGPLLTPALLPHRILSDVTQGLPHAHSACLEEL
                     KRSYEFYRYFETQHQSVPQCLSKTQQKSRELNNVHTAVRSLQLHLKALLNEVIILEDE
                     LEKLVCTKETQELVSEAYPILEQKLKLIQPHVQASNNCWEEAISQVDKLLRRNTDKKG
                     KPEIACENPHCTVVPLKQPTLHIADKDPIPEEQELEAYVDDIDIDSDFRKDDFYYLSQ
                     EDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLKSLSPVDPVEP
                     ISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVF
                     PQGAEERMCYQCESEDEPQADGSGLTTAPPTPRDSLQPSIKQRLARLQLSPDFTFTAG
                     LAAEVAARSLSFTTMQEQTFGGEEEEQIIEENKNEIEEK"
     exon            81..212
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            213..302
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            303..478
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            479..754
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            755..892
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1040
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1372
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1566
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1667
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1875
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..4510
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2861..2866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /note="hexamer: AATAAA"
     polyA_site      2883
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /note="major polyA site"
     regulatory      4202..4207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /note="hexamer: CATAAA"
     polyA_site      4222
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
     regulatory      4282..4287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /note="hexamer: GATAAA"
     polyA_site      4308
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
     regulatory      4387..4392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /note="hexamer: AATAAA"
     polyA_site      4413
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
     regulatory      4483..4488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
                     /note="hexamer: AATAAA"
     polyA_site      4510
                     /gene="VEZT"
                     /gene_synonym="VEZATIN"
ORIGIN      
        1 cttcatttcc catcgtgctg aggcgggtgg catggcggag aaggatgaca ccggagtttg
       61 acgaagaggt ggtttttgag aattctccac tttaccaata cttacaggat ctgggacaca
      121 cagactttga aatatgttct tctttgtcac caaaaacaga aaaatgcaca acagagggac
      181 aacaaaagcc tcctacaaga gtcctaccaa aacaaggtat cctgttaaaa gtggctgaaa
      241 ccatcaaaag ttggattttt ttttctcagt gcaataagaa agatgactta cttcacaagt
      301 tggatattgg attccgactc gactcattac ataccatcct gcaacaggaa gtcctgttac
      361 aagaggatgt ggagctgatt gagctacttg atcccagtat cctgtctgca gggcaatctc
      421 aacaacagga aaatggacac cttccaacac tttgctccct ggcaacccct aatatttggg
      481 atctctcaat gctatttgcc ttcattagct tgctcgttat gcttcccact tggtggattg
      541 tgtcttcctg gctggtatgg ggagtgattc tatttgtgta tctggtcata agagctttga
      601 gattatggag gacagccaaa ctacaagtga ccctaaaaaa atacagcgtt catttggaag
      661 atatggccac aaacagccga gcttttacta acctcgtgag aaaagcttta cgtctcattc
      721 aagaaaccga agtgatttcc agaggattta cactggtcag tgctgcttgc ccatttaata
      781 aagctggaca gcatccaagt cagcatctca tcggtcttcg gaaagctgtc taccgaactc
      841 taagagccaa cttccaagca gcaaggctag ctaccctata tatgctgaaa aactaccccc
      901 tgaactctga gagtgacaat gtaaccaact acatctgtgt ggtgcctttt aaagagctgg
      961 gccttggact tagtgaagag cagatttcag aagaggaagc acataacttt acagatggct
     1021 tcagcctgcc tgcattgaag gttttgttcc aactctgggt ggcacagagt tcagagttct
     1081 tcagacggtt agccctatta ctttctacag ccaattcacc tcctgggccc ttacttactc
     1141 cagcacttct gcctcatcgt atcttatctg atgtgactca aggtctacct catgctcatt
     1201 ctgcctgttt ggaagagctt aagcgcagct atgagttcta tcggtacttt gaaactcagc
     1261 accagtcagt accgcagtgt ttatccaaaa ctcaacagaa gtcaagagaa ctgaataatg
     1321 ttcacacagc agtgcgtagc ttgcagctcc atctgaaagc attactgaat gaggtaataa
     1381 ttcttgaaga tgaacttgaa aagcttgttt gtactaaaga aacacaagaa ctagtgtcag
     1441 aggcttatcc catcctagaa cagaaattaa agttgattca gccccacgtt caagcaagca
     1501 acaattgctg ggaagaggcc atttctcagg tcgacaaact gctacgaaga aatacagata
     1561 aaaaaggcaa gcctgaaata gcatgtgaaa acccacattg tacagtagta cctttgaagc
     1621 agcctactct acacattgca gacaaagatc caatcccaga ggagcaggaa ttagaagctt
     1681 atgtagatga tatagatatt gatagtgatt tcagaaagga tgatttttat tacttgtctc
     1741 aagaagacaa agagagacag aagcgtgagc atgaagaatc caagagggtg ctccaagaat
     1801 taaaatctgt gctgggattt aaagcttcag aggcagaaag gcagaagtgg aagcaacttc
     1861 tatttagtga tcatgccgtg ttgaaatcct tgtctcctgt agacccagtg gaacccataa
     1921 gtaattcaga accatcaatg aattcagata tgggaaaagt cagtaaaaat gatactgaag
     1981 aggaaagtaa taaatccgcc acaacagaca atgaaataag taggactgag tatttatgtg
     2041 aaaactctct agaaggtaaa aataaagata attcttcaaa tgaagtcttc ccccaaggag
     2101 cagaagaaag aatgtgttac caatgtgaga gtgaagatga accacaagca gatggaagtg
     2161 gtctgaccac tgcccctcca actcccaggg actcattaca gccctccatt aagcagaggc
     2221 tggcacggct acagctgtca ccagatttta ccttcactgc tggccttgct gcagaagtgg
     2281 ctgctagatc tctctccttt accaccatgc aggaacagac ttttggtggt gaggaggaag
     2341 aacaaataat agaagaaaat aaaaatgaga tagaagaaaa gtaagaacca agattcatat
     2401 gaagtgatat tagattgttc cttttacaaa agtgtttagc ttcaagactg gaaagggaat
     2461 atgagtgtaa gtttactata tataaagcta agatgtggat ttacaggaag aaccctggtt
     2521 tgaataactg atctgaaatt agtagttacc tgtaaatggc agatctttta ggaaaataag
     2581 agaaaggtaa gggctctttt gaataaactg ctgttttatt tgtggcacaa ctgatcaatc
     2641 ttggaaattc tttaagtatt tttaataaga aatgaattat catttcttgc cagaatttgc
     2701 taccttaagg tgattgggaa aattctgttg caagaacatt aacatttagt atgactcctt
     2761 tttactgtat tcttgcagtt aataactgca gctattatgt taataacaag ttgtttgtat
     2821 tttatttttg tttataccag tcttaaagat ccaggttctg aataaaaaaa ttaattgata
     2881 caattgatgt gtgctggggt ttggaactaa aagtagtttc aacagtgcgt gggttatgac
     2941 atttcttatg tttctttgtt catgtgtgta tttagtagtt aattttaaga tgtcctagtg
     3001 atctttaaaa gaaaaatatt gtaccatttt ttagaattac actttcacct ttctttttgc
     3061 aattgaaagt gatgatgtca aagtgggatt tctgtactcc aaggccccac ccccaattta
     3121 gcaagcagaa aaacgttcct tgtatcactt taccttggat aattgggtgc cattaacaca
     3181 aacaggtcac aatcctgctg ttttctagcc ctgtccacca taatgagatt caggaaacat
     3241 cctgtcagcc tcctggaaag catccttgtc tccttagtat ttcatttaca aactacctct
     3301 taacagagac tgcttttcaa attggccaat cttacctgtt ttgtgttgtg attgcatttt
     3361 caaagagtaa ttattttcag catatacagt tttgaaacct gtagctccta tgcaataaca
     3421 tagttctata gacattattt gggggaaatg tagtaataac tcaatctatg ttgctgtcct
     3481 agaaaggaaa ttgcatgatg aatctagatt gtctttagag taaagaaaca cattcaaatt
     3541 cctgtaactt atcactttca gtgagtaaat ttacttatac caaaggggat tttttttctt
     3601 tcaggaatct aaggaaattt actttttaac ctgagaaaaa aacttggttc tgctttatat
     3661 aaacagtaga gattattgta ctataagtga ttttgccttt ttgccaaaat cctggaactc
     3721 atctataatt aacctcttcg gagcaatacc ttaggttggg ccttgcttta ctacttagaa
     3781 atagctaaat ttcaatttta aaaatctttg tgtgttataa ctgttaaatt attcaataat
     3841 acttagggtt tactttctta tttaaatcac ttatttagtt taccgacttc atttttcttt
     3901 ggatttagaa gaagcaatta tggaaaaact tggtaatctc tctcaaccta taaccttaca
     3961 caggaagaat tagagtttaa taatttttaa ttcttttatt gtatgttact tttattacac
     4021 cagtttgggg gaaaatcttc ataaaattgt atcagtttta ttcagtgttc tctaaggtga
     4081 taccttttaa ttttgaaaga ctaaataatt ttaatcgaga atttccagtc tttcagtctg
     4141 atctatttaa ttcactactt gttacataat ccagtgaaaa ctctacttgt tgaaattatg
     4201 acataaagat cttgcagctt tatttgagta tttgttcttt tgtgtagttt ccatctttta
     4261 aaatatttaa aatattttca agataaagta ttatcttctc tgcaaaaatt cctggagtaa
     4321 ttttctctca taatatttga agtcagtggt tctcagttgt attagtgggg taactacatc
     4381 aaaataaata aagtcttatt tttaaaatgc aaattttaga ccatactccc agtgattctt
     4441 agttggtctt tttggaatga gccataggta atgtttatgt ccaataaaat ctaggaacct
     4501 ctgtctggaa
//
