LOCUS       NM_001078               3101 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens vascular cell adhesion molecule 1 (VCAM1), transcript
            variant 1, mRNA.
ACCESSION   NM_001078
VERSION     NM_001078.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3101)
  AUTHORS   Sibiya,S., Mlambo,Z.P., Mthembu,M.H., Mkhwanazi,N.P. and Naicker,T.
  TITLE     Analysis of ICAM-1 rs3093030, VCAM-1 rs3783605, and E-Selectin
            rs1805193 Polymorphisms in African Women Living with HIV and
            Preeclampsia
  JOURNAL   Int J Mol Sci 25 (19), 10860 (2024)
   PUBMED   39409189
  REMARK    GeneRIF: Analysis of ICAM-1 rs3093030, VCAM-1 rs3783605, and
            E-Selectin rs1805193 Polymorphisms in African Women Living with HIV
            and Preeclampsia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3101)
  AUTHORS   Pantovic-Stefanovic,M., Petronijevic,N., Dunjic-Kostic,B.,
            Velimirovic,M., Jurisic,V., Nikolic,T., Dodic,S. and Ivkovic,M.
  TITLE     Differentiating Stages of Bipolar and Unipolar Depression-The
            Possible Role of sICAM-1 and sVCAM-1
  JOURNAL   Cells 13 (14), 1213 (2024)
   PUBMED   39056795
  REMARK    GeneRIF: Differentiating Stages of Bipolar and Unipolar
            Depression-The Possible Role of sICAM-1 and sVCAM-1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3101)
  AUTHORS   Zhang,H., Shang,J., Li,W., Gao,D. and Zhang,J.
  TITLE     Increased Expression of VCAM1 on Brain Endothelial Cells Drives
            Blood-Brain Barrier Impairment Following Chronic Cerebral
            Hypoperfusion
  JOURNAL   ACS Chem Neurosci 15 (10), 2028-2041 (2024)
   PUBMED   38710594
  REMARK    GeneRIF: Increased Expression of VCAM1 on Brain Endothelial Cells
            Drives Blood-Brain Barrier Impairment Following Chronic Cerebral
            Hypoperfusion.
REFERENCE   4  (bases 1 to 3101)
  AUTHORS   Pandey,N., Kaur,H., Chorawala,M.R., Anand,S.K., Chandaluri,L.,
            Butler,M.E., Aishwarya,R., Gaddam,S.J., Shen,X., Alfaidi,M.,
            Wang,J., Zhang,X., Beedupalli,K., Bhuiyan,M.S., Bhuiyan,M.A.N.,
            Buchhanolla,P., Rai,P., Shah,R., Chokhawala,H., Jordan,J.D.,
            Magdy,T., Orr,A.W., Stokes,K.Y., Rom,O. and Dhanesha,N.
  TITLE     Interactions between integrin alpha9beta1 and VCAM-1 promote
            neutrophil hyperactivation and mediate poststroke DVT
  JOURNAL   Blood Adv 8 (9), 2104-2117 (2024)
   PUBMED   38498701
  REMARK    GeneRIF: Interactions between integrin alpha9beta1 and VCAM-1
            promote neutrophil hyperactivation and mediate poststroke DVT.
REFERENCE   5  (bases 1 to 3101)
  AUTHORS   Mathew,D.T., Peigh,G., Lima,J.A.C., Bielinski,S.J., Larson,N.B.,
            Allison,M.A., Shah,S.J. and Patel,R.B.
  TITLE     Associations of Circulating Vascular Cell Adhesion Molecule-1 and
            Intercellular Adhesion Molecule-1 With Long-Term Cardiac Function
  JOURNAL   J Am Heart Assoc 13 (6), e032213 (2024)
   PUBMED   38497480
  REMARK    GeneRIF: Associations of Circulating Vascular Cell Adhesion
            Molecule-1 and Intercellular Adhesion Molecule-1 With Long-Term
            Cardiac Function.
REFERENCE   6  (bases 1 to 3101)
  AUTHORS   Neish,A.S., Williams,A.J., Palmer,H.J., Whitley,M.Z. and Collins,T.
  TITLE     Functional analysis of the human vascular cell adhesion molecule 1
            promoter
  JOURNAL   J Exp Med 176 (6), 1583-1593 (1992)
   PUBMED   1281211
REFERENCE   7  (bases 1 to 3101)
  AUTHORS   Pepinsky,B., Hession,C., Chen,L.L., Moy,P., Burkly,L.,
            Jakubowski,A., Chow,E.P., Benjamin,C., Chi-Rosso,G., Luhowskyj,S.
            et al.
  TITLE     Structure/function studies on vascular cell adhesion molecule-1
  JOURNAL   J Biol Chem 267 (25), 17820-17826 (1992)
   PUBMED   1381355
REFERENCE   8  (bases 1 to 3101)
  AUTHORS   Iademarco,M.F., McQuillan,J.J., Rosen,G.D. and Dean,D.C.
  TITLE     Characterization of the promoter for vascular cell adhesion
            molecule-1 (VCAM-1)
  JOURNAL   J Biol Chem 267 (23), 16323-16329 (1992)
   PUBMED   1379595
REFERENCE   9  (bases 1 to 3101)
  AUTHORS   Osborn,L., Vassallo,C. and Benjamin,C.D.
  TITLE     Activated endothelium binds lymphocytes through a novel binding
            site in the alternately spliced domain of vascular cell adhesion
            molecule-1
  JOURNAL   J Exp Med 176 (1), 99-107 (1992)
   PUBMED   1377228
REFERENCE   10 (bases 1 to 3101)
  AUTHORS   Polte,T., Newman,W. and Gopal,T.V.
  TITLE     Full length vascular cell adhesion molecule 1 (VCAM-1)
  JOURNAL   Nucleic Acids Res 18 (19), 5901 (1990)
   PUBMED   1699207
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB096825.1, BC017276.2 and
            BF791565.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001078.3.
            
            Summary: This gene is a member of the Ig superfamily and encodes a
            cell surface sialoglycoprotein expressed by cytokine-activated
            endothelium. This type I membrane protein mediates
            leukocyte-endothelial cell adhesion and signal transduction, and
            may play a role in the development of artherosclerosis and
            rheumatoid arthritis. Three alternatively spliced transcripts
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) encodes the predominant,
            full-length isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068490.1, AK223266.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294728.7/ ENSP00000294728.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DB096825.1         103-120
            19-2326             BC017276.2         1-2308
            2327-2785           BF791565.1         125-583
            2786-3101           BC017276.2         2768-3083
FEATURES             Location/Qualifiers
     source          1..3101
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.2"
     gene            1..3101
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /note="vascular cell adhesion molecule 1"
                     /db_xref="GeneID:7412"
                     /db_xref="HGNC:HGNC:12663"
                     /db_xref="MIM:192225"
     exon            1..183
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2339
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; CD106 antigen; vascular cell adhesion protein
                     1"
                     /codon_start=1
                     /product="vascular cell adhesion protein 1 isoform a
                     precursor"
                     /protein_id="NP_001069.1"
                     /db_xref="CCDS:CCDS773.1"
                     /db_xref="GeneID:7412"
                     /db_xref="HGNC:HGNC:12663"
                     /db_xref="MIM:192225"
                     /translation="MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVS
                     LTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESR
                     KLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMK
                     SQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQ
                     VYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL
                     TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLT
                     CSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKL
                     EKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENI
                     EFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVN
                     VAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTL
                     ISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCT
                     CGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLT
                     LDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYSLVEAQKSKV"
     exon            184..459
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /inference="alignment:Splign:2.1.0"
     exon            460..780
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1047
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1323
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1644
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1911
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2178
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..3101
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3074..3079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /note="hexamer: AGTAAA"
     polyA_site      3101
                     /gene="VCAM1"
                     /gene_synonym="CD106; INCAM-100"
                     /note="major polyA site"
ORIGIN      
        1 gcggtatctg catcgggcct cactggcttc aggagctgaa taccctccca ggcacacaca
       61 ggtgggacac aaataagggt tttggaacca ctattttctc atcacgacag caacttaaaa
      121 tgcctgggaa gatggtcgtg atccttggag cctcaaatat actttggata atgtttgcag
      181 cttctcaagc ttttaaaatc gagaccaccc cagaatctag atatcttgct cagattggtg
      241 actccgtctc attgacttgc agcaccacag gctgtgagtc cccatttttc tcttggagaa
      301 cccagataga tagtccactg aatgggaagg tgacgaatga ggggaccaca tctacgctga
      361 caatgaatcc tgttagtttt gggaacgaac actcttacct gtgcacagca acttgtgaat
      421 ctaggaaatt ggaaaaagga atccaggtgg agatctactc ttttcctaag gatccagaga
      481 ttcatttgag tggccctctg gaggctggga agccgatcac agtcaagtgt tcagttgctg
      541 atgtataccc atttgacagg ctggagatag acttactgaa aggagatcat ctcatgaaga
      601 gtcaggaatt tctggaggat gcagacagga agtccctgga aaccaagagt ttggaagtaa
      661 cctttactcc tgtcattgag gatattggaa aagttcttgt ttgccgagct aaattacaca
      721 ttgatgaaat ggattctgtg cccacagtaa ggcaggctgt aaaagaattg caagtctaca
      781 tatcacccaa gaatacagtt atttctgtga atccatccac aaagctgcaa gaaggtggct
      841 ctgtgaccat gacctgttcc agcgagggtc taccagctcc agagattttc tggagtaaga
      901 aattagataa tgggaatcta cagcaccttt ctggaaatgc aactctcacc ttaattgcta
      961 tgaggatgga agattctgga atttatgtgt gtgaaggagt taatttgatt gggaaaaaca
     1021 gaaaagaggt ggaattaatt gttcaagaga aaccatttac tgttgagatc tcccctggac
     1081 cccggattgc tgctcagatt ggagactcag tcatgttgac atgtagtgtc atgggctgtg
     1141 aatccccatc tttctcctgg agaacccaga tagacagccc tctgagcggg aaggtgagga
     1201 gtgaggggac caattccacg ctgaccctga gccctgtgag ttttgagaac gaacactctt
     1261 atctgtgcac agtgacttgt ggacataaga aactggaaaa gggaatccag gtggagctct
     1321 actcattccc tagagatcca gaaatcgaga tgagtggtgg cctcgtgaat gggagctctg
     1381 tcactgtaag ctgcaaggtt cctagcgtgt acccccttga ccggctggag attgaattac
     1441 ttaaggggga gactattctg gagaatatag agtttttgga ggatacggat atgaaatctc
     1501 tagagaacaa aagtttggaa atgaccttca tccctaccat tgaagatact ggaaaagctc
     1561 ttgtttgtca ggctaagtta catattgatg acatggaatt cgaacccaaa caaaggcaga
     1621 gtacgcaaac actttatgtc aatgttgccc ccagagatac aaccgtcttg gtcagccctt
     1681 cctccatcct ggaggaaggc agttctgtga atatgacatg cttgagccag ggctttcctg
     1741 ctccgaaaat cctgtggagc aggcagctcc ctaacgggga gctacagcct ctttctgaga
     1801 atgcaactct caccttaatt tctacaaaaa tggaagattc tggggtttat ttatgtgaag
     1861 gaattaacca ggctggaaga agcagaaagg aagtggaatt aattatccaa gttactccaa
     1921 aagacataaa acttacagct tttccttctg agagtgtcaa agaaggagac actgtcatca
     1981 tctcttgtac atgtggaaat gttccagaaa catggataat cctgaagaaa aaagcggaga
     2041 caggagacac agtactaaaa tctatagatg gcgcctatac catccgaaag gcccagttga
     2101 aggatgcggg agtatatgaa tgtgaatcta aaaacaaagt tggctcacaa ttaagaagtt
     2161 taacacttga tgttcaagga agagaaaaca acaaagacta tttttctcct gagcttctcg
     2221 tgctctattt tgcatcctcc ttaataatac ctgccattgg aatgataatt tactttgcaa
     2281 gaaaagccaa catgaagggg tcatatagtc ttgtagaagc acagaagtca aaagtgtagc
     2341 taatgcttga tatgttcaac tggagacact atttatctgt gcaaatcctt gatactgctc
     2401 atcattcctt gagaaaaaca atgagctgag aggcagactt ccctgaatgt attgaacttg
     2461 gaaagaaatg cccatctatg tcccttgctg tgagcaagaa gtcaaagtaa aacttgctgc
     2521 ctgaagaaca gtaactgcca tcaagatgag agaactggag gagttccttg atctgtatat
     2581 acaataacat aatttgtaca tatgtaaaat aaaattatgc catagcaaga ttgcttaaaa
     2641 tagcaacact ctatatttag attgttaaaa taactagtgt tgcttggact attataattt
     2701 aatgcatgtt aggaaaattt cacattaata tttgctgaca gctgaccttt gtcatctttc
     2761 ttctatttta ttccctttca caaaatttta ttcctatata gtttattgac aataatttca
     2821 ggttttgtaa agatgccggg ttttatattt ttatagacaa ataataagca aagggagcac
     2881 tgggttgact ttcaggtact aaatacctca acctatggta taatggttga ctgggtttct
     2941 ctgtatagta ctggcatggt acggagatgt ttcacgaagt ttgttcatca gactcctgtg
     3001 caactttccc aatgtggcct aaaaatgcaa cttcttttta ttttcttttg taaatgttta
     3061 ggtttttttg tatagtaaag tgataatttc tggaattaga a
//
