LOCUS       NM_020927               3791 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens vesicle amine transport 1 like (VAT1L), mRNA.
ACCESSION   NM_020927
VERSION     NM_020927.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3791)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3791)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3791)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 3791)
  AUTHORS   Sherva,R., Tripodis,Y., Bennett,D.A., Chibnik,L.B., Crane,P.K., de
            Jager,P.L., Farrer,L.A., Saykin,A.J., Shulman,J.M., Naj,A. and
            Green,R.C.
  CONSRTM   GENAROAD Consortium; Alzheimer's Disease Neuroimaging Initiative;
            Alzheimer's Disease Genetics Consortium
  TITLE     Genome-wide association study of the rate of cognitive decline in
            Alzheimer's disease
  JOURNAL   Alzheimers Dement 10 (1), 45-52 (2014)
   PUBMED   23535033
REFERENCE   5  (bases 1 to 3791)
  AUTHORS   Wang,K.S., Liu,X.F. and Aragam,N.
  TITLE     A genome-wide meta-analysis identifies novel loci associated with
            schizophrenia and bipolar disorder
  JOURNAL   Schizophr Res 124 (1-3), 192-199 (2010)
   PUBMED   20889312
REFERENCE   6  (bases 1 to 3791)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY132852.1, AK290153.1, BC033537.1, AC010650.9 and AA609348.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020927.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.22362.1,
                                           SRR1803611.64862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302536.3/ ENSP00000303129.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                HY132852.1         2-23
            23-1095             AK290153.1         1-1073
            1096-2909           BC033537.1         1074-2887
            2910-3782           AC010650.9         35033-35905         c
            3783-3791           AA609348.1         19-27               c
FEATURES             Location/Qualifiers
     source          1..3791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..3791
                     /gene="VAT1L"
                     /note="vesicle amine transport 1 like"
                     /db_xref="GeneID:57687"
                     /db_xref="HGNC:HGNC:29315"
                     /db_xref="MIM:620202"
     exon            1..352
                     /gene="VAT1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1379
                     /gene="VAT1L"
                     /note="vesicle amine transport protein 1 homolog-like (T.
                     californica); vesicle amine transport protein 1 homolog
                     (T. californica)-like"
                     /codon_start=1
                     /product="synaptic vesicle membrane protein VAT-1
                     homolog-like"
                     /protein_id="NP_065978.1"
                     /db_xref="CCDS:CCDS32492.1"
                     /db_xref="GeneID:57687"
                     /db_xref="HGNC:HGNC:29315"
                     /db_xref="MIM:620202"
                     /translation="MAKEGVEKAEETEQMIEKEAGKEPAEGGGGDGSHRLGDAQEMRA
                     VVLAGFGGLNKLRLFRKAMPEPQDGELKIRVKACGLNFIDLMVRQGNIDNPPKTPLVP
                     GFECSGIVEALGDSVKGYEIGDRVMAFVNYNAWAEVVCTPVEFVYKIPDDMSFSEAAA
                     FPMNFVTAYVMLFEVANLREGMSVLVHSAGGGVGQAVAQLCSTVPNVTVFGTASTFKH
                     EAIKDSVTHLFDRNADYVQEVKRISAEGVDIVLDCLCGDNTGKGLSLLKPLGTYILYG
                     SSNMVTGETKSFFSFAKSWWQVEKVNPIKLYEENKVIAGFSLLNLLFKQGRAGLIRGV
                     VEKLIGLYNQKKIKPVVDSLWALEEVKEAMQRIHDRGNIGKLILDVEKTPTPLMANDS
                     TETSEAGEEEEDHEGDSENKERMPFIQ"
     exon            353..482
                     /gene="VAT1L"
                     /inference="alignment:Splign:2.1.0"
     exon            483..698
                     /gene="VAT1L"
                     /inference="alignment:Splign:2.1.0"
     exon            699..841
                     /gene="VAT1L"
                     /inference="alignment:Splign:2.1.0"
     exon            842..945
                     /gene="VAT1L"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1001
                     /gene="VAT1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1196
                     /gene="VAT1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1280
                     /gene="VAT1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..3791
                     /gene="VAT1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3763..3768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VAT1L"
                     /note="hexamer: AATAAA"
     polyA_site      3791
                     /gene="VAT1L"
                     /note="major polyA site"
ORIGIN      
        1 attgcacagc cgagcatccc acattcaaca ggaggaaccc gcgggagagg agccccactc
       61 ccccagcgcc gcagccaccg cagccaccgc agcccgtgcg ccccgcgccc tcgagcgcca
      121 tggccaagga aggcgtggag aaggcggagg agacggagca aatgatcgag aaggaggcag
      181 gcaaggagcc ggcggagggc ggcggcggcg acggctcgca ccgcctcggg gacgcccagg
      241 agatgcgcgc ggtggtgctg gctggcttcg gggggctcaa caagctgcgg ctcttcagga
      301 aggccatgcc cgagcctcag gacggcgagc tcaagatccg cgtcaaagcc tgtggattaa
      361 acttcattga cttgatggtg cgacaaggga atattgacaa ccctcccaag actcccctgg
      421 tgccaggatt tgagtgttct gggattgttg aagctctggg ggacagcgtg aaaggatatg
      481 agattggaga ccgtgtcatg gcatttgtca attacaatgc ctgggcagag gtggtctgca
      541 caccagtgga gtttgtctac aagatcccgg atgacatgag cttctccgag gctgctgcat
      601 tccccatgaa cttcgtcaca gcctatgtga tgctgtttga agttgccaac ctccgggaag
      661 ggatgtctgt gctcgtgcac tcagctggtg ggggcgtggg tcaagctgtg gctcagctgt
      721 gttccactgt ccccaacgtg actgtctttg gaacagcctc tactttcaag catgaagcaa
      781 tcaaagactc tgtgacccac ctctttgaca gaaatgcaga ctacgtgcaa gaagttaaaa
      841 gaatctctgc tgaaggtgtg gacatcgttt tggattgcct ctgtggggac aacactggaa
      901 aaggtctcag tcttctcaaa cccctgggaa cctacatttt atatggctca tccaacatgg
      961 taactggaga gaccaagagc ttcttcagct ttgcaaaatc atggtggcag gtggagaagg
     1021 tgaaccccat caagctgtat gaggagaaca aagtcatcgc ggggttttcc cttttaaatc
     1081 tgctcttcaa acaaggccgg gcgggcctca ttcggggagt ggtggaaaaa ctcatagggc
     1141 tctacaacca gaagaagatc aagcctgtgg tggactcctt gtgggctctg gaggaggtga
     1201 aggaggccat gcagcggatt cacgaccgag ggaacattgg caagttaatt ctggatgtag
     1261 aaaagacccc aactccactg atggccaatg acagcacaga gaccagtgaa gcaggggaag
     1321 aggaggagga ccacgaggga gacagcgaga acaaggagcg gatgcccttt atccagtaac
     1381 tgaggaccca ggtgggagaa tgtgaaggat ggtttggaag atgaggaccc ggctgagaaa
     1441 actcttctgt gccccagtga acaaatgctg tagtccagtg cgtgtcgtgt ttgtctgcag
     1501 tcagctgagc taaaaagctg ttgatcactg ttgttttttg aagtgccaat cccatgccat
     1561 gcagtattat gtccctctcc tatctgtgta ttacacattc ccctctcccc tgtatcaaaa
     1621 ccatccatct gtgggttctt cttgacagtt ctagaacagc cttgcaaatt aatacaagtc
     1681 ccaggcccaa tgcctaagag accagacgtg ggcaaagaca agtttggatg gaaaggtgtt
     1741 atcacagagc cctgtccagc tcctagaatt cctcaggcca gtgacacttt tttgctgctg
     1801 gccacccatg cctctgatga gaacacttgc caatttggcc agcagaaaga gagtaggccg
     1861 gatgttttca tgagcccaca aatttagaaa ctctcctagt agtacttttt ctctctccat
     1921 ttaagagaca actacggtca aaagtttgag ccattctctt ctaccccttc agtgtctgac
     1981 cctttcactg gctcttatct gtaaacacag ggaggcaggt atggattttt cacagtagac
     2041 aatgggtcaa cagcatgagt ttgaggacct gctgtgaaga tttctcctcc aaaatacatc
     2101 tcatgggcag gattcttcct gctccatatc tgtttcaatt ttaagaaagc accacataca
     2161 agacacattc agaagtcatt cctgagcatt gctggtgttt gcacacttgc cacctgcatt
     2221 accaattctg taaatttcaa ttcctggtgg aaagtgacca ctttgaccat ggatttccca
     2281 aagaagagtt cctttgcaga ccataggtgg aaaagtcaat gagcatctcc ttccttgcca
     2341 aagcatgtcc caacatgtaa caaactctag ggatacaaaa ggtttatatt cagcatctga
     2401 tgtcagatgt acagttcctc ccctcccata tataaacccc ggtgtagaat ctgcagcgcc
     2461 ctgctcttcg gaaaccaagg aacaagccac ctgctcacac accttgttca acttttcagc
     2521 tcctaaggaa ccccaccccc atgcaatttg actgtgcttg agaggtgaat acagttacct
     2581 tcgagaaaca gagggagctc ctcaccccgt ccttccagtc cttttggcta aaatgcttaa
     2641 ctatcactca caaacaaatg tggagatacc aggagctcat ttgattcata ccccaacttt
     2701 gtgttctgaa aaacatcaga gggattttac attgcccagt ttctccacca acaagcctta
     2761 gggtggaccc aaccctttcc gcaagtggta ggaacgaatg catcttagca attacctgat
     2821 ttccaaagtc cttttgtagc aaatgtcacc tcattcgtgg tctttttacc tatcctaagc
     2881 ttatgatgat gagttatgta tgccaaatac ttatctgaag agtttctcct cattgtgaat
     2941 gtgtatgtaa aatatgaaga caagaaaggg tgctttcatc tgaggaacca aggggtgaga
     3001 gtatcccaaa ggaggacacc agcatcatct tttcttcgta ctccaggacc caccaatatt
     3061 ccagttctgg gtcatttaga gagataatgg ggcgtttatt cccctattac ctttgctaag
     3121 tgctatatta ttggctgttt ctcccgtaac catgctgaaa agggggtctt agggagaact
     3181 gtcatccaag tggcattcct agtaagttgg gtagaaatga cattttccag agctgaagga
     3241 gtgaagagcc cttggccata ctagggctct ccttcccccg gggagtggga actcagccac
     3301 attcagaatt cacatcgcct ttgttatgtc cagaggagag gcataaaaag gcactctccc
     3361 ccaccacccc taccaaatct gggtttggtt tggttttatt taactagcaa agttaatcca
     3421 gtaatcgcaa attactccag atggttaaag aaaacccttt cagaatacag aacgagaaaa
     3481 ctagagtttg accaataaga ccaatttctg ccatgaagaa ccgggggacg caagttaatt
     3541 gtttaacgta ctctcatttt aagcaccttc tttcctgtct cttgattgtt ttttctgaag
     3601 gaagtgtaaa gaatgtctca gtctgcctta aaggaactgt gaaggcttct ctgtaattta
     3661 agcttgatag aagtgaactg aaacattgtc taatgtcttt gtggctttag agcttttgtt
     3721 atattgtgcc tataaagcaa attatgttta cataaaaata taaataaagt attcagcata
     3781 gcaaaacctc a
//
