LOCUS       NM_001393662             781 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens variable charge X-linked (VCX), transcript variant 2,
            mRNA.
ACCESSION   NM_001393662
VERSION     NM_001393662.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 781)
  AUTHORS   Hu,X.Q., Zhou,Y., Chen,J., Zhao,Y., Lu,Y.Y., Chen,Q.L., Hu,Y.,
            Hu,Y.Y. and Su,S.B.
  TITLE     DNA Methylation and SNPs in VCX are Correlated with Sex Differences
            in the Response to Chronic Hepatitis B
  JOURNAL   Virol Sin 34 (5), 489-500 (2019)
   PUBMED   31161555
  REMARK    GeneRIF: SNPs and DNA methylation at the CHR X: 7810800 locus
            cooperatively regulate VCX expression in chronic hepatitis B (CHB).
            The upregulated VCX expression in female CHB patients might
            represent a mechanism of protection from more severe liver
            dysfunction and extensive fibrosis, as observed in male CHB
            patients.
REFERENCE   2  (bases 1 to 781)
  AUTHORS   Ji,J., Qin,Y., Wang,R., Huang,Z., Zhang,Y., Zhou,R., Song,L.,
            Ling,X., Hu,Z., Miao,D., Shen,H., Xia,Y., Wang,X. and Lu,C.
  TITLE     Copy number gain of VCX, X-linked multi-copy gene, leads to cell
            proliferation and apoptosis during spermatogenesis
  JOURNAL   Oncotarget 7 (48), 78532-78540 (2016)
   PUBMED   27705943
  REMARK    GeneRIF: Increasing copy number of VCX could upregulate the gene
            expression and regulate cell proliferation and apoptosis during
            spermatogenesis in non-obstructive azoospermia.
REFERENCE   3  (bases 1 to 781)
  AUTHORS   Taguchi,A., Taylor,A.D., Rodriguez,J., Celiktas,M., Liu,H., Ma,X.,
            Zhang,Q., Wong,C.H., Chin,A., Girard,L., Behrens,C., Lam,W.L.,
            Lam,S., Minna,J.D., Wistuba,I.I., Gazdar,A.F. and Hanash,S.M.
  TITLE     A search for novel cancer/testis antigens in lung cancer identifies
            VCX/Y genes, expanding the repertoire of potential
            immunotherapeutic targets
  JOURNAL   Cancer Res 74 (17), 4694-4705 (2014)
   PUBMED   24970476
  REMARK    GeneRIF: Identified members of the VCX/Y gene family as novel CT
            antigens.
REFERENCE   4  (bases 1 to 781)
  AUTHORS   Hansen,M.A., Nielsen,J.E., Retelska,D., Larsen,N. and Leffers,H.
  TITLE     A shared promoter region suggests a common ancestor for the human
            VCX/Y, SPANX, and CSAG gene families and the murine CYPT family
  JOURNAL   Mol Reprod Dev 75 (2), 219-229 (2008)
   PUBMED   17342728
  REMARK    GeneRIF: Human VCX/Y, SPANX, and CSAG2 gene families together with
            the murine SPANX gene and the CYPT family may share a common
            ancestor.
REFERENCE   5  (bases 1 to 781)
  AUTHORS   Sy,S.M., Wong,N., Mok,T.S., Tsao,M.S., Lee,T.W., Tse,G.,
            Blackhall,F.H., Johnson,P.J. and Yim,A.P.
  TITLE     Genetic alterations of lung adenocarcinoma in relation to smoking
            and ethnicity
  JOURNAL   Lung Cancer 41 (1), 91-99 (2003)
   PUBMED   12826317
REFERENCE   6  (bases 1 to 781)
  AUTHORS   Zou,S.W., Zhang,J.C., Zhang,X.D., Miao,S.Y., Zong,S.D., Sheng,Q.
            and Wang,L.F.
  TITLE     Expression and localization of VCX/Y proteins and their possible
            involvement in regulation of ribosome assembly during
            spermatogenesis
  JOURNAL   Cell Res 13 (3), 171-177 (2003)
   PUBMED   12862317
REFERENCE   7  (bases 1 to 781)
  AUTHORS   Fukami,M., Kirsch,S., Schiller,S., Richter,A., Benes,V., Franco,B.,
            Muroya,K., Rao,E., Merker,S., Niesler,B., Ballabio,A., Ansorge,W.,
            Ogata,T. and Rappold,G.A.
  TITLE     A member of a gene family on Xp22.3, VCX-A, is deleted in patients
            with X-linked nonspecific mental retardation
  JOURNAL   Am J Hum Genet 67 (3), 563-573 (2000)
   PUBMED   10903929
REFERENCE   8  (bases 1 to 781)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     A human sex-chromosomal gene family expressed in male germ cells
            and encoding variably charged proteins
  JOURNAL   Hum Mol Genet 9 (2), 311-319 (2000)
   PUBMED   10607842
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005296.2.
            
            Summary: This gene belongs to the VCX/Y gene family, which has
            multiple members on both X and Y chromosomes, and all are expressed
            exclusively in male germ cells. The X-linked members are clustered
            on chromosome Xp22 and Y-linked members are two identical copies of
            the gene within a palindromic region on Yq11. The family members
            share a high degree of sequence identity, with the exception that a
            30-bp unit is tandemly repeated in X-linked members but occurs only
            once in Y-linked members. The VCX gene cluster is polymorphic in
            terms of copy number; different individuals may have a different
            number of VCX genes. VCX/Y genes encode small and highly charged
            proteins of unknown function. The presence of a putative bipartite
            nuclear localization signal suggests that VCX/Y members are nuclear
            proteins. This gene contains 10 repeats of the 30-bp unit.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF159129.1, BP273934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000688183.1/ ENSP00000509688.1
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC005296.2         163500-163634       c
            136-781             AC005296.2         162662-163307       c
FEATURES             Location/Qualifiers
     source          1..781
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.31"
     gene            1..781
                     /gene="VCX"
                     /gene_synonym="VCX-10r; VCX-B1; VCX1; VCX10R; VCXB1"
                     /note="variable charge X-linked"
                     /db_xref="GeneID:26609"
                     /db_xref="HGNC:HGNC:12667"
                     /db_xref="MIM:300229"
     exon            1..135
                     /gene="VCX"
                     /gene_synonym="VCX-10r; VCX-B1; VCX1; VCX10R; VCXB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..654
                     /gene="VCX"
                     /gene_synonym="VCX-10r; VCX-B1; VCX1; VCX10R; VCXB1"
                     /note="variable charge, X chromosome; variably charged
                     protein X-B1; variable charge protein on X with ten
                     repeats"
                     /codon_start=1
                     /product="variable charge X-linked protein 1"
                     /protein_id="NP_001380591.1"
                     /db_xref="CCDS:CCDS14128.1"
                     /db_xref="GeneID:26609"
                     /db_xref="HGNC:HGNC:12667"
                     /db_xref="MIM:300229"
                     /translation="MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKA
                     VRRGRRGKKGAATKMAAVTAPEAESAPAAPGPSDQPSQELPQHELPPEEPVSEGTQHD
                     PLSQEAELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEV
                     EEPLSQESQVEEPLSQESEMEEPLSQESQVEEPPSQESEMEELPSV"
     exon            136..781
                     /gene="VCX"
                     /gene_synonym="VCX-10r; VCX-B1; VCX1; VCX10R; VCXB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      761..766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VCX"
                     /gene_synonym="VCX-10r; VCX-B1; VCX1; VCX10R; VCXB1"
                     /note="hexamer: AATGAA"
     polyA_site      781
                     /gene="VCX"
                     /gene_synonym="VCX-10r; VCX-B1; VCX1; VCX10R; VCXB1"
                     /note="major polyA site"
ORIGIN      
        1 agccgaccgt tgcgagacgt tgagctgcgg aagatgagtc caaagccgag agcctcggga
       61 cctccggcca aggccacgga ggcaggaaag aggaagtcct cctctcagcc gagccccagt
      121 gacccgaaga agaagactac caaggtggcc aagaagggaa aagcagttcg tagagggaga
      181 cgcgggaaga aaggggctgc gacaaagatg gcggccgtga cggcacctga ggcggagagc
      241 gcgccagcgg cacccggccc cagcgaccag cccagccagg agctccctca gcacgagctg
      301 ccgccggagg agccagtgag cgaggggacc cagcacgacc ccctgagtca ggaggccgag
      361 ctggaggaac cactgagtca ggagagcgag gtggaagaac cactgagtca ggagagccag
      421 gtggaggaac cactgagtca ggagagcgag gtggaagaac cactgagtca ggagagccag
      481 gtggaggaac cactgagtca ggagagcgag gtggaggaac cactgagtca ggagagccag
      541 gtggaggaac cactgagtca ggagagcgag atggaagaac cactgagtca ggagagccag
      601 gtggaggaac caccgagtca ggagagcgag atggaagaac taccgagtgt gtagacggcc
      661 aagtactccc ctatctccga gagcagcgac taagttcagg cccagccgcc agacctcaga
      721 gatctcacca gcggggtgct tgccattctg aagataataa aatgaatgtg ttgcaaattg
      781 a
//
