LOCUS       NM_138440               2816 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens vasorin (VASN), mRNA.
ACCESSION   NM_138440
VERSION     NM_138440.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2816)
  AUTHORS   Qin,Z., Zhong,Y., Li,P., Ma,Z., Kang,H., Huang,Y., Zhong,Y. and
            Wang,L.
  TITLE     Vasorin promotes endothelial differentiation of glioma stem cells
            via stimulating the transcription of VEGFR2
  JOURNAL   FASEB J 38 (10), e23682 (2024)
   PUBMED   38780524
  REMARK    GeneRIF: Vasorin promotes endothelial differentiation of glioma
            stem cells via stimulating the transcription of VEGFR2.
REFERENCE   2  (bases 1 to 2816)
  AUTHORS   Liang,J. and Smith,A.W.
  TITLE     The Oligomeric State of Vasorin in the Plasma Membrane Measured
            Non-Invasively by Quantitative Fluorescence Fluctuation
            Spectroscopy
  JOURNAL   Int J Mol Sci 25 (7), 4115 (2024)
   PUBMED   38612924
  REMARK    GeneRIF: The Oligomeric State of Vasorin in the Plasma Membrane
            Measured Non-Invasively by Quantitative Fluorescence Fluctuation
            Spectroscopy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2816)
  AUTHORS   Wan,F., Li,H., Huang,S., Sun,J., Li,J., Li,Y., Yang,L. and He,M.
  TITLE     Vasorin promotes proliferation and migration via STAT3 signaling
            and acts as a promising therapeutic target of hepatocellular
            carcinoma
  JOURNAL   Cell Signal 110, 110809 (2023)
   PUBMED   37454705
  REMARK    GeneRIF: Vasorin promotes proliferation and migration via STAT3
            signaling and acts as a promising therapeutic target of
            hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 2816)
  AUTHORS   Taggi,M., Liuzzi,F., Botticelli,L., De Carlini,S., Longo,M.,
            Donno,V., Fabbiani,L. and La Marca,A.
  TITLE     Evidence for the expression of vasorin in the human female
            reproductive tissues
  JOURNAL   Gynecol Endocrinol 39 (1), 2224457 (2023)
   PUBMED   37331376
  REMARK    GeneRIF: Evidence for the expression of vasorin in the human female
            reproductive tissues.
REFERENCE   5  (bases 1 to 2816)
  AUTHORS   Zhou,J., Peng,X., Ru,Y. and Xu,J.
  TITLE     Circ_0060077 Knockdown Alleviates High-Glucose-Induced Cell
            Apoptosis, Oxidative Stress, Inflammation and Fibrosis in HK-2
            Cells via miR-145-5p/VASN Pathway
  JOURNAL   Inflammation 45 (5), 1911-1923 (2022)
   PUBMED   35729462
  REMARK    GeneRIF: Circ_0060077 Knockdown Alleviates High-Glucose-Induced
            Cell Apoptosis, Oxidative Stress, Inflammation and Fibrosis in HK-2
            Cells via miR-145-5p/VASN Pathway.
            Erratum:[Inflammation. 2023 Apr;46(2):780. doi:
            10.1007/s10753-022-01740-y.. PMID: 36112240]
REFERENCE   6  (bases 1 to 2816)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 2816)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   8  (bases 1 to 2816)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   9  (bases 1 to 2816)
  AUTHORS   Ikeda,Y., Imai,Y., Kumagai,H., Nosaka,T., Morikawa,Y., Hisaoka,T.,
            Manabe,I., Maemura,K., Nakaoka,T., Imamura,T., Miyazono,K.,
            Komuro,I., Nagai,R. and Kitamura,T.
  TITLE     Vasorin, a transforming growth factor beta-binding protein
            expressed in vascular smooth muscle cells, modulates the arterial
            response to injury in vivo
  JOURNAL   Proc Natl Acad Sci U S A 101 (29), 10732-10737 (2004)
   PUBMED   15247411
  REMARK    GeneRIF: results suggest that down-regulation of vasorin expression
            contributes to neointimal formation after vascular injury and that
            vasorin modulates cellular responses to pathological stimuli in the
            vessel wall [vasorin]
REFERENCE   10 (bases 1 to 2816)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC068575.1, BC013767.1 and AC012676.5.
            
            On Nov 23, 2018 this sequence version replaced NM_138440.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068575.1, AY358299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304735.4/ ENSP00000306864.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-478               BC068575.1         1-478
            479-2806            BC013767.1         108-2435
            2807-2816           AC012676.5         83897-83906
FEATURES             Location/Qualifiers
     source          1..2816
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2816
                     /gene="VASN"
                     /gene_synonym="SLITL2"
                     /note="vasorin"
                     /db_xref="GeneID:114990"
                     /db_xref="HGNC:HGNC:18517"
                     /db_xref="MIM:608843"
     exon            1..146
                     /gene="VASN"
                     /gene_synonym="SLITL2"
                     /inference="alignment:Splign:2.1.0"
     exon            147..2816
                     /gene="VASN"
                     /gene_synonym="SLITL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2177
                     /gene="VASN"
                     /gene_synonym="SLITL2"
                     /note="protein slit-like 2"
                     /codon_start=1
                     /product="vasorin precursor"
                     /protein_id="NP_612449.2"
                     /db_xref="CCDS:CCDS10514.1"
                     /db_xref="GeneID:114990"
                     /db_xref="HGNC:HGNC:18517"
                     /db_xref="MIM:608843"
                     /translation="MCSRVPLLLPLLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGT
                     TVPRDVPPDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANL
                     SNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNEL
                     RALPPLRLPRLLLLDLSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNL
                     HDLDVSDNQLERVPPVIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSL
                     QALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKN
                     AGRLLLELDYADFGCPATTTTATVPTTRPVVREPTALSSSLAPTWLSPTEPATEAPSP
                     PSTAPPTVGPVPQPQDCPPSTCLNGGTCHLGTRHHLACLCPEGFTGLYCESQMGQGTR
                     PSPTPVTPRPPRSLTLGIEPVSPTSLRVGLQRYLQGSSVQLRSLRLTYRNLSGPDKRL
                     VTLRLPASLAEYTVTQLRPNATYSVCVMPLGPGRVPEGEEACGEAHTPPAVHSNHAPV
                     TQAREGNLPLLIAPALAAVLLAALAAVGAAYCVRRGRAMAAAAQDKGQVGPGAGPLEL
                     EGVKVPLEPGPKATEGGGEALPSGSECEVPLMGFPGPGLQSPLHAKPYI"
     regulatory      2663..2668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VASN"
                     /gene_synonym="SLITL2"
                     /note="hexamer: AATATA"
     polyA_site      2683
                     /gene="VASN"
                     /gene_synonym="SLITL2"
                     /note="major polyA site"
ORIGIN      
        1 gactccggag cccgagcccg gggcgggtgg acgcggactc gaacgcagtt gcttcgggac
       61 ccaggacccc ctcgggcccg acccgccagg aaagactgag gccgcggcct gccccgcccg
      121 gctccctgcg ccgccgccgc ctcccgggac agaagatgtg ctccagggtc cctctgctgc
      181 tgccgctgct cctgctactg gccctggggc ctggggtgca gggctgccca tccggctgcc
      241 agtgcagcca gccacagaca gtcttctgca ctgcccgcca ggggaccacg gtgccccgag
      301 acgtgccacc cgacacggtg gggctgtacg tctttgagaa cggcatcacc atgctcgacg
      361 caggcagctt tgccggcctg ccgggcctgc agctcctgga cctgtcacag aaccagatcg
      421 ccagcctgcc cagcggggtc ttccagccac tcgccaacct cagcaacctg gacctgacag
      481 ccaacaggct gcatgaaatc accaatgaga ccttccgtgg cctgcggcgc ctcgagcgcc
      541 tctacctggg caagaaccgc atccgccaca tccagcctgg tgccttcgac acgctcgacc
      601 gcctcctgga gctcaagctg caggacaacg agctgcgggc actgcccccg ctgcgcctgc
      661 cccgcctgct gctgctggac ctcagccaca acagcctcct ggccctggag cccggcatcc
      721 tggacactgc caacgtggag gcgctgcggc tggctggtct ggggctgcag cagctggacg
      781 aggggctctt cagccgcttg cgcaacctcc acgacctgga tgtgtccgac aaccagctgg
      841 agcgagtgcc acctgtgatc cgaggcctcc ggggcctgac gcgcctgcgg ctggccggca
      901 acacccgcat tgcccagctg cggcccgagg acctggccgg cctggctgcc ctgcaggagc
      961 tggatgtgag caacctaagc ctgcaggccc tgcctggcga cctctcgggc ctcttccccc
     1021 gcctgcggct gctggcagct gcccgcaacc ccttcaactg cgtgtgcccc ctgagctggt
     1081 ttggcccctg ggtgcgcgag agccacgtca cactggccag ccctgaggag acgcgctgcc
     1141 acttcccgcc caagaacgct ggccggctgc tcctggagct tgactacgcc gactttggct
     1201 gcccagccac caccaccaca gccacagtgc ccaccacgag gcccgtggtg cgggagccca
     1261 cagccttgtc ttctagcttg gctcctacct ggcttagccc cacagagccg gccactgagg
     1321 cccccagccc gccctccact gccccaccga ctgtagggcc tgtcccccag ccccaggact
     1381 gcccaccgtc cacctgcctc aatgggggca catgccacct ggggacacgg caccacctgg
     1441 cgtgcttgtg ccccgaaggc ttcacgggcc tgtactgtga gagccagatg gggcagggga
     1501 cacggcccag ccctacacca gtcacgccga ggccaccacg gtccctgacc ctgggcatcg
     1561 agccggtgag ccccacctcc ctgcgcgtgg ggctgcagcg ctacctccag gggagctccg
     1621 tgcagctcag gagcctccgt ctcacctatc gcaacctatc gggccctgat aagcggctgg
     1681 tgacgctgcg actgcctgcc tcgctcgctg agtacacggt cacccagctg cggcccaacg
     1741 ccacttactc cgtctgtgtc atgcctttgg ggcccgggcg ggtgccggag ggcgaggagg
     1801 cctgcgggga ggcccataca cccccagccg tccactccaa ccacgcccca gtcacccagg
     1861 cccgcgaggg caacctgccg ctcctcattg cgcccgccct ggccgcggtg ctcctggccg
     1921 cgctggctgc ggtgggggca gcctactgtg tgcggcgggg gcgggccatg gcagcagcgg
     1981 ctcaggacaa agggcaggtg gggccagggg ctgggcccct ggaactggag ggagtgaagg
     2041 tccccttgga gccaggcccg aaggcaacag agggcggtgg agaggccctg cccagcgggt
     2101 ctgagtgtga ggtgccactc atgggcttcc cagggcctgg cctccagtca cccctccacg
     2161 caaagcccta catctaagcc agagagagac agggcagctg gggccgggct ctcagccagt
     2221 gagatggcca gccccctcct gctgccacac cacgtaagtt ctcagtccca acctcgggga
     2281 tgtgtgcaga cagggctgtg tgaccacagc tgggccctgt tccctctgga cctcggtctc
     2341 ctcatctgtg agatgctgtg gcccagctga cgagccctaa cgtccccaga accgagtgcc
     2401 tatgaggaca gtgtccgccc tgccctccgc aacgtgcagt ccctgggcac ggcgggccct
     2461 gccatgtgct ggtaacgcat gcctgggccc tgctgggctc tcccactcca ggcggaccct
     2521 gggggccagt gaaggaagct cccggaaaga gcagagggag agcgggtagg cggctgtgtg
     2581 actctagtct tggccccagg aagcgaagga acaaaagaaa ctggaaagga agatgcttta
     2641 ggaacatgtt ttgctttttt aaaatatata tatatttata agagatcctt tcccatttat
     2701 tctgggaaga tgtttttcaa actcagagac aaggactttg gtttttgtaa gacaaacgat
     2761 gatatgaagg ccttttgtaa gaaaaaataa aagatgaagt gtgtttcttg ggctca
//
