LOCUS       NM_016378                815 bp    mRNA    linear   PRI 05-JUN-2024
DEFINITION  Homo sapiens variable charge X-linked 2 (VCX2), mRNA.
ACCESSION   NM_016378 XM_005274546 XM_946075
VERSION     NM_016378.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 815)
  AUTHORS   Cuevas-Covarrubias,S.A. and Gonzalez-Huerta,L.M.
  TITLE     Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene
            deletion is not sufficient to result in mental retardation in
            X-linked ichthyosis
  JOURNAL   Br J Dermatol 158 (3), 483-486 (2008)
   PUBMED   18076704
REFERENCE   2  (bases 1 to 815)
  AUTHORS   Fukami,M., Kirsch,S., Schiller,S., Richter,A., Benes,V., Franco,B.,
            Muroya,K., Rao,E., Merker,S., Niesler,B., Ballabio,A., Ansorge,W.,
            Ogata,T. and Rappold,G.A.
  TITLE     A member of a gene family on Xp22.3, VCX-A, is deleted in patients
            with X-linked nonspecific mental retardation
  JOURNAL   Am J Hum Genet 67 (3), 563-573 (2000)
   PUBMED   10903929
REFERENCE   3  (bases 1 to 815)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     A human sex-chromosomal gene family expressed in male germ cells
            and encoding variably charged proteins
  JOURNAL   Hum Mol Genet 9 (2), 311-319 (2000)
   PUBMED   10607842
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF167079.1, AC097626.9,
            BC134350.1 and AI015625.1.
            
            On Feb 13, 2015 this sequence version replaced NM_016378.2.
            
            Summary: This gene belongs to the VCX/Y gene family, which has
            multiple members on both X and Y chromosomes that are expressed
            exclusively in male germ cells. The VCX gene cluster is polymorphic
            in terms of copy number; different individuals may have a different
            number of VCX genes. This gene contains two copies of a 30 nt
            tandem repeat. Deletion of a nearby member of this family was
            implicated in cognitive disability. [provided by RefSeq, Feb 2015].
            
            ##Evidence-Data-START##
            CDS exon combination :: AF159127.1, AI015625.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA1968968,
                                    SAMEA2151119 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317103.5/ ENSP00000321309.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AF167079.1         1-112
            113-113             AC097626.9         28501-28501
            114-276             AF167079.1         114-276
            277-743             BC134350.1         71-537
            744-815             AI015625.1         3-74                c
FEATURES             Location/Qualifiers
     source          1..815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.31"
     gene            1..815
                     /gene="VCX2"
                     /gene_synonym="VCX-2r; VCX2R; VCXB"
                     /note="variable charge X-linked 2"
                     /db_xref="GeneID:51480"
                     /db_xref="HGNC:HGNC:18158"
                     /db_xref="MIM:300532"
     exon            1..161
                     /gene="VCX2"
                     /gene_synonym="VCX-2r; VCX2R; VCXB"
                     /inference="alignment:Splign:2.1.0"
     exon            162..409
                     /gene="VCX2"
                     /gene_synonym="VCX-2r; VCX2R; VCXB"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..727
                     /gene="VCX2"
                     /gene_synonym="VCX-2r; VCX2R; VCXB"
                     /note="variable charge protein on X with two repeats;
                     variably charged protein X-B; variably charged, X
                     chromosome 2; variably charged, X chromosome, with 2
                     repeats; variably charged, X chromosome B"
                     /codon_start=1
                     /product="variable charge X-linked protein 2"
                     /protein_id="NP_057462.2"
                     /db_xref="CCDS:CCDS35200.1"
                     /db_xref="GeneID:51480"
                     /db_xref="HGNC:HGNC:18158"
                     /db_xref="MIM:300532"
                     /translation="MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKA
                     VRRGRRGKKGAATKMAAVTAPEAESAPAAPGPSDQPSQELPQHELPPEEPVSEGTQHD
                     PLSQESEVEEPLSQESEVEEPLTVWMASFSPVSESTD"
     exon            410..815
                     /gene="VCX2"
                     /gene_synonym="VCX-2r; VCX2R; VCXB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      790..795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VCX2"
                     /gene_synonym="VCX-2r; VCX2R; VCXB"
     polyA_site      815
                     /gene="VCX2"
                     /gene_synonym="VCX-2r; VCX2R; VCXB"
ORIGIN      
        1 atgtggatgc tgggagaagt atgtgagatg gaaaagttgt ttcatggcat ccaagaagtg
       61 aatgatcctc aaggtgtagc agaggaattt gtaggagaga gggatgattg acgtcttcgt
      121 atagccctcc atccatccca gttagcatgg agggatttta gggctaccat tggctgggta
      181 gtggagtgtt gaccaatcac agctcagggg cgtgattgtc tcgtcctggg atcgcgagag
      241 gggtatatac agggaggcca ggcagcctgg agttagtcga ccgttgcgag acgttgagct
      301 gcggaagatg agtccaaagc cgagagcctc gggacctccg gccaaggcca cggaggcagg
      361 aaagaggaag tcctcctctc agccgagccc cagtgacccg aagaagaaga ctaccaaggt
      421 ggccaagaag ggaaaagcag ttcgtagagg gagacgcggg aagaaagggg ctgcgacaaa
      481 gatggcggcc gtgacggcac ctgaggcgga gagcgcgcca gcggcacccg gccccagcga
      541 ccagcccagc caggagctcc ctcagcacga gctgccgccg gaggagccag tgagcgaggg
      601 gacccagcac gaccccctga gtcaggagag cgaggtggaa gaaccactga gtcaggagag
      661 cgaggtggaa gaaccactga ctgtgtggat ggccagcttt tcccctgtct ccgagagcac
      721 cgactaagtt caggcccagc cgccagacct cagagatctc accagcgggg tgcttgccat
      781 tctgaagata ataaaatgaa tgtgttgcaa attga
//
