LOCUS       NM_003372               1616 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens VHL binding protein 1 (VBP1), transcript variant 1,
            mRNA.
ACCESSION   NM_003372
VERSION     NM_003372.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1616)
  AUTHORS   Miao,H., Gao,W., Zhong,L., Li,H., Chen,D., Xu,C., Wen,Z. and
            Chen,Y.
  TITLE     VBP1 promotes tumor proliferation as a part of the hypoxia-related
            signature in esophageal squamous cell carcinoma
  JOURNAL   Hum Cell 37 (4), 1141-1155 (2024)
   PUBMED   38700744
  REMARK    GeneRIF: VBP1 promotes tumor proliferation as a part of the
            hypoxia-related signature in esophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 1616)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1616)
  AUTHORS   Zhang,H., Rong,X., Wang,C., Liu,Y., Lu,L., Li,Y., Zhao,C. and
            Zhou,J.
  TITLE     VBP1 modulates Wnt/beta-catenin signaling by mediating the
            stability of the transcription factors TCF/LEFs
  JOURNAL   J Biol Chem 295 (49), 16826-16839 (2020)
   PUBMED   32989053
  REMARK    GeneRIF: VBP1 modulates Wnt/beta-catenin signaling by mediating the
            stability of the transcription factors TCF/LEFs.
REFERENCE   4  (bases 1 to 1616)
  AUTHORS   Chesnel,F., Couturier,A., Alusse,A., Gagne,J.P., Poirier,G.G.,
            Jean,D., Boisvert,F.M., Hascoet,P., Paillard,L.,
            Arlot-Bonnemains,Y. and Le Goff,X.
  TITLE     The prefoldin complex stabilizes the von Hippel-Lindau protein
            against aggregation and degradation
  JOURNAL   PLoS Genet 16 (11), e1009183 (2020)
   PUBMED   33137104
  REMARK    GeneRIF: The prefoldin complex stabilizes the von Hippel-Lindau
            protein against aggregation and degradation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1616)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1616)
  AUTHORS   Clifford,S.C., Walsh,S., Hewson,K., Green,E.K., Brinke,A.,
            Green,P.M., Gianelli,F., Eng,C. and Maher,E.R.
  TITLE     Genomic organization and chromosomal localization of the human CUL2
            gene and the role of von Hippel-Lindau tumor suppressor-binding
            protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma
            development
  JOURNAL   Genes Chromosomes Cancer 26 (1), 20-28 (1999)
   PUBMED   10441001
REFERENCE   7  (bases 1 to 1616)
  AUTHORS   Hemberger,M., Himmelbauer,H., Neumann,H.P., Plate,K.H.,
            Schwarzkopf,G. and Fundele,R.
  TITLE     Expression of the von Hippel-Lindau-binding protein-1 (Vbp1) in
            fetal and adult mouse tissues
  JOURNAL   Hum Mol Genet 8 (2), 229-236 (1999)
   PUBMED   9931330
REFERENCE   8  (bases 1 to 1616)
  AUTHORS   Vainberg,I.E., Lewis,S.A., Rommelaere,H., Ampe,C.,
            Vandekerckhove,J., Klein,H.L. and Cowan,N.J.
  TITLE     Prefoldin, a chaperone that delivers unfolded proteins to cytosolic
            chaperonin
  JOURNAL   Cell 93 (5), 863-873 (1998)
   PUBMED   9630229
REFERENCE   9  (bases 1 to 1616)
  AUTHORS   Brinke,A., Green,P.M. and Giannelli,F.
  TITLE     Characterization of the gene (VBP1) and transcript for the von
            Hippel-Lindau binding protein and isolation of the highly conserved
            murine homologue
  JOURNAL   Genomics 45 (1), 105-112 (1997)
   PUBMED   9339366
REFERENCE   10 (bases 1 to 1616)
  AUTHORS   Tsuchiya,H., Iseda,T. and Hino,O.
  TITLE     Identification of a novel protein (VBP-1) binding to the von
            Hippel-Lindau (VHL) tumor suppressor gene product
  JOURNAL   Cancer Res 56 (13), 2881-2885 (1996)
   PUBMED   8674032
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA610631.1, BC046094.1,
            BC009570.1 and AA626259.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003372.6.
            
            Summary: The protein encoded by this gene interacts with the Von
            Hippel-Lindau protein to form an intracellular complex. The encoded
            protein functions as a chaperone protein, and may play a role in
            the transport of the Von Hippel-Lindau protein from the perinuclear
            granules to the nucleus or cytoplasm. Alternative splicing and the
            use of alternate transcription start sites results in multiple
            transcript variants encoding different protein isoforms. [provided
            by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.223287.1,
                                           SRR1660807.138566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286428.7/ ENSP00000286428.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA610631.1         37-47
            12-950              BC046094.1         1-939
            951-1590            BC009570.1         954-1593
            1591-1616           AA626259.1         4-29                c
FEATURES             Location/Qualifiers
     source          1..1616
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1616
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /note="VHL binding protein 1"
                     /db_xref="GeneID:7411"
                     /db_xref="HGNC:HGNC:12662"
                     /db_xref="MIM:300133"
     exon            1..116
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..617
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     prefoldin subunit 3; von Hippel-Lindau binding protein 1"
                     /codon_start=1
                     /product="prefoldin subunit 3 isoform 1"
                     /protein_id="NP_003363.1"
                     /db_xref="CCDS:CCDS14765.1"
                     /db_xref="GeneID:7411"
                     /db_xref="HGNC:HGNC:12662"
                     /db_xref="MIM:300133"
                     /translation="MAAVKDSCGKGEMATGNGRRLHLGIPEAVFVEDVDSFMKQPGNE
                     TADTVLKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYMQKKKESTNSME
                     TRFLLADNLYCKASVPPTDKVCLWLGANVMLEYDIDEAQALLEKNLSTATKNLDSLEE
                     DLDFLRDQFTTTEVNMARVYNWDVKRRNKDDSTKNKA"
     exon            117..241
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            242..308
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..407
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..546
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..1616
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1569..1574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1592
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgcgc tcgcatcccc aagatggcgg ccgttaagga cagttgtggc aaaggagaaa
       61 tggccacagg gaatgggcgg cggctccacc tggggattcc tgaggccgtg tttgtggaag
      121 atgtagattc cttcatgaaa cagcctggga atgagactgc agatacagta ttaaagaagc
      181 tggatgaaca gtaccagaag tataagttta tggaactcaa ccttgctcaa aagaaaagaa
      241 ggctaaaagg tcagattcct gaaattaaac agactttgga aattctaaaa tacatgcaga
      301 agaaaaaaga gtccaccaac tcaatggaga ccagattctt gctggcagat aacctgtatt
      361 gcaaagcttc agttcctcct accgataaag tgtgtctgtg gttgggggct aatgtaatgc
      421 ttgaatatga tattgatgaa gctcaggcat tgttggaaaa gaatttatcg actgccacaa
      481 agaatcttga ttccctggag gaagaccttg actttcttcg agatcaattt actaccacag
      541 aagtcaatat ggccagggtt tataattggg atgtaaaaag aagaaacaag gatgactcta
      601 ccaagaacaa agcataatgc tggcaattaa aaatgtggtt tagttttcca aacatgttat
      661 cttaaatacc cctttatcct tacaggttga cataactttg aatgttttaa cagcaagaat
      721 tttaagaaaa gataaacacc attttattta tttataaaaa caaaattagt ttcaaatatt
      781 tttgacattg tgattttttt ttccacattt ctcagcaaag ctaatggtat tttaatcatt
      841 atttttgcct gtcataagaa aactcttagc tgaaatggcc gaaaactgtg agacatgcta
      901 tggaagctga atgccggacg ctagcacagt ttactttttc cctttctaat tggctgatgt
      961 tactctcact tgatgtggtt aaaccatttt agaggtagag aagacagaca gtttgaatat
     1021 ttgtaaactt gtttttcttt ggtatattta ggacttagtg gtcctctgtt gctattgtct
     1081 tctataagtg gagtttcatg acttactgct taacgaataa ctaactacta tgatattctg
     1141 gacattttag gaaatggtaa tttgccttgc tacacattaa gagggctatt aagactacat
     1201 tttttctaac ctcagataag tgcagtgtct ttgcaatgcc aacataaggg agatcttggc
     1261 caacgtgaaa taaaattact cattcaaaac tctgcctaag gtgattttgt agttcttaac
     1321 agttctccag agcatcttga acaggaatat taagataaat gtgaatctgc aatggctgaa
     1381 aagagttgtg agctttttta ttcatgataa aaccttatag gaatagtata aaaaatccct
     1441 gtggaaagct actagtacat tgaccagcgc tgggtgatac agattctgat aaaaacataa
     1501 atgtattagt tcatctccat gtagtaaaaa gtatacttat acaatgtttt gtacttgtat
     1561 ttcatgaaat taaaacagtg atgctaaaac tatggcagag cacttttttc atgtta
//
