LOCUS       NM_138959               8671 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens VANGL planar cell polarity protein 1 (VANGL1),
            transcript variant 1, mRNA.
ACCESSION   NM_138959 NM_024062
VERSION     NM_138959.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8671)
  AUTHORS   Feng,X., Ye,Y., Zhang,J., Zhang,Y., Zhao,S., Mak,J.C.W., Otomo,N.,
            Zhao,Z., Niu,Y., Yonezawa,Y., Li,G., Lin,M., Li,X., Cheung,P.W.H.,
            Xu,K., Takeda,K., Wang,S., Xie,J., Kotani,T., Choi,V.N.T.,
            Song,Y.Q., Yang,Y., Luk,K.D.K., Lee,K.S., Li,Z., Li,P.S.,
            Leung,C.Y.H., Lin,X., Wang,X., Qiu,G., Watanabe,K., Wu,Z.,
            Posey,J.E., Ikegawa,S., Lupski,J.R., Cheung,J.P.Y., Zhang,T.J.,
            Gao,B. and Wu,N.
  CONSRTM   DISCO (Deciphering disorders Involving Scoliosis and COmorbidities)
            study group; Japanese Early Onset Scoliosis Research Group
  TITLE     Core planar cell polarity genes VANGL1 and VANGL2 in predisposition
            to congenital vertebral malformations
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2310283121 (2024)
   PUBMED   38669183
  REMARK    GeneRIF: Core planar cell polarity genes VANGL1 and VANGL2 in
            predisposition to congenital vertebral malformations.
REFERENCE   2  (bases 1 to 8671)
  AUTHORS   Fatima,U., Khan,S., Riaz,S.U., Mehdi,H., Iftikhar,M. and Fatima,N.
  TITLE     Myelomeningocele among Pakistani population
  JOURNAL   J Pak Med Assoc 72 (5), 874-877 (2022)
   PUBMED   35713047
  REMARK    GeneRIF: Myelomeningocele among Pakistani population.
REFERENCE   3  (bases 1 to 8671)
  AUTHORS   Jiang,S.H., Mercan,S., Papa,I., Moldovan,M., Walters,G.D.,
            Koina,M., Fadia,M., Stanley,M., Lea-Henry,T., Cook,A., Ellyard,J.,
            McMorran,B., Sundaram,M., Thomson,R., Canete,P.F., Hoy,W.,
            Hutton,H., Srivastava,M., McKeon,K., de la Rua Figueroa,I.,
            Cervera,R., Faria,R., D'Alfonso,S., Gatto,M., Athanasopoulos,V.,
            Field,M., Mathews,J., Cho,E., Andrews,T.D., Kitching,A.R.,
            Cook,M.C., Riquelme,M.A., Bahlo,M. and Vinuesa,C.G.
  TITLE     Deletions in VANGL1 are a risk factor for antibody-mediated kidney
            disease
  JOURNAL   Cell Rep Med 2 (12), 100475 (2021)
   PUBMED   35028616
  REMARK    GeneRIF: Deletions in VANGL1 are a risk factor for
            antibody-mediated kidney disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8671)
  AUTHORS   Zhou,H., Wu,J., Leng,S., Hou,C., Mo,L., Xie,X., Wang,L. and Xu,Y.
  TITLE     Knockdown of circular RNA VANGL1 inhibits TGF-beta-induced
            epithelial-mesenchymal transition in melanoma cells by sponging
            miR-150-5p
  JOURNAL   J Cell Mol Med 25 (23), 10837-10845 (2021)
   PUBMED   34750955
  REMARK    GeneRIF: Knockdown of circular RNA VANGL1 inhibits TGF-beta-induced
            epithelial-mesenchymal transition in melanoma cells by sponging
            miR-150-5p.
REFERENCE   5  (bases 1 to 8671)
  AUTHORS   Hao,C.C., Xu,C.Y., Zhao,X.Y., Luo,J.N., Wang,G., Zhao,L.H., Ge,X.
            and Ge,X.F.
  TITLE     Up-regulation of VANGL1 by IGF2BPs and miR-29b-3p attenuates the
            detrimental effect of irradiation on lung adenocarcinoma
  JOURNAL   J Exp Clin Cancer Res 39 (1), 256 (2020)
   PUBMED   33228740
  REMARK    GeneRIF: Up-regulation of VANGL1 by IGF2BPs and miR-29b-3p
            attenuates the detrimental effect of irradiation on lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8671)
  AUTHORS   Kalabis,J., Rosenberg,I. and Podolsky,D.K.
  TITLE     Vangl1 protein acts as a downstream effector of intestinal trefoil
            factor (ITF)/TFF3 signaling and regulates wound healing of
            intestinal epithelium
  JOURNAL   J Biol Chem 281 (10), 6434-6441 (2006)
   PUBMED   16410243
  REMARK    GeneRIF: VANGL protein may serve as an effector mediating the
            intestinal trefoil factor (ITF) healing response of the intestinal
            mucosa.
REFERENCE   7  (bases 1 to 8671)
  AUTHORS   Doudney,K., Ybot-Gonzalez,P., Paternotte,C., Stevenson,R.E.,
            Greene,N.D., Moore,G.E., Copp,A.J. and Stanier,P.
  TITLE     Analysis of the planar cell polarity gene Vangl2 and its
            co-expressed paralogue Vangl1 in neural tube defect patients
  JOURNAL   Am J Med Genet A 136 (1), 90-92 (2005)
   PUBMED   15952208
  REMARK    Erratum:[Am J Med Genet A. 2005 Nov 1;138(4):415]
REFERENCE   8  (bases 1 to 8671)
  AUTHORS   Lee,J.H., Park,S.R., Chay,K.O., Seo,Y.W., Kook,H., Ahn,K.Y.,
            Kim,Y.J. and Kim,K.K.
  TITLE     KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of
            the tetraspanin family, interacts with KAI1, a tumor metastasis
            suppressor, and enhances metastasis of cancer
  JOURNAL   Cancer Res 64 (12), 4235-4243 (2004)
   PUBMED   15205336
REFERENCE   9  (bases 1 to 8671)
  AUTHORS   Yagyu,R., Hamamoto,R., Furukawa,Y., Okabe,H., Yamamura,T. and
            Nakamura,Y.
  TITLE     Isolation and characterization of a novel human gene, VANGL1, as a
            therapeutic target for hepatocellular carcinoma
  JOURNAL   Int J Oncol 20 (6), 1173-1178 (2002)
   PUBMED   12011995
REFERENCE   10 (bases 1 to 8671)
  AUTHORS   Katoh,M.
  TITLE     Molecular cloning and characterization of Strabismus 2 (STB2)
  JOURNAL   Int J Oncol 20 (5), 993-998 (2002)
   PUBMED   11956595
  REMARK    GeneRIF: Molecular cloning and characterization of Strabismus 2
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM552933.1, AB075805.1 and
            AL450389.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_138959.2.
            
            Summary: This gene encodes a member of the tretraspanin family. The
            encoded protein may be involved in mediating intestinal trefoil
            factor induced wound healing in the intestinal mucosa. Mutations in
            this gene are associated with neural tube defects. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2473988.1,
                                           SRR14038192.396826.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355485.7/ ENSP00000347672.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-486               BM552933.1         37-522
            487-2304            AB075805.1         245-2062
            2305-8671           AL450389.12        55279-61645
FEATURES             Location/Qualifiers
     source          1..8671
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.1"
     gene            1..8671
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /note="VANGL planar cell polarity protein 1"
                     /db_xref="GeneID:81839"
                     /db_xref="HGNC:HGNC:15512"
                     /db_xref="MIM:610132"
     exon            1..117
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            118..325
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1829
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     strabismus 2; KAI1 C-terminal interacting tetraspanin;
                     vang-like protein 1; van Gogh-like protein 1; loop-tail
                     protein 2 homolog; vang-like 1 (van gogh, Drosophila)"
                     /codon_start=1
                     /product="vang-like protein 1 isoform 1"
                     /protein_id="NP_620409.1"
                     /db_xref="CCDS:CCDS883.1"
                     /db_xref="GeneID:81839"
                     /db_xref="HGNC:HGNC:15512"
                     /db_xref="MIM:610132"
                     /translation="MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEK
                     SVTIQPPTGEPLLGNDSTRTEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDS
                     VGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTICEGLFISMAFKL
                     LILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQG
                     IVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAA
                     LVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAAR
                     RRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPRE
                     AAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPT
                     LQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFID
                     PKSHKFVLRLQSETSV"
     exon            326..458
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            459..1066
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1200
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1333
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1568
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..8671
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4118..4123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /note="hexamer: AATAAA"
     polyA_site      4141
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /note="major polyA site"
     regulatory      5898..5903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /note="hexamer: AATAAA"
     polyA_site      5923
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
     regulatory      8653..8658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /note="hexamer: AATAAA"
     polyA_site      8671
                     /gene="VANGL1"
                     /gene_synonym="KITENIN; LPP2; STB2; STBM2"
                     /note="major polyA site"
ORIGIN      
        1 agtgcagcgg cggcggcggc ggggctctgc ctctccagga gcccagcgca ggccgcagag
       61 ccggggccgc tgtgagccga gaccgcgggc cgcggagctc gggcggccgg cgcggagaat
      121 ttgttcctgt tgaagagtgg ctcctcttct aatttccaga ctccttgagg ttttaggagt
      181 ctggtaggtg aaattttcta cctctaagga gaaacagtac ctgctccttc ctcaagcgca
      241 agccctccat tgctatggat accgaatcca cttattctgg atattcttac tattcaagtc
      301 attcgaaaaa atctcacaga caaggggaaa gaactagaga gagacacaag tcaccccgga
      361 ataaagacgg cagagggtca gaaaagtctg tcaccattca acctcccact ggagagcccc
      421 tgttgggaaa tgattctact cggacagagg aagttcagga tgacaactgg ggagagacca
      481 ccacggccat cacaggcacc tcggagcaca gcatatccca agaggacatt gccaggatca
      541 gcaaggacat ggaggacagc gtggggctgg attgcaaacg ctacctgggc ctcaccgtcg
      601 cctcttttct tggacttcta gttttcctca cccctattgc cttcatcctt ttacctccga
      661 tcctgtggag ggatgagctg gagccttgtg gcacaatttg tgaggggctc tttatctcca
      721 tggcattcaa actcctcatt ctgctcatag ggacctgggc actttttttc cgcaagcgga
      781 gagctgacat gccacgggtg tttgtgtttc gtgccctttt gttggtcctc atctttctct
      841 ttgtggtttc ctattggctt ttttacgggg tccgcatttt ggactctcgg gaccggaatt
      901 accagggcat tgtgcaatat gcagtctccc ttgtggatgc cctcctcttc atccattacc
      961 tggccatcgt cctgctggag ctcaggcagc tgcagcccat gttcacgctg caggtggtcc
     1021 gctccaccga tggcgagtcc cgcttctaca gcctgggaca cctgagtatc cagcgagcag
     1081 cattggtggt cctagaaaat tactacaaag atttcaccat ctataaccca aacctcctaa
     1141 cagcctccaa attccgagca gccaagcata tggccgggct gaaagtctac aatgtagatg
     1201 gccccagtaa caatgccact ggccagtccc gggccatgat tgctgcagct gctcggcgca
     1261 gggactcaag ccacaacgag ttgtattatg aagaggccga acatgaacgg cgagtaaaga
     1321 agcggaaagc aaggctggtg gttgcagtgg aagaggcctt catccacatt cagcgtctcc
     1381 aggctgagga gcagcagaaa gccccagggg aggtgatgga ccctagggag gccgcccagg
     1441 ccattttccc ctccatggcc agggctctcc agaagtacct gcgcatcacc cggcagcaga
     1501 actaccacag catggagagc atcctgcagc acctggcctt ctgcatcacc aacggcatga
     1561 cccccaaggc cttcctagaa cggtacctca gtgcgggccc caccctgcaa tatgacaagg
     1621 accgctggct ctctacacag tggaggcttg tcagtgatga ggctgtgact aatggattac
     1681 gggatggaat tgtgttcgtc cttaagtgct tggacttcag cctcgtagtc aatgtgaaga
     1741 aaattccatt catcatactc tctgaagagt tcatagaccc caaatctcac aaatttgtcc
     1801 ttcgcttaca gtctgagaca tccgtttaaa agttctatat ttgtggcttt attaaaaaaa
     1861 aaagaaaaat atatagagag atatatatct atgccagagg ggtgtctttt ttaaaaattc
     1921 ttcttcattg ctgactgaaa ctggcagatg attgaccagt atcctttgac catctgcact
     1981 ttatttggaa ggaagcaggg gctgtccacc ctgaaaaaga gtgactgatg acatctgact
     2041 tttgtcgatg ggacttctca agaagccatt ccttggagct tctgttacag ctgtaaacca
     2101 aagtggagct ggtgcttctt gggagcctcg ccttacaact aattcctgcc tttcgtccag
     2161 taccaagtcc cccgttgctt ctggtcagcc cacttgtaga cttccagggg acacatcttt
     2221 attctgtttc aggaaaccag tcacgacacg tccacatatg tatttgtgta tgttaatgtc
     2281 cagtatcaca tcacccatga aagtcgtggg cagttcagga gatacctgcc ttcatctttg
     2341 ttctttgttg ccttaggttc ttcagagaaa gatcacaaca aaaaatgtac actgtcgttt
     2401 acagctatta agtgatttga ttttgttttt ttcccaaaga gaaaacctac ctgccctgtt
     2461 tctgatccca cccctctgct ggcttgaagc aggtaaccct ttcccagccc tgcagctgcc
     2521 cacctggcct ccatgccatc ctgcccccac ctggctggca gccctggctc tccatgtgtg
     2581 ccctccggct ctgtgtgaag cctcaagtca gtcccagcat tgtttccata gggaagtgtg
     2641 gggtgcccag caggtaaagc acagggagag agggcagtgg gaatgccacc tttaggctgc
     2701 agcaggagcc ccacactgcc cagttttcct ccccactgtt ctacaccaac caggggagac
     2761 taacactgtg actctgggat tggcaggtgc aacttggagc cacttaattt cctggggacg
     2821 taagttcttc ccaagcttag agcaagctgc cctgccaaag gagaccaaac catgccaacc
     2881 acgctggcaa ctgctgctgt ccagtccctg tgttttctga ccaccgtcac tgtgcaactc
     2941 atcgcctctg ccacttagga ccaggaaaga ggctggtttt gctcccactc ttagttgctg
     3001 ataaagtggg gagaaggaaa atggacactc tacagagttt ggggaaggga gagtagggag
     3061 cccatcttgt ccagaaagat tcatctgtgg tctgtctgtt aaacacagct gatttcagtg
     3121 ggctttcccc tggccctggg ggagcagaca ctgactgggt tgtgggcaga ggagccatcc
     3181 tggcggagcc ctgctgcagg ggagctcctt caggagcccc atccggacct cttgcactgg
     3241 gctgcctttg cctccatttg ccttcctgta tctgcaacaa accttttaaa agtgttcact
     3301 cttgcttttt ccagtatttc ggtaatcagc catcttgctg tagtacagga tgacattgtc
     3361 gaatgctctt tgtatgtgtg cacaccccct tactccctta ctgcttcata cactccacaa
     3421 gtggtacagt attttgtgtc attgtaaaaa tcaaaattgg ctttggatct ttgtaataca
     3481 cctgtacctg aaaaagtaaa caacattctt caattactag ccttcagctt gaaaagacat
     3541 gctggagaag aaggaagggg gaacccatag gtgtggcgtg gagccaagat gtactattca
     3601 actatgtgtt tctgtttata aaaaacacat accatggaac catggtgctt ttgttcttag
     3661 tttttgccgt tagatccctt caaactggaa gttccttaca atatctttct caggaaatat
     3721 tttgggaaat ggggtaagag atggcaagtg tgagacgggc tgtgtcagag gttgctacgt
     3781 catggataca gtgcagttcc aagtgccata agtgtatgta catatagtta ataatgacac
     3841 tgttcatcac cattctaaaa tactgttctt ccaaccctat cttcaatgac cagtccagaa
     3901 ggggttaagc tggattcatt tgctctggca tgtgcattcc cagcagggtg aagaaaggtt
     3961 taaattaaag aatttatttt ctctctcccc cttcctcttt ctcccagtct ttgcatagga
     4021 gaatgttaga cattcagaaa ttactgtttc tgttttaaat tgagtattga tttttttata
     4081 ttgactttgt attgagttct ttttgaaaga ataacaaaat aaaatgcagg atctttgtaa
     4141 agcctttgca ctttcaacct ctttatagct tgagttactt ttgcagtggg aacaatgtaa
     4201 atgacattta aaagatttaa ggtttcagaa agctgcatcc cacaattgaa cacaatgcat
     4261 ttttatttca attcttggaa ctggtaggct attcttttta aaagggggta aacttcgccc
     4321 taaggctggt agaatgtatg ttcacattat agtagacagg atttcatttg ccttatatgt
     4381 ttatagattt tttataattt tcatcctacg ttattaaaat tagagcattg agtgttaaag
     4441 aacttaatga ggagtctata tctgagattg ctctcttccc tggtgatgtt ttaactggta
     4501 gataatttgt tcttaaatat gtacttttga agataggaca gtttttatag tccatgaact
     4561 gaatgttaaa aagttctgta tgcattctca gagaggattt taaagctata tagttcatcc
     4621 atcctttgca ttatcaaaat gttaagtcaa atctgtaata ctttggctaa aattcataaa
     4681 gtaagcccta gagaaaatac ttgaccacca aatttttgcc caactatcat cacctccctt
     4741 cccccgcctc tgttcttgcc ttttgacatc tacatggaag acaagttctt tacagcaaat
     4801 ggtaagaggc aggtgacctg gtgtgtttgc tgtgttgtag ttcattgcct ggggcttggg
     4861 actccttttt taatggagag actagctgtg caggtgtgtg ttggataggg ataaagtgct
     4921 cacccctgcc ctctctacag tagttggtgg tagatttctc tctcattttg cctcataatc
     4981 actttcgagt gcatgtattt acctaagggc tgtagctctg tgggatgcta ccagcatatt
     5041 ggactgacag aaattgatta ccttgccact ccaacctacg tactgagtga gtgctccagc
     5101 cactcagtga aaccaacaaa agtgagtcct tggtttacct tccaatctgg gtcctgctgt
     5161 gtaagtatcc ctaagtgggg atgcatattt gtttgtgcgt ttttatttcc atatatgtga
     5221 gcatttctct gagtgtatta ccagacggat agcacattta tatgtcagac atcttaacat
     5281 ctgtgttatc tgtagcaggt gtgtagctca gcagatacgt gtcattgtgt atatagctga
     5341 gtgtgtgagg gtgtctgtgt ttctgcagtc ccctgtgttt gagagatgac ttaataaccc
     5401 tgtgttttga gaggtcgctc taaaccagtg acttttccct cccctgcttt attcctttcc
     5461 ctcactgaca ctggcttctc ccgctagagt aaatggcttt agcacagcac tgtcttctgg
     5521 ggagcctgct gtcctgcagg caagtccatt aaactctttc ttgctttagg actctgaaaa
     5581 cagcaagaaa caaacaaaca aaggtcaagc tctaagaaaa ttactgctca aacttcacta
     5641 ccctggaagc cttactagat atttcttaag gtaacttaaa aattgggctt tatttttaaa
     5701 aagtgatagg ttacttacag tagcacagaa atgttagcat atttatttaa atagtcctgc
     5761 agcagagacc ctgcgattgt aaagtgattt aagtatttct gggtagtgtt tgtgatttac
     5821 ggatttgtta ctgaaaaaca aaaaaatcac tactgtgaat ttactactat gtaaccttgt
     5881 ggtcgtattt cattataaat aaaataagaa ttgctcttct gcccaccgtt cttgattggt
     5941 attcagtgca gtagcgaaat gagatagttt agacactgtt gaaataactg cattgagctt
     6001 taaccaagtg tatgctcaga aaattcagtt ttggatcaca ttttgacaaa acatgttttg
     6061 gtcaaagaaa ggaaaggcta ctaacacatt tatcaggtaa tgtatgtcac agtccgtgtt
     6121 ccacccagcc ttgttatccc cacattcttt caagatagga gtcatcttgg tttttcgggt
     6181 gaaaaacgga aggtcagaga ggaaggggct tgtccaaggt ctcatgtctg gttaacagaa
     6241 tttcaaacta gatgtttgat tctaacccct cagtccactg taccttgaag tatggtctaa
     6301 atgattcggc acttctggat gttgaggaag gacctagaga cacatccttg aactagaacc
     6361 tggggtgaga gttcattggg aggcaggatc tcttctttca ctttggattt acaccttgtc
     6421 ccttggaaag cttctccact atgctagcaa atatcttagg atatttgatg gaaagaactt
     6481 gagaatccct tctggaaaac ccagcctttc agtgttaaca cctgctgcaa gacagggatg
     6541 ctgttgttct ggcagccccc ctttgctttt gcctggcccc accttctgct cccactctgc
     6601 tggcttgggc aagatgcgtg ccttgggcct tgggtgcagg gaggcaggca ggggcttgac
     6661 ctggcctctc tctggtgcca tggcaacatt atgccccaaa cttcttccct ggttggagtg
     6721 agaggggctg tccacagccc catcctgtgg ggatctcaag ccggagtccc tggcctggcc
     6781 tccttgacgt aggtgttctc agcaagcagt ttgcatccca ccgtctttct cacacttgcc
     6841 cccaagactt ttgacagagc agacgtaaaa caggactcag aaaaccattt ttctctgttc
     6901 ccatatgtag taagttttga ttcagttgtg cataaaccat agttttctgc cctgctgttt
     6961 gctttcaatg gaagacagta aagggaagat ggtgctcaca tctctccatg tgacatctca
     7021 ttaggaatta agatgcgatg gattagaaat gtaaaacttc agaataaaat taaatttcag
     7081 ggctctataa gtcccgtttt cccaggtcct gttccgtttc tacgtagata acccaatttg
     7141 ttttgtctat gaaataagcc tctttagtgg gttgttttag tctctccaac aaaagagcag
     7201 attcctaaag ccaggtgcag cactgtgaaa agtttctttc aatatggcac caagactcta
     7261 ccatttatgt ctctctcagc ttacaaacat cagcgttttg tccttgtcat agtggaagaa
     7321 agacacttac tttaagcttt ggggacaaag gtgacaaacc ccaggctttt atcttaaaag
     7381 tgtctttggc acttcttttg gcactgaaat ggtatttggg aagcattatt tgaatgtaca
     7441 gttgtttggt tttgtatgtg cttatcttta tctgagcttt cacttgtaga catggccttt
     7501 tgttgtgaag ttgctcatca tttaggagtg tttaattcta aaaagccttc agcctaagaa
     7561 agcttcatct gtggggacca gagacttgtt gctcagggag ttagtgatgg gacttgggca
     7621 tctgatctgc aggtgacaag tttagttcaa ctgaagttgt agggaattta gacagttgca
     7681 catcattgcc gttctagggg ccttgtagaa agatgaaaca gttgtttttc atttaccagc
     7741 acctctcagt tatagaggta atggaacatt cgcttacttt tcatcatcat tctttaaaaa
     7801 gggaacatac aaaaatctaa actatggcaa taatttattt ttataatagt ttacggtagg
     7861 ctttaattaa atggcaaact cctctgggac ccctaagtta tggcgtgatt agccaaattt
     7921 gatttccaac agtcatttat ggccataact attgcataga gtgcaggatg ccagcaaaga
     7981 tgagggtggg ggcagatact ggctcagtga tttaactcac attatagatg accccttcct
     8041 caacagaaat gctactgaga gaaccagaga ggcctgggcc aggcaggtct tatttgagag
     8101 gagattattt gataattgct ttggttagaa ggactttaca tttcctgatt tcaagtccag
     8161 caccaattta gaaagttcag agatgaaacc acctgtcttt acctgacaga gtcataacgg
     8221 tttgtgtaaa aatgtggtca gggacctttt ttgttctttc tgattagtta atactgtaca
     8281 ttgtaaccag gaggggcagt tttgccaacc agcctctgct catggtcacc atatgtgtat
     8341 gacaaggcct gagtgagttc ctgcataaac tgggtagtgg gctcttttga cacatttgca
     8401 agcatgtaaa tgaatgaatg acactaccag caaccatctg tacaggtcca tttacttaca
     8461 ttcataaggt ttatgctatg aaacttcttc tcattgtgat gtcagtaaca gagttagtgt
     8521 ctctgatgga atagtgtacc tgtcacccaa gttattttgt tcctttttgg gtcctccagt
     8581 ataatccccc cctcatccca attaactgta aaatgtttta cacatcacat tttttatact
     8641 gtaaacttgg aaaataaact gaaatatcaa a
//
