LOCUS       NM_004738               7829 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens VAMP associated protein B and C (VAPB), transcript
            variant 1, mRNA.
ACCESSION   NM_004738
VERSION     NM_004738.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7829)
  AUTHORS   James,C., Moller,U., Spillner,C., Konig,S., Dybkov,O., Urlaub,H.,
            Lenz,C. and Kehlenbach,R.H.
  TITLE     Phosphorylation of ELYS promotes its interaction with VAPB at
            decondensing chromosomes during mitosis
  JOURNAL   EMBO Rep 25 (5), 2391-2417 (2024)
   PUBMED   38605278
  REMARK    GeneRIF: Phosphorylation of ELYS promotes its interaction with VAPB
            at decondensing chromosomes during mitosis.
REFERENCE   2  (bases 1 to 7829)
  AUTHORS   Markovinovic,A., Martin-Guerrero,S.M., Morotz,G.M., Salam,S.,
            Gomez-Suaga,P., Paillusson,S., Greig,J., Lee,Y., Mitchell,J.C.,
            Noble,W. and Miller,C.C.J.
  TITLE     Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS
            mutant TDP43 linked Ca2+ and synaptic defects
  JOURNAL   Acta Neuropathol Commun 12 (1), 32 (2024)
   PUBMED   38395965
  REMARK    GeneRIF: Stimulating VAPB-PTPIP51 ER-mitochondria tethering
            corrects FTD/ALS mutant TDP43 linked Ca[2+] and synaptic defects.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7829)
  AUTHORS   Obara,C.J., Nixon-Abell,J., Moore,A.S., Riccio,F., Hoffman,D.P.,
            Shtengel,G., Xu,C.S., Schaefer,K., Pasolli,H.A., Masson,J.B.,
            Hess,H.F., Calderon,C.P., Blackstone,C. and Lippincott-Schwartz,J.
  TITLE     Motion of VAPB molecules reveals ER-mitochondria contact site
            subdomains
  JOURNAL   Nature 626 (7997), 169-176 (2024)
   PUBMED   38267577
  REMARK    GeneRIF: Motion of VAPB molecules reveals ER-mitochondria contact
            site subdomains.
REFERENCE   4  (bases 1 to 7829)
  AUTHORS   Faria Assoni,A., Giove Mitsugi,T., Wardenaar,R., Oliveira
            Ferreira,R., Farias Jandrey,E.H., Machado Novaes,G., Fonseca de
            Oliveira Granha,I., Bakker,P., Kaid,C., Zatz,M., Foijer,F. and
            Keith Okamoto,O.
  TITLE     Neurodegeneration-associated protein VAPB regulates proliferation
            in medulloblastoma
  JOURNAL   Sci Rep 13 (1), 19481 (2023)
   PUBMED   37945695
  REMARK    GeneRIF: Neurodegeneration-associated protein VAPB regulates
            proliferation in medulloblastoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7829)
  AUTHORS   Nachreiner,T., Esser,M., Tenten,V., Troost,D., Weis,J. and
            Kruttgen,A.
  TITLE     Novel splice variants of the amyotrophic lateral
            sclerosis-associated gene VAPB expressed in human tissues
  JOURNAL   Biochem Biophys Res Commun 394 (3), 703-708 (2010)
   PUBMED   20227395
  REMARK    GeneRIF: under conditions of proteasomal inhibition, as encountered
            in many neurodegenerative diseases including ALS, variant VAPB
            proteins might accumulate in affected cells and contribute to ALS
            pathogenesis.
REFERENCE   6  (bases 1 to 7829)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   7  (bases 1 to 7829)
  AUTHORS   Paumet,F., Le Mao,J., Martin,S., Galli,T., David,B., Blank,U. and
            Roa,M.
  TITLE     Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast
            cells: functional role of syntaxin 4 in exocytosis and
            identification of a vesicle-associated membrane protein
            8-containing secretory compartment
  JOURNAL   J Immunol 164 (11), 5850-5857 (2000)
   PUBMED   10820264
REFERENCE   8  (bases 1 to 7829)
  AUTHORS   Bastepe,M., Pincus,J.E. and Juppner,H.
  TITLE     Two frequent tetra-nucleotide repeat polymorphisms between VAPB and
            STX16 on chromosome 20q13
  JOURNAL   Mol Cell Probes 13 (6), 449-451 (1999)
   PUBMED   10657150
REFERENCE   9  (bases 1 to 7829)
  AUTHORS   Nishimura,Y., Hayashi,M., Inada,H. and Tanaka,T.
  TITLE     Molecular cloning and characterization of mammalian homologues of
            vesicle-associated membrane protein-associated (VAMP-associated)
            proteins
  JOURNAL   Biochem Biophys Res Commun 254 (1), 21-26 (1999)
   PUBMED   9920726
REFERENCE   10 (bases 1 to 7829)
  AUTHORS   Siddique,N. and Siddique,T.
  TITLE     Amyotrophic Lateral Sclerosis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK023241.1, AL035455.30,
            AK124571.1 and BM968517.1.
            
            On Aug 31, 2019 this sequence version replaced NM_004738.4.
            
            Summary: The protein encoded by this gene is a type IV membrane
            protein found in plasma and intracellular vesicle membranes. The
            encoded protein is found as a homodimer and as a heterodimer with
            VAPA. This protein also can interact with VAMP1 and VAMP2 and may
            be involved in vesicle trafficking. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.18789.1,
                                           SRR14038197.341706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000475243.6/ ENSP00000417175.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2244              AK023241.1         108-2351
            2245-4392           AL035455.30        145362-147509
            4393-7822           AK124571.1         252-3681
            7823-7829           BM968517.1         16-22               c
FEATURES             Location/Qualifiers
     source          1..7829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.32"
     gene            1..7829
                     /gene="VAPB"
                     /gene_synonym="ALS8; VAMP-B; VAP-B"
                     /note="VAMP associated protein B and C"
                     /db_xref="GeneID:9217"
                     /db_xref="HGNC:HGNC:12649"
                     /db_xref="MIM:605704"
     exon            1..289
                     /gene="VAPB"
                     /gene_synonym="ALS8; VAMP-B; VAP-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..963
                     /gene="VAPB"
                     /gene_synonym="ALS8; VAMP-B; VAP-B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     VAMP-associated 33 kDa protein; vesicle-associated
                     membrane protein-associated protein B/C; VAMP
                     (vesicle-associated membrane protein)-associated protein B
                     and C"
                     /codon_start=1
                     /product="vesicle-associated membrane protein-associated
                     protein B/C isoform 1"
                     /protein_id="NP_004729.1"
                     /db_xref="CCDS:CCDS33498.1"
                     /db_xref="GeneID:9217"
                     /db_xref="HGNC:HGNC:12649"
                     /db_xref="MIM:605704"
                     /translation="MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKV
                     KTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDM
                     EAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSS
                     LDDTEVKKVMEECKRLQGEVQRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEE
                     GLSTRLLALVVLFFIVGVIIGKIAL"
     exon            290..442
                     /gene="VAPB"
                     /gene_synonym="ALS8; VAMP-B; VAP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            443..546
                     /gene="VAPB"
                     /gene_synonym="ALS8; VAMP-B; VAP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            547..627
                     /gene="VAPB"
                     /gene_synonym="ALS8; VAMP-B; VAP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            628..804
                     /gene="VAPB"
                     /gene_synonym="ALS8; VAMP-B; VAP-B"
                     /inference="alignment:Splign:2.1.0"
     exon            805..7829
                     /gene="VAPB"
                     /gene_synonym="ALS8; VAMP-B; VAP-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2259..2264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VAPB"
                     /gene_synonym="ALS8; VAMP-B; VAP-B"
                     /note="hexamer: AATAAA"
     polyA_site      2280
                     /gene="VAPB"
                     /gene_synonym="ALS8; VAMP-B; VAP-B"
                     /note="major polyA site"
     regulatory      7800..7805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VAPB"
                     /gene_synonym="ALS8; VAMP-B; VAP-B"
                     /note="hexamer: AATAAA"
     polyA_site      7829
                     /gene="VAPB"
                     /gene_synonym="ALS8; VAMP-B; VAP-B"
ORIGIN      
        1 gcgtgccgtc agctcgccgg gcaccgcggc ctcgccctcg ccctccgccc ctgcgcctgc
       61 accgcgtaga ccgacccccc cccagcgcgc ccacccggta gaggaccccc gcccgtgccc
      121 cgaccggtcc ccgccttttt gtaaaactta aagcgggcgc agcattaacg cttcccgccc
      181 cggtgacctc tcaggggtct ccccgccaaa ggtgctccgc cgctaaggaa catggcgaag
      241 gtggagcagg tcctgagcct cgagccgcag cacgagctca aattccgagg tcccttcacc
      301 gatgttgtca ccaccaacct aaagcttggc aacccgacag accgaaatgt gtgttttaag
      361 gtgaagacta cagcaccacg taggtactgt gtgaggccca acagcggaat catcgatgca
      421 ggggcctcaa ttaatgtatc tgtgatgtta cagcctttcg attatgatcc caatgagaaa
      481 agtaaacaca agtttatggt tcagtctatg tttgctccaa ctgacacttc agatatggaa
      541 gcagtatgga aggaggcaaa accggaagac cttatggatt caaaacttag atgtgtgttt
      601 gaattgccag cagagaatga taaaccacat gatgtagaaa taaataaaat tatatccaca
      661 actgcatcaa agacagaaac accaatagtg tctaagtctc tgagttcttc tttggatgac
      721 accgaagtta agaaggttat ggaagaatgt aagaggctgc aaggtgaagt tcagaggcta
      781 cgggaggaga acaagcagtt caaggaagaa gatggactgc ggatgaggaa gacagtgcag
      841 agcaacagcc ccatttcagc attagcccca actgggaagg aagaaggcct tagcacccgg
      901 ctcttggctc tggtggtttt gttctttatc gttggtgtaa ttattgggaa gattgccttg
      961 tagaggtagc atgcacagga tggtaaattg gattggtgga tccaccatat catgggattt
     1021 aaatttatca taaccatgtg taaaaagaaa ttaatgtatg atgacatctc acaggtcttg
     1081 cctttaaatt acccctccct gcacacacat acacagatac acacacacaa atataatgta
     1141 acgatctttt agaaagttaa aaatgtatag taactgattg agggggaaaa gaatgatctt
     1201 tattaatgac aagggaaacc atgagtaatg ccacaatggc atattgtaaa tgtcatttta
     1261 aacattggta ggccttggta catgatgctg gattacctct cttaaaatga cacccttcct
     1321 cgcctgttgg tgctggccct tggggagctg gagcccagca tgctggggag tgcggtcagc
     1381 tccacacagt agtccccacg tggcccactc ccggcccagg ctgctttccg tgtcttcagt
     1441 tctgtccaag ccatcagctc cttgggactg atgaacagag tcagaagccc aaaggaattg
     1501 cactgtggca gcatcagacg tactcgtcat aagtgagagg cgtgtgttga ctgattgacc
     1561 cagcgctttg gaaataaatg gcagtgcttt gttcacttaa agggaccaag ctaaatttgt
     1621 attggttcat gtagtgaagt caaactgtta ttcagagatg tttaatgcat atttaactta
     1681 tttaatgtat ttcatctcat gttttcttat tgtcacaaga gtacagttaa tgctgcgtgc
     1741 tgctgaactc tgttgggtga actggtattg ctgctggagg gctgtgggct cctctgtctc
     1801 tggagagtct ggtcatgtgg aggtggggtt tattgggatg ctggagaaga gctgccagga
     1861 agtgtttttt ctgggtcagt aaataacaac tgtcataggg agggaaattc tcagtagtga
     1921 cagtcaactc taggttacct tttttaatga agagtagtca gtcttctaga ttgttcttat
     1981 accacctctc aaccattact cacacttcca gcgcccaggt ccaagtctga gcctgacctc
     2041 cccttgggga cctagcctgg agtcaggaca aatggatcgg gctgcagagg gttagaagcg
     2101 agggcaccag cagttgtggg tggggagcaa gggaagagag aaactcttca gcgaatcctt
     2161 ctagtactag ttgagagttt gactgtgaat taattttatg ccataaaaga ccaacccagt
     2221 tctgtttgac tatgtagcat cttgaaaaga aaaattataa taaagcccca aaattaagaa
     2281 ttcttttgtc attttgtcac atttgctcta tggggggaat tattatttta tcatttttat
     2341 tattttgcca ttggaaggtt aactttaaaa tgagccctat cactgagaaa tacgtgtttc
     2401 atgatttaac tctgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tttttttttt
     2461 ggttgtcttc agctgacagt atgaaaaatg aaactgctga aaaagctgag cacctggtca
     2521 cccttggcct tccattgctt tggccttcag taaaaagcag cctcccttct aggtcaggga
     2581 accatgccat tgagactagt aacgggcgtt ctgggcacag tcccactgtg cacaggtttg
     2641 agaggacaag ttcatcagaa ggaaggcagt ccttagaagt cacatacgtt gagccacgtt
     2701 gctcctaagc ctggctctgt caagctgggt caggggcctt gaaactggag aagtggaagt
     2761 ctatggttgg tctgagtaag taacttcctg tcttcatgaa aaaagttgac tttgaatccc
     2821 aggtactcac agaaatggtg aacagactta gttgttaccc aggcacccat ggattgtgtt
     2881 gagtgtgcag acagggaggc caccccaata ggaattcgtc tccaggattt ttcccatgtg
     2941 tcccccagta cttataaaag ggagtgaaaa gaccgagctg taaggcatgt gccttctgcc
     3001 acctgacttt ccgtgagggg actaaaattt actaattgta gttgctgcag ccagttaagt
     3061 cctgtagctt ccaggccctc atgtctttga taggagagtg cttaggtggt ccccaacagt
     3121 gcctaggggt acagtacagt cccattacac tagagcaggg ctctatttat ttttaaagga
     3181 tatggccgtg tgttttgata aaactttatt cacaaaaaca gccgggtcat gggatttggc
     3241 ttgtgagtct gtaacagttc ttaaaaagaa tatctgagaa actactctgt tttagacctt
     3301 tgaaggtgat ttagagtttt gtgtacatct aggagaaggt gttcagcttc tcagaggatg
     3361 tggacatttt ggttgcagct aaaaatcagt ctctgaagtc tctctccctt ctagaggtta
     3421 ggacttggtg aacatgtttg tgggcctttt gactgagtgg cagaaggaaa ctgctcagga
     3481 agagaaacag gtgactgatg ggaaggttga ttattttctc agtcatcctg gcagccaaaa
     3541 atgtgccagg aaaagaaaga atgtggagca cgcgtggctc ctggaggact tggagatgca
     3601 tgcacattta gggtgttttc cctagaatta cataatgaaa aaaagaataa ggcaaagagg
     3661 aggtgaatat ggggcctgtc acaacggcct gccctgcccc aagagggtta agagtcagat
     3721 aatcgggacg aaactggcat ggaaagagcg agcctaggga ggatgccgct gggcagtgtg
     3781 catgggggag ctgctgccag gctgccctcc agtctgctcc tgtggttact ggctccacag
     3841 cacctcagag agggcggccc tggcttcaga aatgccagcc atagtgctca caaatgcaga
     3901 agagatggaa gcggtgacag aatcctgaaa gtttttattg attgaagttt taaattggta
     3961 acttaagctt ccttggcacg atacaaaata cctcttaaag acagcaggct tttttatttg
     4021 taggtgtgag gaactggctt taactttttt ctcctcctag tttgcatgtt ttccttctct
     4081 cgtcttctga actgctggca ccagcagtaa tacatactga taaaatcaaa attgattttt
     4141 accagtggcc agtttatggc tagagagacg acttatacct ccataacaca gaagggggaa
     4201 aaatgaagaa cctccagtga tccgtgaaaa cctaaacgct ttcaaacaaa tcccaggaac
     4261 agaattgcta tcgaaagata tcattgccca gtttgcaggc tatgttgagt cagatagaac
     4321 tgaatgtagt gagagctcag agctacagag cctttcagat gaatttgaaa acagactctg
     4381 tgtgtgtgtg catgtgtgca tgtgtgcatg tgtggcatat gtgccgtatg tcagtagctt
     4441 gacagttttc aaatcgtgcc tatatttttt tgcatacaca aatttttgtg tttgcaaact
     4501 cagaatccat gccaaaatac aatgttatat gtcattttca gctccttctc taaaggaatg
     4561 gcccatttct cattgtagtt tgagaaatac atgtatgaag agataggggt cttgggcttc
     4621 ccagtgtcac tttgaacacc tgaataacat ttaactcctg agaccttctc ggtgtagagg
     4681 ccactgcttc cccctgctgg agatggcatt tcattgaagg gcctctcgtg gctttccctg
     4741 cccccggctg tctggcctga agaaggagaa agaaccaaac tgaactatga aaagttacca
     4801 ctctgaggag acctctctta attaacactt ggggccatgt ttgctgttgt tgagaaggag
     4861 tgttctcaaa gatgagctgg aatggaattg tatttagaaa ggcccctgca aagtatatag
     4921 atggatgact ctagttcatg acatacaaat cccataaggc caacgaccac tcttctggaa
     4981 caccaagagc agctctgaga tcatgctggc cctacgcgaa ttgagtttct gtggcctaat
     5041 tggatttgga gaacgccttc cctggcccct tttcctcaga cagatctgct ctgataggaa
     5101 ccttttcaag aaagttactg ttgtttcaat gccactcctt acctgtatag aacatttcca
     5161 atacattcgc tcattgaact taatccttgc aactgtgact ggggggtaga tggctctgtt
     5221 tgcatacgaa gaaataaagg ctccaggagg ttaaatcggg caacttttta gaactaaatc
     5281 agtctctgta aggcctacat tgctaagata ccatttcagc tctgaaaatc tgcttcaggg
     5341 aagtgagtgg atgaggcctt cctgcctcag ctactctgcc cgtctgtaca tcttttgtgt
     5401 ctgcctccgt accttattca gttattttca cactaaagta agtagaatta agactgtagt
     5461 tcagatgctt tttctttttc tgttggaaac tgaacacact acagacagtg aaaaaaggta
     5521 catattccat tttctcattg cctgaagatc tctgctgatg ctcctggaga atgactttgg
     5581 gggctttaga aagaatattg ccagtccgtc tcggcaagga gatgatggga gcgctttata
     5641 tggaggcttt acatgacttg taaattaaat gtgaatgagg gcagttgatt aaaattggta
     5701 ttacagaagg gccctgctga ggtttgaaaa cagctgagct gctgatgtct caggcctttc
     5761 cctgaattag cactgcggtt ctccaggata tcagcaaaga gggcaagtaa tagaagcccc
     5821 tgataaggag cgtcagccga caggcaagct tgggaggctg tgggaatggg tctgccccca
     5881 gcttcacaga cctcttcctc cagcctctga atcccattag ccacagccta gaacattagc
     5941 tgagctgcac aagctcaccc acccctgtgc cagggggccc tgacctccct ccatgccatg
     6001 tttttggctg tatctacggc acttaacaat aggggctttt tattttcatt acagagatat
     6061 tttgaaaaat ttaaaagaca tgaactcaca taaacagtta tggatgatag ttaaaagaga
     6121 aacgggtgga ggtggatgag aggttgtctt catgaatata attacttgag attttttttt
     6181 cttaatggaa ttagtttatt agaaaatgtc tgtgttaaat ccgtagaaaa ggaagaaaag
     6241 tgtagcaaca aaaatgtagc cattatctaa cttgccataa atatttgcag ttatgatacc
     6301 ttggaatgtt gccacgatat ggattgcttt gattaaaaga tgtcagttga ataaaacagt
     6361 actgtgggag aatcgctttc tgctgctaga taaatgctga tgtttatttt taaaccagga
     6421 aacattgatc ctgtaacaat gcccgattac aattgcttta ttacacccca gggctgatgg
     6481 agatgtaatc acttggctaa tggatgtggg tgcaggacag atgctcgctt gctggcctgc
     6541 tttcctgctt gcattctgat gagctgcagg agtgcgcctg gccttctgca ggtggagctg
     6601 ctgtcagagc ttcgtttcac tgatacccaa agccatgtct gactgaaata aaacaggttc
     6661 cctttttttt tccctttgga aaatgccaac taagggagac taatcagata tcttaacaca
     6721 atttcatcca ggcttagtgc taacaagatt gcggggcttt ttagggttta agaagatgag
     6781 aaatgagtgt gcacgtttca cacgttgact tgccggtttt tccatgtcat acaaaaaagt
     6841 cctggctgtt tctccgaact ggctgcctgc attcccgtct ttcttttgtt tttaagaaat
     6901 agactgaatt cagctgttaa tcctctagta cagtatccat gttaaaatgt ttttccattg
     6961 catcttttat gtgaattcaa aggtcagaat ttattgtctg tgatattgag accatgtgta
     7021 caagaactac tttttgcttt tcatcattca ctccttagca aacgtttcgt aagtaccctc
     7081 tgtctgtttg ctactatatg aggtgctgcg aaattagtgg gcgtggcttt ttatattttt
     7141 cattcgtgtg tagcctaagt aaggtgactc aagatgatac accgagagaa aaatgcaaaa
     7201 tatatttggt tctcatttct gttgctgtcg tttccttttt aaagacgatt tatcaactgc
     7261 tgccatttgg aacttcctat aagaaactaa aaatgatcta tttcagtgtt cctttcgcct
     7321 ttcctctgct ttctgaataa atggtttcag taacccatgc tgttctctcc ctattctacg
     7381 tctttctccc tatgttgaaa aaagattccc acagtttctg atgtgtgtgt ttatagtctt
     7441 caatgtatgt taacatgtta ggaactgagt atcttaagag atgtcttaga atgctttagt
     7501 tttcataatt tgtcctttat gtatttttca ttgtatttgc tgttttgaca tggaagtaat
     7561 ttaaaaagtt ggtgcaggaa aggactcttt actgttgcac attttggttt tctgatatgt
     7621 aataaattca tggcttggca gctgacatga tgtttcccag agagaaggag atgtatttct
     7681 gcagggtcca gaccaaaaga gccatttaca gcatgttctc ccatgttcca ttatcagcct
     7741 gatgaaacct gccctgccaa ggcataaact tttgtactag ctgtctccat attatgttca
     7801 ataaattctg tgctctgaat atatttaaa
//
