LOCUS       NM_001301056            4473 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens vasohibin 2 (VASH2), transcript variant 4, mRNA.
ACCESSION   NM_001301056 XM_006711541
VERSION     NM_001301056.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4473)
  AUTHORS   Ding,Y., Su,N., Luan,J., Xu,J., Qiu,S. and Sun,Z.
  TITLE     High Vasohibin-2 expression correlated with autophagy in
            proliferative diabetic retinopathy
  JOURNAL   Exp Eye Res 240, 109808 (2024)
   PUBMED   38278467
  REMARK    GeneRIF: High Vasohibin-2 expression correlated with autophagy in
            proliferative diabetic retinopathy.
REFERENCE   2  (bases 1 to 4473)
  AUTHORS   Liu,W., Fu,Y., Wang,M., Zhao,J., Chen,J., Wang,Y. and Qin,H.
  TITLE     A preliminary study on the mechanism of VASH2 in childhood
            medulloblastoma
  JOURNAL   Sci Rep 13 (1), 17153 (2023)
   PUBMED   37821528
  REMARK    GeneRIF: A preliminary study on the mechanism of VASH2 in childhood
            medulloblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4473)
  AUTHORS   Isoda,R., Morita,I., Ishida,A., Mikami,Y., Monobe,Y., Sato,Y. and
            Moriya,T.
  TITLE     Pathological Study on the Expression of Vasohibins in Peripheral
            Artery Disease
  JOURNAL   Tohoku J Exp Med 258 (2), 121-128 (2022)
   PUBMED   35922907
  REMARK    GeneRIF: Pathological Study on the Expression of Vasohibins in
            Peripheral Artery Disease.
REFERENCE   4  (bases 1 to 4473)
  AUTHORS   Wang,J., Yu,C., Jiang,X., Wu,X., Jia,Y., Zhang,H. and Li,Z.
  TITLE     [Vasohibin-2 promotes proliferation and metastasis of cervical
            cancer cells by regulating epithelial-mesenchymal transition]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (7), 966-975 (2022)
   PUBMED   35869758
  REMARK    GeneRIF: [Vasohibin-2 promotes proliferation and metastasis of
            cervical cancer cells by regulating epithelial-mesenchymal
            transition].
REFERENCE   5  (bases 1 to 4473)
  AUTHORS   Inoue,C., Miki,Y., Saito-Koyama,R., Kobayashi,K., Seyama,K.,
            Okada,Y. and Sasano,H.
  TITLE     Vasohibin-1 and -2 in pulmonary lymphangioleiomyomatosis (LAM)
            cells associated with angiogenic and prognostic factors
  JOURNAL   Pathol Res Pract 230, 153758 (2022)
   PUBMED   35026646
  REMARK    GeneRIF: Vasohibin-1 and -2 in pulmonary lymphangioleiomyomatosis
            (LAM) cells associated with angiogenic and prognostic factors.
REFERENCE   6  (bases 1 to 4473)
  AUTHORS   Xue,X., Gao,W., Sun,B., Xu,Y., Han,B., Wang,F., Zhang,Y., Sun,J.,
            Wei,J., Lu,Z., Zhu,Y., Sato,Y., Sekido,Y., Miao,Y. and Kondo,Y.
  TITLE     Vasohibin 2 is transcriptionally activated and promotes
            angiogenesis in hepatocellular carcinoma
  JOURNAL   Oncogene 32 (13), 1724-1734 (2013)
   PUBMED   22614011
  REMARK    GeneRIF: VASH2 contributes to the angiogenesis in hepatocellular
            carcinoma via an Small vasohibin binding protein-mediated paracrine
            mechanism.
REFERENCE   7  (bases 1 to 4473)
  AUTHORS   Shen,Z., Kauttu,T., Seppanen,H., Vainionpaa,S., Ye,Y., Wang,S.,
            Mustonen,H. and Puolakkainen,P.
  TITLE     Vasohibin-1 and vasohibin-2 expression in gastric cancer cells and
            TAMs
  JOURNAL   Med Oncol 29 (4), 2718-2726 (2012)
   PUBMED   22438034
  REMARK    GeneRIF: vasohibin-1 and vasohibin-2 mRNA are expressed in gastric
            cancer cells and in tumor-associated macrophages (TAMs), and their
            expressions are altered by hypoxia.
REFERENCE   8  (bases 1 to 4473)
  AUTHORS   Takahashi,Y., Koyanagi,T., Suzuki,Y., Saga,Y., Kanomata,N.,
            Moriya,T., Suzuki,M. and Sato,Y.
  TITLE     Vasohibin-2 expressed in human serous ovarian adenocarcinoma
            accelerates tumor growth by promoting angiogenesis
  JOURNAL   Mol Cancer Res 10 (9), 1135-1146 (2012)
   PUBMED   22826464
  REMARK    GeneRIF: VASH2 expressed in serous ovarian carcinoma cells promoted
            tumor growth and peritoneal dissemination by promoting
            angiogenesis.
REFERENCE   9  (bases 1 to 4473)
  AUTHORS   Kimura,H., Miyashita,H., Suzuki,Y., Kobayashi,M., Watanabe,K.,
            Sonoda,H., Ohta,H., Fujiwara,T., Shimosegawa,T. and Sato,Y.
  TITLE     Distinctive localization and opposed roles of vasohibin-1 and
            vasohibin-2 in the regulation of angiogenesis
  JOURNAL   Blood 113 (19), 4810-4818 (2009)
   PUBMED   19204325
REFERENCE   10 (bases 1 to 4473)
  AUTHORS   Shibuya,T., Watanabe,K., Yamashita,H., Shimizu,K., Miyashita,H.,
            Abe,M., Moriya,T., Ohta,H., Sonoda,H., Shimosegawa,T., Tabayashi,K.
            and Sato,Y.
  TITLE     Isolation and characterization of vasohibin-2 as a homologue of
            VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin
  JOURNAL   Arterioscler Thromb Vasc Biol 26 (5), 1051-1057 (2006)
   PUBMED   16528006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290973.1, CB960087.1, AY834202.1 and AL592449.8.
            
            On Jun 2, 2019 this sequence version replaced NM_001301056.1.
            
            Transcript Variant: This variant (4) contains two alternate
            in-frame exons, compared to variant 1. The encoded isoform (4) is
            longer than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1597307.1,
                                           SRR14038193.4422070.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000517399.3/ ENSP00000428324.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AK290973.1         22-64
            44-404              CB960087.1         28-388
            405-1472            AY834202.1         1-1068
            1473-4473           AL592449.8         58028-61028
FEATURES             Location/Qualifiers
     source          1..4473
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..4473
                     /gene="VASH2"
                     /note="vasohibin 2"
                     /db_xref="GeneID:79805"
                     /db_xref="HGNC:HGNC:25723"
                     /db_xref="MIM:610471"
     exon            1..200
                     /gene="VASH2"
                     /inference="alignment:Splign:2.1.0"
     exon            201..680
                     /gene="VASH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..1472
                     /gene="VASH2"
                     /EC_number="3.4.17.17"
                     /note="isoform 4 is encoded by transcript variant 4;
                     vasohibin-like protein; testicular tissue protein Li 222;
                     tubulinyl-Tyr carboxypeptidase 2"
                     /codon_start=1
                     /product="tubulinyl-Tyr carboxypeptidase 2 isoform 4"
                     /protein_id="NP_001287985.1"
                     /db_xref="CCDS:CCDS73026.1"
                     /db_xref="GeneID:79805"
                     /db_xref="HGNC:HGNC:25723"
                     /db_xref="MIM:610471"
                     /translation="MTGSAADTHRCPHPKGAKGTRSRSSHARPVSLATSGGSEEEDKD
                     GGVLFHVNKSGFPIDSHTWERMWMHVAKVHPKGGEMVGAIRNAAFLAKPSIPQVPNYR
                     LSMTIPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLE
                     AVILGIYLTNGQPSIERFPISFKTYFSGNYFHHVVLGIYCNGRYGSLGMSRRAELMDK
                     PLTFRTLSDLIFDFEDSYKKYLHTVKKVKIGLYVPHEPHSFQPIEWKQLVLNVSKMLR
                     ADIRKELEKYARDMRMKILKPASAHSPTQVRSRGKSLSPRRRQASPPRRLGRREKSPA
                     LPEKKVADLSTLNEVGYQIRI"
     exon            681..769
                     /gene="VASH2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..826
                     /gene="VASH2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..901
                     /gene="VASH2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1283
                     /gene="VASH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1399
                     /gene="VASH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..4473
                     /gene="VASH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4450..4455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VASH2"
                     /note="hexamer: AATAAA"
     polyA_site      4473
                     /gene="VASH2"
                     /note="major polyA site"
ORIGIN      
        1 attcggaaca tcggcggctg cccgggtgac ttggttatat gtcacagaat aacattcgag
       61 aatgggacat ggaatgaggc gacggcccca gcaagcccca gcagccccag ccccagcccc
      121 aggcccagca gcagcagcag cagcccctgc tctcccgccg cccggagagg ctctgcagcc
      181 atgaagccaa ccgtcccgag gcaccgccgg taagcaggga gcctccgcgg agctcccgcc
      241 gccgctcccc cttggtgagt cctgccgcag cgagaggcat ggagaaggcc gcccccgcgg
      301 ggcgctgatc ccctcgccgc gcccgcgcgc acacgccccc cgccgccgcc gccgctgccg
      361 ccgccgcgcg cccccagtac ctcgctcccc gcccaggccc caccatgacc ggctccgcgg
      421 ccgacactca ccgctgcccc caccccaaag gcgccaaagg cacccggtcc cggagcagcc
      481 acgcgcggcc cgtgagcctc gccaccagcg ggggctcaga ggaggaggac aaagacggcg
      541 gggtgctgtt ccacgtcaac aagagcggct tccccatcga cagccacacc tgggagcgca
      601 tgtggatgca cgtggccaag gtgcacccta aggggggaga aatggtgggc gccatcagga
      661 acgccgcctt cttggcaaag ccttcaatac cccaggtccc aaactacagg ctgtcgatga
      721 cgatcccaga ctggctccag gcgatccaga attacatgaa gaccctacaa tataatcaca
      781 cagggaccca gttctttgaa attaggaaaa tgagaccgct gagtgggtta atggaaacag
      841 caaaagaaat gacccgagag tccttgccta tcaaatgcct tgaagctgtc atcctgggca
      901 tctacttaac caatgggcag ccttccattg agcggttccc catcagcttt aaaacctact
      961 tctcaggaaa ctactttcac cacgttgtgc tggggattta ctgcaatggc cgctatggct
     1021 cattgggcat gagccgcagg gctgagctga tggacaagcc attgactttt cggactctga
     1081 gtgacctcat ctttgacttt gaggactctt acaagaaata cctgcacaca gtcaagaagg
     1141 tcaagattgg gctgtacgtc ccccatgagc ctcatagctt ccagcccatt gagtggaagc
     1201 agctggtcct caacgtctca aagatgctga gggctgacat aaggaaggag ctggagaaat
     1261 atgccaggga catgagaatg aagatcctga aacctgcaag tgcccactct ccgacccaag
     1321 tgagaagccg gggaaaatcc ctgtccccca gaaggagaca ggcaagcccc ccgaggaggc
     1381 tcggccggcg agagaagtcg cctgcactgc ctgaaaagaa ggtggctgat ctgagcactc
     1441 tgaatgaagt gggctatcaa atccgaattt agccaagcca taccggccag caagagggtt
     1501 tctgtggtgc ttctctctgc actttaccca gcatcttcag gaggaactgc aactatttat
     1561 taagaacttg tgaattttat ttttaaggat tcacctggaa atagaatctg agtgggtggt
     1621 aaccattagc tttaaaaaat tcactaaaag gcaccatgaa aaggctgaag taataagccc
     1681 cactggggtt ggactatgtc cctcactcaa gatcttaagg ataaccgtaa ctgaagtttt
     1741 atatttttcc atttacctac tttcttttac ttgctttgaa cattatgcct caccaatagt
     1801 aaatgttcat gaaataatct cttgaacttt tggtatagta aggtaactct aacagtatta
     1861 ctgtcttttt cagcaataac agaaagcaaa aatgggtggg ttttttttaa gcagttatta
     1921 cctcagcatt ttgacatcag atatgcaaac ttaatggcgt tttgtttttt tatattctat
     1981 ttgtattctt tccccagtat ttcccatggg gatctccaca agtttggagt tttttcctgg
     2041 tgcacacacg tgaggagatt taaggtacta tatgcaagtg ttttactaaa aagcactgaa
     2101 attcttctgg caatacaaga accattttca ggatcttgga gttacttcct tcttaatctt
     2161 tcttaaagca ttcactgatg tttttgtttt ttcaaaatga aacaaaaata tcacattgag
     2221 aagctagtct atgttctgtc actaacattt aaactttgca gactctaaca aaaagcacaa
     2281 gaggtcacgt actattatac aaatttagcg gtactggatt tacctctgac attaacacac
     2341 tcaggcagag accaggagtg atcagcaggt cttcagaacc aaaaaacctt tctgttcaca
     2401 tttcatctga tttttaaact gaggcaggct ttgattcttc tgaaggatgc caagaatcaa
     2461 actaagggag gactcactgt taaagatgtg ttctgatgtc ttatattaag accaaatgtg
     2521 acatgatgtg attatcttcc agtactttgc ttttaggtac catttcatga cattttagga
     2581 atgagtattg gaaaatataa agaattagaa aagcagcact ttttttttaa tggaaaagtc
     2641 ttcggtccag tgttacacct tatagtgtaa ttcagtccct aagcacagaa tgaatgtctg
     2701 gcctgcatat ggtagttaca gtgtaacctc tggctgcaga ccacacagga caaccctaac
     2761 agcctagtct tgtatggtgt aaatatcaag agtacagctt caatttcatt tgctttatct
     2821 tagcaacaat gccaactcag gagagcagac ggccgatttc agtgaagtct ggtagtcaac
     2881 agatgttatt tcagtctcag tgcatctcct ctggctttct ttgactgaag gtgtttatag
     2941 gaaggaagtt aaaaaaaaaa aaagctcatt gagattcttt accaattctt tacaagattt
     3001 ctgggggtga cagggaaagc aaaaggactt caaagcaaaa gggtgcacaa gagcttactt
     3061 caccctgaaa atcagtatta ttaatgaaaa gtactgtttt cttaaagaag tcgaatgtcc
     3121 tttagatgaa caagaccaag tatacatctc cattagatta aaatgtagca cagggttaaa
     3181 aattatcagt ttaatctctt taagaacagt attatcagag tttaaaatga gttagctctg
     3241 tttatctaca cacagcaaac ccattcgcag cctcttggcc acatgtattc agatgtttga
     3301 aatagtgaat catttcattt tcattctaaa acaatactga cttagccata taccttctgt
     3361 ttgtcaatct gaaacttgct tacatctaat aagtagacct cttataacac tgcaaccatt
     3421 ctaagagttg gaatttattt ttgccaagta ttaagtactg ttacatctaa aatacagaat
     3481 gtcaaatggt tgcatagctt gtttcccaca acaaggagga aaagaacagg aatacaaact
     3541 ctgtaatatg ctgataaaga agccttagaa ctgccaactg gcttgatggt tcaattagta
     3601 agctaatttc tcccacaccc gctccttgat ttttagacta attttcccaa agcaaggttt
     3661 agtcacacaa acttgaaagt acatttaaaa tgttcttagt tgtcatccta cttttattgc
     3721 ctatggaata tgctaatttc taaaaaaaat acgggagagg caccaaaccc ctaaattcta
     3781 gtgcaataat ttaaaaaaca aaaaacaaaa caaaacaaaa aacatgttat atgcaccccc
     3841 ctcccaaagc tgattttaag actggctaga attcaaaata taaaaaataa aactatgaag
     3901 tgatttgaaa tcggttttaa aaagttgtta gtgcaagaga aattttatgt ttaagccatc
     3961 atggcaatat atgcaaagtt taaatgaatg acagaaatct tgattttaga ctgtatgttg
     4021 tgctgttttg agtacacttt atttcggaga tatttagtat tttctataca ctctgaaatc
     4081 atgagcattt cactttttct aagtcaatta tttcataagg attttattaa tagatattgg
     4141 taaatagaac tttggaaatc ttaattcaga attcttacta tacctgagtc ttttgtaagc
     4201 tatagtttta tgtacaacct tgtacagttt ttttgacata caattcagaa ctttgtttat
     4261 tctcttggac tttgttctgg ccaatacatt ttttttaaat ctttaagaag aactgtgatt
     4321 gttttagtgg gtatttttct aattaaatga aaacttgtat aatggtattt tagagaatgc
     4381 cagtaagtgc atgtttcaag ttaatgtttt tctcatcact tgtatgtttc taacacagca
     4441 tgggacttta ataaaaccat cctggaaact taa
//
