LOCUS       NM_006373               2699 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens vesicle amine transport 1 (VAT1), mRNA.
ACCESSION   NM_006373 XR_017880
VERSION     NM_006373.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2699)
  AUTHORS   Ikemizu,A., Hatta,D., Fujimoto,K., Honda,M., Watanabe,K.,
            Ohyama,K., Kuroda,N., Tanaka,T., Shirotani,K. and Iwata,N.
  TITLE     Identification and Characterization of Synaptic Vesicle Membrane
            Protein VAT-1 Homolog as a New Catechin-Binding Protein
  JOURNAL   Biol Pharm Bull 47 (2), 509-517 (2024)
   PUBMED   38403661
  REMARK    GeneRIF: Identification and Characterization of Synaptic Vesicle
            Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein.
REFERENCE   2  (bases 1 to 2699)
  AUTHORS   Yang,P., Wang,K., Zhang,C., Wang,Z., Liu,Q., Wang,J., Jiang,T. and
            Shan,X.
  TITLE     Novel roles of VAT1 expression in the immunosuppressive action of
            diffuse gliomas
  JOURNAL   Cancer Immunol Immunother 70 (9), 2589-2600 (2021)
   PUBMED   33576871
  REMARK    GeneRIF: Novel roles of VAT1 expression in the immunosuppressive
            action of diffuse gliomas.
REFERENCE   3  (bases 1 to 2699)
  AUTHORS   Kim,S.Y., Mori,T., Chek,M.F., Furuya,S., Matsumoto,K., Yajima,T.,
            Ogura,T. and Hakoshima,T.
  TITLE     Structural insights into vesicle amine transport-1 (VAT-1) as a
            member of the NADPH-dependent quinone oxidoreductase family
  JOURNAL   Sci Rep 11 (1), 2120 (2021)
   PUBMED   33483563
  REMARK    GeneRIF: Structural insights into vesicle amine transport-1 (VAT-1)
            as a member of the NADPH-dependent quinone oxidoreductase family.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2699)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2699)
  AUTHORS   Watanabe,Y., Tamura,Y., Kakuta,C., Watanabe,S. and Endo,T.
  TITLE     Structural basis for interorganelle phospholipid transport mediated
            by VAT-1
  JOURNAL   J Biol Chem 295 (10), 3257-3268 (2020)
   PUBMED   32005660
  REMARK    GeneRIF: Structural basis for interorganelle phospholipid transport
            mediated by VAT-1.
REFERENCE   6  (bases 1 to 2699)
  AUTHORS   Smith,T.M., Lee,M.K., Szabo,C.I., Jerome,N., McEuen,M., Taylor,M.,
            Hood,L. and King,M.C.
  TITLE     Complete genomic sequence and analysis of 117 kb of human DNA
            containing the gene BRCA1
  JOURNAL   Genome Res 6 (11), 1029-1049 (1996)
   PUBMED   8938427
REFERENCE   7  (bases 1 to 2699)
  AUTHORS   Harshman,K., Bell,R., Rosenthal,J., Katcher,H., Miki,Y.,
            Swenson,J., Gholami,Z., Frye,C., Ding,W., Dayananth,P. et al.
  TITLE     Comparison of the positional cloning methods used to isolate the
            BRCA1 gene
  JOURNAL   Hum Mol Genet 4 (8), 1259-1266 (1995)
   PUBMED   7581362
REFERENCE   8  (bases 1 to 2699)
  AUTHORS   Friedman,L.S., Ostermeyer,E.A., Lynch,E.D., Szabo,C.I.,
            Anderson,L.A., Dowd,P., Lee,M.K., Rowell,S.E., Boyd,J. and
            King,M.C.
  TITLE     The search for BRCA1
  JOURNAL   Cancer Res 54 (24), 6374-6382 (1994)
   PUBMED   7987831
REFERENCE   9  (bases 1 to 2699)
  AUTHORS   Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
            Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
  TITLE     A strong candidate for the breast and ovarian cancer susceptibility
            gene BRCA1
  JOURNAL   Science 266 (5182), 66-71 (1994)
   PUBMED   7545954
REFERENCE   10 (bases 1 to 2699)
  AUTHORS   Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135721.4 and AC055866.19.
            
            On Nov 22, 2018 this sequence version replaced NM_006373.3.
            
            Summary: Synaptic vesicles are responsible for regulating the
            storage and release of neurotransmitters in the nerve terminal. The
            protein encoded by this gene is an abundant integral membrane
            protein of cholinergic synaptic vesicles and is thought to be
            involved in vesicular transport. It belongs to the quinone
            oxidoreductase subfamily of zinc-containing alcohol dehydrogenase
            proteins. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090858.1, BC015041.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355653.8/ ENSP00000347872.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               AC135721.4         137035-137484
            451-658             AC055866.19        202883-203090       c
            659-829             AC055866.19        202327-202497       c
            830-919             AC055866.19        202132-202221       c
            920-1161            AC055866.19        200598-200839       c
            1162-2699           AC055866.19        198898-200435       c
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2699
                     /gene="VAT1"
                     /gene_synonym="VATI"
                     /note="vesicle amine transport 1"
                     /db_xref="GeneID:10493"
                     /db_xref="HGNC:HGNC:16919"
                     /db_xref="MIM:604631"
     exon            1..450
                     /gene="VAT1"
                     /gene_synonym="VATI"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1245
                     /gene="VAT1"
                     /gene_synonym="VATI"
                     /note="membrane protein of cholinergic synaptic vesicles;
                     vesicle amine transport protein 1 homolog (T.
                     californica)"
                     /codon_start=1
                     /product="synaptic vesicle membrane protein VAT-1 homolog"
                     /protein_id="NP_006364.2"
                     /db_xref="CCDS:CCDS11451.1"
                     /db_xref="GeneID:10493"
                     /db_xref="HGNC:HGNC:16919"
                     /db_xref="MIM:604631"
                     /translation="MSDEREVAEAATGEDASSPPPKTEAASDPQHPAASEGAAAAAAS
                     PPLLRCLVLTGFGGYDKVKLQSRPAAPPAPGPGQLTLRLRACGLNFADLMARQGLYDR
                     LPPLPVTPGMEGAGVVIAVGEGVSDRKAGDRVMVLNRSGMWQEEVTVPSVQTFLIPEA
                     MTFEEAAALLVNYITAYMVLFDFGNLQPGHSVLVHMAAGGVGMAAVQLCRTVENVTVF
                     GTASASKHEALKENGVTHPIDYHTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYNLL
                     KPMGKVVTYGMANLLTGPKRNLMALARTWWNQFSVTALQLLQANRAVCGFHLGYLDGE
                     VELVSGVVARLLALYNQGHIKPHIDSVWPFEKVADAMKQMQEKKNVGKVLLVPGPEKE
                     N"
     exon            451..658
                     /gene="VAT1"
                     /gene_synonym="VATI"
                     /inference="alignment:Splign:2.1.0"
     exon            659..829
                     /gene="VAT1"
                     /gene_synonym="VATI"
                     /inference="alignment:Splign:2.1.0"
     exon            830..919
                     /gene="VAT1"
                     /gene_synonym="VATI"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1161
                     /gene="VAT1"
                     /gene_synonym="VATI"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..2699
                     /gene="VAT1"
                     /gene_synonym="VATI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2681..2686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VAT1"
                     /gene_synonym="VATI"
                     /note="hexamer: AATAAA"
     polyA_site      2699
                     /gene="VAT1"
                     /gene_synonym="VATI"
                     /note="major polyA site"
ORIGIN      
        1 gttccgcctt ccccagctgt gcactctcca tccagctgtg cgctctcgtc gggagtccca
       61 gccatgtccg acgagagaga ggtagccgag gcagcgaccg gggaagacgc ctcttcgccg
      121 cctccgaaaa ccgaggcagc gagcgacccc cagcatcccg cggcctccga aggggccgcc
      181 gccgccgccg cctcgccgcc actgctgcgc tgcctagtgc tcaccggctt tggaggctac
      241 gacaaggtga agctgcagag ccggccggca gcgcccccgg cccctgggcc cggccagctg
      301 acgctgcgtc tgcgggcctg cgggctcaac ttcgcagacc tcatggctag gcaggggctg
      361 tacgaccgtc tcccgcctct gcctgtcact ccgggcatgg agggcgcggg tgttgtgatc
      421 gcagtgggcg agggagtcag cgaccgcaag gcaggagacc gggtgatggt gttgaaccgg
      481 tcagggatgt ggcaggaaga ggtgactgtg ccctcggtcc agaccttcct gattcctgag
      541 gccatgacct ttgaggaagc tgctgccttg ctcgtcaatt acattacagc ctacatggtc
      601 ctctttgact tcggcaacct acagcctggc cacagcgtct tggtacacat ggctgcaggg
      661 ggtgtgggta tggctgccgt gcagctgtgc cgtacagtgg agaatgtgac agtgttcgga
      721 acggcctcgg ccagcaagca cgaggcactg aaggagaatg gggtcacaca tcccatcgac
      781 tatcacacga ctgactacgt ggatgagatc aagaagattt cccctaaagg agtggacatt
      841 gtcatggacc ctctgggtgg gtcagatact gccaagggct acaacctcct gaaacccatg
      901 ggcaaagtcg tcacctatgg aatggccaac ctgctgacgg gccccaaacg gaacctgatg
      961 gccctggccc ggacatggtg gaatcagttc agcgtgacag ctctgcagct gctgcaggcc
     1021 aaccgggctg tgtgtggctt ccacctgggc tacctggatg gtgaggtgga gctggtcagt
     1081 ggtgtggtgg cccgcctcct ggctctgtac aaccagggcc acatcaagcc ccacattgac
     1141 tcagtctggc ccttcgagaa ggtggctgat gccatgaaac agatgcagga gaagaagaat
     1201 gtgggcaagg tcctcctggt tccagggcca gagaaggaga actagggcaa gtggctgtga
     1261 gaccctagag accagcgaag ggagaagttg ggaagctacg ttctgttggc caccagactt
     1321 gcatttcagc ctctgtcata atgctctgcc ctccctcccc cgaaggtctc tgtggtgatg
     1381 accgctctcc cctgcccctc cccgcttcct gacctctgaa gaggttggga agtgaccatt
     1441 tggatgtctg ggccctgcca aggcgacagg gagggtcaga gggaggccgg ctgcttcctg
     1501 cccccaccct ttccccgggc ctgctgtgct gcttttgtgc caaggttagc cagtcccccc
     1561 tgttgtgttc catgtgcttt cacctctgcc tcatctttcc tcccgtccct gccccgccac
     1621 ctccccaaag aattgaaacg tcagctcagg atatggggcc aatctctgtg agtccagcat
     1681 gtacctgtct ctccctagtg tcccttcagc ctgggctgac cagtgcccgc ctctgggctt
     1741 gaccagttcc caatctcgtc ctctgtcccc aacttcttaa gcacaattgg gcttcttcca
     1801 tctccaggtt ttctgccatt cttaaccaag gctgcctctt ccaacagggc gggaatcaga
     1861 cctactcccc taggtcacaa ctctgggaag gatacagagc ccccaccctt cactgagttc
     1921 tctggatttg ttctcagtgc cttagcaacg aaaacctgtg cttgtgtgtg tgtggcggcg
     1981 gggagggagg atcctgtttc ccacctcctt ctcctcccct gtactcccca gtgccttcct
     2041 tgttctggtg gagctggggt ttctctcctc cccagtccca caacactgcc aaaaatctgt
     2101 gtatgtgcca ttgggtgggg cagccccaag cctcctgggg aggcagggca aaaacaggtg
     2161 ccctcatcgt ggtctgtgcc atgtcccgtc tctatggtgg ttgaggagaa aggcggggaa
     2221 gcttcctcag ccttgcagat atgtgtggca tttactagcc agagctctga aaggcagtgc
     2281 tgtctgtttc ttgtactggg accaaagtaa aaatccaagc acattcccct tgcagttagg
     2341 ggaggcccta ctgccttctc aaagcagaga ggcagcttat caaactcagc ccaaaactct
     2401 gtttacatgg gtggggagat ggagcaggga agtacagagt gggatggtca ggacctgggc
     2461 cattgcaacc aaaatgggga cttcctgggt agggaggtca ctccctctac tcactgagct
     2521 aggattaggg agggttattg ccccaaccat tgcaatggga ggtggaggga caggctcagc
     2581 ctcctcattg tctaaatgag gcctaaatgt gtgaagtgcg atttctgctt ttgtgtaccc
     2641 caccacccca ttaccacagc tgcctttgtg tgtttgtgtc aataaaaagc caaaccctg
//
