LOCUS       NM_005638               2594 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens vesicle associated membrane protein 7 (VAMP7),
            transcript variant 1, mRNA.
ACCESSION   NM_005638
VERSION     NM_005638.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2594)
  AUTHORS   Jian,F., Wang,S., Tian,R., Wang,Y., Li,C., Li,Y., Wang,S., Fang,C.,
            Ma,C. and Rong,Y.
  TITLE     The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex
            mediating autophagosome-lysosome fusion
  JOURNAL   Cell Res 34 (2), 151-168 (2024)
   PUBMED   38182888
  REMARK    GeneRIF: The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE
            complex mediating autophagosome-lysosome fusion.
REFERENCE   2  (bases 1 to 2594)
  AUTHORS   Huang,Y., Wu,M., Li,J.D., Qin,Z., Huang,K.Q., Cui,J.Z. and Ou,H.L.
  TITLE     Upregulation of vesicle-associated membrane protein 7 in breast
            cancer tissues
  JOURNAL   Technol Health Care 32 (4), 2141-2157 (2024)
   PUBMED   38393934
  REMARK    GeneRIF: Upregulation of vesicle-associated membrane protein 7 in
            breast cancer tissues.
REFERENCE   3  (bases 1 to 2594)
  AUTHORS   Gasparotto,M., Dall'Ara,E., Vacca,M. and Filippini,F.
  TITLE     VAMP7j: A Splice Variant of Human VAMP7 That Modulates Neurite
            Outgrowth by Regulating L1CAM Transport to the Plasma Membrane
  JOURNAL   Int J Mol Sci 24 (24), 17326 (2023)
   PUBMED   38139155
  REMARK    GeneRIF: VAMP7j: A Splice Variant of Human VAMP7 That Modulates
            Neurite Outgrowth by Regulating L1CAM Transport to the Plasma
            Membrane.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2594)
  AUTHORS   Li,D., Xu,M., Wang,Z., Huang,P., Huang,C., Chen,Z., Tang,G.,
            Zhu,X., Cai,M. and Qin,S.
  TITLE     The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1
            expression and drives gastric cancer via miR-29a-3p/VAMP7 axis
  JOURNAL   Cell Death Dis 13 (1), 84 (2022)
   PUBMED   35082283
  REMARK    GeneRIF: The EMT-induced lncRNA NR2F1-AS1 positively modulates
            NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7
            axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2594)
  AUTHORS   Ward,D.M., Pevsner,J., Scullion,M.A., Vaughn,M. and Kaplan,J.
  TITLE     Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor
            attachment protein receptors required for late endosome-lysosome
            and homotypic lysosome fusion in alveolar macrophages
  JOURNAL   Mol Biol Cell 11 (7), 2327-2333 (2000)
   PUBMED   10888671
REFERENCE   6  (bases 1 to 2594)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   7  (bases 1 to 2594)
  AUTHORS   Matarazzo,M.R., Cuccurese,M., Strazzullo,M., Vacca,M., Curci,A.,
            Miano,M.G., Cocchia,M., Mercadante,G., Torino,A., D'Urso,M.,
            Ciccodicola,A. and D'Esposito,M.
  TITLE     Human and mouse SYBL1 gene structure and expression
  JOURNAL   Gene 240 (1), 233-238 (1999)
   PUBMED   10564831
REFERENCE   8  (bases 1 to 2594)
  AUTHORS   Advani,R.J., Yang,B., Prekeris,R., Lee,K.C., Klumperman,J. and
            Scheller,R.H.
  TITLE     VAMP-7 mediates vesicular transport from endosomes to lysosomes
  JOURNAL   J Cell Biol 146 (4), 765-776 (1999)
   PUBMED   10459012
REFERENCE   9  (bases 1 to 2594)
  AUTHORS   Galli,T., Zahraoui,A., Vaidyanathan,V.V., Raposo,G., Tian,J.M.,
            Karin,M., Niemann,H. and Louvard,D.
  TITLE     A novel tetanus neurotoxin-insensitive vesicle-associated membrane
            protein in SNARE complexes of the apical plasma membrane of
            epithelial cells
  JOURNAL   Mol Biol Cell 9 (6), 1437-1448 (1998)
   PUBMED   9614185
REFERENCE   10 (bases 1 to 2594)
  AUTHORS   D'Esposito,M., Ciccodicola,A., Gianfrancesco,F., Esposito,T.,
            Flagiello,L., Mazzarella,R., Schlessinger,D. and D'Urso,M.
  TITLE     A synaptobrevin-like gene in the Xq28 pseudoautosomal region
            undergoes X inactivation
  JOURNAL   Nat Genet 13 (2), 227-229 (1996)
   PUBMED   8640232
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC056141.1 and AI522002.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005638.5.
            
            Summary: This gene encodes a transmembrane protein that is a member
            of the soluble N-ethylmaleimide-sensitive factor attachment protein
            receptor (SNARE) family. The encoded protein localizes to late
            endosomes and lysosomes and is involved in the fusion of transport
            vesicles to their target membranes. Alternate splicing results in
            multiple transcript variants.[provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056141.1, SRR1660805.39672.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286448.12/ ENSP00000286448.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2411              BC056141.1         66-2476
            2412-2594           AI522002.1         6-188               c
FEATURES             Location/Qualifiers
     source          1..2594
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="Xq28 and Yq12"
     gene            1..2594
                     /gene="VAMP7"
                     /gene_synonym="SYBL1; TI-VAMP; TIVAMP; VAMP-7"
                     /note="vesicle associated membrane protein 7"
                     /db_xref="GeneID:6845"
                     /db_xref="HGNC:HGNC:11486"
                     /db_xref="MIM:300053"
     exon            1..104
                     /gene="VAMP7"
                     /gene_synonym="SYBL1; TI-VAMP; TIVAMP; VAMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            105..259
                     /gene="VAMP7"
                     /gene_synonym="SYBL1; TI-VAMP; TIVAMP; VAMP-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..776
                     /gene="VAMP7"
                     /gene_synonym="SYBL1; TI-VAMP; TIVAMP; VAMP-7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptobrevin-like 1; tetanus neurotoxin-insensitive VAMP;
                     tetanus-insensitive VAMP; synaptobrevin-like protein 1"
                     /codon_start=1
                     /product="vesicle-associated membrane protein 7 isoform 1"
                     /protein_id="NP_005629.1"
                     /db_xref="CCDS:CCDS14770.4"
                     /db_xref="GeneID:6845"
                     /db_xref="HGNC:HGNC:11486"
                     /db_xref="MIM:300053"
                     /translation="MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLT
                     YSHGNYLFHYICQDRIVYLCITDDDFERSRAFNFLNEIKKRFQTTYGSRAQTALPYAM
                     NSEFSSVLAAQLKHHSENKGLDKVMETQAQVDELKGIMVRNIDLVAQRGERLELLIDK
                     TENLVDSSVTFKTTSRNLARAMCMKNLKLTIIIIIVSIVFIYIIVSPLCGGFTWPSCV
                     KK"
     exon            260..317
                     /gene="VAMP7"
                     /gene_synonym="SYBL1; TI-VAMP; TIVAMP; VAMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            318..455
                     /gene="VAMP7"
                     /gene_synonym="SYBL1; TI-VAMP; TIVAMP; VAMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            456..546
                     /gene="VAMP7"
                     /gene_synonym="SYBL1; TI-VAMP; TIVAMP; VAMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            547..614
                     /gene="VAMP7"
                     /gene_synonym="SYBL1; TI-VAMP; TIVAMP; VAMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            615..707
                     /gene="VAMP7"
                     /gene_synonym="SYBL1; TI-VAMP; TIVAMP; VAMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            708..2594
                     /gene="VAMP7"
                     /gene_synonym="SYBL1; TI-VAMP; TIVAMP; VAMP-7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2569..2574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VAMP7"
                     /gene_synonym="SYBL1; TI-VAMP; TIVAMP; VAMP-7"
                     /note="hexamer: AATAAA"
     polyA_site      2594
                     /gene="VAMP7"
                     /gene_synonym="SYBL1; TI-VAMP; TIVAMP; VAMP-7"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtccggt cccagcctcc tctgggagcg ggcagttggc gaccctgcac tgacccgcgt
       61 ccctccgtcc cgagcccgcg cgccctcaga gggtgcccgg acagactgaa gccatggcga
      121 ttctttttgc tgttgttgcc agggggacca ctatccttgc caaacatgct tggtgtggag
      181 gaaacttcct ggaggtgaca gagcagattc tggctaagat accttctgaa aataacaaac
      241 taacgtactc acatggcaat tatttgtttc attacatctg ccaagacagg attgtatatc
      301 tttgtatcac tgatgatgat tttgaacgtt cccgagcctt taattttctg aatgagataa
      361 agaagaggtt ccagactact tacggttcaa gagcacagac agcacttcca tatgccatga
      421 atagcgagtt ctcaagtgtc ttagctgcac agctgaagca tcactctgag aataagggcc
      481 tagacaaagt gatggagact caagcccaag tggatgaact gaaaggaatc atggtcagaa
      541 acatagatct ggtagctcag cgaggagaaa gattggaatt attgattgac aaaacagaaa
      601 atcttgtgga ttcttctgtc accttcaaaa ctaccagcag aaatcttgct cgagccatgt
      661 gtatgaagaa cctcaagctc actattatca tcatcatcgt atcaattgtg ttcatctata
      721 tcattgtttc acctctctgt ggtggattta catggccaag ctgtgtgaag aaataggaaa
      781 gaagaagtta ccattaacca aggatatgag agaacaagga gttaaaagca atccatgtga
      841 ctcaagcctt tcacatactg acagatggta tctgccagtc tcttcaaccc tcttctcact
      901 ttttaaaatc ttgttccatg cctccaggtt tatctttgtc ttatctacca gtttattcct
      961 gtgaacttca gattgaacca ttcattgcag cagtagcctt aaaaaggctt ttgtttattt
     1021 ctttggtttg ttaactagtg tcatctattt agagaaacat ttttgttttt aattgctcaa
     1081 agctgtcgcc gctagtctta tgagctatct actaaaacta tggagaaact ttgtatgtgc
     1141 acacaaaagt attcaagaga cagtattgct aacatctcat cttaatgtct tttgttattg
     1201 agaagtttta ggtgcttcaa aacaatataa atggataata gttgttattt ggggaattgt
     1261 aatgatgttg gtgctgcttc cttctaagag ctcagacaag taaagtatga aacattctta
     1321 tttcagttag atggggaaca ttttgctagc ccattagaag cacacagaat tatccttgtc
     1381 ctcctaatat tgactttcag gaataaagtt cagtgtgctg atcattcaca atacagtgga
     1441 tagcttgata tcttctgttt tcccattgca gttgatttga gaagatgaag gtttaaatat
     1501 tgttgaaagt tgcagttttt taaatgtgtt cctttttctt ctgtgaatat ttagggcaat
     1561 cgtgtcgcta atagaatatg tagtagaggg ggtggggagg taaattcctc tgacttgcca
     1621 aagaaaaaga agggaaccac agtggatatg ctagcatttt agctgtgcaa agggaggtag
     1681 tgtgggaaaa gtgtttccat tctgggaaaa gcccaaaccg aatacggtca gcagtcaact
     1741 ccagggtttg ggcttgattc ctgttgaata atagttttga gcattctttg tggttaaata
     1801 aattcttaaa tctgcctagt tttgatgaat tcttttgtga aacttgaaag agaatagaca
     1861 gtatgacata tagaattaat acaaaacagt ttaacaacca tttaactgca gtgtaagaaa
     1921 attggactgt aatcatatcg ctactggcat ctgttatcta gtatgcattt ctggtgtgta
     1981 tctgaaagga agacattttc taccctagat ccaattgcat ttatttatca ataagtgcca
     2041 ttaaattgaa attatattac attttacact ttctcaatga atgaacaaat tagtctgtag
     2101 aatctagcca cctgtttagc ctagtcatgt gccttgaaca tatatgtgtc ccataatctg
     2161 gctcatggta cctgttcttc tatccaaacc tttcaattca tgctacctga ttcatttatt
     2221 tgacatagat cttaggccca cttgaactct tttcttgttt atctagcata gcacaaacgt
     2281 ttttccagtc ttctttatca acactaatgc ctcttaattg catcagtatt tcctattgga
     2341 aaatacatct gttccagaaa aacatttggc attcctgaat aatttccaaa tgtttttaat
     2401 ccaaagaaaa aggtttaaag cttatttccc tttcttatac acacctgaat aaaattgatg
     2461 tgcatgtttt agggatcaat tacctaactg ttccttggtc tatttatgta taagaatgct
     2521 ttttaaagca catgtctcat tttaaatgac gcacaaactg aagatgttaa taaaatttaa
     2581 gagtaataca atga
//
