LOCUS       NM_005428               2892 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1),
            transcript variant 1, mRNA.
ACCESSION   NM_005428
VERSION     NM_005428.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2892)
  AUTHORS   Zhu,C., Hu,H., Ma,Y., Xiong,S. and Zhu,D.
  TITLE     Vav1-dependent Rac1 activation mediates hypoxia-induced gemcitabine
            resistance in pancreatic ductal adenocarcinoma cells through
            upregulation of HIF-1alpha expression
  JOURNAL   Cell Biol Int 47 (11), 1835-1842 (2023)
   PUBMED   37545183
  REMARK    GeneRIF: Vav1-dependent Rac1 activation mediates hypoxia-induced
            gemcitabine resistance in pancreatic ductal adenocarcinoma cells
            through upregulation of HIF-1alpha expression.
REFERENCE   2  (bases 1 to 2892)
  AUTHORS   Rump,A., Ratas,K., Lepasepp,T.K., Suurvali,J., Smolander,O.P.,
            Gross-Paju,K., Toomsoo,T., Kanellopoulos,J. and Ruutel Boudinot,S.
  TITLE     Sex-dependent expression levels of VAV1 and P2X7 in PBMC of
            multiple sclerosis patients
  JOURNAL   Scand J Immunol 98 (2), e13283 (2023)
   PUBMED   38441379
  REMARK    GeneRIF: Sex-dependent expression levels of VAV1 and P2X7 in PBMC
            of multiple sclerosis patients.
REFERENCE   3  (bases 1 to 2892)
  AUTHORS   Shalom,B., Salaymeh,Y., Risling,M. and Katzav,S.
  TITLE     Unraveling the Oncogenic Potential of VAV1 in Human Cancer: Lessons
            from Mouse Models
  JOURNAL   Cells 12 (9), 1276 (2023)
   PUBMED   37174676
  REMARK    GeneRIF: Unraveling the Oncogenic Potential of VAV1 in Human
            Cancer: Lessons from Mouse Models.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2892)
  AUTHORS   Nakamura,S., Kitazawa,M., Miyagawa,Y., Koyama,M., Miyazaki,S.,
            Hondo,N., Muranaka,F., Tokumaru,S., Yamamoto,Y., Ehara,T.,
            Matsumura,T., Takeoka,M. and Soejima,Y.
  TITLE     RhoA G17E/Vav1 Signaling Induces Cancer Invasion via Matrix
            Metalloproteinase-9 in Gastric Cancer
  JOURNAL   Technol Cancer Res Treat 22, 15330338221146024 (2023)
   PUBMED   36617975
  REMARK    GeneRIF: RhoA G17E/Vav1 Signaling Induces Cancer Invasion via
            Matrix Metalloproteinase-9 in Gastric Cancer.
REFERENCE   5  (bases 1 to 2892)
  AUTHORS   Grewal,R.K. and Das,J.
  TITLE     Spatially resolved in silico modeling of NKG2D signaling kinetics
            suggests a key role of NKG2D and Vav1 Co-clustering in generating
            natural killer cell activation
  JOURNAL   PLoS Comput Biol 18 (5), e1010114 (2022)
   PUBMED   35584138
  REMARK    GeneRIF: Spatially resolved in silico modeling of NKG2D signaling
            kinetics suggests a key role of NKG2D and Vav1 Co-clustering in
            generating natural killer cell activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2892)
  AUTHORS   Bustelo,X.R. and Barbacid,M.
  TITLE     Tyrosine phosphorylation of the vav proto-oncogene product in
            activated B cells
  JOURNAL   Science 256 (5060), 1196-1199 (1992)
   PUBMED   1375396
REFERENCE   7  (bases 1 to 2892)
  AUTHORS   Adams,J.M., Houston,H., Allen,J., Lints,T. and Harvey,R.
  TITLE     The hematopoietically expressed vav proto-oncogene shares homology
            with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene
            (CDC24) involved in cytoskeletal organization
  JOURNAL   Oncogene 7 (4), 611-618 (1992)
   PUBMED   1565462
REFERENCE   8  (bases 1 to 2892)
  AUTHORS   Bustelo,X.R., Ledbetter,J.A. and Barbacid,M.
  TITLE     Product of vav proto-oncogene defines a new class of tyrosine
            protein kinase substrates
  JOURNAL   Nature 356 (6364), 68-71 (1992)
   PUBMED   1311423
REFERENCE   9  (bases 1 to 2892)
  AUTHORS   Katzav,S., Cleveland,J.L., Heslop,H.E. and Pulido,D.
  TITLE     Loss of the amino-terminal helix-loop-helix domain of the vav
            proto-oncogene activates its transforming potential
  JOURNAL   Mol Cell Biol 11 (4), 1912-1920 (1991)
   PUBMED   2005887
REFERENCE   10 (bases 1 to 2892)
  AUTHORS   Katzav,S., Martin-Zanca,D. and Barbacid,M.
  TITLE     vav, a novel human oncogene derived from a locus ubiquitously
            expressed in hematopoietic cells
  JOURNAL   EMBO J 8 (8), 2283-2290 (1989)
   PUBMED   2477241
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC408645.1, AK313307.1 and
            BC013361.2.
            
            On Nov 23, 2018 this sequence version replaced NM_005428.3.
            
            Summary: This gene is a member of the VAV gene family. The VAV
            proteins are guanine nucleotide exchange factors (GEFs) for Rho
            family GTPases that activate pathways leading to actin cytoskeletal
            rearrangements and transcriptional alterations. The encoded protein
            is important in hematopoiesis, playing a role in T-cell and B-cell
            development and activation. The encoded protein has been identified
            as the specific binding partner of Nef proteins from HIV-1.
            Coexpression and binding of these partners initiates profound
            morphological changes, cytoskeletal rearrangements and the JNK/SAPK
            signaling cascade, leading to increased levels of viral
            transcription and replication. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene. [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.108247.1,
                                           SRR1660805.210017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000602142.6/ ENSP00000472929.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               DC408645.1         41-229
            190-1057            AK313307.1         172-1039
            1058-2892           BC013361.2         878-2712
FEATURES             Location/Qualifiers
     source          1..2892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2892
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /note="vav guanine nucleotide exchange factor 1"
                     /db_xref="GeneID:7409"
                     /db_xref="HGNC:HGNC:12657"
                     /db_xref="MIM:164875"
     exon            1..304
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2638
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /note="isoform 1 is encoded by transcript variant 1; vav 1
                     oncogene; proto-oncogene vav; vav 1 guanine nucleotide
                     exchange factor"
                     /codon_start=1
                     /product="proto-oncogene vav isoform 1"
                     /protein_id="NP_005419.2"
                     /db_xref="CCDS:CCDS12174.1"
                     /db_xref="GeneID:7409"
                     /db_xref="HGNC:HGNC:12657"
                     /db_xref="MIM:164875"
                     /translation="MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLC
                     QLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDV
                     QDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLY
                     DCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQ
                     HFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKER
                     FLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVL
                     KYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIEN
                     LDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLH
                     SFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYP
                     ENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGR
                     HGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDI
                     VELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAGAE
                     SILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTE
                     LVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDR
                     SELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYC"
     exon            305..421
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            422..480
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            481..549
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            550..658
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            659..754
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            755..823
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            824..927
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1027
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1123
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1192
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1279
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1365
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1498
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1608
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1710
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1808
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1831
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1877
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2014
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2080
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2112
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2229
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2317
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2432
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2584
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2892
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2873..2878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /note="hexamer: AATAAA"
     polyA_site      2892
                     /gene="VAV1"
                     /gene_synonym="VAV"
                     /note="major polyA site"
ORIGIN      
        1 agcactagct gtcgctccac aggcgagcag ggcaggcgtg cgggcgggtg ggtggtggag
       61 gctgcgaggg tgcacggccg gccctgggca ggcggtagcc atggagctgt ggcgccaatg
      121 cacccactgg ctcatccagt gccgggtgct gccgcccagc caccgcgtga cctgggatgg
      181 ggctcaggtg tgtgaactgg cccaggccct ccgggatggt gtccttctgt gtcagctgct
      241 taacaacctg ctaccccatg ccatcaacct gcgtgaggtc aacctgcgcc cccagatgtc
      301 ccagttcctg tgccttaaga acattagaac cttcctgtcc acctgctgtg agaagttcgg
      361 cctcaagcgg agcgagctct tcgaagcctt tgacctcttc gatgtgcagg attttggcaa
      421 ggtcatctac accctgtctg ctctgtcctg gaccccgatc gcccagaaca gggggatcat
      481 gcccttcccc accgaggagg agagtgtagg tgatgaagac atctacagtg gcctgtccga
      541 ccagatcgac gacacggtgg aggaggatga ggacctgtat gactgcgtgg agaatgagga
      601 ggcggaaggc gacgagatct atgaggacct catgcgctcg gagcccgtgt ccatgccgcc
      661 caagatgaca gagtatgaca agcgctgctg ctgcctgcgg gagatccagc agacggagga
      721 gaagtacact gacacgctgg gctccatcca gcagcatttc ttgaagcccc tgcaacggtt
      781 cctgaaacct caagacattg agatcatctt tatcaacatt gaggacctgc ttcgtgttca
      841 tactcacttc ctaaaggaga tgaaggaagc cctgggcacc cctggcgcag ccaatctcta
      901 ccaggtcttc atcaaataca aggagaggtt cctcgtctat ggccgctact gcagccaggt
      961 ggagtcagcc agcaaacacc tggaccgtgt ggccgcagcc cgggaggacg tgcagatgaa
     1021 gctggaggaa tgttctcaga gagccaacaa cgggaggttc accctgcggg acctgctgat
     1081 ggtgcctatg cagcgagttc tcaaatatca cctccttctc caggagctgg tgaaacacac
     1141 gcaggaggcg atggagaagg agaacctgcg gctggccctg gatgccatga gggacctggc
     1201 tcagtgcgtg aacgaggtca agcgagacaa cgagacactg cgacagatca ccaatttcca
     1261 gctgtccatt gagaacctgg accagtctct ggctcactat ggccggccca agatcgacgg
     1321 ggaactcaag atcacctcgg tggaacggcg ctccaagatg gacaggtatg ccttcctgct
     1381 cgacaaagct ctactcatct gtaagcgcag gggagactcc tatgacctca aggactttgt
     1441 aaacctgcac agcttccagg ttcgggatga ctcttcagga gaccgagaca acaagaagtg
     1501 gagccacatg ttcctcctga tcgaggacca aggtgcccag ggctatgagc tgttcttcaa
     1561 gacaagagaa ttgaagaaga agtggatgga gcagtttgag atggccatct ccaacatcta
     1621 tccggagaat gccaccgcca acgggcatga cttccagatg ttctcctttg aggagaccac
     1681 atcctgcaag gcctgtcaga tgctgcttag aggtaccttc tatcagggct accgctgcca
     1741 tcggtgccgg gcatctgcac acaaggagtg tctggggagg gtccctccat gtggccgaca
     1801 tgggcaagat ttcccaggaa ctatgaagaa ggacaaacta catcgcaggg ctcaggacaa
     1861 aaagaggaat gagctgggtc tgcccaagat ggaggtgttt caggaatact acgggcttcc
     1921 tccaccccct ggagccattg gaccctttct acggctcaac cctggagaca ttgtggagct
     1981 cacgaaggct gaggctgaac agaactggtg ggagggcaga aatacatcta ctaatgaaat
     2041 tggctggttt ccttgtaaca gggtgaagcc ctatgtccat ggccctcctc aggacctgtc
     2101 tgttcatctc tggtacgcag gccccatgga gcgggcaggg gcagagagca tcctggccaa
     2161 ccgctcggac gggactttct tggtgcggca gagggtgaag gatgcagcag aatttgccat
     2221 cagcattaaa tataacgtcg aggtcaagca cattaaaatc atgacagcag aaggactgta
     2281 ccggatcaca gagaaaaagg ctttccgggg gcttacggag ctggtggagt tttaccagca
     2341 gaactctcta aaggattgct tcaagtctct ggacaccacc ttgcagttcc ccttcaagga
     2401 gcctgaaaag agaaccatca gcaggccagc agtgggaagc acaaagtatt ttggcacagc
     2461 caaagcccgc tatgacttct gcgcccgaga ccgatcagag ctgtcgctca aggagggtga
     2521 catcatcaag atccttaaca agaagggaca gcaaggctgg tggcgagggg agatctatgg
     2581 ccgggttggc tggttccctg ccaactacgt ggaggaagat tattctgaat actgctgagc
     2641 cctggtgcct tggcagagag acgagaaact ccaggctctg agcccggcgt gggcaggcag
     2701 cggagccagg ggctgtgaca gctcccggcg ggtggagact ttgggatgga ctggaggagg
     2761 ccagcgtcca gctggcggtg ctcccgggat gtgccctgac atggttaatt tataacaccc
     2821 cgatttcctc ttgggtcccc tcaagcagac ggggctcaag ggggttacat ttaataaaag
     2881 gatgaagatg ga
//
