LOCUS       NM_004469               2069 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens vascular endothelial growth factor D (VEGFD), mRNA.
ACCESSION   NM_004469
VERSION     NM_004469.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2069)
  AUTHORS   Chen,T., Ruan,Y., Ji,L., Cai,J., Tong,M., Xue,Y., Zhao,H., Cai,X.
            and Xu,J.
  TITLE     S100A6 drives lymphatic metastasis of liver cancer via activation
            of the RAGE/NF-kB/VEGF-D pathway
  JOURNAL   Cancer Lett 587, 216709 (2024)
   PUBMED   38350547
  REMARK    GeneRIF: S100A6 drives lymphatic metastasis of liver cancer via
            activation of the RAGE/NF-kB/VEGF-D pathway.
REFERENCE   2  (bases 1 to 2069)
  AUTHORS   Li,J., Li,X.L., Liu,F.H., Yu,Y.F. and Du,Y.
  TITLE     Vascular endothelial growth factor-D plasma levels in fluid
            overload and cardiac function evaluation of elderly patients with
            cardiovascular disease
  JOURNAL   Medicine (Baltimore) 102 (46), e36062 (2023)
   PUBMED   37986336
  REMARK    GeneRIF: Vascular endothelial growth factor-D plasma levels in
            fluid overload and cardiac function evaluation of elderly patients
            with cardiovascular disease.
REFERENCE   3  (bases 1 to 2069)
  AUTHORS   Bokhari,S.M.Z. and Hamar,P.
  TITLE     Vascular Endothelial Growth Factor-D (VEGF-D): An Angiogenesis
            Bypass in Malignant Tumors
  JOURNAL   Int J Mol Sci 24 (17), 13317 (2023)
   PUBMED   37686121
  REMARK    GeneRIF: Vascular Endothelial Growth Factor-D (VEGF-D): An
            Angiogenesis Bypass in Malignant Tumors.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2069)
  AUTHORS   Davidsson,P., Eketjall,S., Eriksson,N., Walentinsson,A.,
            Becker,R.C., Cavallin,A., Bogstedt,A., Collen,A., Held,C.,
            James,S., Siegbahn,A., Stewart,R., Storey,R.F., White,H. and
            Wallentin,L.
  TITLE     Vascular endothelial growth factor-D plasma levels and VEGFD
            genetic variants are independently associated with outcomes in
            patients with cardiovascular disease
  JOURNAL   Cardiovasc Res 119 (7), 1596-1605 (2023)
   PUBMED   36869765
  REMARK    GeneRIF: Vascular endothelial growth factor-D plasma levels and
            VEGFD genetic variants are independently associated with outcomes
            in patients with cardiovascular disease.
            Erratum:[Cardiovasc Res. 2023 Jun 13;119(6):1454. doi:
            10.1093/cvr/cvad047.. PMID: 36972152]
REFERENCE   5  (bases 1 to 2069)
  AUTHORS   Nguyen,T.T.U., Kim,H., Chae,Y.J., Jung,J.H. and Kim,W.
  TITLE     Serum VEGF-D level is correlated with renal dysfunction and
            proteinuria in patients with diabetic chronic kidney disease
  JOURNAL   Medicine (Baltimore) 101 (7), e28804 (2022)
   PUBMED   35363168
  REMARK    GeneRIF: Serum VEGF-D level is correlated with renal dysfunction
            and proteinuria in patients with diabetic chronic kidney disease.
REFERENCE   6  (bases 1 to 2069)
  AUTHORS   Wartiovaara,U., Salven,P., Mikkola,H., Lassila,R., Kaukonen,J.,
            Joukov,V., Orpana,A., Ristimaki,A., Heikinheimo,M., Joensuu,H.,
            Alitalo,K. and Palotie,A.
  TITLE     Peripheral blood platelets express VEGF-C and VEGF which are
            released during platelet activation
  JOURNAL   Thromb Haemost 80 (1), 171-175 (1998)
   PUBMED   9684805
REFERENCE   7  (bases 1 to 2069)
  AUTHORS   Achen,M.G., Jeltsch,M., Kukk,E., Makinen,T., Vitali,A., Wilks,A.F.,
            Alitalo,K. and Stacker,S.A.
  TITLE     Vascular endothelial growth factor D (VEGF-D) is a ligand for the
            tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
  JOURNAL   Proc Natl Acad Sci U S A 95 (2), 548-553 (1998)
   PUBMED   9435229
REFERENCE   8  (bases 1 to 2069)
  AUTHORS   Rocchigiani,M., Lestingi,M., Luddi,A., Orlandini,M., Franco,B.,
            Rossi,E., Ballabio,A., Zuffardi,O. and Oliviero,S.
  TITLE     Human FIGF: cloning, gene structure, and mapping to chromosome
            Xp22.1 between the PIGA and the GRPR genes
  JOURNAL   Genomics 47 (2), 207-216 (1998)
   PUBMED   9479493
REFERENCE   9  (bases 1 to 2069)
  AUTHORS   Yamada,Y., Nezu,J., Shimane,M. and Hirata,Y.
  TITLE     Molecular cloning of a novel vascular endothelial growth factor,
            VEGF-D
  JOURNAL   Genomics 42 (3), 483-488 (1997)
   PUBMED   9205122
REFERENCE   10 (bases 1 to 2069)
  AUTHORS   Orlandini,M., Marconcini,L., Ferruzzi,R. and Oliviero,S.
  TITLE     Identification of a c-fos-induced gene that is related to the
            platelet-derived growth factor/vascular endothelial growth factor
            family
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11675-11680 (1996)
   PUBMED   8876195
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1997 Feb 18;94(4):1603]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA587496.1 and BC027948.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004469.4.
            
            Summary: The protein encoded by this gene is a member of the
            platelet-derived growth factor/vascular endothelial growth factor
            (PDGF/VEGF) family and is active in angiogenesis,
            lymphangiogenesis, and endothelial cell growth. This secreted
            protein undergoes a complex proteolytic maturation, generating
            multiple processed forms which bind and activate VEGFR-2 and
            VEGFR-3 receptors. This protein is structurally and functionally
            similar to vascular endothelial growth factor C. Read-through
            transcription has been observed between this locus and the upstream
            PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.286389.1, AK223160.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297904.4/ ENSP00000297904.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               DA587496.1         1-235
            236-1628            BC027948.1         205-1597
            1629-2069           BC027948.1         1599-2039
FEATURES             Location/Qualifiers
     source          1..2069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..2069
                     /gene="VEGFD"
                     /gene_synonym="FIGF; VEGF-D"
                     /note="vascular endothelial growth factor D"
                     /db_xref="GeneID:2277"
                     /db_xref="HGNC:HGNC:3708"
                     /db_xref="MIM:300091"
     exon            1..557
                     /gene="VEGFD"
                     /gene_synonym="FIGF; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..1532
                     /gene="VEGFD"
                     /gene_synonym="FIGF; VEGF-D"
                     /note="c-fos induced growth factor (vascular endothelial
                     growth factor D)"
                     /codon_start=1
                     /product="vascular endothelial growth factor D
                     preproprotein"
                     /protein_id="NP_004460.1"
                     /db_xref="CCDS:CCDS14166.1"
                     /db_xref="GeneID:2277"
                     /db_xref="HGNC:HGNC:3708"
                     /db_xref="MIM:300091"
                     /translation="MYREWVVVNVFMMLYVQLVQGSSNEHGPVKRSSQSTLERSEQQI
                     RAASSLEELLRITHSEDWKLWRCRLRLKSFTSMDSRSASHRSTRFAATFYDIETLKVI
                     DEEWQRTQCSPRETCVEVASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTSY
                     ISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPRHPYSIIRRSIQIPEEDRCSHS
                     KKLCPIDMLWDSNKCKCVLQEENPLAGTEDHSHLQEPALCGPHMMFDEDRCECVCKTP
                     CPKDLIQHPKNCSCFECKESLETCCQKHKLFHPDTCSCEDRCPFHTRPCASGKTACAK
                     HCRFPKEKRAAQGPHSRKNP"
     exon            558..768
                     /gene="VEGFD"
                     /gene_synonym="FIGF; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     exon            769..959
                     /gene="VEGFD"
                     /gene_synonym="FIGF; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1108
                     /gene="VEGFD"
                     /gene_synonym="FIGF; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1209
                     /gene="VEGFD"
                     /gene_synonym="FIGF; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1405
                     /gene="VEGFD"
                     /gene_synonym="FIGF; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..2069
                     /gene="VEGFD"
                     /gene_synonym="FIGF; VEGF-D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2047..2052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VEGFD"
                     /gene_synonym="FIGF; VEGF-D"
                     /note="hexamer: AATAAA"
     polyA_site      2069
                     /gene="VEGFD"
                     /gene_synonym="FIGF; VEGF-D"
                     /note="major polyA site"
ORIGIN      
        1 aagacacatg cttctgcaag cttccatgaa ggttgtgcaa aaaagtttca atccagagtt
       61 gggttccagc tttctgtagc tgtaagcatt ggtggccaca ccacctcctt acaaagcaac
      121 tagaacctgc ggcatacatt ggagagattt ttttaatttt ctggacatga agtaaattta
      181 gagtgctttc taatttcagg tagaagacat gtccaccttc tgattatttt tggagaacat
      241 tttgattttt ttcatctctc tctccccacc cctaagattg tgcaaaaaaa gcgtaccttg
      301 cctaattgaa ataatttcat tggattttga tcagaactga ttatttggtt ttctgtgtga
      361 agttttgagg tttcaaactt tccttctgga gaatgccttt tgaaacaatt ttctctagct
      421 gcctgatgtc aactgcttag taatcagtgg atattgaaat attcaaaatg tacagagagt
      481 gggtagtggt gaatgttttc atgatgttgt acgtccagct ggtgcagggc tccagtaatg
      541 aacatggacc agtgaagcga tcatctcagt ccacattgga acgatctgaa cagcagatca
      601 gggctgcttc tagtttggag gaactacttc gaattactca ctctgaggac tggaagctgt
      661 ggagatgcag gctgaggctc aaaagtttta ccagtatgga ctctcgctca gcatcccatc
      721 ggtccactag gtttgcggca actttctatg acattgaaac actaaaagtt atagatgaag
      781 aatggcaaag aactcagtgc agccctagag aaacgtgcgt ggaggtggcc agtgagctgg
      841 ggaagagtac caacacattc ttcaagcccc cttgtgtgaa cgtgttccga tgtggtggct
      901 gttgcaatga agagagcctt atctgtatga acaccagcac ctcgtacatt tccaaacagc
      961 tctttgagat atcagtgcct ttgacatcag tacctgaatt agtgcctgtt aaagttgcca
     1021 atcatacagg ttgtaagtgc ttgccaacag ccccccgcca tccatactca attatcagaa
     1081 gatccatcca gatccctgaa gaagatcgct gttcccattc caagaaactc tgtcctattg
     1141 acatgctatg ggatagcaac aaatgtaaat gtgttttgca ggaggaaaat ccacttgctg
     1201 gaacagaaga ccactctcat ctccaggaac cagctctctg tgggccacac atgatgtttg
     1261 acgaagatcg ttgcgagtgt gtctgtaaaa caccatgtcc caaagatcta atccagcacc
     1321 ccaaaaactg cagttgcttt gagtgcaaag aaagtctgga gacctgctgc cagaagcaca
     1381 agctatttca cccagacacc tgcagctgtg aggacagatg cccctttcat accagaccat
     1441 gtgcaagtgg caaaacagca tgtgcaaagc attgccgctt tccaaaggag aaaagggctg
     1501 cccaggggcc ccacagccga aagaatcctt gattcagcgt tccaagttcc ccatccctgt
     1561 catttttaac agcatgctgc tttgccaagt tgctgtcact gtttttttcc caggtgttaa
     1621 aaaaaaaatc cattttacac agcaccacag tgaatccaga ccaaccttcc attcacacca
     1681 gctaaggagt ccctggttca ttgatggatg tcttctagct gcagatgcct ctgcgcacca
     1741 aggaatggag aggaggggac ccatgtaatc cttttgttta gttttgtttt tgttttttgg
     1801 tgaatgagaa aggtgtgctg gtcatggaat ggcaggtgtc atatgactga ttactcagag
     1861 cagatgagga aaactgtagt ctctgagtcc tttgctaatc gcaactcttg tgaattattc
     1921 tgattctttt ttatgcagaa tttgattcgt atgatcagta ctgactttct gattactgtc
     1981 cagcttatag tcttccagtt taatgaacta ccatctgatg tttcatattt aagtgtattt
     2041 aaagaaaata aacaccatta ttcaagcca
//
