LOCUS       NM_003377               1805 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens vascular endothelial growth factor B (VEGFB),
            transcript variant VEGFB-186, mRNA.
ACCESSION   NM_003377 XM_938483
VERSION     NM_003377.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Huang,Y., Zhang,Z., Tong,H., Qin,W., Li,Q., Ma,L., Ren,Z., Chen,W.,
            Zhang,Y., Zhong,Y., Yao,L. and Zhou,P.
  TITLE     Chondroitin polymerizing factor promotes development and
            progression of colorectal cancer via facilitating transcription of
            VEGFB
  JOURNAL   J Cell Mol Med 28 (10), e18268 (2024)
   PUBMED   38775031
  REMARK    GeneRIF: Chondroitin polymerizing factor promotes development and
            progression of colorectal cancer via facilitating transcription of
            VEGFB.
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Zhang,H., Hu,S., Sanches,J.G.P., Li,Y., Wei,Y., Pu,C. and Zhang,J.
  TITLE     Sorcin promotes proliferation of hepatocellular carcinoma by
            regulating VEGFA/B via PI3K pathway
  JOURNAL   J Physiol Biochem 80 (2), 381-392 (2024)
   PUBMED   38536659
  REMARK    GeneRIF: Sorcin promotes proliferation of hepatocellular carcinoma
            by regulating VEGFA/B via PI3K pathway.
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Lee,C., Chen,R., Sun,G., Liu,X., Lin,X., He,C., Xing,L., Liu,L.,
            Jensen,L.D., Kumar,A., Langer,H.F., Ren,X., Zhang,J., Huang,L.,
            Yin,X., Kim,J., Zhu,J., Huang,G., Li,J., Lu,W., Chen,W., Liu,J.,
            Hu,J., Sun,Q., Lu,W., Fang,L., Wang,S., Kuang,H., Zhang,Y.,
            Tian,G., Mi,J., Kang,B.A., Narazaki,M., Prodeus,A., Schoonjans,L.,
            Ornitz,D.M., Gariepy,J., Eelen,G., Dewerchin,M., Yang,Y., Ou,J.S.,
            Mora,A., Yao,J., Zhao,C., Liu,Y., Carmeliet,P., Cao,Y. and Li,X.
  TITLE     VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1
            pathway
  JOURNAL   Signal Transduct Target Ther 8 (1), 305 (2023)
   PUBMED   37591843
  REMARK    GeneRIF: VEGF-B prevents excessive angiogenesis by inhibiting
            FGF2/FGFR1 pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Wei,Y., Han,S., Zhou,R., Xu,P., Zhou,L., Zhu,Z., Kan,Y., Yang,X.,
            Xiang,Y., Cao,Y., Jin,Y., Yan,J., Yu,X., Wang,X. and Shang,W.
  TITLE     Increased Serum VEGF-B Level Is Associated With Renal Function
            Impairment in Patients With Type 2 Diabetes
  JOURNAL   Front Endocrinol (Lausanne) 13, 862545 (2022)
   PUBMED   35399943
  REMARK    GeneRIF: Increased Serum VEGF-B Level Is Associated With Renal
            Function Impairment in Patients With Type 2 Diabetes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1805)
  AUTHORS   Mota,F., Yelland,T., Hutton,J.A., Parker,J., Patsiarika,A.,
            Chan,A.W.E., O'Leary,A., Fotinou,C., Martin,J.F., Zachary,I.C.,
            Djordjevic,S., Frankel,P. and Selwood,D.L.
  TITLE     Peptides Derived from Vascular Endothelial Growth Factor B Show
            Potent Binding to Neuropilin-1
  JOURNAL   Chembiochem 23 (1), e202100463 (2022)
   PUBMED   34647407
  REMARK    GeneRIF: Peptides Derived from Vascular Endothelial Growth Factor B
            Show Potent Binding to Neuropilin-1.
REFERENCE   6  (bases 1 to 1805)
  AUTHORS   Wartiovaara,U., Salven,P., Mikkola,H., Lassila,R., Kaukonen,J.,
            Joukov,V., Orpana,A., Ristimaki,A., Heikinheimo,M., Joensuu,H.,
            Alitalo,K. and Palotie,A.
  TITLE     Peripheral blood platelets express VEGF-C and VEGF which are
            released during platelet activation
  JOURNAL   Thromb Haemost 80 (1), 171-175 (1998)
   PUBMED   9684805
REFERENCE   7  (bases 1 to 1805)
  AUTHORS   Joukov,V., Kaipainen,A., Jeltsch,M., Pajusola,K., Olofsson,B.,
            Kumar,V., Eriksson,U. and Alitalo,K.
  TITLE     Vascular endothelial growth factors VEGF-B and VEGF-C
  JOURNAL   J Cell Physiol 173 (2), 211-215 (1997)
   PUBMED   9365524
  REMARK    Review article
REFERENCE   8  (bases 1 to 1805)
  AUTHORS   Olofsson,B., Pajusola,K., von Euler,G., Chilov,D., Alitalo,K. and
            Eriksson,U.
  TITLE     Genomic organization of the mouse and human genes for vascular
            endothelial growth factor B (VEGF-B) and characterization of a
            second splice isoform
  JOURNAL   J Biol Chem 271 (32), 19310-19317 (1996)
   PUBMED   8702615
REFERENCE   9  (bases 1 to 1805)
  AUTHORS   Olofsson,B., Pajusola,K., Kaipainen,A., von Euler,G., Joukov,V.,
            Saksela,O., Orpana,A., Pettersson,R.F., Alitalo,K. and Eriksson,U.
  TITLE     Vascular endothelial growth factor B, a novel growth factor for
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 93 (6), 2576-2581 (1996)
   PUBMED   8637916
REFERENCE   10 (bases 1 to 1805)
  AUTHORS   Grimmond,S., Lagercrantz,J., Drinkwater,C., Silins,G., Townson,S.,
            Pollock,P., Gotley,D., Carson,E., Rakar,S., Nordenskjold,M.,
            Ward,L., Hayward,N. and Weber,G.
  TITLE     Cloning and characterization of a novel human gene related to
            vascular endothelial growth factor
  JOURNAL   Genome Res 6 (2), 124-131 (1996)
   PUBMED   8919691
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001453.6, BC008818.2,
            BM694361.1 and BU730521.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_003377.4.
            
            Summary: This gene encodes a member of the PDGF (platelet-derived
            growth factor)/VEGF (vascular endothelial growth factor) family.
            The VEGF family members regulate the formation of blood vessels and
            are involved in endothelial cell physiology. This member is a
            ligand for VEGFR-1 (vascular endothelial growth factor receptor 1)
            and NRP-1 (neuropilin-1). Studies in mice showed that this gene was
            co-expressed with nuclear-encoded mitochondrial genes and the
            encoded protein specifically controlled endothelial uptake of fatty
            acids. Alternatively spliced transcript variants encoding distinct
            isoforms have been identified. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (VEGFB-186) encodes the longer
            isoform (VEGFB-186, also known as VRF186). This isoform lacks the
            heparin binding domain and is secreted freely from cells.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.169474.1, BC008818.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309422.7/ ENSP00000311127.2
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AP001453.6         6766-6975
            211-1328            BC008818.2         1-1118
            1329-1703           BM694361.1         170-544
            1704-1745           BU730521.1         79-120              c
            1746-1805           BU730521.1         18-77               c
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1805
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
                     /note="vascular endothelial growth factor B"
                     /db_xref="GeneID:7423"
                     /db_xref="HGNC:HGNC:12681"
                     /db_xref="MIM:601398"
     exon            1..310
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..874
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
                     /note="isoform VEGFB-186 precursor is encoded by
                     transcript variant VEGFB-186; VEGF-related factor"
                     /codon_start=1
                     /product="vascular endothelial growth factor B isoform
                     VEGFB-186 precursor"
                     /protein_id="NP_003368.1"
                     /db_xref="CCDS:CCDS8062.1"
                     /db_xref="GeneID:7423"
                     /db_xref="HGNC:HGNC:12681"
                     /db_xref="MIM:601398"
                     /translation="MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTR
                     ATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQIL
                     MIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAP
                     SPADITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA"
     exon            311..353
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
                     /inference="alignment:Splign:2.1.0"
     exon            354..550
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
                     /inference="alignment:Splign:2.1.0"
     exon            551..624
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
                     /inference="alignment:Splign:2.1.0"
     exon            625..660
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
                     /inference="alignment:Splign:2.1.0"
     exon            661..896
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1805
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1310..1315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
                     /note="hexamer: GATAAA"
     polyA_site      1328
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
                     /note="major polyA site"
     polyA_site      1406
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
     regulatory      1772..1777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
                     /note="hexamer: AATAGA"
     polyA_site      1805
                     /gene="VEGFB"
                     /gene_synonym="VEGFL; VRF"
ORIGIN      
        1 gccgtccccg ccgccgctgc ccgccgccac cggccgcccg cccgcccggc tcctccggcc
       61 gcctccgctg cgctgcgctg cgctgcctgc acccagggct cgggaggggg ccgcggagga
      121 gtcgcccccc gcgcccggcc cccgcccgcc gcgcccgggc ccgcgccatg gggctctggc
      181 tgtcgccgcc ccccgcgccg ccgggctagg gcgatgcggg cgcccccggc gggcggcccc
      241 ggcgggcacc atgagccctc tgctccgccg cctgctgctc gccgcactcc tgcagctggc
      301 ccccgcccag gcccctgtct cccagcctga tgcccctggc caccagagga aagtggtgtc
      361 atggatagat gtgtatactc gcgctacctg ccagccccgg gaggtggtgg tgcccttgac
      421 tgtggagctc atgggcaccg tggccaaaca gctggtgccc agctgcgtga ctgtgcagcg
      481 ctgtggtggc tgctgccctg acgatggcct ggagtgtgtg cccactgggc agcaccaagt
      541 ccggatgcag atcctcatga tccggtaccc gagcagtcag ctgggggaga tgtccctgga
      601 agaacacagc cagtgtgaat gcagacctaa aaaaaaggac agtgctgtga agccagacag
      661 ggctgccact ccccaccacc gtccccagcc ccgttctgtt ccgggctggg actctgcccc
      721 cggagcaccc tccccagctg acatcaccca tcccactcca gccccaggcc cctctgccca
      781 cgctgcaccc agcaccacca gcgccctgac ccccggacct gccgctgccg ctgccgacgc
      841 cgcagcttcc tccgttgcca agggcggggc ttagagctca acccagacac ctgcaggtgc
      901 cggaagctgc gaaggtgaca catggctttt cagactcagc agggtgactt gcctcagagg
      961 ctatatccca gtgggggaac aaagaggagc ctggtaaaaa acagccaagc ccccaagacc
     1021 tcagcccagg cagaagctgc tctaggacct gggcctctca gagggctctt ctgccatccc
     1081 ttgtctccct gaggccatca tcaaacagga cagagttgga agaggagact gggaggcagc
     1141 aagaggggtc acataccagc tcaggggaga atggagtact gtctcagttt ctaaccactc
     1201 tgtgcaagta agcatcttac aactggctct tcctcccctc actaagaaga cccaaacctc
     1261 tgcataatgg gatttgggct ttggtacaag aactgtgacc cccaaccctg ataaaagaga
     1321 tggaaggagc tgtccctgcc tgtgtcactg tttgtcactg tccaggctgg ctggtttggg
     1381 catgaatgtc tgcatcacta aatccagagc ttgtcttgct ccctcattgt gcagatggag
     1441 gaaatgagga ctaaggcccc acagcagatc ccaggcaggg ccagaattat gtattcatca
     1501 ctttcaagtt attgccacgc atgggagtca gggatagccc agtcaataca gactgcctgc
     1561 cctcctgctc ttcaccaggg ttcttttcta gaaggagaca gccttctgtg gccagagagc
     1621 ttggggtagg acccagatct actgagtgac cttgcttgtc actacccctg cctctctgag
     1681 cagcagtttc cacatgtgca catagaggga acagaagatt gctgtggttg gcgtcctcgg
     1741 gccccagaga agtttgagac tatctttacg taatagaaaa gaacacttgt tcttcctgcc
     1801 aggca
//
