LOCUS       NM_005429               2259 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens vascular endothelial growth factor C (VEGFC), mRNA.
ACCESSION   NM_005429
VERSION     NM_005429.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2259)
  AUTHORS   Zhu,J., Qiu,X., Jin,X., Nie,X., Ou,S., Wu,G., Shen,J. and Zhang,R.
  TITLE     ZNF468-mediated epigenetic upregulation of VEGF-C facilitates
            lymphangiogenesis and lymphatic metastasis in ESCC via PI3K/Akt and
            ERK1/2 signaling pathways
  JOURNAL   Cell Oncol (Dordr) 47 (5), 1927-1942 (2024)
   PUBMED   39141315
  REMARK    GeneRIF: ZNF468-mediated epigenetic upregulation of VEGF-C
            facilitates lymphangiogenesis and lymphatic metastasis in ESCC via
            PI3K/Akt and ERK1/2 signaling pathways.
REFERENCE   2  (bases 1 to 2259)
  AUTHORS   He,H., Wang,J., Zhang,Y., Wang,Y., Liu,Y., Li,X., Zhang,Y.,
            Yang,J., Hao,X., Wang,H. and Liu,H.
  TITLE     miR-455-3p regulates lymphangiogenesis in silicosis by regulating
            VEGF-C/VEGFR3
  JOURNAL   Ecotoxicol Environ Saf 278, 116444 (2024)
   PUBMED   38728943
  REMARK    GeneRIF: miR-455-3p regulates lymphangiogenesis in silicosis by
            regulating VEGF-C/VEGFR3.
REFERENCE   3  (bases 1 to 2259)
  AUTHORS   Tuerxun,M., Zheng,X., Xu,J., Yang,Q., Yuan,T., Zhang,C. and Zhou,S.
  TITLE     High expression of DEC2 distinguishes chondroblastic osteosarcoma
            and promotes tumour growth by activating the VEGFC/VEGFR2
            signalling pathway
  JOURNAL   J Cell Mol Med 28 (11), e18462 (2024)
   PUBMED   38847478
  REMARK    GeneRIF: High expression of DEC2 distinguishes chondroblastic
            osteosarcoma and promotes tumour growth by activating the
            VEGFC/VEGFR2 signalling pathway.
REFERENCE   4  (bases 1 to 2259)
  AUTHORS   Pan,Q., Liu,X., Xu,C. and Yu,C.
  TITLE     Comparative study on the expression of Pax3, Rad51 and VEGF-C in
            esophageal gastric junction adenocarcinoma and distal gastric
            adenocarcinoma
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (1), 40-45 (2024)
   PUBMED   38372116
  REMARK    GeneRIF: Comparative study on the expression of Pax3, Rad51 and
            VEGF-C in esophageal gastric junction adenocarcinoma and distal
            gastric adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2259)
  AUTHORS   Fitz,L.J., Morris,J.C., Towler,P., Long,A., Burgess,P., Greco,R.,
            Wang,J., Gassaway,R., Nickbarg,E., Kovacic,S., Ciarletta,A.,
            Giannotti,J., Finnerty,H., Zollner,R., Beier,D.R., Leak,L.V.,
            Turner,K.J. and Wood,C.R.
  TITLE     Characterization of murine Flt4 ligand/VEGF-C
  JOURNAL   Oncogene 15 (5), 613-618 (1997)
   PUBMED   9247316
REFERENCE   6  (bases 1 to 2259)
  AUTHORS   Joukov,V., Sorsa,T., Kumar,V., Jeltsch,M., Claesson-Welsh,L.,
            Cao,Y., Saksela,O., Kalkkinen,N. and Alitalo,K.
  TITLE     Proteolytic processing regulates receptor specificity and activity
            of VEGF-C
  JOURNAL   EMBO J 16 (13), 3898-3911 (1997)
   PUBMED   9233800
REFERENCE   7  (bases 1 to 2259)
  AUTHORS   Joukov,V., Pajusola,K., Kaipainen,A., Chilov,D., Lahtinen,I.,
            Kukk,E., Saksela,O., Kalkkinen,N. and Alitalo,K.
  TITLE     A novel vascular endothelial growth factor, VEGF-C, is a ligand for
            the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
  JOURNAL   EMBO J 15 (7), 1751 (1996)
   PUBMED   8612600
  REMARK    Correction to:[EMBO J. 1996 Jan 15;15(2):290-98.. PMID: 8617204]
REFERENCE   8  (bases 1 to 2259)
  AUTHORS   Paavonen,K., Horelli-Kuitunen,N., Chilov,D., Kukk,E., Pennanen,S.,
            Kallioniemi,O.P., Pajusola,K., Olofsson,B., Eriksson,U., Joukov,V.,
            Palotie,A. and Alitalo,K.
  TITLE     Novel human vascular endothelial growth factor genes VEGF-B and
            VEGF-C localize to chromosomes 11q13 and 4q34, respectively
  JOURNAL   Circulation 93 (6), 1079-1082 (1996)
   PUBMED   8653826
REFERENCE   9  (bases 1 to 2259)
  AUTHORS   Lee,J., Gray,A., Yuan,J., Luoh,S.M., Avraham,H. and Wood,W.I.
  TITLE     Vascular endothelial growth factor-related protein: a ligand and
            specific activator of the tyrosine kinase receptor Flt4
  JOURNAL   Proc Natl Acad Sci U S A 93 (5), 1988-1992 (1996)
   PUBMED   8700872
REFERENCE   10 (bases 1 to 2259)
  AUTHORS   Joukov,V., Pajusola,K., Kaipainen,A., Chilov,D., Lahtinen,I.,
            Kukk,E., Saksela,O., Kalkkinen,N. and Alitalo,K.
  TITLE     A novel vascular endothelial growth factor, VEGF-C, is a ligand for
            the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
  JOURNAL   EMBO J 15 (2), 290-298 (1996)
   PUBMED   8617204
  REMARK    Erratum:[EMBO J. 1996 Apr 1;15(7):1751.. PMID: 8612600]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092673.3, DA044965.1,
            BC063685.1 and AW294939.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005429.4.
            
            Summary: The protein encoded by this gene is a member of the
            platelet-derived growth factor/vascular endothelial growth factor
            (PDGF/VEGF) family. The encoded protein promotes angiogenesis and
            endothelial cell growth, and can also affect the permeability of
            blood vessels. The proprotein is further cleaved into a fully
            processed form that can bind and activate VEGFR-2 and VEGFR-3
            receptors. [provided by RefSeq, Apr 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035212.1, BC063685.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618562.2/ ENSP00000480043.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC092673.3         79398-79574         c
            178-311             DA044965.1         1-134
            312-2256            BC063685.1         117-2061
            2257-2259           AW294939.1         22-24               c
FEATURES             Location/Qualifiers
     source          1..2259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.3"
     gene            1..2259
                     /gene="VEGFC"
                     /gene_synonym="Flt4-L; LMPH1D; LMPHM4; VRP"
                     /note="vascular endothelial growth factor C"
                     /db_xref="GeneID:7424"
                     /db_xref="HGNC:HGNC:12682"
                     /db_xref="MIM:601528"
     exon            1..758
                     /gene="VEGFC"
                     /gene_synonym="Flt4-L; LMPH1D; LMPHM4; VRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             612..1871
                     /gene="VEGFC"
                     /gene_synonym="Flt4-L; LMPH1D; LMPHM4; VRP"
                     /note="FLT4 ligand DHM; vascular endothelial growth
                     factor-related protein"
                     /codon_start=1
                     /product="vascular endothelial growth factor C
                     preproprotein"
                     /protein_id="NP_005420.1"
                     /db_xref="CCDS:CCDS43285.1"
                     /db_xref="GeneID:7424"
                     /db_xref="HGNC:HGNC:12682"
                     /db_xref="MIM:601528"
                     /translation="MHLLGFFSVACSLLAAALLPGPREAPAAAAAFESGLDLSDAEPD
                     AGEATAYASKDLEEQLRSVSSVDELMTVLYPEYWKMYKCQLRKGGWQHNREQANLNSR
                     TEETIKFAAAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVY
                     RCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVY
                     RQVHSIIRRSLPATLPQCQAANKTCPTNYMWNNHICRCLAQEDFMFSSDAGDDSTDGF
                     HDICGPNKELDEETCQCVCRAGLRPASCGPHKELDRNSCQCVCKNKLFPSQCGANREF
                     DENTCQCVCKRTCPRNQPLNPGKCACECTESPQKCLLKGKKFHHQTCSCYRRPCTNRQ
                     KACEPGFSYSEEVCRCVPSYWKRPQMS"
     exon            759..972
                     /gene="VEGFC"
                     /gene_synonym="Flt4-L; LMPH1D; LMPHM4; VRP"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1163
                     /gene="VEGFC"
                     /gene_synonym="Flt4-L; LMPH1D; LMPHM4; VRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1315
                     /gene="VEGFC"
                     /gene_synonym="Flt4-L; LMPH1D; LMPHM4; VRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1422
                     /gene="VEGFC"
                     /gene_synonym="Flt4-L; LMPH1D; LMPHM4; VRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1756
                     /gene="VEGFC"
                     /gene_synonym="Flt4-L; LMPH1D; LMPHM4; VRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..2259
                     /gene="VEGFC"
                     /gene_synonym="Flt4-L; LMPH1D; LMPHM4; VRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2241..2246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VEGFC"
                     /gene_synonym="Flt4-L; LMPH1D; LMPHM4; VRP"
                     /note="hexamer: AATGAA"
     polyA_site      2259
                     /gene="VEGFC"
                     /gene_synonym="Flt4-L; LMPH1D; LMPHM4; VRP"
                     /note="major polyA site"
ORIGIN      
        1 atgccctgcc cctgcgcccg ccgccgccgc cgccgccgct cagcccggcg cgctctggag
       61 gatcctgcgc cgcggcgctc ccgggccccg ccgccgccag ccgccccgcc gccctcctcc
      121 cgcccccggc accgccgcca gcgcccccgc cgcagcgccc gcggcccggc tcctctcact
      181 tcggggaagg ggagggagga gggggacgag ggctctggcg ggtttggagg ggctgaacat
      241 cgcggggtgt tctggtgtcc cccgccccgc ctctccaaaa agctacaccg acgcggaccg
      301 cggcggcgtc ctccctcgcc ctcgcttcac ctcgcgggct ccgaatgcgg ggagctcgga
      361 tgtccggttt cctgtgaggc ttttacctga cacccgccgc ctttccccgg cactggctgg
      421 gagggcgccc tgcaaagttg ggaacgcgga gccccggacc cgctcccgcc gcctccggct
      481 cgcccagggg gggtcgccgg gaggagcccg ggggagaggg accaggaggg gcccgcggcc
      541 tcgcaggggc gcccgcgccc ccacccctgc ccccgccagc ggaccggtcc cccacccccg
      601 gtccttccac catgcacttg ctgggcttct tctctgtggc gtgttctctg ctcgccgctg
      661 cgctgctccc gggtcctcgc gaggcgcccg ccgccgccgc cgccttcgag tccggactcg
      721 acctctcgga cgcggagccc gacgcgggcg aggccacggc ttatgcaagc aaagatctgg
      781 aggagcagtt acggtctgtg tccagtgtag atgaactcat gactgtactc tacccagaat
      841 attggaaaat gtacaagtgt cagctaagga aaggaggctg gcaacataac agagaacagg
      901 ccaacctcaa ctcaaggaca gaagagacta taaaatttgc tgcagcacat tataatacag
      961 agatcttgaa aagtattgat aatgagtgga gaaagactca atgcatgcca cgggaggtgt
     1021 gtatagatgt ggggaaggag tttggagtcg cgacaaacac cttctttaaa cctccatgtg
     1081 tgtccgtcta cagatgtggg ggttgctgca atagtgaggg gctgcagtgc atgaacacca
     1141 gcacgagcta cctcagcaag acgttatttg aaattacagt gcctctctct caaggcccca
     1201 aaccagtaac aatcagtttt gccaatcaca cttcctgccg atgcatgtct aaactggatg
     1261 tttacagaca agttcattcc attattagac gttccctgcc agcaacacta ccacagtgtc
     1321 aggcagcgaa caagacctgc cccaccaatt acatgtggaa taatcacatc tgcagatgcc
     1381 tggctcagga agattttatg ttttcctcgg atgctggaga tgactcaaca gatggattcc
     1441 atgacatctg tggaccaaac aaggagctgg atgaagagac ctgtcagtgt gtctgcagag
     1501 cggggcttcg gcctgccagc tgtggacccc acaaagaact agacagaaac tcatgccagt
     1561 gtgtctgtaa aaacaaactc ttccccagcc aatgtggggc caaccgagaa tttgatgaaa
     1621 acacatgcca gtgtgtatgt aaaagaacct gccccagaaa tcaaccccta aatcctggaa
     1681 aatgtgcctg tgaatgtaca gaaagtccac agaaatgctt gttaaaagga aagaagttcc
     1741 accaccaaac atgcagctgt tacagacggc catgtacgaa ccgccagaag gcttgtgagc
     1801 caggattttc atatagtgaa gaagtgtgtc gttgtgtccc ttcatattgg aaaagaccac
     1861 aaatgagcta agattgtact gttttccagt tcatcgattt tctattatgg aaaactgtgt
     1921 tgccacagta gaactgtctg tgaacagaga gacccttgtg ggtccatgct aacaaagaca
     1981 aaagtctgtc tttcctgaac catgtggata actttacaga aatggactgg agctcatctg
     2041 caaaaggcct cttgtaaaga ctggttttct gccaatgacc aaacagccaa gattttcctc
     2101 ttgtgatttc tttaaaagaa tgactatata atttatttcc actaaaaata ttgtttctgc
     2161 attcattttt atagcaacaa caattggtaa aactcactgt gatcaatatt tttatatcat
     2221 gcaaaatatg tttaaaataa aatgaaaatt gtattataa
//
