LOCUS       NP_006625                116 aa            linear   PRI 19-SEP-2024
DEFINITION  vesicle-associated membrane protein 5 [Homo sapiens].
ACCESSION   NP_006625
VERSION     NP_006625.1
DBSOURCE    REFSEQ: accession NM_006634.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 116)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 116)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 116)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   4  (residues 1 to 116)
  AUTHORS   Zhao,J., Xie,X., Yao,Y., He,Q., Zhang,R., Xia,H. and Zhang,Y.
  TITLE     Association of VAMP5 and MCC genetic polymorphisms with increased
            risk of Hirschsprung disease susceptibility in Southern Chinese
            children
  JOURNAL   Aging (Albany NY) 10 (4), 689-700 (2018)
   PUBMED   29695640
  REMARK    GeneRIF: This study provided new evidence of epistatic association
            of VAMP5 and MCC with increased risk of Hirschsprung disease
REFERENCE   5  (residues 1 to 116)
  AUTHORS   Shin,J.G., Kim,D.Y., Seo,J.M., Oh,J.T., Park,K.W., Kim,H.Y.,
            Park,B.L., Kim,J.H. and Shin,H.D.
  TITLE     Potential association of VAMP5 polymorphisms with total colonic
            aganglionosis in Hirschsprung disease
  JOURNAL   Neurogastroenterol Motil 28 (7), 1055-1063 (2016)
   PUBMED   26970437
  REMARK    GeneRIF: VAMP5 polymorphisms were found to be associated with the
            total colonic aganglionosis of Hirschsprung disease.
REFERENCE   6  (residues 1 to 116)
  AUTHORS   Hasan,N., Corbin,D. and Hu,C.
  TITLE     Fusogenic pairings of vesicle-associated membrane proteins (VAMPs)
            and plasma membrane t-SNAREs--VAMP5 as the exception
  JOURNAL   PLoS One 5 (12), e14238 (2010)
   PUBMED   21151919
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 116)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   8  (residues 1 to 116)
  AUTHORS   Brinkman,J.F., Ottenheim,C.P., de Jong,L.A., Zegers,R.H., de
            Smet,M.D., de Jong,P.T. and Bergen,A.A.
  TITLE     VAMP5 and VAMP8 are most likely not involved in primary open-angle
            glaucoma
  JOURNAL   Mol Vis 11, 582-586 (2005)
   PUBMED   16110299
  REMARK    GeneRIF: Our findings indicate that VAMP5 and VAMP8 are not
            involved in POAG in the Dutch population.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 116)
  AUTHORS   Zeng,Q., Tran,T.T., Tan,H.X. and Hong,W.
  TITLE     The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their
            correct subcellular targeting: the N-terminal extenSion of VAMP4
            contains a dominant autonomous targeting signal for the trans-Golgi
            network
  JOURNAL   J Biol Chem 278 (25), 23046-23054 (2003)
   PUBMED   12682051
REFERENCE   10 (residues 1 to 116)
  AUTHORS   Zeng,Q., Subramaniam,V.N., Wong,S.H., Tang,B.L., Parton,R.G.,
            Rea,S., James,D.E. and Hong,W.
  TITLE     A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased
            during in vitro myogenesis and present in the plasma membrane
  JOURNAL   Mol Biol Cell 9 (9), 2423-2437 (1998)
   PUBMED   9725904
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017891.1 and AC016753.9.
            
            Summary: Synaptobrevins/VAMPs, syntaxins, and the 25-kD
            synaptosomal-associated protein are the main components of a
            protein complex involved in the docking and/or fusion of vesicles
            and cell membranes. The VAMP5 gene is a member of the
            vesicle-associated membrane protein (VAMP)/synaptobrevin family and
            the SNARE superfamily. This VAMP family member may participate in
            vesicle trafficking events that are associated with myogenesis.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.541171.1, BC017891.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306384.5/ ENSP00000305647.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..116
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     Protein         1..116
                     /product="vesicle-associated membrane protein 5"
                     /note="myobrevin; VAMP-5"
                     /calculated_mol_wt=12674
     Region          3..70
                     /region_name="R-SNARE_VAMP5"
                     /note="SNARE motif of VAMP5; cd15872"
                     /db_xref="CDD:277225"
     Site            order(5..7,9..10,12..17,19..21,23,26..27,29..31,33..38,
                     40..45,47..52,54..59,61..63)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277225"
     Site            30
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277225"
     Site            40..41
                     /site_type="other"
                     /note="(Microbial infection) Cleavage, by C.botulinum
                     neurotoxin type X (BoNT/X).
                     /evidence=ECO:0000269|PubMed:28770820; propagated from
                     UniProtKB/Swiss-Prot (O95183.1)"
     Site            41
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z2P8; propagated from
                     UniProtKB/Swiss-Prot (O95183.1)"
     Site            48
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (O95183.1)"
     Site            49
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (O95183.1)"
     Site            73..93
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O95183.1)"
     Region          96..116
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O95183.1)"
     CDS             1..116
                     /gene="VAMP5"
                     /coded_by="NM_006634.3:61..411"
                     /db_xref="CCDS:CCDS1980.1"
                     /db_xref="GeneID:10791"
                     /db_xref="HGNC:HGNC:12646"
                     /db_xref="MIM:607029"
ORIGIN      
        1 magielercq qqanevteim rnnfgkvler gvklaelqqr sdqlldmsst fnkttqnlaq
       61 kkcweniryr icvglvvvgv lliilivllv vflpqssdss saprtqdagi asgpgn
//
