LOCUS       NM_006113               5025 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens vav guanine nucleotide exchange factor 3 (VAV3),
            transcript variant 1, mRNA.
ACCESSION   NM_006113
VERSION     NM_006113.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5025)
  AUTHORS   Shi,Y., Wang,J., Yuan,Q., Chen,Y., Zhao,M., Li,X., Wang,Z.,
            Zhou,H., Zhu,F., Wei,B., Jiang,Y., Zhao,J., Qiao,Y., Dong,Z. and
            Liu,K.
  TITLE     DDX5 promotes esophageal squamous cell carcinoma growth through
            sustaining VAV3 mRNA stability
  JOURNAL   Oncogene 43 (44), 3240-3254 (2024)
   PUBMED   39289531
  REMARK    GeneRIF: DDX5 promotes esophageal squamous cell carcinoma growth
            through sustaining VAV3 mRNA stability.
REFERENCE   2  (bases 1 to 5025)
  AUTHORS   Xia,C., Zhu,K., Zhang,Y., Chen,J., Yu,C., Gao,T. and Zheng,G.
  TITLE     Serum exosome-derived miR-146a-3p promotes macrophage M2
            polarization in allergic rhinitis by targeting VAV3 via
            PI3K/AKT/mTOR pathway
  JOURNAL   Int Immunopharmacol 124 (Pt B), 110997 (2023)
   PUBMED   37783052
  REMARK    GeneRIF: Serum exosome-derived miR-146a-3p promotes macrophage M2
            polarization in allergic rhinitis by targeting VAV3 via
            PI3K/AKT/mTOR pathway.
REFERENCE   3  (bases 1 to 5025)
  AUTHORS   Al-Hawary,S.I.S., Alsalamy,A., Gupta,R., Alsaab,H.O., Hjazi,A.,
            Edilboyev,U., Ramadan,M.F., Hussien,B.M., Ahmed,M. and
            Hosseini-Fard,S.R.
  TITLE     VAV3 in human cancers: Mechanism and clinical implication
  JOURNAL   Pathol Res Pract 248, 154681 (2023)
   PUBMED   37467637
  REMARK    GeneRIF: VAV3 in human cancers: Mechanism and clinical implication.
            Review article
REFERENCE   4  (bases 1 to 5025)
  AUTHORS   Gleeson,P.J., Sokol,H. and Monteiro,R.C.
  TITLE     CARD9, VAV3, and infection risk in IgA nephropathy
  JOURNAL   Kidney Int 103 (5), 996-997 (2023)
   PUBMED   37085264
  REMARK    GeneRIF: CARD9, VAV3, and infection risk in IgA nephropathy.
REFERENCE   5  (bases 1 to 5025)
  AUTHORS   Kherrour,W., Benbia,S., Hambaba,L. and Kalicanin,D.
  TITLE     Rs7537605 polymorphism in VAV3 gene and rs28665122 polymorphism in
            SEPS gene are not associated with Hashimoto's thyroiditis in
            North-East Algerian population
  JOURNAL   Afr Health Sci 22 (4), 252-260 (2022)
   PUBMED   37092056
  REMARK    GeneRIF: Rs7537605 polymorphism in VAV3 gene and rs28665122
            polymorphism in SEPS gene are not associated with Hashimoto's
            thyroiditis in North-East Algerian population.
REFERENCE   6  (bases 1 to 5025)
  AUTHORS   Trenkle,T., McClelland,M., Adlkofer,K. and Welsh,J.
  TITLE     Major transcript variants of VAV3, a new member of the VAV family
            of guanine nucleotide exchange factors
  JOURNAL   Gene 245 (1), 139-149 (2000)
   PUBMED   10713454
REFERENCE   7  (bases 1 to 5025)
  AUTHORS   Movilla,N. and Bustelo,X.R.
  TITLE     Biological and regulatory properties of Vav-3, a new member of the
            Vav family of oncoproteins
  JOURNAL   Mol Cell Biol 19 (11), 7870-7885 (1999)
   PUBMED   10523675
REFERENCE   8  (bases 1 to 5025)
  AUTHORS   Trenkle,T., Welsh,J., Jung,B., Mathieu-Daude,F. and McClelland,M.
  TITLE     Non-stoichiometric reduced complexity probes for cDNA arrays
  JOURNAL   Nucleic Acids Res 26 (17), 3883-3891 (1998)
   PUBMED   9705494
REFERENCE   9  (bases 1 to 5025)
  AUTHORS   Crespo,P., Schuebel,K.E., Ostrom,A.A., Gutkind,J.S. and
            Bustelo,X.R.
  TITLE     Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by
            the vav proto-oncogene product
  JOURNAL   Nature 385 (6612), 169-172 (1997)
   PUBMED   8990121
REFERENCE   10 (bases 1 to 5025)
  AUTHORS   Hobert,O., Schilling,J.W., Beckerle,M.C., Ullrich,A. and Jallal,B.
  TITLE     SH3 domain-dependent interaction of the proto-oncogene product Vav
            with the focal contact protein zyxin
  JOURNAL   Oncogene 12 (7), 1577-1581 (1996)
   PUBMED   8622875
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391235.4, DR002311.1,
            AF067817.1, AF118887.1, AC114491.1 and AI304566.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006113.4.
            
            Summary: This gene is a member of the VAV gene family. The VAV
            proteins are guanine nucleotide exchange factors (GEFs) for Rho
            family GTPases that activate pathways leading to actin cytoskeletal
            rearrangements and transcriptional alterations. This gene product
            acts as a GEF preferentially for RhoG, RhoA, and to a lesser
            extent, RAC1, and it associates maximally with the nucleotide-free
            states of these GTPases. Alternatively spliced transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1, also known as VAV-3alpha)
            encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF067817.1, AF118887.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370056.9/ ENSP00000359073.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AL391235.4         51681-51937         c
            258-274             DR002311.1         229-245
            275-629             AF067817.1         1-355
            630-3662            AF118887.1         365-3397
            3663-4881           AC114491.1         45801-47019
            4882-5025           AI304566.1         9-152               c
FEATURES             Location/Qualifiers
     source          1..5025
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..5025
                     /gene="VAV3"
                     /note="vav guanine nucleotide exchange factor 3"
                     /db_xref="GeneID:10451"
                     /db_xref="HGNC:HGNC:12659"
                     /db_xref="MIM:605541"
     exon            1..515
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..2855
                     /gene="VAV3"
                     /note="isoform 1 is encoded by transcript variant 1; vav 3
                     oncogene; guanine nucleotide exchange factor VAV3; VAV-3;
                     vav 3 guanine nucleotide exchange factor"
                     /codon_start=1
                     /product="guanine nucleotide exchange factor VAV3 isoform
                     1"
                     /protein_id="NP_006104.4"
                     /db_xref="CCDS:CCDS785.1"
                     /db_xref="GeneID:10451"
                     /db_xref="HGNC:HGNC:12659"
                     /db_xref="MIM:605541"
                     /translation="MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLC
                     QLLNNLRAHSINLKEINLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDV
                     RDFGKVIETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLY
                     DCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYF
                     MAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLV
                     IYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKY
                     HLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLN
                     QPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQY
                     KIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDY
                     ADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVN
                     SGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDT
                     VELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQA
                     ETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLM
                     ELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYD
                     FCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE"
     exon            516..632
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            633..691
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            692..757
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            758..866
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            867..959
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1028
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1132
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1232
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1328
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1397
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1484
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1570
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1703
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1813
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1915
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2016
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2042
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2088
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2225
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2291
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2326
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2443
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2531
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2661
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2813
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..5025
                     /gene="VAV3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5005..5010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VAV3"
                     /note="hexamer: AATAAA"
     polyA_site      5025
                     /gene="VAV3"
                     /note="major polyA site"
ORIGIN      
        1 agtggcgggc cgggcgctgg agtcggaagc ctgtgcgcgg cagccgccgc cgagccggcc
       61 ggggcgcacg gagagcgcgc gggactcgct gcagcggcgg ccgggtcgcg gcgcacccgg
      121 gccgggaccg gagccgagcc tagcgcggcg cccgcgaccc gtcagccgcg gctcctgctc
      181 cctcgatccc gcgcggggaa agggccggcg gctgttggcg tcggcggggc gcggaggaac
      241 cgcggcggcg gcggcggcgg ccgcatcctt gccgcccgcc ccggcccagc cgcgtcccgg
      301 agccgtcggg catggagccg tggaagcagt gcgcgcagtg gctcatccat tgcaaggtgc
      361 tgcccaccaa ccaccgggtg acctgggact cggctcaggt gttcgacctt gcgcagaccc
      421 tccgcgatgg agtcctgctc tgccagctgc ttaacaacct ccgggcgcac tccatcaacc
      481 tgaaggagat caacctgagg ccgcagatgt cccagtttct ctgtttgaag aacataagga
      541 catttctcac ggcctgttgt gagacgtttg gaatgaggaa aagtgaactt ttcgaggcat
      601 ttgacttgtt tgatgttcgt gactttggaa aggttataga aacattatca cgactttctc
      661 gaacacctat agcattggcc acaggaatca ggcccttccc aacagaagaa agcattaatg
      721 atgaagacat ctacaaaggc cttcctgatt taatagatga aacccttgtg gaagatgaag
      781 aagatctcta tgactgtgtt tatggggaag atgaaggtgg agaagtctat gaggacttaa
      841 tgaaggcaga ggaagcacat cagcccaaat gtccagaaaa tgatatacga agttgttgtc
      901 tagcagaaat taagcagaca gaagaaaaat atacagaaac tttggagtca atagaaaagt
      961 atttcatggc accactaaaa agatttctga cagcagcaga atttgattca gtattcatca
     1021 acattcctga acttgtaaaa cttcatcgga acctaatgca agagattcat gattccattg
     1081 taaataaaaa tgaccagaac ttgtaccaag tttttattaa ctacaaggaa agattggtta
     1141 tttacgggca gtactgcagt ggagtggagt cagccatctc tagtttagac tacatttcta
     1201 agacaaaaga agatgtcaaa ctgaaattag aggaatgttc caaaagagca aataatggga
     1261 aatttactct tcgagacttg cttgtggttc ctatgcaacg tgttttaaag taccaccttc
     1321 tcctccagga actggtcaaa cataccactg atccgactga gaaggcaaat ctgaaactgg
     1381 ctcttgatgc catgaaggac ttggcacaat atgtgaatga agtgaaaaga gataatgaga
     1441 cccttcgtga aattaaacag tttcagctat ctatagagaa tttgaaccaa ccagttttgc
     1501 tttttggacg acctcaggga gatggtgaaa ttcgaataac cactctagac aagcatacca
     1561 aacaagaaag gcatatcttc ttatttgatt tggcagtgat cgtatgtaag agaaaaggtg
     1621 ataactatga aatgaaggaa ataatagatc ttcagcagta caagatagcc aataatccta
     1681 caaccgataa agaaaacaaa aagtggtctt atggcttcta cctcatccat acccaaggac
     1741 aaaatgggtt agaattttat tgcaaaacaa aagatttaaa gaagaaatgg ctagaacagt
     1801 ttgaaatggc tttgtctaac ataagaccag actatgcaga ctccaatttc cacgacttca
     1861 agatgcatac cttcactcga gtcacatcct gcaaagtctg ccagatgctc ctgaggggaa
     1921 cattttatca aggctattta tgttttaagt gtggagcgag agcacacaaa gaatgtttgg
     1981 gaagagtaga caattgtggc agagttaatt ctggtgaaca agggacactc aaactaccag
     2041 agaaacggac caatggactg cgaagaactc ctaaacaggt ggatccaggt ttaccaaaga
     2101 tgcaggtcat taggaactat tctggaacac cacccccagc tctgcatgaa ggaccccctt
     2161 tacagctcca ggccggggat accgttgaac ttctgaaagg agatgcacac agtctgtttt
     2221 ggcagggcag aaatttagca tctggagagg ttggattttt tccaagtgat gcagtcaagc
     2281 cttgcccatg tgtgcccaaa ccagtagatt attcttgcca accctggtat gctggagcaa
     2341 tggaaagatt gcaagcagag accgaactta ttaatagggt aaatagtact taccttgtga
     2401 ggcacaggac caaagagtca ggagaatatg caattagcat taagtacaat aatgaagcaa
     2461 agcacatcaa gattttaaca agagatggct tttttcacat tgcagaaaat agaaaattta
     2521 aaagtttaat ggaacttgtg gagtactaca agcatcattc tctcaaggaa gggttcagaa
     2581 ccttagatac aactctgcag tttccataca aggagccaga acattcagct ggacagaggg
     2641 gtaatagagc aggcaacagc ttgttaagtc caaaagtgct gggcattgcc atcgctcggt
     2701 atgacttctg tgcaagagat atgagagagt tgtccttgtt gaaaggagat gtggtgaaga
     2761 tttacacaaa gatgagtgca aatggctggt ggagaggaga agtaaatggc agggtgggct
     2821 ggtttccatc cacatatgtg gaagaggatg aataaattca aatcccgtgt tgcaccctgc
     2881 accaaaaatt tcagagaagg gataaataga agcctgcaca gcatcgtgaa ttaactgaag
     2941 tgtttaaaaa gctgcatttc tggctgttca acatcctccc tccttagccc ctcctaagtc
     3001 ttaatgctga gatttctaaa gatgctggta ctgacagatt aatggcttgc ctagagctgt
     3061 gcaagaaaca gcctgccagt ctgtcattgt cagggaccag ggcaaaacca agagctgttc
     3121 ttcccagaag agccctgcaa acacattggt tcgtgcttcc ctttacttct tctggtcaga
     3181 taccatgaat gccagtcatc agtaaatctt aatacacttt tgctttattc tcacatgcca
     3241 ttcaccagat tatttgatgg tacaaagaag cagaagtgta attttccttt tcccagcatg
     3301 acgaaaaatt ggagttctgc catttgagca gcttactgga aagatccagc cttacttgtc
     3361 ttaaattgtc caacaaggtg actcattgcc cggcaaacac ttttaccctc agatgttact
     3421 catgatatta taaaatatga ggccagtgct caggtttgca tcataagtga gctatccctg
     3481 aagggtttta attacttatt tggtgtcctg attatatttg caaacttctt tataaaaggt
     3541 gaaaaaagca cacaaaagag agggtgtctt catattaaac cttcacaacc ttcatgattt
     3601 cataggatta ttttggaaat atagcacttg actttatgaa aggatctggg ctaggtatat
     3661 taagggtagt tgccaataac ctgaagaagc tggcattgtt tacagaaaca gatcaagggc
     3721 tataatttat gtcattttat agcagcagta tctattaata catgcctttt cctcccatcc
     3781 acctcccccg cacacacaca aagatgacct gggacatgat ttttttattc ccacattttc
     3841 ttggagcaca aacaactttg ttgaggattt tggaaggaaa gcacaactgg gtcctttatt
     3901 catttctggg acagaaagag ggtcagtgga cttttgtggg cctccagctt ctctcagagt
     3961 ctccccctct gcagcccatc ctgggagtgt attaactgga gggaagatgg gtcttgcagt
     4021 acatttgttt tgcccagcca tcactctttt ttgtgaggag cctaaataca ttcttcctgg
     4081 ggtccagagt ccccattcaa ggcagtcaag ttaagacact aacttggccc tttcctgatg
     4141 gaaatatttc ctccatagca gaagttgtgt tctgacaaga ctgagagagt tacatgttgg
     4201 gaaaaaaaag aagcattaac ttagtagaac tgaaccagga gcattaagtt ctgaaatttt
     4261 gaatcatctc tgaaatgaag caggtgtagc ctgccctctc atcaatccgt ctgggtgcca
     4321 gaactcaagg ttcagtggac acatccccct gttagagacc ctcatgggct aggacttttc
     4381 atctaggata gattcaagac ctttacctca gaattatgta aactgtgatt gtgttttaga
     4441 aaaattatta tttgctaaaa ccatttaagt ctttgtatat gtgtaaatga tcacaaaaat
     4501 gtattttata aaatgttctg tacaataaag ttacacctca aagtgtactc ttggaatgga
     4561 ttctttcctg taaagtctta tctgcgactc tgtctcggga atgttttgtc tgttgccgtc
     4621 agccgaactt tgttatggag ggagcagcct cacacaagca gaaacactcc tgtggatggt
     4681 attgtagcat gtattgttta ttttagtcaa tagaccctct ccttataaat ggtgtttagt
     4741 cttcctgttg catttcatgg gcctgggggt ttcctagcag aggatattgg agcccctttt
     4801 tgtgacatta ccaattacat ctttgtccac gtttaatact ttgttttgga aaatttaaat
     4861 gctgcagatt tgtgtagagt tctaatacca aagacagaag taaatgtttt ccatatactt
     4921 tgtcttgcct gtatgcagcc ctcgtgtaat acggtgaatt agagtggtat ttcactttgt
     4981 attattttgt aaatatgtca atataataaa tagtgactaa attga
//
