LOCUS       NM_001167912            4191 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ventricular zone expressed PH domain containing 1
            (VEPH1), transcript variant 2, mRNA.
ACCESSION   NM_001167912
VERSION     NM_001167912.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4191)
  AUTHORS   Nie,X., Zhou,Z., Chen,Y., Chen,S., Chen,Y., Lei,J., Wu,X. and He,S.
  TITLE     VEPH1 suppresses the progression of gastric cancer by regulating
            the Hippo-YAP signalling pathway
  JOURNAL   Dig Liver Dis 56 (1), 187-197 (2024)
   PUBMED   37244789
  REMARK    GeneRIF: VEPH1 suppresses the progression of gastric cancer by
            regulating the Hippo-YAP signalling pathway.
REFERENCE   2  (bases 1 to 4191)
  AUTHORS   Kollara,A., Burt,B.D., Ringuette,M.J. and Brown,T.J.
  TITLE     The adaptor protein VEPH1 interacts with the kinase domain of ERBB2
            and impacts EGF signaling in ovarian cancer cells
  JOURNAL   Cell Signal 106, 110634 (2023)
   PUBMED   36828346
  REMARK    GeneRIF: The adaptor protein VEPH1 interacts with the kinase domain
            of ERBB2 and impacts EGF signaling in ovarian cancer cells.
REFERENCE   3  (bases 1 to 4191)
  AUTHORS   Dong,P., Wang,X., Liu,L., Tang,W., Ma,L., Zeng,W., Sun,S.,
            Zhang,L., Zhang,N., Shen,X., Janssen,H.L.A., Dong,L., Zhang,S. and
            Chen,S.
  TITLE     Dampened VEPH1 activates mTORC1 signaling by weakening the
            TSC1/TSC2 association in hepatocellular carcinoma
  JOURNAL   J Hepatol 73 (6), 1446-1459 (2020)
   PUBMED   32610114
  REMARK    GeneRIF: Dampened VEPH1 activates mTORC1 signaling by weakening the
            TSC1/TSC2 association in hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 4191)
  AUTHORS   Shi,X., Xu,C., Li,Y., Wang,H., Ma,W., Tian,Y., Yang,H. and Li,L.
  TITLE     A novel role of VEPH1 in regulating AoSMC phenotypic switching
  JOURNAL   J Cell Physiol 235 (12), 9336-9346 (2020)
   PUBMED   32342520
  REMARK    GeneRIF: A novel role of VEPH1 in regulating AoSMC phenotypic
            switching.
REFERENCE   5  (bases 1 to 4191)
  AUTHORS   Kollara,A., Shathasivam,P., Park,S., Ringuette,M.J. and Brown,T.J.
  TITLE     Increased androgen receptor levels and signaling in ovarian cancer
            cells by VEPH1 associated with suppression of SMAD3 and AKT
            activation
  JOURNAL   J Steroid Biochem Mol Biol 196, 105498 (2020)
   PUBMED   31614206
  REMARK    GeneRIF: VEPH1 acts to enhance Androgen Receptor (AR) activity in
            ovarian cancer cells by decreasing SMAD3 and pAKT levels, resulting
            in increased levels of AR protein.
REFERENCE   6  (bases 1 to 4191)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4191)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4191)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   9  (bases 1 to 4191)
  AUTHORS   Muto,E., Tabata,Y., Taneda,T., Aoki,Y., Muto,A., Arai,K. and
            Watanabe,S.
  TITLE     Identification and characterization of Veph, a novel gene encoding
            a PH domain-containing protein expressed in the developing central
            nervous system of vertebrates
  JOURNAL   Biochimie 86 (8), 523-531 (2004)
   PUBMED   15388229
REFERENCE   10 (bases 1 to 4191)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020630.21, AB051479.1 and AC092944.14.
            
            On Nov 23, 2018 this sequence version replaced NM_001167912.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051479.1, DRR138524.250390.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362010.7/ ENSP00000354919.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC020630.21        130972-131040       c
            70-4188             AB051479.1         1-4119
            4189-4191           AC092944.14        114267-114269
FEATURES             Location/Qualifiers
     source          1..4191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31-q25.32"
     gene            1..4191
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /note="ventricular zone expressed PH domain containing 1"
                     /db_xref="GeneID:79674"
                     /db_xref="HGNC:HGNC:25735"
                     /db_xref="MIM:609594"
     exon            1..140
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     exon            141..435
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..2799
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /note="isoform 1 is encoded by transcript variant 2;
                     ventricular zone-expressed PH domain-containing protein
                     homolog 1; protein melted; ventricular zone expressed PH
                     domain homolog 1"
                     /codon_start=1
                     /product="ventricular zone-expressed PH domain-containing
                     protein homolog 1 isoform 1"
                     /protein_id="NP_001161384.1"
                     /db_xref="CCDS:CCDS3179.1"
                     /db_xref="GeneID:79674"
                     /db_xref="HGNC:HGNC:25735"
                     /db_xref="MIM:609594"
                     /translation="MHQLFRLVLGQKDLSRAGDLFSLDDSEIEDSLTEALEQIKIISS
                     SSDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPFGKDED
                     TPHAKIASDIMSCILQNYNRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKA
                     DLLADHTEVIVKSILQGNTMLLRVLPAVYEKQPQPINRHLTELLALMSQLEQPEQYHL
                     LRLLHVAAKKKQLEVVQKCIPFLIGHLKDSTHNDIILNILIEIAVYEPVALNSFLPML
                     KEIGERFPYLTGQMARIYGAVGHVDEERARSCLTYLVSQLANMEHSFHHILLLEIKSI
                     TDTFSSILGPQSRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEET
                     KLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFNRSKSL
                     AFHTMLTKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSV
                     SYPNIIHIDSENLSETVKENSQEETPETTASPIEYQDKLYLHLKKNLSKVKAYAMEIG
                     KKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQ
                     QSLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETAMMESTFPQQKDLDQVQLHLEEV
                     RFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRY
                     FTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYV
                     FKAKDEKNAEEWLQCINVAVAQAKERESREVTTYL"
     exon            436..651
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     exon            652..826
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     exon            827..993
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1203
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1424
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1634
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..2032
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2172
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2307
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2425
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2562
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..4191
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4164..4169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /note="hexamer: AATAAA"
     polyA_site      4191
                     /gene="VEPH1"
                     /gene_synonym="MELT; VEPH"
                     /note="major polyA site"
ORIGIN      
        1 gagacgcggc tgcagcccac aggactgggc agcagctgca aggctgcctc tgagcatggt
       61 catgggtccc agctgcagtg ctctaaagat caaggatttt gccttctatt ttctatgacc
      121 agagattcct gtgcaaagag agagtgtcaa tgaagacctc aaagtctgga gaaaaatgac
      181 ctttcatgga ataagaagta tacctccttc tacatgtttt tgtcttactg acctctgata
      241 actggaacac atgactctgg gtctgtagaa agtcaactga tcaaactcat cctcaccatg
      301 catcaactgt tcagactggt tttgggacaa aaagatcttt cacgagctgg ggacctcttc
      361 tccttagatg actctgagat tgaagacagc cttacagaag ctttggagca aattaagata
      421 attagctcat cttcagatta ccaaaccaat aacaatgacc aggcagtagt tgaaatctgt
      481 atcacaagaa tcacaacagc catcagagag accgagtcca ttgaaaagca tgcaaaggcc
      541 cttgtggggc tctgggactc ctgcttggaa cataacctga gaccctttgg gaaagacgaa
      601 gacactcctc atgcaaaaat cgcatctgat atcatgagtt gcattttaca gaattacaac
      661 cgacccccag tgatggcatt agccatcccc attgcagtga aattcctcca cagaggcaac
      721 aaggaactgt gcaggaatat gtctaactac ctgtctctgg ctgcaattac caaggcagat
      781 ctcctggctg atcacacgga agttatagta aagagcatac tccaaggtaa caccatgttg
      841 ttgagagtgt tacctgctgt gtatgaaaag cagcctcagc caattaatag acacctgaca
      901 gaactcctgg ccttgatgtc tcagctggaa cagccagaac agtaccatct actacggctt
      961 ttgcatgtag cagcaaagaa aaaacaactc gaggtagttc agaagtgtat tcctttccta
     1021 attgggcatt tgaaggattc aacccataat gacatcatcc taaacatcct catagagata
     1081 gcagtctatg agccagtggc tttgaacagt tttcttccaa tgctgaaaga gattggtgag
     1141 agattcccct acctcactgg acagatggca aggatttatg gagctgttgg gcatgtggat
     1201 gaagagagag ccaggagctg cctgacatac ctggtgagcc aactggccaa catggagcat
     1261 tcgtttcacc atattctcct gctggagatt aaaagcatca ccgacacctt ctcctcaatc
     1321 ttgggccctc agagcagaga catcttccgc atgagcaaca gcttcaccgc cattgctaaa
     1381 ctccttaccc gacaactgga aaataccaag gctggaagtg gcaggagaaa aatcagcact
     1441 gaaattgaat tccctgagaa actggaagaa accaagctca tagtaactga aaatgaagac
     1501 catgaaaaac tccaagttaa aatccaggct tttgaagaca agataaatgc agggagcaat
     1561 acccctggct ctatcagaag atatagtctg ggccaagttt ctaaagaaga aagaaaaaac
     1621 attagattta acaggtcaaa aagtttggct ttccacacta tgctcacaaa gggtgtgggt
     1681 tcagatgacg gcgaagatga aaacagggga gacataccag ccagcatctc tctttcagaa
     1741 atagacccac ttggccaagg aaatgacaag ctgccgttta agacagacac tgagagatca
     1801 cagctggggg agtcttcagt ttcataccca aatattatac atatagactc agagaatttg
     1861 tcagaaactg ttaaagaaaa ctcccaggaa gaaactccag agacaactgc aagtcctata
     1921 gaataccaag ataagctcta cttgcactta aaaaaaaacc tcagcaaagt gaaagcatat
     1981 gccatggaaa ttggaaagaa gattccagtc cctgatcagt gtaccattga agacactgtg
     2041 agaagttgtg tagcaaagtt gttcttcacc tgctccctga agggtcatta ctgcctatac
     2101 agtaagtcca gttttattct catcagccaa gaacctcagc catggatcca gatcatgttt
     2161 ctatttcagc agagcctgtt tcctgaaccc ctgtccattc agagtcattc tgtgcaattc
     2221 ctcagagctc tgtgggagaa gacccaggca gggggtgctc acagctttga aactgccatg
     2281 atggagtcca cgtttccaca gcagaaggat ctggaccagg tacagctcca tctggaagaa
     2341 gtgaggttct ttgacgtgtt tggcttcagt gaaacagcag gagcatggca atgcttcatg
     2401 tgcaacaatc ctgagaaagc aactgttgta aatcaagatg gccagcctct catagaagga
     2461 aaacttaaag agaagcaagt cagatggaag ttcatcaaaa ggtggaaaac acgctatttt
     2521 acactggctg gaaatcaact tctgtttcaa aaaggaaagt ctaaagatga ccctgacgac
     2581 tgcccaatag aactcagcaa agtacagagt gtgaaggctg tggccaagaa acgcagggac
     2641 cgctctctcc cccgggcttt cgaaatcttc acagacaata aaacctatgt ctttaaggcc
     2701 aaggatgaga agaatgcaga agaatggctc cagtgcatca acgtggcagt tgcccaagcc
     2761 aaagaaaggg aaagtagaga agtaaccaca tatctgtagg gatttataag tcagccatga
     2821 caattataca ccacaggcat tgtattatca ttgccaatgt caagaaaaag agctaaattt
     2881 accaagccat gttgtttttt actaaatacc aatggaattg ttgtccttta agaagaaggg
     2941 cctaaaatgg caggattctt agtaaatgtc atactctaac agctttagta ttgacttcag
     3001 aatatatctg atgcccacaa aaataaaata aaataaaagg agctacagag tatgccctca
     3061 gatagtgtgg ggccaggaag ggaaaagtca ctgataaaag aacttctgta gatatgtcat
     3121 ttaaaactgt gagaaaacaa catgaaaaga tgcctgaact ctccatcctg aggaaagatt
     3181 agcacttctg atgaaaatca cagtctgtca aaggtattaa aagaaaactt taaaaaaaaa
     3241 aacctttaga aacgttgaac taatgtacac tgagaaaaac catataactt acttatagac
     3301 atataattac atgatcctct cttactacaa ctgaggctaa cacatggtaa aatggttccc
     3361 aaatcaagcc agttatgtca ttaaatactt gtctttcaga attacttatt taattattcc
     3421 atttaagttc atataatata atctacagtt tagatacttg gacatatatc ctgcccaagg
     3481 cactaagtgt aatataggaa aaggatagaa agccattttc tctatcttca aaataatgtg
     3541 ccatctccgt taaaattaag actttaaagt tctataattt tttctttgta ttcaactttt
     3601 taatacctcc aaattacaaa catctatttt tttcactaca tagatatata attacactat
     3661 gatagacaga attctagagt gattctcaat aatccatgcc ttggtataat cctctccccc
     3721 attgagtgtg ggtgggacat gtaacctgct tctaaccaac agaatatggc aaaagtgatg
     3781 ggatcatctc tcccatatta tgttatgtta tataacaaaa gtgaagagaa gttgcagata
     3841 tacataaggt ttctaatcag ctgactttga gttaatcaaa gagatcccct gggtgggcct
     3901 gacctaatca gactagtcct ttaaaagaga gtgaaccagt cagagactct ctctcctatt
     3961 agccttaaat aagcaagctg ccatgagctc tacggctgca aggaaataag ttttgtgaac
     4021 aaccatgtga tcttggaaga agcatctgaa cctcagataa aagcccagcc ccagccaacg
     4081 ccttgcttgc agctttgtga aactctgagc agaggaccca gctaaatcac gtttggactc
     4141 ctgacccaca gaaactttca gataataaat gtatgctgtt ttaaatctaa a
//
