LOCUS       NM_001098832            2876 bp    mRNA    linear   PRI 25-FEB-2025
DEFINITION  Homo sapiens VCP nuclear cofactor family member 1 (VCF1),
            transcript variant 1, mRNA.
ACCESSION   NM_001098832
VERSION     NM_001098832.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2876)
  AUTHORS   Korner,M., Meyer,S.R., Marincola,G., Kern,M.J., Grimm,C.,
            Schuelein-Voelk,C., Fischer,U., Hofmann,K. and Buchberger,A.
  TITLE     The FAM104 proteins VCF1/2 promote the nuclear localization of
            p97/VCP
  JOURNAL   Elife 12, e92409 (2023)
   PUBMED   37713320
  REMARK    GeneRIF: The FAM104 proteins VCF1/2 promote the nuclear
            localization of p97/VCP.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2876)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2876)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2876)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2876)
  AUTHORS   Reddy,P.H., Stockburger,E., Gillevet,P. and Tagle,D.A.
  TITLE     Mapping and characterization of novel (CAG)n repeat cDNAs from
            adult human brain derived by the oligo capture method
  JOURNAL   Genomics 46 (2), 174-182 (1997)
   PUBMED   9417904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC097641.6.
            
            On Feb 9, 2021 this sequence version replaced NM_001098832.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537858.1, BX648968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405159.8/ ENSP00000384832.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               AC097641.6         4834-5142
            310-409             AC097641.6         9964-10063
            410-472             AC097641.6         24488-24550
            473-2876            AC097641.6         27460-29863
FEATURES             Location/Qualifiers
     source          1..2876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..2876
                     /gene="VCF1"
                     /gene_synonym="FAM104A"
                     /note="VCP nuclear cofactor family member 1"
                     /db_xref="GeneID:84923"
                     /db_xref="HGNC:HGNC:25918"
                     /db_xref="MIM:621109"
     exon            1..309
                     /gene="VCF1"
                     /gene_synonym="FAM104A"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..712
                     /gene="VCF1"
                     /gene_synonym="FAM104A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM104A; family with sequence similarity 104
                     member A; protein VCF1"
                     /codon_start=1
                     /product="protein VCF1 isoform 1"
                     /protein_id="NP_001092302.1"
                     /db_xref="CCDS:CCDS45766.1"
                     /db_xref="GeneID:84923"
                     /db_xref="HGNC:HGNC:25918"
                     /db_xref="MIM:621109"
                     /translation="MGGRGADAGSSGGTGPTEGYSPPAASTRAAARAKARGGGRGGRR
                     NTTPSVPSLRGAAPRSFHPPAAMSERLRPRKRRRNGNEEDNHLPPQTKRSSRNPVFQD
                     SWDTETVPVMRNSKENRLRGNKAFCASSGSDSGGSSSSSSSSINSPDRASGPEGSLSQ
                     TMAGSSPNTPQPVPEQSALCQGLYFHINQTLREAHFHSLQHRGRPLT"
     exon            310..409
                     /gene="VCF1"
                     /gene_synonym="FAM104A"
                     /inference="alignment:Splign:2.1.0"
     exon            410..472
                     /gene="VCF1"
                     /gene_synonym="FAM104A"
                     /inference="alignment:Splign:2.1.0"
     exon            473..2876
                     /gene="VCF1"
                     /gene_synonym="FAM104A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1103..1108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VCF1"
                     /gene_synonym="FAM104A"
                     /note="hexamer: AATAAA"
     polyA_site      1121
                     /gene="VCF1"
                     /gene_synonym="FAM104A"
                     /note="major polyA site"
     regulatory      2856..2861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VCF1"
                     /gene_synonym="FAM104A"
                     /note="hexamer: ATTAAA"
     polyA_site      2876
                     /gene="VCF1"
                     /gene_synonym="FAM104A"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcccgt gggcggggtt accagtcggt gcggttggga tggtgccact gcgcagccgc
       61 gagagggcgg taccacggcg gcagcgacat gggggggcgc ggagcagacg ccggaagtag
      121 tggtggtacg ggtccgactg aggggtactc gccaccggct gcgtccaccc gagcggctgc
      181 gagagccaag gcccgagggg gtgggcgtgg cggccgccga aacacaaccc cctctgttcc
      241 ctctcttcgc ggagcggcgc cgcgtagctt ccatccgcca gctgccatga gcgagcgcct
      301 ccgtcccagg aaaaggagaa ggaatggcaa cgaagaagac aaccatcttc ccccccagac
      361 caaaagaagt agcagaaacc ctgtctttca ggattcctgg gacacagaga cagtacctgt
      421 aatgagaaac agtaaagaaa acagactaag aggaaacaaa gcgttctgcg cgtcttcagg
      481 cagtgacagt ggtgggagca gcagcagcag cagcagcagc atcaatagcc cggacagggc
      541 cagcgggccg gaaggcagct tgagccagac catggccgga tccagcccta acacgcctca
      601 gcccgtgccc gagcagtccg cgctgtgcca aggcctctac ttccacatca accagaccct
      661 gagggaggcc cacttccaca gcctacagca ccgagggcgg cctctgacat gatgtgccgg
      721 cagtttcttg ccttctgtga agggacagcg ctgtgcagat ttgatatttc aacttacaac
      781 ttgttttaaa agaaaaattg cacacgaaaa atgcctgttg gcttttcagt ctatatttga
      841 aataacaggt taacaggcag ttgtttactt gtggttttgc tgcactattg caatttcaaa
      901 ggggctttga agcaattttt tataggattc ttttgaggga gggtatcaaa tctatgtcaa
      961 ggtagtggtt tgaggaaaac tcattctgtg tgttgaatcc atagtatgtc ccattcagac
     1021 tgatttccaa atctgtcaac tagaaactct actttatgta aagggccttt taaaaatgcg
     1081 ggatcttcaa ttttttttat tcaataaact agtaaagagt atctagtttc catgaaaaaa
     1141 cataagtttt tttccaaaat ataggaagct tgattcagtc ttgcactgaa attaactgcc
     1201 atactacctc tcagtatgta gatgttctat tgaaagtact ctctcctgtg taacaggaga
     1261 acaatcagat ccaattcaga ctgtcagtga agcacactcc ctaataatag tctctactct
     1321 ttgttatata tttgtatttc cagagagaat gtcttttaga ttcttgtata cccagataac
     1381 ttctgtgtca ctattccacc agagtctgca cctcagactt tagtaggaaa catggcacag
     1441 ttctgcaagt aaagtaatat gtaatgactt tttgtcctac aaacttggtc agtcagcagc
     1501 ttacatgatc tcattgacaa ttccaccttg tagtgtcaac aattaaggtg ttgttgaacg
     1561 ctgataaaat gtaagctacc tgaactgatg tctaaagcaa caagtattgt gaaattttgg
     1621 gacaaggatt aacttgatgc ttaaagtaac ccccaacagt aactaggggg ccacattcca
     1681 tcagtgaaac tggaaagatt ggtgtggctg agaatcagat gagcagaggc acctttagaa
     1741 gaaataatgt ggtagtattt atttagggag agacagatgt gttgccatgt tacttagtca
     1801 tactagagag ccagccaagt ttgaataatg aaggtgcaga cgtgttgtct tcttcactga
     1861 caagctgtct gaacaaggag ccaggaactg tcgggtcacc agctgtggag cgtgccgggg
     1921 ggacaacctg ccattggatg tagagaaaag tgccttagag ttggcctgag ccctcctgcc
     1981 cactcgccct ccgcgcgacg ccactcggag tccacacggc acacacaagc ggagctgaga
     2041 agcacgatgg ctctagtcag aggactttgc tgtcggtcca gatttgaaga ggacacggaa
     2101 cagcatgagc ctttgtgaca aaactagaat ttggaaatga ggactgtctt gggaaaaggg
     2161 tagacacagg cacttctctc cacagcctgc taacctaatg tgggcagaac tgaaagatca
     2221 ctgcagtgga aactgttctg gaagaggctg caacatagcc catgcttagg gactggatgg
     2281 tttttgcaag agcttttttt ttttttaaac taccatctcc caacttttaa agccagatac
     2341 ttgacaagga ttttagatct taatgggttc gatggtaggg aatacggaaa ggatacactg
     2401 ctaatattgt gtctaacaat aaagcaaaca actcgatgct gtaagaagac aagctgtttg
     2461 agctttcaaa cacacatgca cacagcacaa ttcagaaata cccaggagga ttcctgcagg
     2521 cttaacagtt ggcatcgtac tgaaatgaaa cgtgtattaa caagaaaatg tcaaactttt
     2581 ggggaaacaa attttctgtt acttcccacc caactaaaag ggaagataaa accatcatca
     2641 ccagaacaaa acagattttc tccaaacaag tacaatgata gtgccgggtt ggcagttaac
     2701 tctttcaccc tactaaattc aagagctcat ctccaccctg tcctgtatat tttctacatt
     2761 tctattaaga ggctacttgg tagtgtcagc gggcatcttt tacaccttct agtagctcaa
     2821 gctagtaaaa ccttgtactt ctctattgcg ccgccattaa aagcagcatt agtgca
//
