LOCUS       NM_016379                995 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens variable charge X-linked 3A (VCX3A), mRNA.
ACCESSION   NM_016379 XM_379695 XM_943431 XM_943432 XM_943435
VERSION     NM_016379.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 995)
  AUTHORS   Jiao,X., Chen,H., Chen,J., Herrup,K., Firestein,B.L. and
            Kiledjian,M.
  TITLE     Modulation of neuritogenesis by a protein implicated in X-linked
            mental retardation
  JOURNAL   J Neurosci 29 (40), 12419-12427 (2009)
   PUBMED   19812318
  REMARK    GeneRIF: We demonstrate that VCX-A can specifically bind a subset
            of mRNAs involved in neuritogenesis and is also capable of
            promoting translational silencing.
REFERENCE   2  (bases 1 to 995)
  AUTHORS   Cuevas-Covarrubias,S.A. and Gonzalez-Huerta,L.M.
  TITLE     Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene
            deletion is not sufficient to result in mental retardation in
            X-linked ichthyosis
  JOURNAL   Br J Dermatol 158 (3), 483-486 (2008)
   PUBMED   18076704
  REMARK    GeneRIF: two different deletion patterns were observed: the first
            group included 62 patients with deletion of VCX3A & VCX genes. The
            second group included 18 patients with breakpoints at several
            regions on either side of the STS gene not including the VCX3A
            gene.
REFERENCE   3  (bases 1 to 995)
  AUTHORS   Jiao,X., Wang,Z. and Kiledjian,M.
  TITLE     Identification of an mRNA-decapping regulator implicated in
            X-linked mental retardation
  JOURNAL   Mol Cell 24 (5), 713-722 (2006)
   PUBMED   17157254
  REMARK    GeneRIF: Our data demonstrate that VCX-A can regulate mRNA
            stability and that it is an example of a tissue-specific decapping
            regulator.
REFERENCE   4  (bases 1 to 995)
  AUTHORS   Fukami,M., Kirsch,S., Schiller,S., Richter,A., Benes,V., Franco,B.,
            Muroya,K., Rao,E., Merker,S., Niesler,B., Ballabio,A., Ansorge,W.,
            Ogata,T. and Rappold,G.A.
  TITLE     A member of a gene family on Xp22.3, VCX-A, is deleted in patients
            with X-linked nonspecific mental retardation
  JOURNAL   Am J Hum Genet 67 (3), 563-573 (2000)
   PUBMED   10903929
REFERENCE   5  (bases 1 to 995)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     A human sex-chromosomal gene family expressed in male germ cells
            and encoding variably charged proteins
  JOURNAL   Hum Mol Genet 9 (2), 311-319 (2000)
   PUBMED   10607842
REFERENCE   6  (bases 1 to 995)
  AUTHORS   Li,X.M., Yen,P.H. and Shapiro,L.J.
  TITLE     Characterization of a low copy repetitive element S232 involved in
            the generation of frequent deletions of the distal short arm of the
            human X chromosome
  JOURNAL   Nucleic Acids Res 20 (5), 1117-1122 (1992)
   PUBMED   1549475
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF167078.1, AC108684.7 and
            BC039722.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_016379.3.
            
            Summary: This gene belongs to the VCX/Y gene family, which has
            multiple members on both X and Y chromosomes, and all are expressed
            exclusively in male germ cells. The X-linked members are clustered
            on chromosome Xp22 and Y-linked members are two identical copies of
            the gene within a palindromic region on Yq11. The family members
            share a high degree of sequence identity, with the exception that a
            30-bp unit is tandemly repeated in X-linked members but occurs only
            once in Y-linked members. The VCX gene cluster is polymorphic in
            terms of copy number; different individuals may have a different
            number of VCX genes. VCX/Y genes encode small and highly charged
            proteins of unknown function. The presence of a putative bipartite
            nuclear localization signal suggests that VCX/Y members are nuclear
            proteins. This gene contains 8 repeats of the 30-bp unit. [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF167078.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2161674
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381089.7/ ENSP00000370479.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AF167078.1         1-238
            239-246             AC108684.7         114012-114019
            247-991             AF167078.1         247-991
            992-995             BC039722.1         703-706
FEATURES             Location/Qualifiers
     source          1..995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.31"
     gene            1..995
                     /gene="VCX3A"
                     /gene_synonym="VCX-8r; VCX-A; VCX3; VCX8R; VCXA"
                     /note="variable charge X-linked 3A"
                     /db_xref="GeneID:51481"
                     /db_xref="HGNC:HGNC:18159"
                     /db_xref="MIM:300533"
     exon            1..161
                     /gene="VCX3A"
                     /gene_synonym="VCX-8r; VCX-A; VCX3; VCX8R; VCXA"
                     /inference="alignment:Splign:2.1.0"
     exon            162..409
                     /gene="VCX3A"
                     /gene_synonym="VCX-8r; VCX-A; VCX3; VCX8R; VCXA"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..868
                     /gene="VCX3A"
                     /gene_synonym="VCX-8r; VCX-A; VCX3; VCX8R; VCXA"
                     /note="variable charge protein on X with eight repeats;
                     variably charged X-A; variably charged protein X-A"
                     /codon_start=1
                     /product="variable charge X-linked protein 3"
                     /protein_id="NP_057463.2"
                     /db_xref="CCDS:CCDS35199.1"
                     /db_xref="GeneID:51481"
                     /db_xref="HGNC:HGNC:18159"
                     /db_xref="MIM:300533"
                     /translation="MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKA
                     VRRGRRGKKGAATKMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEGTQHD
                     PLSQESELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEV
                     EEPLSQESQVEEPLSQESEMEELPSV"
     exon            410..995
                     /gene="VCX3A"
                     /gene_synonym="VCX-8r; VCX-A; VCX3; VCX8R; VCXA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggatgc tgggagaagt atgtgagatg gaaaagttgt ttcatggcat ccaagaagtg
       61 aatgatcctc aaggtgtagc agaggaatct gtaggagaga gggatgattg acgtcttcgt
      121 atagccctcc atccatccca gttagcatgg agggatttta gggctaccat tggctgggta
      181 gtggagtgtt gaccaatcac agctcagggg cgtgattgtc tcgtcctggg atcgcgagag
      241 gggtatatac agggaggcca ggcagcctgg agttagtcga ccgttgcgag acgttgagct
      301 gcggaagatg agtccaaagc cgagagcctc gggacctccg gccaaggcca cggaggcagg
      361 aaagaggaag tcctcctctc agccgagccc cagtgacccg aagaagaaga ctaccaaggt
      421 ggccaagaag ggaaaagcag ttcgtagagg gagacgcggg aagaaagggg ctgcgacaaa
      481 gatggcggcc gtgacggcac ctgaggcgga gagcgggcca gcggcacccg gccccagcga
      541 ccagcccagc caggagctcc ctcagcacga gctgccgccg gaggagccag tgagcgaggg
      601 gacccagcac gaccccctga gtcaggagag cgagctggag gaaccactga gtcaggagag
      661 cgaggtggaa gaaccactga gtcaggagag ccaggtggag gaaccactga gtcaggagag
      721 cgaggtggaa gaaccactga gtcaggagag ccaggtggag gaaccactga gtcaggagag
      781 cgaggtggag gaaccactga gtcaggagag ccaggtggag gaaccactga gtcaggagag
      841 cgagatggaa gaactaccga gtgtgtagac ggccagctac tcccctatct ccgagagcag
      901 cgactaagtt caggcccagc cgccagacct cagagatctc accagcgggg tgcttgccat
      961 tctgaagata ataaaatgaa tgtgttgcaa attga
//
