LOCUS       NM_181880                540 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens variable charge Y-linked 1B (VCY1B), mRNA.
ACCESSION   NM_181880 XM_001133954
VERSION     NM_181880.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 540)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 540)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   3  (bases 1 to 540)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     A human sex-chromosomal gene family expressed in male germ cells
            and encoding variably charged proteins
  JOURNAL   Hum Mol Genet 9 (2), 311-319 (2000)
   PUBMED   10607842
REFERENCE   4  (bases 1 to 540)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Functional coherence of the human Y chromosome
  JOURNAL   Science 278 (5338), 675-680 (1997)
   PUBMED   9381176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018677.3 and BC056508.1.
            
            On May 17, 2019 this sequence version replaced NM_181880.1.
            
            Summary: The protein encoded by this gene is a member of a family
            of human VCX/Y genes. This gene family has multiple members on both
            X and Y chromosomes, and all are expressed exclusively in male germ
            cells. Members of the VCX/Y family share a high degree of sequence
            identity, with the exception that a 30-bp unit is tandemly repeated
            in X-linked members but occurs only once in Y-linked members. VCX/Y
            genes encode small and highly charged proteins of unknown function.
            This gene encodes a small, positively charged protein. The presence
            of a putative bipartite nuclear localization signal suggests that
            this gene encodes a nuclear protein. The genome has two identical
            copies of this gene within a palindromic region; this record
            represents the more telomeric copy. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU595028.1, HY020717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250823.5/ ENSP00000250823.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC018677.3         37653-37656
            5-540               BC056508.1         10-545
FEATURES             Location/Qualifiers
     source          1..540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.221"
     gene            1..540
                     /gene="VCY1B"
                     /gene_synonym="BPY1B"
                     /note="variable charge Y-linked 1B"
                     /db_xref="GeneID:353513"
                     /db_xref="HGNC:HGNC:31751"
                     /db_xref="MIM:400050"
     exon            1..165
                     /gene="VCY1B"
                     /gene_synonym="BPY1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..441
                     /gene="VCY1B"
                     /gene_synonym="BPY1B"
                     /note="testis-specific basic protein on Y, 1; basic
                     protein on Y chromosome, 1; basic charge, Y-linked 1;
                     variably charged protein Y"
                     /codon_start=1
                     /product="testis-specific basic protein Y 1"
                     /protein_id="NP_870996.1"
                     /db_xref="CCDS:CCDS56618.1"
                     /db_xref="GeneID:353513"
                     /db_xref="HGNC:HGNC:31751"
                     /db_xref="MIM:400050"
                     /translation="MSPKPRASGPPAKAKETGKRKSSSQPSPSGPKKKTTKVAEKGEA
                     VRGGRRGKKGAATKMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEGTQHD
                     PLSQESELEEPLSKGRPSTPLSP"
     exon            166..540
                     /gene="VCY1B"
                     /gene_synonym="BPY1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      520..525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VCY1B"
                     /gene_synonym="BPY1B"
                     /note="hexamer: AATGAA"
     polyA_site      540
                     /gene="VCY1B"
                     /gene_synonym="BPY1B"
                     /note="major polyA site"
ORIGIN      
        1 atacacaggg aggccaggca gcctggagtt agtcgaccgt tgcgagacgt tgagctgcgg
       61 cagatgagtc caaagccgag agcctcggga cctccggcca aggccaagga gacaggaaag
      121 aggaagtcct cctctcagcc gagccccagt ggcccgaaga agaagactac caaggtggcc
      181 gagaagggag aagcagttcg tggagggaga cgcgggaaga aaggggctgc gacaaagatg
      241 gcggccgtga cggcacctga ggcggagagc gggccagcgg cacccggccc cagcgaccag
      301 cccagccagg agctccctca gcacgagctg ccgccggagg agccagtgag cgaggggacc
      361 cagcacgacc ccctgagtca ggagagcgag ctggaggaac cactgagtaa ggggcgccca
      421 tctactcccc tatctccctg agcagcaact aagtttaggc ccagctgcca gacctcagag
      481 atctcaccag cagggtgctt cccatgttga tgacaataaa atgaatgtgt tgcaaaccga
//
