LOCUS       NM_007146               4630 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens vascular endothelial zinc finger 1 (VEZF1), transcript
            variant 1, mRNA.
ACCESSION   NM_007146
VERSION     NM_007146.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4630)
  AUTHORS   Li,M., Cui,Y., Qi,Q., Liu,J., Li,J., Huang,G., Yang,J., Sun,J.,
            Ma,Z., Liang,S., Zhang,D., Jiang,J., Zhu,R., Liu,Q., Huang,R. and
            Yan,J.
  TITLE     SPOP downregulation promotes bladder cancer progression based on
            cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis and is
            regulated by VEZF1
  JOURNAL   Theranostics 14 (17), 6543-6559 (2024)
   PUBMED   39479456
  REMARK    GeneRIF: SPOP downregulation promotes bladder cancer progression
            based on cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis
            and is regulated by VEZF1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4630)
  AUTHORS   Shi,H.Y., Xie,M.S., Guo,Y.H., Yang,C.X., Gu,J.N., Qiao,Q., Di,R.M.,
            Qiu,X.B., Xu,Y.J. and Yang,Y.Q.
  TITLE     VEZF1 loss-of-function mutation underlying familial dilated
            cardiomyopathy
  JOURNAL   Eur J Med Genet 66 (3), 104705 (2023)
   PUBMED   36657711
  REMARK    GeneRIF: VEZF1 loss-of-function mutation underlying familial
            dilated cardiomyopathy.
REFERENCE   3  (bases 1 to 4630)
  AUTHORS   Shi,X., Zhao,P. and Zhao,G.
  TITLE     VEZF1, destabilized by STUB1, affects cellular growth and
            metastasis of hepatocellular carcinoma by transcriptionally
            regulating PAQR4
  JOURNAL   Cancer Gene Ther 30 (2), 256-266 (2023)
   PUBMED   36241701
  REMARK    GeneRIF: VEZF1, destabilized by STUB1, affects cellular growth and
            metastasis of hepatocellular carcinoma by transcriptionally
            regulating PAQR4.
REFERENCE   4  (bases 1 to 4630)
  AUTHORS   Huang,J., Xu,W., Liu,P., Liu,Y., Shen,C., Liu,S., Wang,Y., Wang,J.,
            Zhang,T., He,Y., Cheng,C., Yang,L., Zhang,W., Tian,X. and Xu,K.F.
  TITLE     Gene mutations in sporadic lymphangioleiomyomatosis and
            genotype-phenotype correlation analysis
  JOURNAL   BMC Pulm Med 22 (1), 354 (2022)
   PUBMED   36117164
  REMARK    GeneRIF: Gene mutations in sporadic lymphangioleiomyomatosis and
            genotype-phenotype correlation analysis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4630)
  AUTHORS   Qiao,H.Y., Zhang,Q., Wang,J.M., Jiang,J.Y., Huyan,L.Y., Yan,J.,
            Li,C. and Wang,H.Q.
  TITLE     TRIM29 regulates the SETBP1/SET/PP2A axis via transcription factor
            VEZF1 to promote progression of ovarian cancer
  JOURNAL   Cancer Lett 529, 85-99 (2022)
   PUBMED   34973391
  REMARK    GeneRIF: TRIM29 regulates the SETBP1/SET/PP2A axis via
            transcription factor VEZF1 to promote progression of ovarian
            cancer.
REFERENCE   6  (bases 1 to 4630)
  AUTHORS   Liang,J., Huang,W., Cai,W., Wang,L., Guo,L., Paul,C., Yu,X.Y. and
            Wang,Y.
  TITLE     Inhibition of microRNA-495 Enhances Therapeutic Angiogenesis of
            Human Induced Pluripotent Stem Cells
  JOURNAL   Stem Cells 35 (2), 337-350 (2017)
   PUBMED   27538588
REFERENCE   7  (bases 1 to 4630)
  AUTHORS   Gowher,H., Brick,K., Camerini-Otero,R.D. and Felsenfeld,G.
  TITLE     Vezf1 protein binding sites genome-wide are associated with pausing
            of elongating RNA polymerase II
  JOURNAL   Proc Natl Acad Sci U S A 109 (7), 2370-2375 (2012)
   PUBMED   22308494
  REMARK    GeneRIF: find examples of genes in which Vezf1 binding sites are
            located near cassette exons, and in which loss of Vezf1 leads to a
            change in the relative abundance of alternatively spliced messages
REFERENCE   8  (bases 1 to 4630)
  AUTHORS   Aitsebaomo,J., Kingsley-Kallesen,M.L., Wu,Y., Quertermous,T. and
            Patterson,C.
  TITLE     Vezf1/DB1 is an endothelial cell-specific transcription factor that
            regulates expression of the endothelin-1 promoter
  JOURNAL   J Biol Chem 276 (42), 39197-39205 (2001)
   PUBMED   11504723
REFERENCE   9  (bases 1 to 4630)
  AUTHORS   Lebowitz,P.F. and Prendergast,G.C.
  TITLE     Functional interaction between RhoB and the transcription factor
            DB1
  JOURNAL   Cell Adhes Commun 6 (4), 277-287 (1998)
   PUBMED   9865462
REFERENCE   10 (bases 1 to 4630)
  AUTHORS   Koyano-Nakagawa,N., Nishida,J., Baldwin,D., Arai,K. and Yokota,T.
  TITLE     Molecular cloning of a novel human cDNA encoding a zinc finger
            protein that binds to the interleukin-3 promoter
  JOURNAL   Mol Cell Biol 14 (8), 5099-5107 (1994)
   PUBMED   8035792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG718897.1, D28118.1, AA195154.1 and BX648862.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007146.2.
            
            Summary: Transcriptional regulatory proteins containing tandemly
            repeated zinc finger domains are thought to be involved in both
            normal and abnormal cellular proliferation and differentiation.
            ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al.,
            1994 [PubMed 8035792]). See MIM 603971 for general information on
            zinc finger proteins.[supplied by OMIM, Sep 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.211392.1,
                                           SRR1803615.164192.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000581208.2/ ENSP00000462337.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               BG718897.1         7-108
            103-1174            D28118.1           1-1072
            1175-1688           AA195154.1         32-545
            1689-2423           D28118.1           1572-2306
            2424-4630           BX648862.1         1717-3923
FEATURES             Location/Qualifiers
     source          1..4630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..4630
                     /gene="VEZF1"
                     /gene_synonym="CMD1OO; DB1; ZNF161"
                     /note="vascular endothelial zinc finger 1"
                     /db_xref="GeneID:7716"
                     /db_xref="HGNC:HGNC:12949"
                     /db_xref="MIM:606747"
     exon            1..176
                     /gene="VEZF1"
                     /gene_synonym="CMD1OO; DB1; ZNF161"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1709
                     /gene="VEZF1"
                     /gene_synonym="CMD1OO; DB1; ZNF161"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 161; putative transcription factor DB1"
                     /codon_start=1
                     /product="vascular endothelial zinc finger 1 isoform 1"
                     /protein_id="NP_009077.2"
                     /db_xref="CCDS:CCDS32687.1"
                     /db_xref="GeneID:7716"
                     /db_xref="HGNC:HGNC:12949"
                     /db_xref="MIM:606747"
                     /translation="MEANWTAFLFQAHEASHHQQQAAQNSLLPLLSSAVEPPDQKPLL
                     PIPITQKPQGAPETLKDAIGIKKEKPKTSFVCTYCSKAFRDSYHLRRHESCHTGIKLV
                     SRPKKTPTTVVPLISTIAGDSSRTSLVSTIAGILSTVTTSSSGTNPSSSASTTAMPVT
                     QSVKKPSKPVKKNHACEMCGKAFRDVYHLNRHKLSHSDEKPFECPICNQRFKRKDRMT
                     YHVRSHEGGITKPYTCSVCGKGFSRPDHLSCHVKHVHSTERPFKCQTCTAAFATKDRL
                     RTHMVRHEGKVSCNICGKLLSAAYITSHLKTHGQSQSINCNTCKQGISKTCMSEETSN
                     QKQQQQQQQQQQQQQQQQQQHVTSWPGKQVETLRLWEEAVKARKKEAANLCQTSTAAT
                     TPVTLTTPFSITSSVSSGTMSNPVTVAAAMSMRSPVNVSSAVNITSPMNIGHPVTITS
                     PLSMTSPLTLTTPVNLPTPVTAPVNIAHPVTITSPMNLPTPMTLAAPLNIAMRPVESM
                     PFLPQALPTSPPW"
     exon            177..871
                     /gene="VEZF1"
                     /gene_synonym="CMD1OO; DB1; ZNF161"
                     /inference="alignment:Splign:2.1.0"
     exon            872..935
                     /gene="VEZF1"
                     /gene_synonym="CMD1OO; DB1; ZNF161"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1119
                     /gene="VEZF1"
                     /gene_synonym="CMD1OO; DB1; ZNF161"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1281
                     /gene="VEZF1"
                     /gene_synonym="CMD1OO; DB1; ZNF161"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..4630
                     /gene="VEZF1"
                     /gene_synonym="CMD1OO; DB1; ZNF161"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3592..3597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VEZF1"
                     /gene_synonym="CMD1OO; DB1; ZNF161"
                     /note="hexamer: AACAAA"
     polyA_site      3612
                     /gene="VEZF1"
                     /gene_synonym="CMD1OO; DB1; ZNF161"
     regulatory      4609..4614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VEZF1"
                     /gene_synonym="CMD1OO; DB1; ZNF161"
                     /note="hexamer: ATTAAA"
     polyA_site      4630
                     /gene="VEZF1"
                     /gene_synonym="CMD1OO; DB1; ZNF161"
                     /note="major polyA site"
ORIGIN      
        1 gtggccgcgc tcggcgctgc catgttgagg agccgccgct gccgttgccg ccgccgccgc
       61 cgccgctttg ttgtcgcctc ctccggctga ggaggctccc cgagcggggg gagtggggag
      121 gaggggggtc ggccgccgca gccatggagg ccaactggac cgcgttcctg ttccaggccc
      181 atgaagcttc ccatcaccaa cagcaggcag cacagaacag cttgctgccc ctcctgagct
      241 ctgccgtgga gccccctgat cagaaaccat tgcttccaat accaataact cagaaacctc
      301 agggtgcacc agaaacatta aaggatgcca ttgggattaa aaaagaaaaa cccaaaactt
      361 catttgtgtg cacttactgc agtaaagctt tcagggacag ctatcacctg aggcgccacg
      421 aatcctgcca cacagggatc aagttggtgt cccggccaaa gaaaaccccc accacggtgg
      481 ttccccttat ctctaccatc gctggggaca gcagccgaac ttcgttggtc tcgaccattg
      541 caggcatctt gtcaacagtc actacatctt cctcgggcac caaccccagt agcagtgcca
      601 gcaccacagc tatgccagtg acccagtctg tcaagaaacc cagtaagcct gtcaagaaga
      661 accatgcttg tgagatgtgt gggaaggcct tccgagatgt gtaccatctc aatcgacaca
      721 agctctccca ttcagatgag aaaccctttg agtgtcctat ttgtaatcag cgcttcaaga
      781 ggaaggaccg gatgacttac catgtgaggt ctcatgaagg aggcatcacc aaaccctata
      841 cttgcagtgt ttgtgggaaa ggcttctcaa ggcctgacca cttaagctgt catgtaaaac
      901 atgtccattc aacagaaaga cccttcaaat gccaaacgtg cactgctgcc tttgccacca
      961 aagacagact gcggacacac atggtgcgcc atgaaggcaa ggtatcatgt aacatctgtg
     1021 ggaagctcct gagtgcagca tacatcacca gccacttaaa gactcatggg cagagccaaa
     1081 gtatcaactg taatacatgt aaacaaggca tcagtaaaac atgcatgagt gaagagacca
     1141 gtaaccaaaa gcagcagcag cagcagcagc agcagcagca gcagcagcaa caacaacaac
     1201 aacaacatgt gacaagctgg ccagggaagc aagtagaaac actgagactg tgggaagaag
     1261 ctgttaaagc aaggaagaaa gaagctgcta acctgtgcca aacctccacg gctgctacga
     1321 cacctgtgac tctcactact ccattcagta taacatcctc tgtgtcgtct gggactatgt
     1381 caaacccagt cacagtggca gctgcaatga gcatgagaag tccagtaaat gtttcaagtg
     1441 cagttaacat aaccagccca atgaacatag ggcatcctgt aactataacc agtccattat
     1501 ccatgacctc tcctttaaca ctcactaccc cagtcaacct ccccaccccc gtcactgccc
     1561 cagtgaatat agcacaccct gtcaccatca catctccaat gaatctaccc acacctatga
     1621 cattagccgc ccctctcaat atagcaatga gacctgtaga gagcatgcct ttcttgcccc
     1681 aagctttgcc tacatcaccg ccttggtaaa cagtattata aaatcaaaat atgggtaaaa
     1741 gtaaatattt accagcaact taacttttag ttgattaaag caaaaagtaa accatgaaat
     1801 tgggagattt tattacatta gttaataaga gtgtggtagc atttttctcc aatttggctg
     1861 ggattattca aagtagggtg tgtatgtaac ttatcactgg accactttag tttaatcaga
     1921 aattcctttt agctgacaac attgcttaaa caggatagta gttggcaaga tgaaatgcca
     1981 gaattaaaac caatcataag tagaacccac ttcaaaataa aaaaacagca ttactatttc
     2041 taatcccaag gaatcacttt attgtaaaca ctagcagaac tcttctccct atacaaggtg
     2101 gatggctgat tttaacctga aattttaaat ccacagattg agagctagtg tagaattgtc
     2161 tgtgtttatt gtttttatga gtaaatacat gcattgtcat aataaaatgc atttcagaga
     2221 atatgcattt tacctttggg aatatgttaa tttcaggcag cattccctat gggaaaggtg
     2281 ataccagctc tgatatgcaa agcatatgat aatttatcat tctaacttca acgtataata
     2341 gggattgtga cctgatattt ggagatgtaa atattgctca gcatattaat cccgatggaa
     2401 tatagcattg tagttgactt tttaaaaaaa aaaaaaattt aaaaaaaatc tacaaattgt
     2461 gttttgctaa gaaaagcctc aactgacaga ggagaagtca agtgtgtgga caggcaagct
     2521 cctaataaac agagtccagt gggattccta tttaggagcc aaggagtact ttggaacagt
     2581 acaaatatat tgctttaaat tggaagacgc tggaggcact gggatgtgat atgcccctct
     2641 ctctcccaat cagagcctgt tgatattaca acagggacag atgtgttagt tgctcactag
     2701 agtttatgtc ttatattaaa ttgtatacag tttttattct aaccactaac taggtagtgt
     2761 atgccccttc agaacatgca gagtgtatct ttttttaaat ttctccttcc gtttcttaag
     2821 tattgcgcag atttgttcaa ctttgtaaat atggacatca cttttttttt ctttgagaaa
     2881 acacttgtat cagctttgtg gtgttttcag ggagacagct gtctgcattc cctgtagaaa
     2941 cccagcaatg attatgcacg ttgagacatg tgctttttat ttcttagcaa gatattttat
     3001 ctctgtacat aaagtagaaa ccaaaagcta gggaaacaga tactctttac accatcatgc
     3061 cacgcattgt ttttaaagca ttgcgttaaa aaaaaaatta actaaaccaa gatgctgtga
     3121 ttttttaagt tgcaatatgt ttttggtttt tttcattttt taatcattgc agttaagaga
     3181 aatggaaatt agttgtgtta atcttgcaga atgtttgcag gactgactat caaactggat
     3241 gatttccatt tataccctac tgtgtcagtt caagcatcaa aataccttgc atctgagaca
     3301 gacttcctac atcagggaca ggtatctgtg tgtcattata caaaacagtt ctagggggtt
     3361 gaactacata gtaaaaaaat aaaataaata gtacttagtg taaaataatt ttataaatga
     3421 tcttttgtac tttaggacat taaattgtac aacttttgta tatataaaag cttaggaact
     3481 ttctgtttag caggaaggca acacattcct acacttttaa tgtatatgtt tgttataatg
     3541 tccatgtaaa catgccctat gtttgtgcct tttaattagt ttgtctcaat aaacaaaatg
     3601 tagagaaaaa tatgtagcta tgactttgtt acaactgttc ttatccacag tacaaaaatg
     3661 gtttgttttt aatatgtaga gcattatgtg tggactactg gaaggactcg tgtagggaaa
     3721 gcccaagaat gaccttgctg aggcctggat tgggaggcac agtggccaca tttggaggaa
     3781 gttcacattt cctggcatgc agacccaaaa ctgggttctg gctctgcctg ctgggatctg
     3841 ttatctctgg tgggctggca gtcataattc acaattcaga cagcccaggc ttcctccaca
     3901 gtggtccaag gagcagtcct cagtgggggc aggtgtgggc cctaccccta agctagaatg
     3961 tggttgtcag aaccctgaaa gtattagttc taaaaaaaaa aagatatata ctagaagtaa
     4021 ttgttttatc aattcattgt ataataaaca ggagtgagac ttcattgtat gacttcagtt
     4081 aaaatactat tttgtatgca ttctttattc acttaagaag cttgtctgca ataataaagc
     4141 cacgtcatgt cttcttttgg gagggagaga gtcgatggca ggagggggtt ttgggtgggc
     4201 cactgaaaag gggtaccgaa taggttgtgt gatgaaattc tgtgtcttgg aactggaatt
     4261 gagtttcgat gttgatgaac tgattcaacc aggtgttgaa ggcacgacag ccactgctct
     4321 acgaaaaggc agagtacgtt tttcccttct ggttgtaacc tggttgagag cttccccttt
     4381 atcagattgg cagctaaaca gttgtattag ataatcctta aatctgacat ccagcctgtt
     4441 acgctctagg gctcgctgct tggcctgcgt ttgcttttta ttgtgtatcc gttcccctcc
     4501 tacggtgtgc tcctgaatga aggtttctat gtaagcagat gatgatttta cctgtcaata
     4561 ccagcactgt attactaaca tgcaaaatac tgcagattta ttttgaaaat taaagttaac
     4621 tggtcacaaa
//
