LOCUS       NM_014468               2459 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens VENT homeobox (VENTX), mRNA.
ACCESSION   NM_014468
VERSION     NM_014468.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2459)
  AUTHORS   Le,Y., Gao,H., Richards,W., Zhao,L., Bleday,R., Clancy,T. and
            Zhu,Z.
  TITLE     VentX expression in tumor-associated macrophages promotes
            phagocytosis and immunity against pancreatic cancers
  JOURNAL   JCI Insight 5 (14), 137088 (2020)
   PUBMED   32573491
  REMARK    GeneRIF: VentX expression in tumor-associated macrophages promotes
            phagocytosis and immunity against pancreatic cancers.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2459)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2459)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2459)
  AUTHORS   Le,Y., Gao,H., Bleday,R. and Zhu,Z.
  TITLE     The homeobox protein VentX reverts immune suppression in the tumor
            microenvironment
  JOURNAL   Nat Commun 9 (1), 2175 (2018)
   PUBMED   29872044
  REMARK    GeneRIF: Findings suggest potential applications of homeobox
            protein VentX (VentX)-regulated tumor-associated macrophages (TAMs)
            in cancer immunotherapy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2459)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 2459)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 2459)
  AUTHORS   Holland,P.W., Booth,H.A. and Bruford,E.A.
  TITLE     Classification and nomenclature of all human homeobox genes
  JOURNAL   BMC Biol 5, 47 (2007)
   PUBMED   17963489
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2459)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2459)
  AUTHORS   Moretti,P.A., Davidson,A.J., Baker,E., Lilley,B., Zon,L.I. and
            D'Andrea,R.J.
  TITLE     Molecular cloning of a human Vent-like homeobox gene
  JOURNAL   Genomics 76 (1-3), 21-29 (2001)
   PUBMED   11549314
REFERENCE   10 (bases 1 to 2459)
  AUTHORS   Moreau-Aubry,A., Le Guiner,S., Labarriere,N., Gesnel,M.C.,
            Jotereau,F. and Breathnach,R.
  TITLE     A processed pseudogene codes for a new antigen recognized by a
            CD8(+) T cell clone on melanoma
  JOURNAL   J Exp Med 191 (9), 1617-1624 (2000)
   PUBMED   10790436
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445199.37.
            
            On Nov 23, 2018 this sequence version replaced NM_014468.3.
            
            Summary: This gene encodes a member of the Vent family of
            homeodomain proteins. The encoded protein may function as a
            transcriptional repressor and be involved in mesodermal patterning
            and hemopoietic stem cell maintenance. Multiple pseudogenes exist
            for this gene. A transcribed pseudogene located on chromosome X may
            lead to antigen production in certain melanomas. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF068006.1, BC108915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325980.10/ ENSP00000357556.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AL445199.37        206938-207238
            302-462             AL445199.37        208759-208919
            463-2459            AL445199.37        209015-211011
FEATURES             Location/Qualifiers
     source          1..2459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..2459
                     /gene="VENTX"
                     /gene_synonym="HPX42B; NA88A; VENTX2"
                     /note="VENT homeobox"
                     /db_xref="GeneID:27287"
                     /db_xref="HGNC:HGNC:13639"
                     /db_xref="MIM:607158"
     exon            1..301
                     /gene="VENTX"
                     /gene_synonym="HPX42B; NA88A; VENTX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..837
                     /gene="VENTX"
                     /gene_synonym="HPX42B; NA88A; VENTX2"
                     /note="VENT-like homeobox 2; hemopoietic progenitor
                     homeobox protein VENTX2; VENT-like homeobox protein 2;
                     VENT homeobox homolog"
                     /codon_start=1
                     /product="homeobox protein VENTX"
                     /protein_id="NP_055283.1"
                     /db_xref="CCDS:CCDS7675.1"
                     /db_xref="GeneID:27287"
                     /db_xref="HGNC:HGNC:13639"
                     /db_xref="MIM:607158"
                     /translation="MRLSSSPPRGPQQLSSFGSVDWLSQSSCSGPTHTPRPADFSLGS
                     LPGPGQTSGAREPPQAVSIKEAAGSSNLPAPERTMAGLSKEPNTLRAPRVRTAFTMEQ
                     VRTLEGVFQHHQYLSPLERKRLAREMQLSEVQIKTWFQNRRMKHKRQMQDPQLHSPFS
                     GSLHAPPAFYSTSSGLANGLQLLCPWAPLSGPQALMLPPGSFWGLCQVAQEALASAGA
                     SCCGQPLASHPPTPGRPSLGPALSTGPRGLCAMPQTGDAF"
     exon            302..462
                     /gene="VENTX"
                     /gene_synonym="HPX42B; NA88A; VENTX2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..2459
                     /gene="VENTX"
                     /gene_synonym="HPX42B; NA88A; VENTX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1388..1393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VENTX"
                     /gene_synonym="HPX42B; NA88A; VENTX2"
                     /note="hexamer: ATTAAA"
     polyA_site      1411
                     /gene="VENTX"
                     /gene_synonym="HPX42B; NA88A; VENTX2"
                     /note="major polyA site"
     regulatory      1567..1572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VENTX"
                     /gene_synonym="HPX42B; NA88A; VENTX2"
                     /note="hexamer: AGTAAA"
     polyA_site      1602
                     /gene="VENTX"
                     /gene_synonym="HPX42B; NA88A; VENTX2"
                     /note="major polyA site"
     regulatory      2437..2442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VENTX"
                     /gene_synonym="HPX42B; NA88A; VENTX2"
                     /note="hexamer: GATAAA"
     polyA_site      2459
                     /gene="VENTX"
                     /gene_synonym="HPX42B; NA88A; VENTX2"
                     /note="major polyA site"
ORIGIN      
        1 gaggtggatc ctgcgcctgg ccagccccgc ctggccttcc ctccggccca cctggccgcc
       61 atgcgcctct cctcctcccc acctcgtggc ccgcagcagc tctccagctt tggctccgtg
      121 gactggctct cccagagcag ctgctcaggg ccgacccaca cccccaggcc tgccgacttc
      181 tccctgggga gcctccctgg cccaggccag acatccggcg cccgggagcc ccctcaggcc
      241 gtcagcatca aggaggccgc cgggtcctca aatctgcctg cgccggagag gaccatggcc
      301 gggttgagta aggagccaaa taccttgcgg gccccccgtg tccgcacagc cttcaccatg
      361 gagcaggtcc gcaccttgga gggcgtcttc cagcaccacc agtacctgag ccctctggag
      421 cggaagaggc tggccaggga gatgcagctc tcagaggtcc agataaaaac ctggtttcag
      481 aatcgccgca tgaaacacaa acggcaaatg caggaccccc agctgcacag ccccttctcg
      541 gggtctctcc atgcgccccc agctttctac tcaacgtctt ctggccttgc caatggcctg
      601 cagctgctgt gcccttgggc acccctgtcc gggccccagg ctctgatgct gccccctggc
      661 tccttctggg gtctctgcca agtggcacaa gaggccctgg catctgcggg agcttcctgc
      721 tgcgggcagc ctctggcgtc ccacccccct accccaggcc ggccttcgct gggaccagcc
      781 ctgtccacgg ggccccgggg cctgtgtgct atgccacaga cgggggatgc attttgagga
      841 ggcacctctg actcccacac tcgcggtctt gctgatcgca cctggctcct acctggagga
      901 ctcagttgtt ctgtttacat cctggtggca cctctcaccc tgacccacac aaaggttctg
      961 gagattactg gagaatatat ataaatatat atatgtacgt atatatgtaa atacacatat
     1021 acgtatatat aaatatatat atacatatgt gtgtgtatat atatatatat tttttttttt
     1081 tttttttttt ttgagacgga gtgttgctct gtcacccagg ctggagtgca atgacgcaat
     1141 ctcggctcac tgcaacctcc gcctcctggg ttcaagcgat tctccagcct cagcctcccg
     1201 agtagctggg attacagaca cccgccacca cgcccggcta attttttcta tttttagtag
     1261 aaatggggtt tcaccatgtt agccaggctg gtctcaaact cctgaccctg tgatccgccc
     1321 gcctcggcct cccaaagtgc tgggattaca ggcatgagcc actgcacccg gccctgagaa
     1381 tatatttatt aaagccacct cttcactgaa agttaccgaa agagtcggtt taggaaggaa
     1441 acgaagggtc agtgaacaga gtcaaatgca gaagtgggct tgtcatgggt agggctttcg
     1501 gcgtacgata aaaggatcat ttgtttttta aaaggggttg gaaaaactgg ttttccagtt
     1561 ggaaacagta aaggttgtaa gctttgtgtg tacaaaagaa aacagggaat gcaggtgtgt
     1621 ttatagcgtt gtggttcaag tccctcttaa caagaactcc aaagctggaa agcaggaggg
     1681 aacaaaggtg aacatgaagg cgaggatgct ggggccctgc agtgcgctct aggctgtgcg
     1741 tgagccggga ctgtacccac agcttgctga gggctgctct tcttgggcca gggaaagcag
     1801 ggcagccggg acctgcggct gtgcctggac tgaagctgtc ccgcaggtcc ccaccctcca
     1861 acacgtgctc acctgtcccc ctgctcgcag cagcctcggg acaaaacaat gactcaagga
     1921 cagcacttct tgcagaaggt ctggaagtgc ccagaatggg aggcacggaa gcccctcccg
     1981 gggaggactc ccgcgttgat ggaccgttct tggtgcagac tcctgactgc gtgcatgaaa
     2041 cctgagacaa gtgcaattcc ttccatgtcg ccccagagtg cccaggaggc aggcagtgcg
     2101 gggtgcccag gcagacgggt tcagcctgca gaactggagg cgacctgtga aacccacccg
     2161 ggcaccccaa caggaacaga agcgtggtcc tgcggctgcg tccccagcga gtttcacttt
     2221 ccccttgctc gtttctccct tgttgtaagt gtttacaact ggcatgtgct tttaaacgtc
     2281 aggtaagagg ggaacagctg ctgtacatcg tcctggcgag tgacaatgtg acagaagcct
     2341 gggcgaggcc ctcggagggc agcagctgga cagggactac tgggtttggc ctggacagca
     2401 ctgatttgtg gatgtggatg ggggcacgtt gtccgtgata aaagtacaag tgcccctca
//
