LOCUS       NM_001391963            1512 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens voltage dependent anion channel 2 (VDAC2), transcript
            variant 8, mRNA.
ACCESSION   NM_001391963
VERSION     NM_001391963.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1512)
  AUTHORS   Wu,F., Xu,J., Jin,X., Zhu,Y., Gao,W., Liu,M., Zhang,Y., Qian,W.,
            Huang,X., Zhao,D., Feng,G., Hou,S. and Xi,X.
  TITLE     TRIM8 promotes ovarian cancer proliferation and migration by
            targeting VDAC2 for ubiquitination and degradation
  JOURNAL   Cancer Med 13 (11), e7396 (2024)
   PUBMED   38881325
  REMARK    GeneRIF: TRIM8 promotes ovarian cancer proliferation and migration
            by targeting VDAC2 for ubiquitination and degradation.
REFERENCE   2  (bases 1 to 1512)
  AUTHORS   Jahn,H., Bartos,L., Dearden,G.I., Dittman,J.S., Holthuis,J.C.M.,
            Vacha,R. and Menon,A.K.
  TITLE     Phospholipids are imported into mitochondria by VDAC, a dimeric
            beta barrel scramblase
  JOURNAL   Nat Commun 14 (1), 8115 (2023)
   PUBMED   38065946
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1512)
  AUTHORS   Zhu,Z., Zhou,X., Du,H., Cloer,E.W., Zhang,J., Mei,L., Wang,Y.,
            Tan,X., Hepperla,A.J., Simon,J.M., Cook,J.G., Major,M.B., Dotti,G.
            and Liu,P.
  TITLE     STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth
            Independent of Innate Immunity
  JOURNAL   Adv Sci (Weinh) 10 (3), e2203718 (2023)
   PUBMED   36445063
  REMARK    GeneRIF: STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth
            Independent of Innate Immunity.
REFERENCE   4  (bases 1 to 1512)
  AUTHORS   Yoo,B.C., Fountoulakis,M., Cairns,N. and Lubec,G.
  TITLE     Changes of voltage-dependent anion-selective channel proteins VDAC1
            and VDAC2 brain levels in patients with Alzheimer's disease and
            Down syndrome
  JOURNAL   Electrophoresis 22 (1), 172-179 (2001)
   PUBMED   11197169
REFERENCE   5  (bases 1 to 1512)
  AUTHORS   Decker,W.K., Bowles,K.R., Schatte,E.C., Towbin,J.A. and
            Craigen,W.J.
  TITLE     Revised fine mapping of the human voltage-dependent anion channel
            loci by radiation hybrid analysis
  JOURNAL   Mamm Genome 10 (10), 1041-1042 (1999)
   PUBMED   10501981
REFERENCE   6  (bases 1 to 1512)
  AUTHORS   Messina,A., Oliva,M., Rosato,C., Huizing,M., Ruitenbeek,W., van den
            Heuvel,L.P., Forte,M., Rocchi,M. and De Pinto,V.
  TITLE     Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and
            2 reconsidered
  JOURNAL   Biochem Biophys Res Commun 255 (3), 707-710 (1999)
   PUBMED   10049775
REFERENCE   7  (bases 1 to 1512)
  AUTHORS   Yu,W.H., Wolfgang,W. and Forte,M.
  TITLE     Subcellular localization of human voltage-dependent anion channel
            isoforms
  JOURNAL   J Biol Chem 270 (23), 13998-14006 (1995)
   PUBMED   7539795
REFERENCE   8  (bases 1 to 1512)
  AUTHORS   Blachly-Dyson,E., Baldini,A., Litt,M., McCabe,E.R. and Forte,M.
  TITLE     Human genes encoding the voltage-dependent anion channel (VDAC) of
            the outer mitochondrial membrane: mapping and identification of two
            new isoforms
  JOURNAL   Genomics 20 (1), 62-67 (1994)
   PUBMED   7517385
REFERENCE   9  (bases 1 to 1512)
  AUTHORS   Ha,H., Hajek,P., Bedwell,D.M. and Burrows,P.D.
  TITLE     A mitochondrial porin cDNA predicts the existence of multiple human
            porins
  JOURNAL   J Biol Chem 268 (16), 12143-12149 (1993)
   PUBMED   7685033
REFERENCE   10 (bases 1 to 1512)
  AUTHORS   Blachly-Dyson,E., Zambronicz,E.B., Yu,W.H., Adams,V., McCabe,E.R.,
            Adelman,J., Colombini,M. and Forte,M.
  TITLE     Cloning and functional expression in yeast of two human isoforms of
            the outer mitochondrial membrane channel, the voltage-dependent
            anion channel
  JOURNAL   J Biol Chem 268 (3), 1835-1841 (1993)
   PUBMED   8420959
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL392111.12 and AL390034.23.
            
            Summary: This gene encodes a member of the voltage-dependent anion
            channel pore-forming family of proteins that are considered the
            main pathway for metabolite diffusion across the mitochondrial
            outer membrane. The encoded protein is also thought to be involved
            in the mitochondrial apoptotic pathway via regulation of
            BCL2-antagonist/killer 1 protein activity. Pseudogenes have been
            identified on chromosomes 1, 2, 12 and 21, and alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000165.2, DRR138523.570519.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000332211.11/
                                                  ENSP00000361686.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AL392111.12        141681-141823
            144-199             AL392111.12        142019-142074
            200-268             AL392111.12        143115-143183
            269-318             AL392111.12        144906-144955
            319-471             AL392111.12        149948-150100
            472-524             AL392111.12        150189-150241
            525-752             AL392111.12        151628-151855
            753-903             AL392111.12        153137-153287
            904-961             AL390034.23        3164-3221
            962-1512            AL390034.23        4418-4968
FEATURES             Location/Qualifiers
     source          1..1512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..1512
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /note="voltage dependent anion channel 2"
                     /db_xref="GeneID:7417"
                     /db_xref="HGNC:HGNC:12672"
                     /db_xref="MIM:193245"
     exon            1..143
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            144..199
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1053
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /note="isoform 2 is encoded by transcript variant 8;
                     epididymis secretory sperm binding protein; outer
                     mitochondrial membrane protein porin 2; non-selective
                     voltage-gated ion channel VDAC2"
                     /codon_start=1
                     /product="non-selective voltage-gated ion channel VDAC2
                     isoform 2"
                     /protein_id="NP_001378892.1"
                     /db_xref="CCDS:CCDS7348.1"
                     /db_xref="GeneID:7417"
                     /db_xref="HGNC:HGNC:12672"
                     /db_xref="MIM:193245"
                     /translation="MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKT
                     KSCSGVEFSTSGSSNTDTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQI
                     CQGLKLTFDTTFSPNTGKKSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGW
                     LAGYQMTFDSAKSKLTRNNFAVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVN
                     LAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDG
                     KSINAGGHKVGLALELEA"
     exon            200..268
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            269..318
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            319..471
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            472..524
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            525..752
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            753..903
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            904..961
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1512
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1319..1324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /note="hexamer: AATAGA"
     polyA_site      1341
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /note="major polyA site"
     regulatory      1493..1498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VDAC2"
                     /gene_synonym="POR"
                     /note="hexamer: AATAAA"
     polyA_site      1512
                     /gene="VDAC2"
                     /gene_synonym="POR"
ORIGIN      
        1 agaggacagg gttgcggcgg gcggaacggt gtctccttca cttcgccctc cagctgctgg
       61 agctgcagcc cgaccgcgag cgtgccaagc ggcttcagca gctagcggag cggtggcggc
      121 ggcccccctc aggacaccac cagattcccc tcttcccgcg gcctcgccat ggcgacccac
      181 ggacagactt gcgcgcgtcc aatgtgtatt cctccatcat atgctgacct tggcaaagct
      241 gccagagata ttttcaacaa aggatttggt tttgggttgg tgaaactgga tgtgaaaaca
      301 aagtcttgca gtggcgtgga attttcaacg tccggttcat ctaatacaga cactggtaaa
      361 gttactggga ccttggagac caaatacaag tggtgtgagt atggtctgac tttcacagaa
      421 aagtggaaca ctgataacac tctgggaaca gaaatcgcaa ttgaagacca gatttgtcaa
      481 ggtttgaaac tgacatttga tactaccttc tcaccaaaca caggaaagaa aagtggtaaa
      541 atcaagtctt cttacaagag ggagtgtata aaccttggtt gtgatgttga ctttgatttt
      601 gctggacctg caatccatgg ttcagctgtc tttggttatg agggctggct tgctggctac
      661 cagatgacct ttgacagtgc caaatcaaag ctgacaagga ataactttgc agtgggctac
      721 aggactgggg acttccagct acacactaat gtcaatgatg ggacagaatt tggaggatca
      781 atttatcaga aagtttgtga agatcttgac acttcagtaa accttgcttg gacatcaggt
      841 accaactgca ctcgttttgg cattgcagct aaatatcagt tggatcccac tgcttccatt
      901 tctgcaaaag tcaacaactc tagcttaatt ggagtaggct atactcagac tctgaggcct
      961 ggtgtgaagc ttacactctc tgctctggta gatgggaaga gcattaatgc tggaggccac
     1021 aaggttgggc tcgccctgga gttggaggct taatccagct gaaagaaacc tttgggaatg
     1081 gatatcagaa gatttggcct taatatattt ccattgtgac cagcagcagg cttttttccc
     1141 ccaagaagat gatcaaaaca aaggatgatc tcaacaagag ctgtatttta agtatttaga
     1201 cagttctttg ttagctggtt tctagttggt tatctagtta ccaatgctgc agtcctgcag
     1261 tcacctatac attatttaaa tgtatttaac tgttaaatgc gctacccacc aataatgaaa
     1321 tagaccttta tgaaaactgt gcaattgtgt gcatgtttgt ttttatgttc ctttagaaaa
     1381 cattgactgt taccattgaa tgagatggat cagtggatat taagatgagg ttacaaattt
     1441 tgttaagttc agccattatt acttttggta tcccagaaca tgacaaatta tgaataaaac
     1501 aagtatacat aa
//
