LOCUS       NM_007126               3746 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens valosin containing protein (VCP), transcript variant
            1, mRNA.
ACCESSION   NM_007126
VERSION     NM_007126.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3746)
  AUTHORS   Vanderhaeghe,S., Prerad,J., Tharkeshwar,A.K., Goethals,E.,
            Vints,K., Beckers,J., Scheveneels,W., Debroux,E., Princen,K., Van
            Damme,P., Fivaz,M., Griffioen,G. and Van Den Bosch,L.
  TITLE     A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial
            hypermetabolism by modulating the permeability transition pore
  JOURNAL   Acta Neuropathol Commun 12 (1), 161 (2024)
   PUBMED   39390590
  REMARK    GeneRIF: A pathogenic mutation in the ALS/FTD gene VCP induces
            mitochondrial hypermetabolism by modulating the permeability
            transition pore.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3746)
  AUTHORS   Wang,Z., Xiong,S., Wu,Z., Wang,X., Gong,Y., Zhu,W.G. and Xu,X.
  TITLE     VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation
            of autophagy
  JOURNAL   Autophagy 20 (9), 2041-2054 (2024)
   PUBMED   38762759
  REMARK    GeneRIF: VCP/p97 UFMylation stabilizes BECN1 and facilitates the
            initiation of autophagy.
REFERENCE   3  (bases 1 to 3746)
  AUTHORS   Qi,C., Kobayashi,R., Kawakatsu,S., Kametani,F., Scheres,S.H.W.,
            Goedert,M. and Hasegawa,M.
  TITLE     Tau filaments with the chronic traumatic encephalopathy fold in a
            case of vacuolar tauopathy with VCP mutation D395G
  JOURNAL   Acta Neuropathol 147 (1), 86 (2024)
   PUBMED   38758288
  REMARK    GeneRIF: Tau filaments with the chronic traumatic encephalopathy
            fold in a case of vacuolar tauopathy with VCP mutation D395G.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3746)
  AUTHORS   Li,M., Ding,W., Deng,Y., Zhao,Y., Liu,Q. and Zhou,Z.
  TITLE     The AAA-ATPase Ter94 regulates wing size in Drosophila by
            suppressing the Hippo pathway
  JOURNAL   Commun Biol 7 (1), 533 (2024)
   PUBMED   38710747
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3746)
  AUTHORS   Stach,L. and Freemont,P.S.
  TITLE     The AAA+ ATPase p97, a cellular multitool
  JOURNAL   Biochem J 474 (17), 2953-2976 (2017)
   PUBMED   28819009
  REMARK    GeneRIF: Data suggest that AAA+ (ATPases associated with diverse
            cellular activities) ATPase p97 is essential to wide range of
            cellular functions, including endoplasmic reticulum-associated
            degradation, membrane fusion, NFkappaB (nuclear factor
            kappa-light-chain-enhancer of activated B cells) activation, and
            chromatin-associated processes, which are regulated by
            ubiquitination. [REVIEW]
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3746)
  AUTHORS   Rabouille,C., Levine,T.P., Peters,J.M. and Warren,G.
  TITLE     An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from
            mitotic Golgi fragments
  JOURNAL   Cell 82 (6), 905-914 (1995)
   PUBMED   7553851
REFERENCE   7  (bases 1 to 3746)
  AUTHORS   Pleasure,I.T., Black,M.M. and Keen,J.H.
  TITLE     Valosin-containing protein, VCP, is a ubiquitous clathrin-binding
            protein
  JOURNAL   Nature 365 (6445), 459-462 (1993)
   PUBMED   8413590
REFERENCE   8  (bases 1 to 3746)
  AUTHORS   Kimonis,V.
  TITLE     Inclusion Body Myopathy with Paget Disease of Bone and/or
            Frontotemporal Dementia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301649
REFERENCE   9  (bases 1 to 3746)
  AUTHORS   Siddique,N. and Siddique,T.
  TITLE     Amyotrophic Lateral Sclerosis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301623
REFERENCE   10 (bases 1 to 3746)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA880782.1, BC110913.1,
            BC007562.1 and BU689324.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007126.4.
            
            Summary: This gene encodes a member of the AAA ATPase family of
            proteins. The encoded protein plays a role in protein degradation,
            intracellular membrane fusion, DNA repair and replication,
            regulation of the cell cycle, and activation of the NF-kappa B
            pathway. This protein forms a homohexameric complex that interacts
            with a variety of cofactors and extracts ubiquitinated proteins
            from lipid membranes or protein complexes. Mutations in this gene
            cause IBMPFD (inclusion body myopathy with paget disease of bone
            and frontotemporal dementia), ALS (amyotrophic lateral sclerosis)
            and Charcot-Marie-Tooth disease in human patients. [provided by
            RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012195.1, FJ224344.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358901.11/ ENSP00000351777.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                DA880782.1         118-190
            74-2845             BC110913.1         1-2772
            2846-3247           BC007562.1         2089-2490
            3248-3746           BU689324.1         13-511              c
FEATURES             Location/Qualifiers
     source          1..3746
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..3746
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /note="valosin containing protein"
                     /db_xref="GeneID:7415"
                     /db_xref="HGNC:HGNC:12666"
                     /db_xref="MIM:601023"
     exon            1..289
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..2693
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /EC_number="3.6.4.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transitional endoplasmic reticulum ATPase; TER ATPase; 15S
                     Mg(2+)-ATPase p97 subunit"
                     /codon_start=1
                     /product="transitional endoplasmic reticulum ATPase
                     isoform 1"
                     /protein_id="NP_009057.1"
                     /db_xref="CCDS:CCDS6573.1"
                     /db_xref="GeneID:7415"
                     /db_xref="HGNC:HGNC:12666"
                     /db_xref="MIM:601023"
                     /translation="MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQP
                     KMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISI
                     QPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRA
                     VEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKE
                     MVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMS
                     KLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDG
                     LKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLAD
                     DVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMD
                     DFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGM
                     TPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKA
                     RQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATN
                     RPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGF
                     SGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAM
                     RFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGSGGGTGGSVYTE
                     DNDDDLYG"
     exon            290..401
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            402..574
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            575..717
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            718..848
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            849..980
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1083
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1217
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1353
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1466
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1631
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1754
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1967
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2276
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2432
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2587
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..3746
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3225..3230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /note="hexamer: AATAAA"
     polyA_site      3247
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /note="major polyA site"
     regulatory      3714..3719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
                     /note="hexamer: ATTAAA"
     polyA_site      3746
                     /gene="VCP"
                     /gene_synonym="CDC48; FTDALS6; p97; TERA"
ORIGIN      
        1 agtctcagcg aagcgtctgc gaccgtcgtt tgagtcgtcg ctgccgctgc cgctgccact
       61 gccactgcca cctcgcggat caggagccag cgttgttcgc ccgacgcctc gctgccggtg
      121 ggaggaagcg agagggaagc cgcttgcggg tttgtcgccg ctgctcgccc accgcctgga
      181 agagccgagc cccggcccag tcggtcgctt gccaccgctc gtagccgtta cccgcgggcc
      241 gccacagccg ccggccggga gaggcgcgcg ccatggcttc tggagccgat tcaaaaggtg
      301 atgacctatc aacagccatt ctcaaacaga agaaccgtcc caatcggtta attgttgatg
      361 aagccatcaa tgaggacaac agtgtggtgt ccttgtccca gcccaagatg gatgaattgc
      421 agttgttccg aggtgacaca gtgttgctga aaggaaagaa gagacgagaa gctgtttgca
      481 tcgtcctttc tgatgatact tgttctgatg agaagattcg gatgaataga gttgttcgga
      541 ataaccttcg tgtacgccta ggggatgtca tcagcatcca gccatgccct gatgtgaagt
      601 acggcaaacg tatccatgtg ctgcccattg atgacacagt ggaaggcatt actggtaatc
      661 tcttcgaggt ataccttaag ccgtacttcc tggaagcgta tcgacccatc cggaaaggag
      721 acatttttct tgtccgtggt gggatgcgtg ctgtggagtt caaagtggtg gaaacagatc
      781 ctagccctta ttgcattgtt gctccagaca cagtgatcca ctgcgaaggg gagcctatca
      841 aacgagagga tgaggaagag tccttgaatg aagtagggta tgatgacatt ggtggctgca
      901 ggaagcagct agctcagata aaggagatgg tggaactgcc cctgagacat cctgccctct
      961 ttaaggcaat tggtgtgaag cctcctagag gaatcctgct ttacggacct cctggaacag
     1021 gaaagaccct gattgctcga gctgtagcaa atgagactgg agccttcttc ttcttgatca
     1081 atggtcctga gatcatgagc aaattggctg gtgagtctga gagcaacctt cgtaaagcct
     1141 ttgaggaggc tgagaagaat gctcctgcca tcatcttcat tgatgagcta gatgccatcg
     1201 ctcccaaaag agagaaaact catggcgagg tggagcggcg cattgtatca cagttgttga
     1261 ccctcatgga tggcctaaag cagagggcac atgtgattgt tatggcagca accaacagac
     1321 ccaacagcat tgacccagct ctacggcgat ttggtcgctt tgacagggag gtagatattg
     1381 gaattcctga tgctacagga cgcttagaga ttcttcagat ccataccaag aacatgaagc
     1441 tggcagatga tgtggacctg gaacaggtag ccaatgagac tcacgggcat gtgggtgctg
     1501 acttagcagc cctgtgctca gaggctgctc tgcaagccat ccgcaagaag atggatctca
     1561 ttgacctaga ggatgagacc attgatgccg aggtcatgaa ctctctagca gttactatgg
     1621 atgacttccg gtgggccttg agccagagta acccatcagc actgcgggaa accgtggtag
     1681 aggtgccaca ggtaacctgg gaagacatcg ggggcctaga ggatgtcaaa cgtgagctac
     1741 aggagctggt ccagtatcct gtggagcacc cagacaaatt cctgaagttt ggcatgacac
     1801 cttccaaggg agttctgttc tatggacctc ctggctgtgg gaaaactttg ttggccaaag
     1861 ccattgctaa tgaatgccag gccaacttca tctccatcaa gggtcctgag ctgctcacca
     1921 tgtggtttgg ggagtctgag gccaatgtca gagaaatctt tgacaaggcc cgccaagctg
     1981 ccccctgtgt gctattcttt gatgagctgg attcgattgc caaggctcgt ggaggtaaca
     2041 ttggagatgg tggtggggct gctgaccgag tcatcaacca gatcctgaca gaaatggatg
     2101 gcatgtccac aaaaaaaaat gtgttcatca ttggcgctac caaccggcct gacatcattg
     2161 atcctgccat cctcagacct ggccgtcttg atcagctcat ctacatccca cttcctgatg
     2221 agaagtcccg tgttgccatc ctcaaggcta acctgcgcaa gtccccagtt gccaaggatg
     2281 tggacttgga gttcctggct aaaatgacta atggcttctc tggagctgac ctgacagaga
     2341 tttgccagcg tgcttgcaag ctggccatcc gtgaatccat cgagagtgag attaggcgag
     2401 aacgagagag gcagacaaac ccatcagcca tggaggtaga agaggatgat ccagtgcctg
     2461 agatccgtcg agatcacttt gaagaagcca tgcgctttgc gcgccgttct gtcagtgaca
     2521 atgacattcg gaagtatgag atgtttgccc agacccttca gcagagtcgg ggctttggca
     2581 gcttcagatt cccttcaggg aaccagggtg gagctggccc cagtcagggc agtggaggcg
     2641 gcacaggtgg cagtgtatac acagaagaca atgatgatga cctgtatggc taagtggtgg
     2701 tggccagcgt gcagtgagct ggcctgcctg gaccttgttc cctgggggtg ggggcgcttg
     2761 cccaggagag ggaccagggg tgcgcccaca gcctgctcca ttctccagtc tgaacagttc
     2821 agctacagtc tgactctgga cagggggttt ctgttgcaaa aatacaaaac aaaagcgata
     2881 aaataaaagc gattttcatt tggtaggcgg agagtgaatt accaacaggg aattgggcct
     2941 tgggcctatg ccatttctgt tgtagtttgg ggcagtgcag gggacctgtg tggggtgtga
     3001 accaaggcac tactgccacc tgccacagta aagcatctgc acttgactca atgctgcccg
     3061 agccctccct tccccctatc caacctgggt aggtgggtag gggccacagt tgctggatgt
     3121 ttatatagag agtaggttga tttattttac atgcttttga gttaatgttg gaaaactaat
     3181 cacaagcagt ttctaaacca aaaaatgaca tgttgtaaaa ggacaataaa cgttgggtca
     3241 aaatggagcc tgagtcctgg gccctgtgcc tgcttctttt cctgggaaca gccttgggct
     3301 acccaccact cccaaggcat tcttccaaat gtgaaatcct ggaagtaaga ttgcaccttc
     3361 ttcctctcct gatcaacatc ggtatgatgt ctcctgttgc ctcacccttt gtctgcagta
     3421 tcactggata ggactggtgg aaagggagca gcctgacaga gctccaaatg tggagaatat
     3481 ggcatccctc cacctatatt tgatgtggac ggtaaggcta ggcctgcagg atcccttatc
     3541 ctgaccaaag actgtgttgg ggtgccattt gaaaatcgca gggttgcaaa agaatacaat
     3601 cttacttgca ggtggatatt ctctatactc tcttttaatg catctaaaaa tcccaaacat
     3661 cccctggttg gtgatcactt acagttgtgt ccacctttat tttatgtact ttgattaaaa
     3721 aaaaaaaact ttttgttaat ataaaa
//
