LOCUS       NM_001134398            4851 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens vav guanine nucleotide exchange factor 2 (VAV2),
            transcript variant 1, mRNA.
ACCESSION   NM_001134398
VERSION     NM_001134398.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4851)
  AUTHORS   Fernandez-Parejo,N., Lorenzo-Martin,L.F., Garcia-Pedrero,J.M.,
            Rodrigo,J.P., Dosil,M. and Bustelo,X.R.
  TITLE     VAV2 orchestrates the interplay between regenerative proliferation
            and ribogenesis in both keratinocytes and oral squamous cell
            carcinoma
  JOURNAL   Sci Rep 14 (1), 4060 (2024)
   PUBMED   38374399
  REMARK    GeneRIF: VAV2 orchestrates the interplay between regenerative
            proliferation and ribogenesis in both keratinocytes and oral
            squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4851)
  AUTHORS   Chen,Y., Wu,Y., Feng,W., Luo,X., Xiao,B., Ding,X., Gu,Y., Lu,Y. and
            Yu,Y.
  TITLE     Vav2 promotes ductus arteriosus anatomic closure via the remodeling
            of smooth muscle cells by Rac1 activation
  JOURNAL   J Mol Med (Berl) 101 (12), 1567-1585 (2023)
   PUBMED   37804474
  REMARK    GeneRIF: Vav2 promotes ductus arteriosus anatomic closure via the
            remodeling of smooth muscle cells by Rac1 activation.
REFERENCE   3  (bases 1 to 4851)
  AUTHORS   Sun,B., Ding,B., Chen,Y., Peng,C. and Chen,X.
  TITLE     AFAP1L1 promotes gastric cancer progression by interacting with
            VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling
            pathway
  JOURNAL   J Transl Med 21 (1), 18 (2023)
   PUBMED   36631800
  REMARK    GeneRIF: AFAP1L1 promotes gastric cancer progression by interacting
            with VAV2 to facilitate CDC42-mediated activation of ITGA5
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4851)
  AUTHORS   Ren,J., Wu,X., Shang,F.F., Qi,Y., Tang,Z., Wen,C., Cao,W.,
            Cheng,Q., Tan,L., Chen,H., Zhou,H.H. and Zou,H.
  TITLE     The tRNA-Cys-GCA Derived tsRNAs Suppress Tumor Progression of
            Gliomas via Regulating VAV2
  JOURNAL   Dis Markers 2022, 8708312 (2022)
   PUBMED   36426134
  REMARK    GeneRIF: The tRNA-Cys-GCA Derived tsRNAs Suppress Tumor Progression
            of Gliomas via Regulating VAV2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4851)
  AUTHORS   Bai,Y., Zheng,J., Cheng,L., Liu,Q., Zhao,G., Li,J., Gu,Y., Xu,W.,
            Wang,M., Wei,Q. and Zhang,R.
  TITLE     Potentially functional genetic variants of VAV2 and PSMA4 in the
            immune-activation pathway and non-small cell lung cancer survival
  JOURNAL   J Gene Med 24 (10), e3447 (2022)
   PUBMED   36039727
  REMARK    GeneRIF: Potentially functional genetic variants of VAV2 and PSMA4
            in the immune-activation pathway and non-small cell lung cancer
            survival.
REFERENCE   6  (bases 1 to 4851)
  AUTHORS   Han,J., Luby-Phelps,K., Das,B., Shu,X., Xia,Y., Mosteller,R.D.,
            Krishna,U.M., Falck,J.R., White,M.A. and Broek,D.
  TITLE     Role of substrates and products of PI 3-kinase in regulating
            activation of Rac-related guanosine triphosphatases by Vav
  JOURNAL   Science 279 (5350), 558-560 (1998)
   PUBMED   9438848
REFERENCE   7  (bases 1 to 4851)
  AUTHORS   Crespo,P., Schuebel,K.E., Ostrom,A.A., Gutkind,J.S. and
            Bustelo,X.R.
  TITLE     Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by
            the vav proto-oncogene product
  JOURNAL   Nature 385 (6612), 169-172 (1997)
   PUBMED   8990121
REFERENCE   8  (bases 1 to 4851)
  AUTHORS   Romero,F. and Fischer,S.
  TITLE     Structure and function of vav
  JOURNAL   Cell Signal 8 (8), 545-553 (1996)
   PUBMED   9115846
  REMARK    Review article
REFERENCE   9  (bases 1 to 4851)
  AUTHORS   Deckert,M., Tartare-Deckert,S., Couture,C., Mustelin,T. and
            Altman,A.
  TITLE     Functional and physical interactions of Syk family kinases with the
            Vav proto-oncogene product
  JOURNAL   Immunity 5 (6), 591-604 (1996)
   PUBMED   8986718
REFERENCE   10 (bases 1 to 4851)
  AUTHORS   Henske,E.P., Short,M.P., Jozwiak,S., Bovey,C.M., Ramlakhan,S.,
            Haines,J.L. and Kwiatkowski,D.J.
  TITLE     Identification of VAV2 on 9q34 and its exclusion as the tuberous
            sclerosis gene TSC1
  JOURNAL   Ann Hum Genet 59 (1), 25-37 (1995)
   PUBMED   7762982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC132965.1, S76992.1,
            BC033187.1 and BC043615.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001134398.1.
            
            Summary: VAV2 is the second member of the VAV guanine nucleotide
            exchange factor family of oncogenes. Unlike VAV1, which is
            expressed exclusively in hematopoietic cells, VAV2 transcripts were
            found in most tissues. Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S76992.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371850.8/ ENSP00000360916.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BC132965.1         1-61
            62-885              S76992.1           21-844
            886-1453            BC132965.1         871-1438
            1454-1825           S76992.1           1413-1784
            1826-2393           BC132965.1         1796-2363
            2394-2794           S76992.1           2353-2753
            2795-3096           BC033187.1         1223-1524
            3097-4851           BC043615.1         51-1805
FEATURES             Location/Qualifiers
     source          1..4851
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..4851
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /note="vav guanine nucleotide exchange factor 2"
                     /db_xref="GeneID:7410"
                     /db_xref="HGNC:HGNC:12658"
                     /db_xref="MIM:600428"
     exon            1..250
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2683
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /note="isoform 1 is encoded by transcript variant 1; vav 2
                     oncogene; guanine nucleotide exchange factor VAV2"
                     /codon_start=1
                     /product="guanine nucleotide exchange factor VAV2 isoform
                     1"
                     /protein_id="NP_001127870.1"
                     /db_xref="CCDS:CCDS48053.1"
                     /db_xref="GeneID:7410"
                     /db_xref="HGNC:HGNC:12658"
                     /db_xref="MIM:600428"
                     /translation="MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLC
                     QLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDV
                     RDFGKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYD
                     CVPCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLE
                     DIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDF
                     KERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQ
                     RVLKYHLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSS
                     IENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEII
                     ELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFE
                     MAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECL
                     EVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDP
                     ESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQ
                     TDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSL
                     LELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGL
                     SFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWW
                     KGETNGRIGWFPSTYVEEEGIQ"
     exon            251..367
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..426
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..495
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..598
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..613
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            614..712
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..781
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..882
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            883..982
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1078
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1147
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1234
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1320
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1453
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1468
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1578
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1680
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1769
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1786
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1808
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1936
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2011
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2064
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2181
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2269
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2393
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2480
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2635
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..4851
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4828..4833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /note="hexamer: AATAAA"
     polyA_site      4851
                     /gene="VAV2"
                     /gene_synonym="VAV-2"
                     /note="major polyA site"
ORIGIN      
        1 actttggctc gagcactgcc ctgagccggt cgggcccgcg ggcgccatgg agcagtggcg
       61 gcagtgcggc cgctggctca tcgattgcaa ggtcctgccg cccaaccacc gggtggtgtg
      121 gccctcggcc gtggtcttcg acctggcgca ggcgctgcgc gacggggtcc ttctgtgcca
      181 gctgctgcac aacctctccc ccggctccat cgacctcaag gacatcaact tccggccgca
      241 gatgtcccag tttctgtgtt tgaagaacat acgcaccttc ctgaaagtct gccacgataa
      301 atttggatta aggaacagcg agctgtttga cccctttgac ctcttcgatg tgcgagactt
      361 tggaaaggtc atctccgcgg tgtcgaggct ctccctgcac agcatcgcgc agaacaaagg
      421 gatcaggcct tttccctcag aggagaccac agagaatgac gatgacgtct accgcagcct
      481 ggaggagctg gccgacgagc atgacctggg ggaggacatc tacgactgcg tcccgtgtga
      541 ggatggaggg gacgacatct acgaggacat catcaaggtg gaggtgcagc agcccatgat
      601 tagatacatg cagaaaatgg gcatgactga agatgacaag aggaactgct gcctgctgga
      661 gatccaggag accgaggcca agtactaccg caccctggag gacattgaga agaactacat
      721 gagccccctg cggctggtgc tgagcccggc ggacatggca gctgtcttca ttaacctgga
      781 ggacctgatc aaggtgcatc acagcttcct gagggccatc gacgtgtccg tgatggtggg
      841 gggcagcacg ctggccaagg tcttcctcga tttcaaggaa aggcttctga tctacgggga
      901 gtactgcagc cacatggagc acgcccagaa cacactgaac cagctcctgg ccagccggga
      961 ggacttcagg cagaaagtcg aggagtgcac actgaaggtc caggatggaa aatttaagct
     1021 gcaagacctg ctggtggtcc ccatgcagag ggtgctcaaa taccacctgc tcttgaagga
     1081 gcttctgagc cattctgcgg aacggcctga gaggcagcag ctcaaagaag cactggaagc
     1141 catgcaggac ttggcgatgt acatcaatga agttaaacgg gacaaggaga ccttgaggaa
     1201 aatcagcgaa tttcagagtt ctatagaaaa tttgcaagtg aaactggagg aatttggaag
     1261 accaaagatt gacggggaac tgaaagtccg gtccatagtc aaccacacca agcaggacag
     1321 gtacttgttc ctgtttgaca aggtggtcat cgtctgcaag cggaagggct acagctacga
     1381 gctcaaggag atcatcgagc tgctgttcca caagatgacc gacgacccca tgaacaacaa
     1441 ggacgtcaag aagtctcacg ggaaaatgtg gtcctacggc ttctacctaa ttcaccttca
     1501 aggaaagcag ggcttccagt ttttctgcaa aacagaagat atgaagagga agtggatgga
     1561 gcagtttgag atggccatgt caaacatcaa gccagacaaa gccaatgcca accaccacag
     1621 tttccagatg tacacgtttg acaagaccac caactgcaaa gcctgcaaaa tgttcctcag
     1681 gggcaccttc taccagggat acatgtgtac caagtgtggc gtcggggcac acaaggagtg
     1741 cctggaagtg atacctccct gcaagttcac ttctcctgca gatctggacg cctccggagc
     1801 gggaccaggt cccaagatgg tggccatgca gaattaccat ggcaacccag cccctcccgg
     1861 gaagcctgtg ctgaccttcc agacgggcga cgtgcttgag ctgctgaggg gcgaccctga
     1921 gtctccgtgg tgggagggtc gtctggtaca aaccaggaag tcagggtatt tccccagctc
     1981 atctgtgaag ccctgccctg tggatggaag gccgcccatc agccggccgc catcccggga
     2041 gatcgactac actgcatacc cctggtttgc aggtaacatg gagaggcagc agacggacaa
     2101 cctgctcaag tcccacgcca gcgggaccta cctgatcagg gagcggcctg ccgaggctga
     2161 gcgctttgca ataagcatca agttcaatga tgaggtgaag cacatcaagg tggtggagaa
     2221 ggacaactgg atccacatca cagaggccaa gaaattcgac agcctcctgg agttggtgga
     2281 gtactaccag tgccactcac tgaaggagag cttcaagcag ctggacacca cactcaagta
     2341 cccctacaag tcccgggaac gttcggcctc cagggcctcc agccggtccc cagcttcctg
     2401 tgcttcctac aacttttctt ttctcagtcc tcagggcctc agctttgctt ctcagggccc
     2461 ctccgctccc ttctggtcag tgttcacgcc ccgcgtcatc ggcacagctg tggccaggta
     2521 taactttgcc gcccgagata tgagggagct ttcgctgcgg gagggtgacg tggtgaggat
     2581 ctacagccgc atcggcggag accagggctg gtggaagggc gagaccaacg gacggattgg
     2641 ctggtttcct tcaacgtacg tagaagagga gggcatccag tgacggcagg aacgtggaca
     2701 agactcgcag attttcttgg gagagtcact ccagccctga agtctgtctc tagctcctct
     2761 gtgactcaga ggggaaatac caacctccca gtcttccact gcccacaggg atagggaggg
     2821 tgttgagaat cctaaactcg aaccgtttca ctgtcagcct gccctcggcg acccatcact
     2881 gggtatgcta ttgtacatag aggaaacctg ggctagcccc acccagagcg cagaggaggg
     2941 ggcaccgaca gcgctgcgag ccaggctctg ggtagtggct gaggccagag gcccatcgcc
     3001 tgcccctgtc caactgagat ggccttcagg agcctaggtt tgaacagcag atgctgtccc
     3061 aggaagggct agggacatcg gaggggacct gcccccacac cctctgctca gcccctggac
     3121 tcagccttgc ctgtcttttc ctgctgctcc cagggggagg tgtcagacct cgggaggcag
     3181 acgggaccag agccaggctg ttcactgtgg gcccacttgc cccactgtgc tagggcgcgg
     3241 gaggagagag cactgtggtc gccctctgca gccactctgg ctcccaagac ttccctgact
     3301 cccccactcc cctccttgcc aggggcacac ccggacccca cacggcaggc ccctctcttg
     3361 ggaggggcct ttggaatgat gaaattccaa ccctgctgcc cggtcagcgg taccgtttcc
     3421 tgccctctct ctgagaggcc ctttctggag tcctgggaag gtgtctgcct ggccgcgctg
     3481 ccagatcagt acatcttttg taaaaaccct gaaatgggca gggaagaaaa cagggatttc
     3541 ccctctctag atccctgcca ggtccctctc caggaggccc ctctgctctc ctgaagggtg
     3601 gtccctgagg gtctgcccag ccttggcacg agaggttggt tccagcccct ggcagggctt
     3661 ccttccaagg gcccctgcag cctacaaact gggcctcggg cgactcaaaa taagtgctct
     3721 tgggggtggc tctaccccat tacctccccc agccacaact cctggccttc gacttctggc
     3781 tgggttagcc agaccctggt ttctctaccc tgatgttgca tgagacctgg taacagtgtc
     3841 tccctcccag ctccttgcca aagcctctgt tgagacctgg gcttcttgta gccccttctc
     3901 cctctggcca gctgcacagc ctgtgggagg tgcccggccc aggctgggtg tgggggaagc
     3961 tggtccctgc tgtgggtggc gctggggacc taggggctcc ttctgaggtt ggccttgtgg
     4021 cctctgggct gtatgcctct ggggtgtagg gaagaggcgg gaggagtcat ggggatgggg
     4081 agcggcaggg ggagagaggg gccctcgaca aaggcttggg aaatgagggg aggtggaggc
     4141 agggcagggg aagcgaagag tcagccttgg agagagcacc ctggggcctc cgtgtcgggg
     4201 tacacccagc actttgcgac ctgcggccca gcaggcgcgg aggatggcgg ggaggaagcc
     4261 agcagcccct gtgtttactg tcgtcagaaa ggtcttgtgt tttggttttg gggtttttgt
     4321 tttgtttgtg ttttgtttgg cttgtttgtt ttttaagggg aaaaaagttt gtaattattt
     4381 catccaaatc tcccgttata tatctgtgaa taataagaga ttttataata gcaagaaaat
     4441 gatgtatatt ttagtttgtt gacaaataag tcatcatgat cacgaaggac actgagaaaa
     4501 aataatttag aaccctggtt tttgtgaatt tttttgtttt gtgtttcttt gttttgagat
     4561 ttgtgtttgg tttggttttt gcactgcact aaggcaggag ggttggaggg ctgggtgcag
     4621 cctgggagtc cgatggtttt cagcaggaga cggggtgtcc cctgcagggg gctaaactgc
     4681 aggggcctga gattagctgt gaacatgtgg gagcccgatg catgtgggtc agggatctgg
     4741 gggccccccc agctggcggg aaccccaaat ggacacaaac tgtacatttg ccaatgggtt
     4801 tttttcagac catggttttt acttgcaaat aaacctgagt tcttttctgc a
//
