LOCUS       NM_001303544            1741 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens VHL binding protein 1 (VBP1), transcript variant 3,
            mRNA.
ACCESSION   NM_001303544 XM_005274729
VERSION     NM_001303544.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Miao,H., Gao,W., Zhong,L., Li,H., Chen,D., Xu,C., Wen,Z. and
            Chen,Y.
  TITLE     VBP1 promotes tumor proliferation as a part of the hypoxia-related
            signature in esophageal squamous cell carcinoma
  JOURNAL   Hum Cell 37 (4), 1141-1155 (2024)
   PUBMED   38700744
  REMARK    GeneRIF: VBP1 promotes tumor proliferation as a part of the
            hypoxia-related signature in esophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1741)
  AUTHORS   Zhang,H., Rong,X., Wang,C., Liu,Y., Lu,L., Li,Y., Zhao,C. and
            Zhou,J.
  TITLE     VBP1 modulates Wnt/beta-catenin signaling by mediating the
            stability of the transcription factors TCF/LEFs
  JOURNAL   J Biol Chem 295 (49), 16826-16839 (2020)
   PUBMED   32989053
  REMARK    GeneRIF: VBP1 modulates Wnt/beta-catenin signaling by mediating the
            stability of the transcription factors TCF/LEFs.
REFERENCE   4  (bases 1 to 1741)
  AUTHORS   Chesnel,F., Couturier,A., Alusse,A., Gagne,J.P., Poirier,G.G.,
            Jean,D., Boisvert,F.M., Hascoet,P., Paillard,L.,
            Arlot-Bonnemains,Y. and Le Goff,X.
  TITLE     The prefoldin complex stabilizes the von Hippel-Lindau protein
            against aggregation and degradation
  JOURNAL   PLoS Genet 16 (11), e1009183 (2020)
   PUBMED   33137104
  REMARK    GeneRIF: The prefoldin complex stabilizes the von Hippel-Lindau
            protein against aggregation and degradation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1741)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1741)
  AUTHORS   Clifford,S.C., Walsh,S., Hewson,K., Green,E.K., Brinke,A.,
            Green,P.M., Gianelli,F., Eng,C. and Maher,E.R.
  TITLE     Genomic organization and chromosomal localization of the human CUL2
            gene and the role of von Hippel-Lindau tumor suppressor-binding
            protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma
            development
  JOURNAL   Genes Chromosomes Cancer 26 (1), 20-28 (1999)
   PUBMED   10441001
REFERENCE   7  (bases 1 to 1741)
  AUTHORS   Hemberger,M., Himmelbauer,H., Neumann,H.P., Plate,K.H.,
            Schwarzkopf,G. and Fundele,R.
  TITLE     Expression of the von Hippel-Lindau-binding protein-1 (Vbp1) in
            fetal and adult mouse tissues
  JOURNAL   Hum Mol Genet 8 (2), 229-236 (1999)
   PUBMED   9931330
REFERENCE   8  (bases 1 to 1741)
  AUTHORS   Vainberg,I.E., Lewis,S.A., Rommelaere,H., Ampe,C.,
            Vandekerckhove,J., Klein,H.L. and Cowan,N.J.
  TITLE     Prefoldin, a chaperone that delivers unfolded proteins to cytosolic
            chaperonin
  JOURNAL   Cell 93 (5), 863-873 (1998)
   PUBMED   9630229
REFERENCE   9  (bases 1 to 1741)
  AUTHORS   Brinke,A., Green,P.M. and Giannelli,F.
  TITLE     Characterization of the gene (VBP1) and transcript for the von
            Hippel-Lindau binding protein and isolation of the highly conserved
            murine homologue
  JOURNAL   Genomics 45 (1), 105-112 (1997)
   PUBMED   9339366
REFERENCE   10 (bases 1 to 1741)
  AUTHORS   Tsuchiya,H., Iseda,T. and Hino,O.
  TITLE     Identification of a novel protein (VBP-1) binding to the von
            Hippel-Lindau (VHL) tumor suppressor gene product
  JOURNAL   Cancer Res 56 (13), 2881-2885 (1996)
   PUBMED   8674032
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301646.1, BC009570.1 and
            AA626259.1.
            
            On Jan 13, 2015 this sequence version replaced XM_005274729.2.
            
            Summary: The protein encoded by this gene interacts with the Von
            Hippel-Lindau protein to form an intracellular complex. The encoded
            protein functions as a chaperone protein, and may play a role in
            the transport of the Von Hippel-Lindau protein from the perinuclear
            granules to the nucleus or cytoplasm. Alternative splicing and the
            use of alternate transcription start sites results in multiple
            transcript variants encoding different protein isoforms. [provided
            by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (3) has a distinct N-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301646.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-926               AK301646.1         1-926
            927-1715            BC009570.1         805-1593
            1716-1741           AA626259.1         4-29                c
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1741
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /note="VHL binding protein 1"
                     /db_xref="GeneID:7411"
                     /db_xref="HGNC:HGNC:12662"
                     /db_xref="MIM:300133"
     exon            1..133
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..241
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..742
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     prefoldin subunit 3; von Hippel-Lindau binding protein 1"
                     /codon_start=1
                     /product="prefoldin subunit 3 isoform 3"
                     /protein_id="NP_001290473.1"
                     /db_xref="CCDS:CCDS78525.1"
                     /db_xref="GeneID:7411"
                     /db_xref="HGNC:HGNC:12662"
                     /db_xref="MIM:300133"
                     /translation="MAPQPMIHTQQGLRTSSPSTPSPEHQEDVDSFMKQPGNETADTV
                     LKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYMQKKKESTNSMETRFLL
                     ADNLYCKASVPPTDKVCLWLGANVMLEYDIDEAQALLEKNLSTATKNLDSLEEDLDFL
                     RDQFTTTEVNMARVYNWDVKRRNKDDSTKNKA"
     exon            242..366
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..433
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..532
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..671
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..1741
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1694..1699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1717
                     /gene="VBP1"
                     /gene_synonym="HIBBJ46; PFD3; PFDN3; VBP-1"
                     /note="major polyA site"
ORIGIN      
        1 attactcagc ttttcatctg ctgtgttgaa agccaactta tcatttttca cattattgta
       61 tacatctaaa agacatcata aacgaagact ggaagtgaaa actgaaaaac tgagaaagtt
      121 ttatttgttg gaggttccaa ctccattggg agctccttct ctaatggcac ctcaacccat
      181 gattcatacc cagcaaggcc taaggaccag tagtccttcc actccatccc cagagcatca
      241 ggaagatgta gattccttca tgaaacagcc tgggaatgag actgcagata cagtattaaa
      301 gaagctggat gaacagtacc agaagtataa gtttatggaa ctcaaccttg ctcaaaagaa
      361 aagaaggcta aaaggtcaga ttcctgaaat taaacagact ttggaaattc taaaatacat
      421 gcagaagaaa aaagagtcca ccaactcaat ggagaccaga ttcttgctgg cagataacct
      481 gtattgcaaa gcttcagttc ctcctaccga taaagtgtgt ctgtggttgg gggctaatgt
      541 aatgcttgaa tatgatattg atgaagctca ggcattgttg gaaaagaatt tatcgactgc
      601 cacaaagaat cttgattccc tggaggaaga ccttgacttt cttcgagatc aatttactac
      661 cacagaagtc aatatggcca gggtttataa ttgggatgta aaaagaagaa acaaggatga
      721 ctctaccaag aacaaagcat aatgctggca attaaaaatg tggtttagtt ttccaaacat
      781 gttatcttaa ataccccttt atccttacag gttgacataa ctttgaatgt tttaacagca
      841 agaattttaa gaaaagataa acaccatttt atttatttat aaaaacaaaa ttagtttcaa
      901 atatttttga cattgtgatt tttttttcca catttctcag caaagctaat ggtattttaa
      961 tcattatttt tgcctgtcat aagaaaactc ttagctgaaa tggccgaaaa ctgtgagaca
     1021 tgctatggaa gctgaatgcc ggacgctagc acagtttact ttttcccttt ctaattggct
     1081 gatgttactc tcacttgatg tggttaaacc attttagagg tagagaagac agacagtttg
     1141 aatatttgta aacttgtttt tctttggtat atttaggact tagtggtcct ctgttgctat
     1201 tgtcttctat aagtggagtt tcatgactta ctgcttaacg aataactaac tactatgata
     1261 ttctggacat tttaggaaat ggtaatttgc cttgctacac attaagaggg ctattaagac
     1321 tacatttttt ctaacctcag ataagtgcag tgtctttgca atgccaacat aagggagatc
     1381 ttggccaacg tgaaataaaa ttactcattc aaaactctgc ctaaggtgat tttgtagttc
     1441 ttaacagttc tccagagcat cttgaacagg aatattaaga taaatgtgaa tctgcaatgg
     1501 ctgaaaagag ttgtgagctt ttttattcat gataaaacct tataggaata gtataaaaaa
     1561 tccctgtgga aagctactag tacattgacc agcgctgggt gatacagatt ctgataaaaa
     1621 cataaatgta ttagttcatc tccatgtagt aaaaagtata cttatacaat gttttgtact
     1681 tgtatttcat gaaattaaaa cagtgatgct aaaactatgg cagagcactt ttttcatgtt
     1741 a
//
